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MIPSS70 (primary myelofibrosis)

MIPSS70

Sum the Guglielmelli 2018 MIPSS70 (mutation-enhanced international prognostic score system) for transplantation-age primary myelofibrosis and return low (0–1), intermediate (2–4), or high (≥5).

LIVE $0.005 USDC GET /api/calc/mipss70

Markdown: /docs/mipss70.md · Canonical: https://magentlab.com/docs/mipss70

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Guglielmelli 2018 MIPSS70 (mutation-enhanced international prognostic score system) for transplantation-age primary myelofibrosis and return low (0–1), intermediate (2–4), or high (≥5).

When to use

When an agent needs the published MIPSS70 point total and risk band and must not invent a PMF diagnosis or transplant listing, and must not substitute MIPSS70-plus, MIPSS70+ version 2.0, DIPSS, or GIPSS.

When not to use

  • Not a medical device and not a PMF diagnosis or transplant listing. magent does not examine the patient.
  • This is Guglielmelli 2018 MIPSS70 only, not MIPSS70-plus, not MIPSS70+ version 2.0, and not DIPSS or GIPSS.
  • magent does not sequence. calr_type1_like and hmr_mutation_count (ASXL1, EZH2, SRSF2, IDH1, IDH2) are caller-assigned.
  • magent does not grade marrow. fibrosis_grade is the caller-assigned WHO marrow fibrosis grade 0–3.
  • magent does not assay hemoglobin, leukocytes, platelets, or circulating blasts. Labs are caller-supplied. Provide hemoglobin_g_dl or hemoglobin_g_l, not both.
  • Published Italian-cohort median and 5-year survivals are Guglielmelli 2018 cohort figures for the three MIPSS70 bands, not a patient-specific prediction.

Formula

MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5

Citation

Title
MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis
Authors
Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A
Source
J Clin Oncol. 2018;36(4):310-318
DOI
10.1200/JCO.2017.76.4886

Worked example

No adverse MIPSS70 factors

Given: blasts_percent=0calr_type1_like=trueconstitutional_symptoms=falsefibrosis_grade=1hemoglobin_g_dl=12hmr_mutation_count=0leukocytes_10e9_l=10platelets_10e9_l=200

  1. hemoglobin 12 ≥10 → 0; leukocytes 10 ≤25 → 0; platelets 200 ≥100 → 0; blasts 0% <2 → 0; fibrosis 1 <2 → 0; constitutional_symptoms false → 0; calr_type1_like true → 0; hmr_mutation_count 0 → 0
  2. Score = 0 (max 12); risk_band = low (0–1)

All nine MIPSS70 adverse factors

Given: blasts_percent=2calr_type1_like=falseconstitutional_symptoms=truefibrosis_grade=2hemoglobin_g_dl=9.9hmr_mutation_count=2leukocytes_10e9_l=26platelets_10e9_l=80

  1. hemoglobin <10 → 1; leukocytes >25 → 2; platelets <100 → 2; blasts ≥2 → 1; fibrosis ≥2 → 1; constitutional_symptoms → 1; absence of type 1/like CALR → 1; HMR category → 1; two or more HMR → 2
  2. Score = 12 (max 12); risk_band = high (≥5)

Also searched as

  • MIPSS70
  • mutation-enhanced international prognostic score
  • Guglielmelli MIPSS70
  • primary myelofibrosis MIPSS70
  • PMF MIPSS70
  • MIPSS-70
  • HMR myelofibrosis score
  • transplant-age myelofibrosis score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/mipss70?hemoglobin_g_dl=12&leukocytes_10e9_l=10&platelets_10e9_l=200&blasts_percent=0&fibrosis_grade=1&constitutional_symptoms=false&calr_type1_like=true&hmr_mutation_count=0

Full URL: https://api.magentlab.com/api/calc/mipss70?hemoglobin_g_dl=12&leukocytes_10e9_l=10&platelets_10e9_l=200&blasts_percent=0&fibrosis_grade=1&constitutional_symptoms=false&calr_type1_like=true&hmr_mutation_count=0

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. 

