VTE-BLEED calculator

VTE-BLEED

Sum the Klok 2016 VTE-BLEED items for major bleeding on stable anticoagulation after VTE and return low (<2) or high (≥2).

LIVE $0.005 USDC GET /api/calc/vte_bleed

Markdown: /docs/vte-bleed.md · Canonical: https://magentlab.com/docs/vte-bleed

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Klok 2016 VTE-BLEED items for major bleeding on stable anticoagulation after VTE and return low (<2) or high (≥2).

When to use

When an agent needs the published Klok 2016 VTE-BLEED point total and band and must not invent a treatment-duration or HAS-BLED decision.

When not to use

Not a medical device. magent does not diagnose VTE or bleeding and does not assay hemoglobin or eGFR.
Not HAS-BLED. VTE-BLEED is the Klok 2016 six-item score after VTE on stable anticoagulation, not an atrial-fibrillation bleed score.
Not a treatment-duration order, anticoagulation start/stop protocol, or bleed-treatment recommendation. Bands are low (<2) and high (≥2) only.
Anemia, renal dysfunction, and uncontrolled hypertension (SBP ≥140) are caller-assigned booleans. magent does not take a hemoglobin, eGFR, creatinine, or blood-pressure number.

Formula

VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2

Citation

Title: Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment
Authors: Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV
Source: Eur Respir J. 2016;48(5):1369-1376
DOI: 10.1183/13993003.00280-2016

Worked example

Age 70 male, no other items

Given: active_cancer=falseage=70anemia=falsehistory_of_bleeding=falserenal_dysfunction=falsesex=maleuncontrolled_hypertension=false

Age ≥60 → 1.5; active_cancer, male hypertension, anemia, history_of_bleeding, and renal_dysfunction false → 0
Score = 1.5 (max 9); vte_bleed_band = low (<2)

Active cancer alone

Given: active_cancer=trueage=50anemia=falsehistory_of_bleeding=falserenal_dysfunction=falsesex=maleuncontrolled_hypertension=false

active_cancer → 2; age <60 and remaining flags false → 0
Score = 2 (max 9); vte_bleed_band = high (≥2)

Also searched as

VTE-BLEED
VTE BLEED score
Klok VTE-BLEED
Klok 2016 bleed
VTE anticoagulation bleeding
XALIA bleeding score
venous thromboembolism bleed

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/vte_bleed?age=70&sex=male&active_cancer=false&uncontrolled_hypertension=false&anemia=false&history_of_bleeding=false&renal_dysfunction=false

