Infection / VTE · LIVE

MASCC risk index (Klastersky)

MASCC

Sum the Klastersky 2000 MASCC risk-index weights for febrile neutropenia and return low-risk (≥21) or high-risk (<21).

LIVE $0.005 USDC GET /api/calc/mascc

Markdown: /docs/mascc.md · Canonical: https://magentlab.com/docs/mascc

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Klastersky 2000 MASCC risk-index weights for febrile neutropenia and return low-risk (≥21) or high-risk (<21).

When to use

When an agent needs the published MASCC point total and must not invent an outpatient-chemotherapy or admission decision.

When not to use

Not a medical device and not an outpatient-chemotherapy, admission, or discharge order. magent does not examine the patient.
Burden of illness is one caller-assigned value (none_or_mild, moderate, or severe), not cumulative. magent does not grade symptoms from a chart narrative.
no_hypotension is the published SBP >90 mm Hg criterion as assigned by the caller. magent does not read a blood pressure.
solid_tumor_or_no_prior_fungal is one item: solid tumor or hematologic malignancy without previous fungal infection (Klastersky 2000). magent does not classify tumor type from histology text.
Low-risk is score ≥21 (max 26). High-risk is score <21. This is the published index only.

Formula

MASCC = burden (none_or_mild 5, moderate 3, severe 0; one value) + no_hypotension 5 + no_copd 4 + solid_tumor_or_no_prior_fungal 4 + outpatient 3 + no_dehydration 3 + age_lt_60 2; Klastersky 2000; max 26; low-risk ≥21

Citation

Title: The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients
Authors: Klastersky J, Paesmans M, Rubenstein EB, Boyer M, Elting L, Feld R, Gallagher J, Herrstedt J, Rapoport B, Rolston K, Talcott J
Source: J Clin Oncol. 2000;18(16):3038-3051
DOI: 10.1200/JCO.2000.18.16.3038

Worked example

Maximum score, low-risk

Given: age_lt_60=trueburden=none_or_mildno_copd=trueno_dehydration=trueno_hypotension=trueoutpatient=truesolid_tumor_or_no_prior_fungal=true

Burden none_or_mild → 5
no_hypotension → 5; no_copd → 4; solid_tumor_or_no_prior_fungal → 4; outpatient → 3; no_dehydration → 3; age_lt_60 → 2
Score = 26 (max 26); mascc_band = low_risk (≥21)

Severe burden, no protective flags

Given: age_lt_60=falseburden=severeno_copd=falseno_dehydration=falseno_hypotension=falseoutpatient=falsesolid_tumor_or_no_prior_fungal=false

Burden severe → 0; all six flags false → 0
Score = 0 (max 26); mascc_band = high_risk (<21)

Also searched as

MASCC risk index
MASCC score
febrile neutropenia score
Klastersky MASCC
neutropenic fever risk
MASCC index

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/mascc?burden=none_or_mild&no_hypotension=true&no_copd=true&solid_tumor_or_no_prior_fungal=true&outpatient=true&no_dehydration=true&age_lt_60=true

Full URL: https://api.magentlab.com/api/calc/mascc?burden=none_or_mild&no_hypotension=true&no_copd=true&solid_tumor_or_no_prior_fungal=true&outpatient=true&no_dehydration=true&age_lt_60=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/mascc?burden=none_or_mild&no_hypotension=true&no_copd=true&solid_tumor_or_no_prior_fungal=true&outpatient=true&no_dehydration=true&age_lt_60=true"

