WPSS (myelodysplastic syndromes)

WPSS

Sum the Malcovati 2007 WPSS (WHO classification-based prognostic scoring system) for myelodysplastic syndromes and return very_low (0), low (1), intermediate (2), high (3–4), or very_high (5–6).

LIVE $0.005 USDC GET /api/calc/wpss

Markdown: /docs/wpss.md · Canonical: https://magentlab.com/docs/wpss

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Malcovati 2007 WPSS (WHO classification-based prognostic scoring system) for myelodysplastic syndromes and return very_low (0), low (1), intermediate (2), high (3–4), or very_high (5–6).

When to use

When an agent needs the published WPSS point total and risk group and must not invent an MDS diagnosis, transplant listing, or survival estimate, and must not substitute IPSS-R, IPSS 1997, IPSS-M, or DIPSS.

When not to use

Not a medical device and not an MDS diagnosis, treatment choice, or transplant listing. magent does not examine the patient.
This is Malcovati 2007 WPSS (WHO 2001 Table 2) only, not Greenberg 2012 IPSS-R, not Greenberg 1997 IPSS, not IPSS-M, and not DIPSS (myelofibrosis).
magent does not karyotype. cytogenetics is the caller-assigned IPSS three-group class (good, intermediate, poor), not the IPSS-R five-group scale (very_good and very_poor are invalid).
magent does not assign WHO category. who_mds is the caller-mapped 2001 WHO group (RA/RARS/5q-, RCMD/RCMD-RS, RAEB-1, RAEB-2). Later WHO/ICC entities are not mapped.
Regular transfusion is a caller-assigned boolean (at least one RBC transfusion every 8 weeks over 4 months). magent does not count units.
Does not report median overall survival or AML evolution times from the 2007 figures.

Formula

WPSS = WHO (ra_rars_5q 0, rcmd 1, raeb1 2, raeb2 3) + karyotype (good 0, intermediate 1, poor 2) + regular_transfusion 1; Malcovati 2007 Table 2; max 6; very_low 0, low 1, intermediate 2, high 3-4, very_high 5-6

Citation

Title: Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes
Authors: Malcovati L, Germing U, Kuendgen A, et al.
Source: J Clin Oncol. 2007;25(23):3503-3510
DOI: 10.1200/JCO.2006.08.5696

Worked example

RA/RARS/5q-, good karyotype, no regular transfusion

Given: cytogenetics=goodregular_transfusion=falsewho_mds=ra_rars_5q

who_mds ra_rars_5q → 0; cytogenetics good → 0; regular_transfusion false → 0
Score = 0 (max 6); risk_group = very_low

Maximum published score

Given: cytogenetics=poorregular_transfusion=truewho_mds=raeb2

who_mds raeb2 → 3; cytogenetics poor → 2; regular_transfusion → 1
Score = 6 (max 6); risk_group = very_high (5–6)

Also searched as

WPSS
WHO classification-based prognostic scoring system
Malcovati WPSS
WPSS MDS
WHO-based prognostic scoring system
Malcovati 2007 MDS
WPSS myelodysplastic syndrome
WHO WPSS 2007

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/wpss?who_mds=ra_rars_5q&cytogenetics=good&regular_transfusion=false

Full URL: https://api.magentlab.com/api/calc/wpss?who_mds=ra_rars_5q&cytogenetics=good&regular_transfusion=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/wpss?who_mds=ra_rars_5q&cytogenetics=good&regular_transfusion=false"