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/mipss70?hemoglobin_g_dl=12&leukocytes_10e9_l=10&platelets_10e9_l=200&blasts_percent=0&fibrosis_grade=1&constitutional_symptoms=false&calr_type1_like=true&hmr_mutation_count=0"

Parameters

Name Type Required Description
hemoglobin_g_dl number optional Hemoglobin in g/dL (3-22). Provide this or hemoglobin_g_l, not both. <10 g/dL (<100 g/L) scores 1 (Guglielmelli 2018). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin.
hemoglobin_g_l number optional Hemoglobin in g/L (30-220). Converted as hemoglobin_g_dl = hemoglobin_g_l / 10. Provide this or hemoglobin_g_dl, not both. <100 g/L scores 1. 100 is the ≥100 arm and scores 0.
leukocytes_10e9_l number required Leukocyte count in 10^9/L (0.5-200). >25 scores 2 (Guglielmelli 2018). 25.0 is the ≤25 arm and scores 0. magent does not assay leukocytes.
platelets_10e9_l number required Platelet count in 10^9/L (1-2000). <100 scores 2 (Guglielmelli 2018). 100.0 is the ≥100 arm and scores 0. magent does not assay platelets.
blasts_percent number required Circulating blasts as a percent (0-30). ≥2 scores 1 (Guglielmelli 2018). 2.0 scores; 1.9 is the <2 arm and scores 0. magent does not read a smear.
fibrosis_grade integer required WHO bone-marrow fibrosis grade as an integer 0-3, assigned by the caller (Guglielmelli 2018). ≥2 scores 1. Grade 2 scores; grade 1 scores 0. magent does not grade marrow.
constitutional_symptoms boolean required Constitutional symptoms as assigned by the caller (Guglielmelli 2018). true scores 1. magent does not take a history.
calr_type1_like boolean required Presence of a type 1/like CALR mutation as assigned by the caller (Guglielmelli 2018). false (absence) scores 1. true scores 0. magent does not sequence.
hmr_mutation_count integer required Count of high-molecular-risk mutations among ASXL1, EZH2, SRSF2, IDH1, and IDH2 as assigned by the caller (integer 0-5). ≥1 scores 1 (HMR category). ≥2 scores an additional 2 (two or more HMR mutations), so a count of 2 or more contributes 3. Count 0 scores 0. magent does not sequence.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/mipss70 Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