Parameters

Name	Type	Required	Description
`burden`	string	required · none_or_mild, moderate, severe	Caller-assigned burden of illness (none_or_mild, moderate, or severe). Klastersky 2000: none_or_mild → 5, moderate → 3, severe → 0. One value, not cumulative.
`no_hypotension`	boolean	required	No hypotension (SBP >90 mm Hg) as assigned by the caller (Klastersky 2000). true scores 5. magent does not read a blood pressure.
`no_copd`	boolean	required	No COPD as assigned by the caller (Klastersky 2000). true scores 4.
`solid_tumor_or_no_prior_fungal`	boolean	required	Solid tumor, or hematologic malignancy without previous fungal infection, as assigned by the caller (Klastersky 2000). One item. true scores 4.
`outpatient`	boolean	required	Outpatient status at fever onset as assigned by the caller (Klastersky 2000). true scores 3.
`no_dehydration`	boolean	required	No dehydration requiring parenteral fluids as assigned by the caller (Klastersky 2000). true scores 3.
`age_lt_60`	boolean	required	Age <60 years as assigned by the caller (Klastersky 2000). true scores 2. magent does not parse a numeric age here.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/mascc Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age_lt_60": "true",
      "burden": "none_or_mild",
      "no_copd": "true",
      "no_dehydration": "true",
      "no_hypotension": "true",
      "outpatient": "true",
      "solid_tumor_or_no_prior_fungal": "true"
    },
    {
      "age_lt_60": "true",
      "burden": "none_or_mild",
      "no_copd": "true",
      "no_dehydration": "true",
      "no_hypotension": "true",
      "outpatient": "true",
      "solid_tumor_or_no_prior_fungal": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/mascc",
  "items": [
    {
      "components": [
        {
          "value": "none_or_mild",
          "factor": "burden",
          "points": 5,
          "present": true
        },
        {
          "factor": "no_hypotension",
          "points": 5,
          "present": true
        },
        {
          "factor": "no_copd",
          "points": 4,
          "present": true
        },
        {
          "factor": "solid_tumor_or_no_prior_fungal",
          "points": 4,
          "present": true
        },
        {
          "factor": "outpatient",
          "points": 3,
          "present": true
        },
        {
          "factor": "no_dehydration",
          "points": 3,
          "present": true
        },
        {
          "factor": "age_lt_60",
          "points": 2,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Klastersky J, Paesmans M, Rubenstein EB, Boyer M, Elting L, Feld R, Gallagher J, Herrstedt J, Rapoport B, Rolston K, Talcott J",
        "doi": "10.1200/JCO.2000.18.16.3038",
        "id": "klastersky-2000",
        "pmid": "10944139",
        "source": "J Clin Oncol. 2000;18(16):3038-3051",
        "title": "The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients"
      },
      "formula": "mascc",
      "formula_expression": "MASCC = burden (none_or_mild 5, moderate 3, severe 0; one value) + no_hypotension 5 + no_copd 4 + solid_tumor_or_no_prior_fungal 4 + outpatient 3 + no_dehydration 3 + age_lt_60 2; Klastersky 2000; max 26; low-risk ≥21",
      "max_score": 26,
      "score": 26,
      "burden": "none_or_mild",
      "mascc_band": "low_risk"
    },
    {
      "components": [
        {
          "value": "none_or_mild",
          "factor": "burden",
          "points": 5,
          "present": true
        },
        {
          "factor": "no_hypotension",
          "points": 5,
          "present": true
        },
        {
          "factor": "no_copd",
          "points": 4,
          "present": true
        },
        {
          "factor": "solid_tumor_or_no_prior_fungal",
          "points": 4,
          "present": true
        },
        {
          "factor": "outpatient",
          "points": 3,
          "present": true
        },
        {
          "factor": "no_dehydration",
          "points": 3,
          "present": true
        },
        {
          "factor": "age_lt_60",
          "points": 2,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Klastersky J, Paesmans M, Rubenstein EB, Boyer M, Elting L, Feld R, Gallagher J, Herrstedt J, Rapoport B, Rolston K, Talcott J",
        "doi": "10.1200/JCO.2000.18.16.3038",
        "id": "klastersky-2000",
        "pmid": "10944139",
        "source": "J Clin Oncol. 2000;18(16):3038-3051",
        "title": "The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients"
      },
      "formula": "mascc",
      "formula_expression": "MASCC = burden (none_or_mild 5, moderate 3, severe 0; one value) + no_hypotension 5 + no_copd 4 + solid_tumor_or_no_prior_fungal 4 + outpatient 3 + no_dehydration 3 + age_lt_60 2; Klastersky 2000; max 26; low-risk ≥21",
      "max_score": 26,
      "score": 26,
      "burden": "none_or_mild",
      "mascc_band": "low_risk"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	mascc
`formula_expression`	string	Exact expression used
`score`	integer	MASCC points 0-26
`max_score`	integer	Always 26
`mascc_band`	string	low_risk when score ≥21, high_risk when score <21 (Klastersky 2000). Not an outpatient-chemotherapy order.
`burden`	string	Caller-assigned burden of illness used (none_or_mild, moderate, or severe)
`components`	array	Per-factor points
`citation`	object	Klastersky 2000 J Clin Oncol citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "none_or_mild",
      "factor": "burden",
      "points": 5,
      "present": true
    },
    {
      "factor": "no_hypotension",
      "points": 5,
      "present": true
    },
    {
      "factor": "no_copd",
      "points": 4,
      "present": true
    },
    {
      "factor": "solid_tumor_or_no_prior_fungal",
      "points": 4,
      "present": true
    },
    {
      "factor": "outpatient",
      "points": 3,
      "present": true
    },
    {
      "factor": "no_dehydration",
      "points": 3,
      "present": true
    },
    {
      "factor": "age_lt_60",
      "points": 2,
      "present": true
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Klastersky J, Paesmans M, Rubenstein EB, Boyer M, Elting L, Feld R, Gallagher J, Herrstedt J, Rapoport B, Rolston K, Talcott J",
    "doi": "10.1200/JCO.2000.18.16.3038",
    "id": "klastersky-2000",
    "pmid": "10944139",
    "source": "J Clin Oncol. 2000;18(16):3038-3051",
    "title": "The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients"
  },
  "formula": "mascc",
  "formula_expression": "MASCC = burden (none_or_mild 5, moderate 3, severe 0; one value) + no_hypotension 5 + no_copd 4 + solid_tumor_or_no_prior_fungal 4 + outpatient 3 + no_dehydration 3 + age_lt_60 2; Klastersky 2000; max 26; low-risk ≥21",
  "max_score": 26,
  "score": 26,
  "burden": "none_or_mild",
  "mascc_band": "low_risk"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_mascc_burden`	burden must be none_or_mild, moderate, or severe (Klastersky 2000 MASCC; not cumulative). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

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qSOFA — Compute the Sepsis-3 qSOFA score from respiratory rate, caller-assigned altered mentation, and systolic blood pressure.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.