ISTH overt DIC score

ISTH overt DIC

Sum the four Taylor 2001 ISTH SSC overt DIC laboratory items (platelets, fibrin-related marker, PT prolongation, fibrinogen) and return the published <5 / >=5 band.

LIVE $0.005 USDC GET /api/calc/isth_dic

Markdown: /docs/isth-dic.md · Canonical: https://magentlab.com/docs/isth-dic

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the four Taylor 2001 ISTH SSC overt DIC laboratory items (platelets, fibrin-related marker, PT prolongation, fibrinogen) and return the published <5 / >=5 band.

When to use

When an agent needs the published ISTH overt DIC point total and band from laboratory items and must not invent a DIC diagnosis, a D-dimer grade, or the non-overt serial score.

When not to use

Not a medical device.
Not a diagnosis of DIC without an underlying disorder associated with DIC. The ISTH prerequisite (an underlying disorder known to be associated with DIC) is caller-side; magent scores the four laboratory items only.
Not the ISTH non-overt serial DIC algorithm.
magent does not grade D-dimer assays. fibrin_related_marker is a caller-assigned none, moderate, or strong value.
Does not return mortality percents. Band >=5 is compatible with overt DIC; band <5 is not compatible with overt DIC.

Formula

ISTH overt DIC = platelets_10e9_l (>=100 → 0; 50 to <100 → 1; <50 → 2) + fibrin_related_marker (none 0, moderate 2, strong 3) + pt_prolongation_sec (<3 → 0; >=3 and <6 → 1; >=6 → 2) + fibrinogen_g_l (>=1.0 → 0; <1.0 → 1); max 8; bands <5 / >=5

Citation

Title: Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation
Authors: Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M
Source: Thromb Haemost. 2001;86(5):1327-1330
DOI: 10.1055/s-0037-1616068

Worked example

All laboratory items non-scoring

Given: fibrin_related_marker=nonefibrinogen_g_l=2.5platelets_10e9_l=180pt_prolongation_sec=1.0

Platelets 180 >= 100 → 0; fibrin_related_marker none → 0; PT prolongation 1.0 < 3 → 0; fibrinogen 2.5 g/L >= 1.0 → 0
Score = 0 (max 8); band <5 (not compatible with overt DIC)

Also searched as

ISTH DIC score
ISTH overt DIC
Taylor DIC score
disseminated intravascular coagulation ISTH
ISTH SSC DIC
overt DIC criteria
fibrin related marker DIC
ISTH DIC algorithm

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/isth_dic?platelets_10e9_l=180&fibrin_related_marker=none&pt_prolongation_sec=1.0&fibrinogen_g_l=2.5

Full URL: https://api.magentlab.com/api/calc/isth_dic?platelets_10e9_l=180&fibrin_related_marker=none&pt_prolongation_sec=1.0&fibrinogen_g_l=2.5

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/isth_dic?platelets_10e9_l=180&fibrin_related_marker=none&pt_prolongation_sec=1.0&fibrinogen_g_l=2.5"