Full URL: https://api.magentlab.com/api/calc/vte_bleed?age=70&sex=male&active_cancer=false&uncontrolled_hypertension=false&anemia=false&history_of_bleeding=false&renal_dysfunction=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/vte_bleed?age=70&sex=male&active_cancer=false&uncontrolled_hypertension=false&anemia=false&history_of_bleeding=false&renal_dysfunction=false"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (18-120). Age ≥60 scores 1.5 (Klok 2016). magent does not assign age.
`sex`	string	required · female, male	female or male. Uncontrolled hypertension scores 1 only when sex is male (Klok 2016 / XALIA SBP ≥140 item). Female never scores that item.
`active_cancer`	boolean	required	Active cancer as assigned by the caller (Klok 2016). true scores 2. magent does not diagnose cancer.
`uncontrolled_hypertension`	boolean	required	Uncontrolled hypertension (SBP ≥140 mmHg) as assigned by the caller (Klok 2016 / XALIA). true scores 1 only in males; females score 0 even when true. magent does not measure blood pressure.
`anemia`	boolean	required	Anemia as assigned by the caller (Klok 2016: hemoglobin <130 g/L in men or <120 g/L in women). true scores 1.5. magent does not take a hemoglobin number.
`history_of_bleeding`	boolean	required	History of bleeding as assigned by the caller (Klok 2016). true scores 1.5. magent does not grade bleeding.
`renal_dysfunction`	boolean	required	Renal dysfunction (eGFR or CrCl <60) as assigned by the caller (Klok 2016). true scores 1.5. magent does not compute eGFR or creatinine clearance.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/vte_bleed Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "active_cancer": "false",
      "age": "70",
      "anemia": "false",
      "history_of_bleeding": "false",
      "renal_dysfunction": "false",
      "sex": "male",
      "uncontrolled_hypertension": "false"
    },
    {
      "active_cancer": "false",
      "age": "70",
      "anemia": "false",
      "history_of_bleeding": "false",
      "renal_dysfunction": "false",
      "sex": "male",
      "uncontrolled_hypertension": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/vte_bleed",
  "items": [
    {
      "components": [
        {
          "factor": "active_cancer",
          "points": 0,
          "present": false
        },
        {
          "factor": "male_uncontrolled_hypertension",
          "points": 0,
          "present": false,
          "sex": "male",
          "uncontrolled_hypertension": false
        },
        {
          "factor": "anemia",
          "points": 0.0,
          "present": false
        },
        {
          "factor": "history_of_bleeding",
          "points": 0.0,
          "present": false
        },
        {
          "value": 70,
          "factor": "age_ge_60",
          "points": 1.5,
          "present": true
        },
        {
          "factor": "renal_dysfunction",
          "points": 0.0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV",
        "doi": "10.1183/13993003.00280-2016",
        "id": "klok-2016",
        "pmid": "27471209",
        "source": "Eur Respir J. 2016;48(5):1369-1376",
        "title": "Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment"
      },
      "formula": "vte_bleed",
      "formula_expression": "VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2",
      "max_score": 9,
      "score": 1.5,
      "age_years": 70,
      "sex": "male",
      "vte_bleed_band": "low"
    },
    {
      "components": [
        {
          "factor": "active_cancer",
          "points": 0,
          "present": false
        },
        {
          "factor": "male_uncontrolled_hypertension",
          "points": 0,
          "present": false,
          "sex": "male",
          "uncontrolled_hypertension": false
        },
        {
          "factor": "anemia",
          "points": 0.0,
          "present": false
        },
        {
          "factor": "history_of_bleeding",
          "points": 0.0,
          "present": false
        },
        {
          "value": 70,
          "factor": "age_ge_60",
          "points": 1.5,
          "present": true
        },
        {
          "factor": "renal_dysfunction",
          "points": 0.0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV",
        "doi": "10.1183/13993003.00280-2016",
        "id": "klok-2016",
        "pmid": "27471209",
        "source": "Eur Respir J. 2016;48(5):1369-1376",
        "title": "Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment"
      },
      "formula": "vte_bleed",
      "formula_expression": "VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2",
      "max_score": 9,
      "score": 1.5,
      "age_years": 70,
      "sex": "male",
      "vte_bleed_band": "low"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	vte_bleed
`formula_expression`	string	Exact expression used
`score`	number	VTE-BLEED points 0-9 (1.5 steps allowed; not integer-rounded)
`max_score`	integer	Always 9
`vte_bleed_band`	string	low when score is <2, high when score is ≥2 (Klok 2016). Not a treatment-duration order.
`sex`	string	female or male used for the hypertension item
`age_years`	integer	Age used for the ≥60 criterion
`components`	array	Per-factor points
`citation`	object	Klok 2016 Eur Respir J citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "factor": "active_cancer",
      "points": 0,
      "present": false
    },
    {
      "factor": "male_uncontrolled_hypertension",
      "points": 0,
      "present": false,
      "sex": "male",
      "uncontrolled_hypertension": false
    },
    {
      "factor": "anemia",
      "points": 0.0,
      "present": false
    },
    {
      "factor": "history_of_bleeding",
      "points": 0.0,
      "present": false
    },
    {
      "value": 70,
      "factor": "age_ge_60",
      "points": 1.5,
      "present": true
    },
    {
      "factor": "renal_dysfunction",
      "points": 0.0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV",
    "doi": "10.1183/13993003.00280-2016",
    "id": "klok-2016",
    "pmid": "27471209",
    "source": "Eur Respir J. 2016;48(5):1369-1376",
    "title": "Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment"
  },
  "formula": "vte_bleed",
  "formula_expression": "VTE-BLEED = active_cancer 2 + (male AND uncontrolled_hypertension) 1 + anemia 1.5 + history_of_bleeding 1.5 + age_ge_60 1.5 + renal_dysfunction 1.5; Klok 2016; max 9; low <2, high >=2",
  "max_score": 9,
  "score": 1.5,
  "age_years": 70,
  "sex": "male",
  "vte_bleed_band": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_sex`	sex must be female or male Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

HAS-BLED — Compute the HAS-BLED bleeding-risk score from discrete clinical flags.
RIETE — Sum the Ruiz-Giménez 2008 RIETE adverse factors for 3-month major bleeding after documented acute VTE and return low (0), intermediate (1–4), or high (>4).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.