DIPSS (primary myelofibrosis)

DIPSS

Sum the Passamonti 2010 DIPSS (dynamic international prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1–2), intermediate_2 (3–4), or high (5–6).

LIVE $0.005 USDC GET /api/calc/dipss

Markdown: /docs/dipss.md · Canonical: https://magentlab.com/docs/dipss

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Passamonti 2010 DIPSS (dynamic international prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1–2), intermediate_2 (3–4), or high (5–6).

When to use

When an agent needs the published DIPSS point total and risk group and must not invent a myelofibrosis diagnosis or treatment choice, and must not substitute DIPSS Plus, aaDIPSS, or Cervantes 2009 IPSS.

When not to use

Not a medical device and not a myelofibrosis diagnosis or treatment choice. magent does not examine the patient.
This is Passamonti 2010 DIPSS (all-ages Table 3) only, not DIPSS Plus, not aaDIPSS (Table 4), and not Cervantes 2009 IPSS-at-diagnosis.
magent does not read a smear or assay hemoglobin or WBC. hemoglobin_g_dl, wbc_10e9_l, and blasts_percent are caller-supplied labs.
Constitutional symptoms (weight loss >10% in 6 months, night sweats, or unexplained fever >37.5°C) are a single caller-assigned boolean.

Formula

DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6

Citation

Title: A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)
Authors: Passamonti F, Cervantes F, Vannucchi AM, et al.
Source: Blood. 2010;115(9):1703-1708
DOI: 10.1182/blood-2009-09-245837

Worked example

Age 50, no adverse factors

Given: age=50blasts_percent=0constitutional_symptoms=falsehemoglobin_g_dl=12wbc_10e9_l=10

age 50 is not >65 → 0; hemoglobin 12 ≥10 → 0; WBC 10 ≤25 → 0; blasts 0% <1 → 0; constitutional_symptoms false → 0
Score = 0 (max 6); risk_group = low

All five adverse factors

Given: age=66blasts_percent=1constitutional_symptoms=truehemoglobin_g_dl=9.9wbc_10e9_l=25.1

age >65 → 1; hemoglobin <10 → 2; WBC >25 → 1; blasts ≥1 → 1; constitutional_symptoms → 1
Score = 6 (max 6); risk_group = high (5–6)

Also searched as

DIPSS
dynamic international prognostic scoring system
Passamonti DIPSS
primary myelofibrosis DIPSS
PMF DIPSS
IWG-MRT DIPSS
DIPSS myelofibrosis
Passamonti 2010 myelofibrosis

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/dipss?age=50&hemoglobin_g_dl=12&wbc_10e9_l=10&blasts_percent=0&constitutional_symptoms=false

Full URL: https://api.magentlab.com/api/calc/dipss?age=50&hemoglobin_g_dl=12&wbc_10e9_l=10&blasts_percent=0&constitutional_symptoms=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/dipss?age=50&hemoglobin_g_dl=12&wbc_10e9_l=10&blasts_percent=0&constitutional_symptoms=false"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (18-120). Age >65 scores 1 (Passamonti 2010 Table 3). Age 65 is the ≤65 arm and scores 0.
`hemoglobin_g_dl`	number	required	Hemoglobin in g/dL (3-20). <10 scores 2 (Passamonti 2010 Table 3; anemia HR 4.18). 10.0 is the ≥10 arm and scores 0. magent does not assay hemoglobin.
`wbc_10e9_l`	number	required	White-cell count in 10^9/L (0.1-500). >25 scores 1 (Passamonti 2010 Table 3). 25.0 is the ≤25 arm and scores 0. magent does not assay WBC.
`blasts_percent`	number	required	Peripheral-blood blasts as a percent (0-30). ≥1 scores 1 (Passamonti 2010 Table 3). 0.9 is the <1 arm and scores 0. magent does not read a smear.
`constitutional_symptoms`	boolean	required	Weight loss >10% in 6 months, night sweats, or unexplained fever >37.5°C as assigned by the caller (Passamonti 2010 methods). true scores 1. magent does not take a history.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/dipss Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "50",
      "blasts_percent": "0",
      "constitutional_symptoms": "false",
      "hemoglobin_g_dl": "12",
      "wbc_10e9_l": "10"
    },
    {
      "age": "50",
      "blasts_percent": "0",
      "constitutional_symptoms": "false",
      "hemoglobin_g_dl": "12",
      "wbc_10e9_l": "10"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/dipss",
  "items": [
    {
      "components": [
        {
          "value": 50,
          "factor": "age_gt_65",
          "points": 0,
          "present": false
        },
        {
          "value": 10.0,
          "factor": "wbc_gt_25",
          "points": 0,
          "present": false
        },
        {
          "value": 12.0,
          "factor": "hemoglobin_lt_10",
          "points": 0,
          "present": false
        },
        {
          "value": 0.0,
          "factor": "blasts_ge_1",
          "points": 0,
          "present": false
        },
        {
          "factor": "constitutional_symptoms",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Passamonti F, Cervantes F, Vannucchi AM, et al.",
        "doi": "10.1182/blood-2009-09-245837",
        "id": "passamonti-2010",
        "pmid": "20008785",
        "source": "Blood. 2010;115(9):1703-1708",
        "title": "A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)"
      },
      "formula": "dipss",
      "formula_expression": "DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6",
      "age_years": 50,
      "max_score": 6,
      "score": 0,
      "wbc_10e9_l": 10.0,
      "risk_group": "low",
      "blasts_percent": 0.0,
      "constitutional_symptoms": false,
      "hemoglobin_g_dl": 12.0
    },
    {
      "components": [
        {
          "value": 50,
          "factor": "age_gt_65",
          "points": 0,
          "present": false
        },
        {
          "value": 10.0,
          "factor": "wbc_gt_25",
          "points": 0,
          "present": false
        },
        {
          "value": 12.0,
          "factor": "hemoglobin_lt_10",
          "points": 0,
          "present": false
        },
        {
          "value": 0.0,
          "factor": "blasts_ge_1",
          "points": 0,
          "present": false
        },
        {
          "factor": "constitutional_symptoms",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Passamonti F, Cervantes F, Vannucchi AM, et al.",
        "doi": "10.1182/blood-2009-09-245837",
        "id": "passamonti-2010",
        "pmid": "20008785",
        "source": "Blood. 2010;115(9):1703-1708",
        "title": "A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)"
      },
      "formula": "dipss",
      "formula_expression": "DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6",
      "age_years": 50,
      "max_score": 6,
      "score": 0,
      "wbc_10e9_l": 10.0,
      "risk_group": "low",
      "blasts_percent": 0.0,
      "constitutional_symptoms": false,
      "hemoglobin_g_dl": 12.0
    }
  ]
}