  • 1 to 25 items. Each item uses the same keys as the GET query parameters.
  • POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
  • The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
  • HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
  • Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
  • x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "blasts_percent": "0",
      "calr_type1_like": "true",
      "constitutional_symptoms": "false",
      "fibrosis_grade": "1",
      "hemoglobin_g_dl": "12",
      "hmr_mutation_count": "0",
      "leukocytes_10e9_l": "10",
      "platelets_10e9_l": "200"
    },
    {
      "blasts_percent": "0",
      "calr_type1_like": "true",
      "constitutional_symptoms": "false",
      "fibrosis_grade": "1",
      "hemoglobin_g_dl": "12",
      "hmr_mutation_count": "0",
      "leukocytes_10e9_l": "10",
      "platelets_10e9_l": "200"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/mipss70",
  "items": [
    {
      "components": [
        {
          "value": 12.0,
          "factor": "hemoglobin_lt_10",
          "points": 0,
          "present": false
        },
        {
          "value": 10.0,
          "factor": "leukocytes_gt_25",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "platelets_lt_100",
          "points": 0,
          "present": false
        },
        {
          "value": 0.0,
          "factor": "blasts_ge_2",
          "points": 0,
          "present": false
        },
        {
          "value": 1,
          "factor": "fibrosis_ge_2",
          "points": 0,
          "present": false
        },
        {
          "factor": "constitutional_symptoms",
          "points": 0,
          "present": false
        },
        {
          "factor": "absence_of_calr_type1_like",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "hmr_category",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "hmr_two_or_more",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
        "doi": "10.1200/JCO.2017.76.4886",
        "id": "guglielmelli-2018",
        "pmid": "29226763",
        "source": "J Clin Oncol. 2018;36(4):310-318",
        "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
      },
      "formula": "mipss70",
      "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
      "max_score": 12,
      "score": 0,
      "platelets_10e9_l": 200.0,
      "risk_band": "low",
      "hemoglobin_g_dl": 12.0,
      "blasts_percent": 0.0,
      "constitutional_symptoms": false,
      "calr_type1_like": true,
      "five_year_survival_percent": 95,
      "median_survival_years": 27.7,
      "fibrosis_grade": 1,
      "hmr_mutation_count": 0,
      "leukocytes_10e9_l": 10.0
    },
    {
      "components": [
        {
          "value": 12.0,
          "factor": "hemoglobin_lt_10",
          "points": 0,
          "present": false
        },
        {
          "value": 10.0,
          "factor": "leukocytes_gt_25",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "platelets_lt_100",
          "points": 0,
          "present": false
        },
        {
          "value": 0.0,
          "factor": "blasts_ge_2",
          "points": 0,
          "present": false
        },
        {
          "value": 1,
          "factor": "fibrosis_ge_2",
          "points": 0,
          "present": false
        },
        {
          "factor": "constitutional_symptoms",
          "points": 0,
          "present": false
        },
        {
          "factor": "absence_of_calr_type1_like",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "hmr_category",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "hmr_two_or_more",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
        "doi": "10.1200/JCO.2017.76.4886",
        "id": "guglielmelli-2018",
        "pmid": "29226763",
        "source": "J Clin Oncol. 2018;36(4):310-318",
        "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
      },
      "formula": "mipss70",
      "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
      "max_score": 12,
      "score": 0,
      "platelets_10e9_l": 200.0,
      "risk_band": "low",
      "hemoglobin_g_dl": 12.0,
      "blasts_percent": 0.0,
      "constitutional_symptoms": false,
      "calr_type1_like": true,
      "five_year_survival_percent": 95,
      "median_survival_years": 27.7,
      "fibrosis_grade": 1,
      "hmr_mutation_count": 0,
      "leukocytes_10e9_l": 10.0
    }
  ]
}

Response

Field Type Description
formula string mipss70
formula_expression string Exact expression used
score integer MIPSS70 points 0-12
max_score integer Always 12 (1+2+2+1+1+1+1+1+2)
risk_band string low when score is 0-1, intermediate when 2-4, high when ≥5 (Guglielmelli 2018 MIPSS70). Not a PMF diagnosis. Not MIPSS70-plus. Not MIPSS70+ version 2.0.
hemoglobin_g_dl number Hemoglobin in g/dL used for the <10 criterion (g/L inputs converted / 10)
leukocytes_10e9_l number Leukocytes in 10^9/L used for the >25 criterion
platelets_10e9_l number Platelets in 10^9/L used for the <100 criterion
blasts_percent number Circulating blast percent used for the ≥2 criterion
fibrosis_grade integer Caller-assigned WHO marrow fibrosis grade 0-3 used for the ≥2 criterion
constitutional_symptoms boolean Caller-assigned constitutional-symptoms flag used
calr_type1_like boolean Caller-assigned type 1/like CALR flag used
hmr_mutation_count integer Caller-assigned HMR mutation count among ASXL1, EZH2, SRSF2, IDH1, IDH2 (0-5)
median_survival_years number Guglielmelli 2018 Italian-cohort median overall survival in years for this MIPSS70 band (low 27.7, intermediate 7.1, high 2.3). Cohort figure, not a patient-specific prediction.
five_year_survival_percent integer Guglielmelli 2018 Italian-cohort 5-year survival percent for this MIPSS70 band (low 95, intermediate 70, high 29). Cohort figure, not a patient-specific prediction.
components array Per-factor points
citation object Guglielmelli et al. J Clin Oncol 2018 MIPSS70 citation
disclaimer string Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup. 

