NINCDS-ADRDA Alzheimer's criteria (McKhann 1984)

NINCDS-ADRDA

Echo the caller-assigned McKhann 1984 NINCDS-ADRDA diagnostic category (definite, probable, possible, or unlikely) with the published defining-features description. magent does not examine the patient. Not NIA-AA 2011/2018. Not DSM.

LIVE $0.005 USDC GET /api/calc/nincds_adrda

Markdown: /docs/nincds-adrda.md · Canonical: https://magentlab.com/docs/nincds-adrda

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent already has a McKhann 1984 NINCDS-ADRDA category as assigned by the caller and needs the published category description. magent does not examine the patient, apply NIA-AA 2011/2018, apply DSM, or diagnose Alzheimer's disease.

When not to use

Not a medical device. magent does not examine the patient.
The caller assigns McKhann 1984 NINCDS-ADRDA category definite, probable, possible, or unlikely. magent does not apply the criteria to raw findings, read histopathology, or diagnose Alzheimer's disease.
McKhann 1984 NINCDS-ADRDA tokens only. Not NIA-AA 2011 or 2018. Not DSM. This tool does not convert NINCDS-ADRDA to NIA-AA or DSM.
Not an Alzheimer's diagnosis. Not a treatment order.

Formula

category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient.

Citation

Title: Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
Authors: McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM
Source: Neurology. 1984;34(7):939-944
DOI: 10.1212/wnl.34.7.939

Worked example

Probable Alzheimer's disease clinical criteria

Given: category=probable

category probable as assigned by the caller
dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits

Definite with histopathologic confirmation

Given: category=definite

category definite as assigned by the caller
clinical criteria for probable Alzheimer's disease and histopathologic confirmation

Also searched as

NINCDS-ADRDA
McKhann 1984
NINCDS ADRDA criteria
probable Alzheimer's disease
definite Alzheimer's disease
NINCDS-ADRDA Work Group
McKhann Alzheimer criteria
possible Alzheimer
unlikely Alzheimer

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/nincds_adrda?category=probable

Full URL: https://api.magentlab.com/api/calc/nincds_adrda?category=probable

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/nincds_adrda?category=probable"

Parameters

Name	Type	Required	Description
`category`	string	required	McKhann 1984 NINCDS-ADRDA diagnostic category as assigned by the caller (definite: clinical criteria for probable Alzheimer's disease and histopathologic confirmation; probable: dementia, deficits in two or more areas of cognition, progressive worsening, no disturbance of consciousness, onset between 40 and 90, absence of other diseases that could account for the deficits; possible: dementia syndrome with atypical onset, presentation, or course, or a second systemic or brain disease capable of producing dementia but not thought to be the cause; unlikely: sudden onset, early focal neurologic findings, or seizures or gait disturbance at onset). Token definite, probable, possible, or unlikely only; case-insensitive. Reject NIA-AA, DSM, and probable AD. Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/nincds_adrda Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "category": "probable"
    },
    {
      "category": "probable"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/nincds_adrda",
  "items": [
    {
      "description": "Dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits",
      "components": [
        {
          "factor": "definite",
          "met": false
        },
        {
          "factor": "probable",
          "met": true
        },
        {
          "factor": "possible",
          "met": false
        },
        {
          "factor": "unlikely",
          "met": false
        }
      ],
      "category": "probable",
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM",
        "doi": "10.1212/wnl.34.7.939",
        "id": "mckhann-1984",
        "pmid": "6610841",
        "source": "Neurology. 1984;34(7):939-944",
        "title": "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease"
      },
      "formula": "nincds_adrda",
      "formula_expression": "category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient."
    },
    {
      "description": "Dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits",
      "components": [
        {
          "factor": "definite",
          "met": false
        },
        {
          "factor": "probable",
          "met": true
        },
        {
          "factor": "possible",
          "met": false
        },
        {
          "factor": "unlikely",
          "met": false
        }
      ],
      "category": "probable",
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM",
        "doi": "10.1212/wnl.34.7.939",
        "id": "mckhann-1984",
        "pmid": "6610841",
        "source": "Neurology. 1984;34(7):939-944",
        "title": "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease"
      },
      "formula": "nincds_adrda",
      "formula_expression": "category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient."
    }
  ]
}

Response

Field	Type	Description
`formula`	string	nincds_adrda
`formula_expression`	string	Published McKhann 1984 NINCDS-ADRDA category rule
`category`	string	Caller-assigned McKhann 1984 token: definite, probable, possible, or unlikely
`description`	string	McKhann 1984 defining-features wording for that category
`components`	array	Per-category Tree rows definite, probable, possible, unlikely with factor and met; exactly one is met
`citation`	object	McKhann 1984 Neurology citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "description": "Dementia; deficits in two or more areas of cognition; progressive worsening; no disturbance of consciousness; onset between 40 and 90; absence of other diseases that could account for the deficits",
  "components": [
    {
      "factor": "definite",
      "met": false
    },
    {
      "factor": "probable",
      "met": true
    },
    {
      "factor": "possible",
      "met": false
    },
    {
      "factor": "unlikely",
      "met": false
    }
  ],
  "category": "probable",
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM",
    "doi": "10.1212/wnl.34.7.939",
    "id": "mckhann-1984",
    "pmid": "6610841",
    "source": "Neurology. 1984;34(7):939-944",
    "title": "Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease"
  },
  "formula": "nincds_adrda",
  "formula_expression": "category in {definite, probable, possible, unlikely} as assigned by the caller (McKhann 1984 NINCDS-ADRDA diagnostic categories). Not NIA-AA 2011/2018. Not DSM. magent does not examine the patient."
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_nincds_adrda`	NINCDS-ADRDA needs the McKhann 1984 category token definite, probable, possible, or unlikely. Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

GDS-15 — Sum fifteen Sheikh 1986 GDS-15 yes/no items using that paper's reverse-scoring key and return the published 0-15 total. Does not apply later total-score severity bands.
4AT — Sum the Bellelli 2014 4AT items and return unlikely (0), possible cognitive impairment (1–3), or possible delirium (≥4).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.