GIPSS (primary myelofibrosis)

GIPSS

Sum the Tefferi 2018 GIPSS (genetically inspired prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1), intermediate_2 (2), or high (≥3).

LIVE $0.005 USDC GET /api/calc/gipss

Markdown: /docs/gipss.md · Canonical: https://magentlab.com/docs/gipss

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Tefferi 2018 GIPSS (genetically inspired prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1), intermediate_2 (2), or high (≥3).

When to use

When an agent needs the published GIPSS point total and risk group and must not invent a PMF diagnosis or transplant listing, and must not substitute DIPSS, DIPSS Plus, or MIPSS70-plus.

When not to use

Not a medical device and not a PMF diagnosis or transplant listing. magent does not examine the patient.
This is Tefferi 2018 GIPSS only, not DIPSS, not DIPSS Plus, not MIPSS70, and not MIPSS70-plus.
magent does not karyotype. karyotype is the caller-assigned three-tier class (favorable, unfavorable, vhr) from Tefferi 2018 revised cytogenetics.
magent does not sequence. calr_type1_like, asxl1_mutated, srsf2_mutated, and u2af1_q157_mutated are caller-assigned flags. U2AF1 scores only Q157, not S34.
Published median and 5-year survivals are Tefferi 2018 cohort figures for the four GIPSS bands, not a patient-specific prediction.

Formula

GIPSS = karyotype (favorable 0, unfavorable 1, vhr 2) + absence of type 1/like CALR 1 + asxl1_mutated 1 + srsf2_mutated 1 + u2af1_q157_mutated 1; Tefferi 2018; max 6; low 0, intermediate_1 1, intermediate_2 2, high ≥3

Citation

Title: GIPSS: genetically inspired prognostic scoring system for primary myelofibrosis
Authors: Tefferi A, Guglielmelli P, Nicolosi M, Mannelli F, Mudireddy M, Bartalucci N, Finke CM, Lasho TL, Hanson CA, Ketterling RP, Begna KH, Gangat N, Pardanani A, Vannucchi AM
Source: Leukemia. 2018;32(7):1631-1642
DOI: 10.1038/s41375-018-0107-z

Worked example

Favorable karyotype, type 1/like CALR, no high-risk mutations

Given: asxl1_mutated=falsecalr_type1_like=truekaryotype=favorablesrsf2_mutated=falseu2af1_q157_mutated=false

karyotype favorable → 0; calr_type1_like true → 0; asxl1_mutated false → 0; srsf2_mutated false → 0; u2af1_q157_mutated false → 0
Score = 0 (max 6); risk_group = low

VHR karyotype, no type 1/like CALR, ASXL1 and SRSF2

Given: asxl1_mutated=truecalr_type1_like=falsekaryotype=vhrsrsf2_mutated=trueu2af1_q157_mutated=false

karyotype vhr → 2; absence of type 1/like CALR → 1; asxl1_mutated → 1; srsf2_mutated → 1; u2af1_q157_mutated false → 0
Score = 5 (max 6); risk_group = high (≥3)

Also searched as

GIPSS
genetically inspired prognostic scoring system
Tefferi GIPSS
GIPSS myelofibrosis
primary myelofibrosis GIPSS
PMF GIPSS
Tefferi 2018 GIPSS
genetically inspired PMF score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/gipss?karyotype=favorable&calr_type1_like=true&asxl1_mutated=false&srsf2_mutated=false&u2af1_q157_mutated=false

Full URL: https://api.magentlab.com/api/calc/gipss?karyotype=favorable&calr_type1_like=true&asxl1_mutated=false&srsf2_mutated=false&u2af1_q157_mutated=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/gipss?karyotype=favorable&calr_type1_like=true&asxl1_mutated=false&srsf2_mutated=false&u2af1_q157_mutated=false"

