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UISS for localized RCC (Zisman 2002)

UISS

Apply the Zisman 2002 localized N0M0 three-group UISS algorithm to caller-assigned 1997 pathological T, Fuhrman grade, and ECOG PS and return low_risk, intermediate_risk, or high_risk. Does not compute a predicted 5-year disease-specific survival.

LIVE $0.005 USDC GET /api/calc/uiss

Markdown: /docs/uiss.md · Canonical: https://magentlab.com/docs/uiss

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Zisman 2002 localized N0M0 three-group UISS algorithm to caller-assigned 1997 pathological T, Fuhrman grade, and ECOG PS and return low_risk, intermediate_risk, or high_risk. Does not compute a predicted 5-year disease-specific survival.

When to use

When an agent already has surgically resected unilateral RCC that is N0M0, a 1997 pathological T, a Fuhrman 1982 grade, and an ECOG 0-4, and needs the published Zisman 2002 three-group box. magent does not assign TNM, read slides, or observe performance status. Not 2001 UISS I-V, not metastatic UISS, and not SSIGN.

When not to use

• Not a medical device and not a diagnosis of renal cell carcinoma. magent does not assign TNM or read slides.
• Zisman 2002 localized N0M0 three-group algorithm only (as reproduced in EAU/ESMO decision boxes of that paper). Not the 2001 five-group UISS I-V. Not metastatic UISS. N-positive or M-positive disease is out of scope.
• Not SSIGN. This tool does not implement the Mayo SSIGN score.
• t_stage is caller-assigned 1997 pathological T (t1-t4). fuhrman_grade and ecog are caller-assigned. magent does not grade nuclei or observe the patient.
• Requires surgically resected unilateral RCC with explicit n0_m0 true. This tool does not emit a predicted 5-year disease-specific survival; historical cohort percentages in Zisman 2002 are published cohort results, not a calculated field.

Formula

UISS localized N0M0 (Zisman 2002): low_risk if t_stage t1 AND fuhrman_grade in {1, 2} AND ecog 0; high_risk if (t_stage t3 AND fuhrman_grade in {2, 3, 4} AND ecog >= 1) OR t_stage t4; else intermediate_risk. Requires surgically resected unilateral RCC with 1997 pathological T and explicit N0M0. Not 2001 five-group I-V. Not metastatic UISS. Not SSIGN.

Citation

Title

Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma

Authors

Zisman A, Pantuck AJ, Wieder J, Chao DH, Dorey F, Said JW, deKernion JB, Figlin RA, Belldegrun AS

Source

J Clin Oncol. 2002;20(23):4559-4566

DOI

10.1200/JCO.2002.05.111

Worked example

Also searched as

• UISS
• UCLA Integrated Staging System
• Zisman UISS
• Zisman 2002
• localized RCC UISS
• N0M0 UISS
• renal cell carcinoma UISS
• UISS low intermediate high

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/uiss?t_stage=t1&n0_m0=true&fuhrman_grade=1&ecog=0

Full URL: https://api.magentlab.com/api/calc/uiss?t_stage=t1&n0_m0=true&fuhrman_grade=1&ecog=0