{
  "components": [
    {
      "value": 12.0,
      "factor": "hemoglobin_lt_10",
      "points": 0,
      "present": false
    },
    {
      "value": 10.0,
      "factor": "leukocytes_gt_25",
      "points": 0,
      "present": false
    },
    {
      "value": 200.0,
      "factor": "platelets_lt_100",
      "points": 0,
      "present": false
    },
    {
      "value": 0.0,
      "factor": "blasts_ge_2",
      "points": 0,
      "present": false
    },
    {
      "value": 1,
      "factor": "fibrosis_ge_2",
      "points": 0,
      "present": false
    },
    {
      "factor": "constitutional_symptoms",
      "points": 0,
      "present": false
    },
    {
      "factor": "absence_of_calr_type1_like",
      "points": 0,
      "present": false
    },
    {
      "value": 0,
      "factor": "hmr_category",
      "points": 0,
      "present": false
    },
    {
      "value": 0,
      "factor": "hmr_two_or_more",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Guglielmelli P, Lasho TL, Rotunno G, Mudireddy M, Mannarelli C, Nicolosi M, Pacilli A, Pardanani A, Rumi E, Rosti V, Hanson CA, Mannelli F, Ketterling RP, Gangat N, Rambaldi A, Passamonti F, Barosi G, Barbui T, Cazzola M, Vannucchi AM, Tefferi A",
    "doi": "10.1200/JCO.2017.76.4886",
    "id": "guglielmelli-2018",
    "pmid": "29226763",
    "source": "J Clin Oncol. 2018;36(4):310-318",
    "title": "MIPSS70: Mutation-Enhanced International Prognostic Score System for Transplantation-Age Patients With Primary Myelofibrosis"
  },
  "formula": "mipss70",
  "formula_expression": "MIPSS70 = hemoglobin_lt_10 1 + leukocytes_gt_25 2 + platelets_lt_100 2 + blasts_ge_2 1 + fibrosis_ge_2 1 + constitutional_symptoms 1 + absence_of_calr_type1_like 1 + hmr_category 1 + hmr_two_or_more 2; Guglielmelli 2018; max 12; low 0-1, intermediate 2-4, high ≥5",
  "max_score": 12,
  "score": 0,
  "platelets_10e9_l": 200.0,
  "risk_band": "low",
  "hemoglobin_g_dl": 12.0,
  "blasts_percent": 0.0,
  "constitutional_symptoms": false,
  "calr_type1_like": true,
  "five_year_survival_percent": 95,
  "median_survival_years": 27.7,
  "fibrosis_grade": 1,
  "hmr_mutation_count": 0,
  "leukocytes_10e9_l": 10.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP Code When
400 invalid_hemoglobin hemoglobin_g_l (30-220) or hemoglobin_g_dl (3-22) is required, not both. Returned before settlement; you are not charged.
400 invalid_leukocytes leukocytes_10e9_l must be a number from 0.5 to 200 (Guglielmelli 2018 MIPSS70). Returned before settlement; you are not charged.
400 invalid_platelets platelets_10e9_l must be a number from 1 to 2000 Returned before settlement; you are not charged.
400 invalid_mipss_blasts blasts_percent must be a number from 0 to 30 (Guglielmelli 2018 MIPSS70 circulating blasts; magent clamp). Returned before settlement; you are not charged.
400 invalid_fibrosis_grade fibrosis_grade must be an integer 0-3 (Guglielmelli 2018 MIPSS70 WHO marrow fibrosis). Returned before settlement; you are not charged.
400 invalid_flag boolean clinical flags must be true or false Returned before settlement; you are not charged.
400 invalid_items POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400 invalid_item_count items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400 invalid_item each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

  • DIPSS — Sum the Passamonti 2010 DIPSS (dynamic international prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1–2), intermediate_2 (3–4), or high (5–6).
  • GIPSS — Sum the Tefferi 2018 GIPSS (genetically inspired prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1), intermediate_2 (2), or high (≥3).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

  • HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
  • exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
  • HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
  • Execution is timeout-bounded and concurrency-capped.
  • Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.