Parameters

Name	Type	Required	Description
`who_mds`	string	required · ra_rars_5q, rcmd, raeb1, raeb2	Malcovati 2007 Table 2 WHO 2001 group as assigned by the caller. ra_rars_5q is RA, RARS, or MDS with isolated del(5q) and scores 0. rcmd is RCMD or RCMD-RS and scores 1. raeb1 is RAEB-1 and scores 2. raeb2 is RAEB-2 and scores 3. magent does not assign WHO category.
`cytogenetics`	string	required · good, intermediate, poor	IPSS (Greenberg 1997) cytogenetic group as assigned by the caller (good 0, intermediate 1, poor 2). Not the IPSS-R five-group scale (very_good and very_poor are invalid). magent does not karyotype.
`regular_transfusion`	boolean	required	Regular RBC transfusion requirement as assigned by the caller (Malcovati 2007: at least one RBC transfusion every 8 weeks over 4 months). true scores 1. magent does not count units.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/wpss Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "cytogenetics": "good",
      "regular_transfusion": "false",
      "who_mds": "ra_rars_5q"
    },
    {
      "cytogenetics": "good",
      "regular_transfusion": "false",
      "who_mds": "ra_rars_5q"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/wpss",
  "items": [
    {
      "components": [
        {
          "value": "ra_rars_5q",
          "factor": "who_mds",
          "points": 0,
          "present": false
        },
        {
          "value": "good",
          "factor": "cytogenetics",
          "points": 0,
          "present": false
        },
        {
          "factor": "regular_transfusion",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Malcovati L, Germing U, Kuendgen A, et al.",
        "doi": "10.1200/JCO.2006.08.5696",
        "id": "malcovati-2007",
        "pmid": "17687155",
        "source": "J Clin Oncol. 2007;25(23):3503-3510",
        "title": "Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes"
      },
      "formula": "wpss",
      "formula_expression": "WPSS = WHO (ra_rars_5q 0, rcmd 1, raeb1 2, raeb2 3) + karyotype (good 0, intermediate 1, poor 2) + regular_transfusion 1; Malcovati 2007 Table 2; max 6; very_low 0, low 1, intermediate 2, high 3-4, very_high 5-6",
      "max_score": 6,
      "score": 0,
      "risk_group": "very_low",
      "cytogenetics": "good",
      "regular_transfusion": false,
      "who_mds": "ra_rars_5q"
    },
    {
      "components": [
        {
          "value": "ra_rars_5q",
          "factor": "who_mds",
          "points": 0,
          "present": false
        },
        {
          "value": "good",
          "factor": "cytogenetics",
          "points": 0,
          "present": false
        },
        {
          "factor": "regular_transfusion",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Malcovati L, Germing U, Kuendgen A, et al.",
        "doi": "10.1200/JCO.2006.08.5696",
        "id": "malcovati-2007",
        "pmid": "17687155",
        "source": "J Clin Oncol. 2007;25(23):3503-3510",
        "title": "Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes"
      },
      "formula": "wpss",
      "formula_expression": "WPSS = WHO (ra_rars_5q 0, rcmd 1, raeb1 2, raeb2 3) + karyotype (good 0, intermediate 1, poor 2) + regular_transfusion 1; Malcovati 2007 Table 2; max 6; very_low 0, low 1, intermediate 2, high 3-4, very_high 5-6",
      "max_score": 6,
      "score": 0,
      "risk_group": "very_low",
      "cytogenetics": "good",
      "regular_transfusion": false,
      "who_mds": "ra_rars_5q"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	wpss
`formula_expression`	string	Exact expression used
`score`	integer	WPSS points 0-6
`max_score`	integer	Always 6 (3+2+1)
`risk_group`	string	very_low when score is 0, low when 1, intermediate when 2, high when 3-4, very_high when 5-6 (Malcovati 2007 Table 2). Not an MDS diagnosis. Not IPSS-R. Not IPSS 1997. Not DIPSS.
`who_mds`	string	Caller-assigned WHO 2001 Table 2 group used
`cytogenetics`	string	Caller-assigned IPSS three-group karyotype used
`regular_transfusion`	boolean	Caller-assigned regular-transfusion flag used
`components`	array	Per-factor points
`citation`	object	Malcovati et al. J Clin Oncol 2007 WPSS citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "ra_rars_5q",
      "factor": "who_mds",
      "points": 0,
      "present": false
    },
    {
      "value": "good",
      "factor": "cytogenetics",
      "points": 0,
      "present": false
    },
    {
      "factor": "regular_transfusion",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Malcovati L, Germing U, Kuendgen A, et al.",
    "doi": "10.1200/JCO.2006.08.5696",
    "id": "malcovati-2007",
    "pmid": "17687155",
    "source": "J Clin Oncol. 2007;25(23):3503-3510",
    "title": "Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes"
  },
  "formula": "wpss",
  "formula_expression": "WPSS = WHO (ra_rars_5q 0, rcmd 1, raeb1 2, raeb2 3) + karyotype (good 0, intermediate 1, poor 2) + regular_transfusion 1; Malcovati 2007 Table 2; max 6; very_low 0, low 1, intermediate 2, high 3-4, very_high 5-6",
  "max_score": 6,
  "score": 0,
  "risk_group": "very_low",
  "cytogenetics": "good",
  "regular_transfusion": false,
  "who_mds": "ra_rars_5q"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_wpss`	each WPSS 2007 item must be a published WHO, karyotype, or transfusion category. Returned before settlement; you are not charged.
400	`invalid_who_mds`	who_mds must be ra_rars_5q, rcmd, raeb1, or raeb2 (Malcovati 2007 WHO groups). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

IPSS-R — Sum the Greenberg 2012 IPSS-R (revised international prognostic scoring system) for myelodysplastic syndromes and return very_low (≤1.5), low (>1.5–3), intermediate (>3–4.5), high (>4.5–6), or very_high (>6).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.