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/uiss?t_stage=t1&n0_m0=true&fuhrman_grade=1&ecog=0"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/uiss Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "ecog": "0",
      "fuhrman_grade": "1",
      "n0_m0": "true",
      "t_stage": "t1"
    },
    {
      "ecog": "0",
      "fuhrman_grade": "1",
      "n0_m0": "true",
      "t_stage": "t1"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/uiss",
  "items": [
    {
      "components": [
        {
          "value": "t1",
          "factor": "t_stage",
          "met": true
        },
        {
          "factor": "n0_m0",
          "met": true
        },
        {
          "value": 1,
          "factor": "fuhrman_grade",
          "met": true
        },
        {
          "value": 0,
          "factor": "ecog",
          "met": true
        },
        {
          "factor": "low_risk",
          "met": true
        },
        {
          "factor": "intermediate_risk",
          "met": false
        },
        {
          "factor": "high_risk",
          "met": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Zisman A, Pantuck AJ, Wieder J, Chao DH, Dorey F, Said JW, deKernion JB, Figlin RA, Belldegrun AS",
        "doi": "10.1200/JCO.2002.05.111",
        "id": "zisman-2002",
        "pmid": "12454113",
        "source": "J Clin Oncol. 2002;20(23):4559-4566",
        "title": "Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma"
      },
      "formula": "uiss",
      "formula_expression": "UISS localized N0M0 (Zisman 2002): low_risk if t_stage t1 AND fuhrman_grade in {1, 2} AND ecog 0; high_risk if (t_stage t3 AND fuhrman_grade in {2, 3, 4} AND ecog >= 1) OR t_stage t4; else intermediate_risk. Requires surgically resected unilateral RCC with 1997 pathological T and explicit N0M0. Not 2001 five-group I-V. Not metastatic UISS. Not SSIGN.",
      "ecog": 0,
      "fuhrman_grade": 1,
      "n0_m0": true,
      "t_stage": "t1",
      "uiss_group": "low_risk"
    },
    {
      "components": [
        {
          "value": "t1",
          "factor": "t_stage",
          "met": true
        },
        {
          "factor": "n0_m0",
          "met": true
        },
        {
          "value": 1,
          "factor": "fuhrman_grade",
          "met": true
        },
        {
          "value": 0,
          "factor": "ecog",
          "met": true
        },
        {
          "factor": "low_risk",
          "met": true
        },
        {
          "factor": "intermediate_risk",
          "met": false
        },
        {
          "factor": "high_risk",
          "met": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Zisman A, Pantuck AJ, Wieder J, Chao DH, Dorey F, Said JW, deKernion JB, Figlin RA, Belldegrun AS",
        "doi": "10.1200/JCO.2002.05.111",
        "id": "zisman-2002",
        "pmid": "12454113",
        "source": "J Clin Oncol. 2002;20(23):4559-4566",
        "title": "Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma"
      },
      "formula": "uiss",
      "formula_expression": "UISS localized N0M0 (Zisman 2002): low_risk if t_stage t1 AND fuhrman_grade in {1, 2} AND ecog 0; high_risk if (t_stage t3 AND fuhrman_grade in {2, 3, 4} AND ecog >= 1) OR t_stage t4; else intermediate_risk. Requires surgically resected unilateral RCC with 1997 pathological T and explicit N0M0. Not 2001 five-group I-V. Not metastatic UISS. Not SSIGN.",
      "ecog": 0,
      "fuhrman_grade": 1,
      "n0_m0": true,
      "t_stage": "t1",
      "uiss_group": "low_risk"
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "t1",
      "factor": "t_stage",
      "met": true
    },
    {
      "factor": "n0_m0",
      "met": true
    },
    {
      "value": 1,
      "factor": "fuhrman_grade",
      "met": true
    },
    {
      "value": 0,
      "factor": "ecog",
      "met": true
    },
    {
      "factor": "low_risk",
      "met": true
    },
    {
      "factor": "intermediate_risk",
      "met": false
    },
    {
      "factor": "high_risk",
      "met": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Zisman A, Pantuck AJ, Wieder J, Chao DH, Dorey F, Said JW, deKernion JB, Figlin RA, Belldegrun AS",
    "doi": "10.1200/JCO.2002.05.111",
    "id": "zisman-2002",
    "pmid": "12454113",
    "source": "J Clin Oncol. 2002;20(23):4559-4566",
    "title": "Risk group assessment and clinical outcome algorithm to predict the natural history of patients with surgically resected renal cell carcinoma"
  },
  "formula": "uiss",
  "formula_expression": "UISS localized N0M0 (Zisman 2002): low_risk if t_stage t1 AND fuhrman_grade in {1, 2} AND ecog 0; high_risk if (t_stage t3 AND fuhrman_grade in {2, 3, 4} AND ecog >= 1) OR t_stage t4; else intermediate_risk. Requires surgically resected unilateral RCC with 1997 pathological T and explicit N0M0. Not 2001 five-group I-V. Not metastatic UISS. Not SSIGN.",
  "ecog": 0,
  "fuhrman_grade": 1,
  "n0_m0": true,
  "t_stage": "t1",
  "uiss_group": "low_risk"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Fuhrman — Echo the caller-assigned Fuhrman 1982 nuclear grade (1-4) with the published nuclear-feature description. magent does not read slides. Not WHO/ISUP 2016.
• Motzer — Sum the Motzer 1999 MSKCC adverse factors for advanced RCC and return favorable (0), intermediate (1–2), or poor (≥3). Motzer 1999 reported median survival of 20, 10, and 4 months in those interferon-era groups as published cohort results, not a predicted survival.
• IMDC — Sum the Heng 2009 IMDC adverse factors for metastatic RCC treated with VEGF-targeted agents and return favorable (0), intermediate (1–2), or poor (3–6). Heng 2009 reported 2-year OS 75% (median not reached), 53% (median 27 months), and 7% (median 8.8 months) in those groups.
• ECOG — Return the Oken 1982 ECOG performance status grade 0-4 from a caller-assigned integer, with a stable label.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.