Parameters

Name	Type	Required	Description
`platelets_10e9_l`	number	required	Platelet count ×10^9/L (1-2000). >=100 scores 0; 50 to <100 scores 1; <50 scores 2. 100 scores 0; 50 scores 1; 49 scores 2 (Taylor 2001).
`fibrin_related_marker`	string	required · none, moderate, strong	Caller-assigned ISTH fibrin-related marker (Taylor 2001). none scores 0; moderate scores 2; strong scores 3. magent does not grade D-dimer assays.
`pt_prolongation_sec`	number	required	Prothrombin time prolongation in seconds above the laboratory ULN (0-30). <3 scores 0; >=3 and <6 scores 1; >=6 scores 2. 3.0 and 5.9 score 1; 6.0 scores 2; 2.9 scores 0 (Taylor 2001 table gaps filled at 3 and 6).
`fibrinogen_g_l`	number	optional	Fibrinogen in g/L (0.1-10). Provide this or fibrinogen_mg_dl, not both. >=1.0 scores 0; <1.0 scores 1. 1.0 scores 0 (Taylor 2001).
`fibrinogen_mg_dl`	number	optional	Fibrinogen in mg/dL (10-1000). Converted as g/L = mg/dL / 100. Provide this or fibrinogen_g_l, not both.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/isth_dic Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "fibrin_related_marker": "none",
      "fibrinogen_g_l": "2.5",
      "platelets_10e9_l": "180",
      "pt_prolongation_sec": "1.0"
    },
    {
      "fibrin_related_marker": "none",
      "fibrinogen_g_l": "2.5",
      "platelets_10e9_l": "180",
      "pt_prolongation_sec": "1.0"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/isth_dic",
  "items": [
    {
      "components": [
        {
          "value": 180.0,
          "factor": "platelets",
          "points": 0,
          "present": false
        },
        {
          "value": "none",
          "factor": "fibrin_related_marker",
          "points": 0,
          "present": false
        },
        {
          "value": 1.0,
          "factor": "pt_prolongation",
          "points": 0,
          "present": false
        },
        {
          "value": 2.5,
          "factor": "fibrinogen",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M",
        "doi": "10.1055/s-0037-1616068",
        "id": "taylor-2001",
        "pmid": "11816725",
        "source": "Thromb Haemost. 2001;86(5):1327-1330",
        "title": "Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation"
      },
      "formula": "isth_dic",
      "formula_expression": "ISTH overt DIC = platelets_10e9_l (>=100 → 0; 50 to <100 → 1; <50 → 2) + fibrin_related_marker (none 0, moderate 2, strong 3) + pt_prolongation_sec (<3 → 0; >=3 and <6 → 1; >=6 → 2) + fibrinogen_g_l (>=1.0 → 0; <1.0 → 1); max 8; bands <5 / >=5",
      "max_score": 8,
      "score": 0,
      "platelets_10e9_l": 180.0,
      "fibrin_related_marker": "none",
      "fibrinogen_g_l": 2.5,
      "isth_dic_band": "<5",
      "pt_prolongation_sec": 1.0
    },
    {
      "components": [
        {
          "value": 180.0,
          "factor": "platelets",
          "points": 0,
          "present": false
        },
        {
          "value": "none",
          "factor": "fibrin_related_marker",
          "points": 0,
          "present": false
        },
        {
          "value": 1.0,
          "factor": "pt_prolongation",
          "points": 0,
          "present": false
        },
        {
          "value": 2.5,
          "factor": "fibrinogen",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M",
        "doi": "10.1055/s-0037-1616068",
        "id": "taylor-2001",
        "pmid": "11816725",
        "source": "Thromb Haemost. 2001;86(5):1327-1330",
        "title": "Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation"
      },
      "formula": "isth_dic",
      "formula_expression": "ISTH overt DIC = platelets_10e9_l (>=100 → 0; 50 to <100 → 1; <50 → 2) + fibrin_related_marker (none 0, moderate 2, strong 3) + pt_prolongation_sec (<3 → 0; >=3 and <6 → 1; >=6 → 2) + fibrinogen_g_l (>=1.0 → 0; <1.0 → 1); max 8; bands <5 / >=5",
      "max_score": 8,
      "score": 0,
      "platelets_10e9_l": 180.0,
      "fibrin_related_marker": "none",
      "fibrinogen_g_l": 2.5,
      "isth_dic_band": "<5",
      "pt_prolongation_sec": 1.0
    }
  ]
}

Response

Field	Type	Description
`formula`	string	isth_dic
`formula_expression`	string	Exact expression used
`score`	integer	Total points 0-8
`max_score`	integer	Always 8
`isth_dic_band`	string	<5 (not compatible with overt DIC; suggestive of non-overt) or >=5 (compatible with overt DIC). Score 5 is overt. Not a mortality percent.
`platelets_10e9_l`	number	Platelet count used (×10^9/L)
`fibrin_related_marker`	string	Caller-assigned none, moderate, or strong marker used
`pt_prolongation_sec`	number	PT prolongation used, seconds above ULN
`fibrinogen_g_l`	number	Fibrinogen used in g/L (after mg/dL conversion when that unit is supplied)
`components`	array	Per-item points
`citation`	object	Taylor 2001 citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 180.0,
      "factor": "platelets",
      "points": 0,
      "present": false
    },
    {
      "value": "none",
      "factor": "fibrin_related_marker",
      "points": 0,
      "present": false
    },
    {
      "value": 1.0,
      "factor": "pt_prolongation",
      "points": 0,
      "present": false
    },
    {
      "value": 2.5,
      "factor": "fibrinogen",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Taylor FB Jr, Toh CH, Hoots WK, Wada H, Levi M",
    "doi": "10.1055/s-0037-1616068",
    "id": "taylor-2001",
    "pmid": "11816725",
    "source": "Thromb Haemost. 2001;86(5):1327-1330",
    "title": "Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation"
  },
  "formula": "isth_dic",
  "formula_expression": "ISTH overt DIC = platelets_10e9_l (>=100 → 0; 50 to <100 → 1; <50 → 2) + fibrin_related_marker (none 0, moderate 2, strong 3) + pt_prolongation_sec (<3 → 0; >=3 and <6 → 1; >=6 → 2) + fibrinogen_g_l (>=1.0 → 0; <1.0 → 1); max 8; bands <5 / >=5",
  "max_score": 8,
  "score": 0,
  "platelets_10e9_l": 180.0,
  "fibrin_related_marker": "none",
  "fibrinogen_g_l": 2.5,
  "isth_dic_band": "<5",
  "pt_prolongation_sec": 1.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_platelets`	platelets_10e9_l must be a number from 1 to 2000 Returned before settlement; you are not charged.
400	`invalid_fibrin_marker`	fibrin_related_marker must be none, moderate, or strong (Taylor 2001 ISTH DIC). Returned before settlement; you are not charged.
400	`invalid_pt_prolongation`	pt_prolongation_sec must be a number from 0 to 30 (seconds above ULN; Taylor 2001). Returned before settlement; you are not charged.
400	`invalid_fibrinogen`	fibrinogen_g_l (0.1-10) or fibrinogen_mg_dl (10-1000) is required, not both. Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

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4Ts score — Compute the Lo 2006 4Ts score as the sum of four caller-assigned integers 0-2 (thrombocytopenia, timing, thrombosis, other causes).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.