Response

Field	Type	Description
`formula`	string	dipss
`formula_expression`	string	Exact expression used
`score`	integer	DIPSS points 0-6
`max_score`	integer	Always 6 (1+1+2+1+1)
`risk_group`	string	low when score is 0, intermediate_1 when 1-2, intermediate_2 when 3-4, high when 5-6 (Passamonti 2010 Table 3). Not a myelofibrosis diagnosis. Not DIPSS Plus. Not aaDIPSS.
`age_years`	integer	Age used for the >65 criterion
`hemoglobin_g_dl`	number	Hemoglobin in g/dL used for the <10 criterion
`wbc_10e9_l`	number	WBC in 10^9/L used for the >25 criterion
`blasts_percent`	number	Peripheral-blood blast percent used for the ≥1 criterion
`constitutional_symptoms`	boolean	Caller-assigned constitutional-symptoms flag used
`components`	array	Per-factor points
`citation`	object	Passamonti et al. Blood 2010 DIPSS citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 50,
      "factor": "age_gt_65",
      "points": 0,
      "present": false
    },
    {
      "value": 10.0,
      "factor": "wbc_gt_25",
      "points": 0,
      "present": false
    },
    {
      "value": 12.0,
      "factor": "hemoglobin_lt_10",
      "points": 0,
      "present": false
    },
    {
      "value": 0.0,
      "factor": "blasts_ge_1",
      "points": 0,
      "present": false
    },
    {
      "factor": "constitutional_symptoms",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Passamonti F, Cervantes F, Vannucchi AM, et al.",
    "doi": "10.1182/blood-2009-09-245837",
    "id": "passamonti-2010",
    "pmid": "20008785",
    "source": "Blood. 2010;115(9):1703-1708",
    "title": "A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment)"
  },
  "formula": "dipss",
  "formula_expression": "DIPSS = age_gt_65 1 + wbc_gt_25 1 + hemoglobin_lt_10 2 + blasts_ge_1 1 + constitutional_symptoms 1; Passamonti 2010 Table 3; max 6; low 0, intermediate_1 1-2, intermediate_2 3-4, high 5-6",
  "age_years": 50,
  "max_score": 6,
  "score": 0,
  "wbc_10e9_l": 10.0,
  "risk_group": "low",
  "blasts_percent": 0.0,
  "constitutional_symptoms": false,
  "hemoglobin_g_dl": 12.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_dipss`	hemoglobin_g_dl 3-20, wbc_10e9_l 0.1-500, and blasts_percent 0-30 (Passamonti 2010 DIPSS labs; magent clamps, not paper ranges). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

IPSS-R — Sum the Greenberg 2012 IPSS-R (revised international prognostic scoring system) for myelodysplastic syndromes and return very_low (≤1.5), low (>1.5–3), intermediate (>3–4.5), high (>4.5–6), or very_high (>6).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.