Parameters

Name	Type	Required	Description
`karyotype`	string	required · favorable, unfavorable, vhr	Tefferi 2018 revised three-tier karyotype as assigned by the caller (mutually exclusive). favorable is a normal karyotype or sole 13q−, +9, 20q−, chromosome 1 translocation/duplication, or sex chromosome abnormality including −Y and scores 0. unfavorable is all other abnormalities and scores 1. vhr is very high risk: single/multiple −7, i(17q), inv(3)/3q21, 12p−/12p11.2, 11q−/11q23, +21, or other autosomal trisomies not including +8/+9 and scores 2. magent does not karyotype.
`calr_type1_like`	boolean	required	Presence of a type 1/like CALR mutation as assigned by the caller (Tefferi 2018). false (absence) scores 1. true scores 0. Type 2/like CALR, JAK2, MPL, and triple-negative are absence of type 1/like CALR. magent does not sequence.
`asxl1_mutated`	boolean	required	ASXL1 mutation as assigned by the caller (Tefferi 2018). true scores 1. magent does not sequence.
`srsf2_mutated`	boolean	required	SRSF2 mutation as assigned by the caller (Tefferi 2018). true scores 1. magent does not sequence.
`u2af1_q157_mutated`	boolean	required	U2AF1 Q157 mutation (Q157P or Q157R) as assigned by the caller (Tefferi 2018). true scores 1. U2AF1 S34 does not score. magent does not sequence.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/gipss Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "asxl1_mutated": "false",
      "calr_type1_like": "true",
      "karyotype": "favorable",
      "srsf2_mutated": "false",
      "u2af1_q157_mutated": "false"
    },
    {
      "asxl1_mutated": "false",
      "calr_type1_like": "true",
      "karyotype": "favorable",
      "srsf2_mutated": "false",
      "u2af1_q157_mutated": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/gipss",
  "items": [
    {
      "components": [
        {
          "value": "favorable",
          "factor": "karyotype",
          "points": 0,
          "present": false
        },
        {
          "factor": "absence_of_calr_type1_like",
          "points": 0,
          "present": false
        },
        {
          "factor": "asxl1_mutated",
          "points": 0,
          "present": false
        },
        {
          "factor": "srsf2_mutated",
          "points": 0,
          "present": false
        },
        {
          "factor": "u2af1_q157_mutated",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Tefferi A, Guglielmelli P, Nicolosi M, Mannelli F, Mudireddy M, Bartalucci N, Finke CM, Lasho TL, Hanson CA, Ketterling RP, Begna KH, Gangat N, Pardanani A, Vannucchi AM",
        "doi": "10.1038/s41375-018-0107-z",
        "id": "tefferi-2018",
        "pmid": "29654267",
        "source": "Leukemia. 2018;32(7):1631-1642",
        "title": "GIPSS: genetically inspired prognostic scoring system for primary myelofibrosis"
      },
      "formula": "gipss",
      "formula_expression": "GIPSS = karyotype (favorable 0, unfavorable 1, vhr 2) + absence of type 1/like CALR 1 + asxl1_mutated 1 + srsf2_mutated 1 + u2af1_q157_mutated 1; Tefferi 2018; max 6; low 0, intermediate_1 1, intermediate_2 2, high ≥3",
      "max_score": 6,
      "score": 0,
      "risk_group": "low",
      "asxl1_mutated": false,
      "calr_type1_like": true,
      "five_year_survival_percent": 94,
      "karyotype": "favorable",
      "median_survival_years": 26.4,
      "srsf2_mutated": false,
      "u2af1_q157_mutated": false
    },
    {
      "components": [
        {
          "value": "favorable",
          "factor": "karyotype",
          "points": 0,
          "present": false
        },
        {
          "factor": "absence_of_calr_type1_like",
          "points": 0,
          "present": false
        },
        {
          "factor": "asxl1_mutated",
          "points": 0,
          "present": false
        },
        {
          "factor": "srsf2_mutated",
          "points": 0,
          "present": false
        },
        {
          "factor": "u2af1_q157_mutated",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Tefferi A, Guglielmelli P, Nicolosi M, Mannelli F, Mudireddy M, Bartalucci N, Finke CM, Lasho TL, Hanson CA, Ketterling RP, Begna KH, Gangat N, Pardanani A, Vannucchi AM",
        "doi": "10.1038/s41375-018-0107-z",
        "id": "tefferi-2018",
        "pmid": "29654267",
        "source": "Leukemia. 2018;32(7):1631-1642",
        "title": "GIPSS: genetically inspired prognostic scoring system for primary myelofibrosis"
      },
      "formula": "gipss",
      "formula_expression": "GIPSS = karyotype (favorable 0, unfavorable 1, vhr 2) + absence of type 1/like CALR 1 + asxl1_mutated 1 + srsf2_mutated 1 + u2af1_q157_mutated 1; Tefferi 2018; max 6; low 0, intermediate_1 1, intermediate_2 2, high ≥3",
      "max_score": 6,
      "score": 0,
      "risk_group": "low",
      "asxl1_mutated": false,
      "calr_type1_like": true,
      "five_year_survival_percent": 94,
      "karyotype": "favorable",
      "median_survival_years": 26.4,
      "srsf2_mutated": false,
      "u2af1_q157_mutated": false
    }
  ]
}

Response

Field	Type	Description
`formula`	string	gipss
`formula_expression`	string	Exact expression used
`score`	integer	GIPSS points 0-6
`max_score`	integer	Always 6 (2+1+1+1+1)
`risk_group`	string	low when score is 0, intermediate_1 when 1, intermediate_2 when 2, high when ≥3 (Tefferi 2018). Not a PMF diagnosis. Not DIPSS. Not MIPSS70-plus.
`karyotype`	string	Caller-assigned three-tier karyotype used (favorable, unfavorable, or vhr)
`calr_type1_like`	boolean	Caller-assigned type 1/like CALR flag used
`asxl1_mutated`	boolean	Caller-assigned ASXL1 mutation flag used
`srsf2_mutated`	boolean	Caller-assigned SRSF2 mutation flag used
`u2af1_q157_mutated`	boolean	Caller-assigned U2AF1 Q157 mutation flag used (not S34)
`median_survival_years`	number	Tefferi 2018 published median overall survival in years for this GIPSS band (low 26.4, intermediate_1 8.0, intermediate_2 4.2, high 2). Cohort figure, not a patient-specific prediction.
`five_year_survival_percent`	integer	Tefferi 2018 published 5-year survival percent for this GIPSS band (low 94, intermediate_1 73, intermediate_2 40, high 14). Cohort figure, not a patient-specific prediction.
`components`	array	Per-factor points
`citation`	object	Tefferi et al. Leukemia 2018 GIPSS citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "favorable",
      "factor": "karyotype",
      "points": 0,
      "present": false
    },
    {
      "factor": "absence_of_calr_type1_like",
      "points": 0,
      "present": false
    },
    {
      "factor": "asxl1_mutated",
      "points": 0,
      "present": false
    },
    {
      "factor": "srsf2_mutated",
      "points": 0,
      "present": false
    },
    {
      "factor": "u2af1_q157_mutated",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Tefferi A, Guglielmelli P, Nicolosi M, Mannelli F, Mudireddy M, Bartalucci N, Finke CM, Lasho TL, Hanson CA, Ketterling RP, Begna KH, Gangat N, Pardanani A, Vannucchi AM",
    "doi": "10.1038/s41375-018-0107-z",
    "id": "tefferi-2018",
    "pmid": "29654267",
    "source": "Leukemia. 2018;32(7):1631-1642",
    "title": "GIPSS: genetically inspired prognostic scoring system for primary myelofibrosis"
  },
  "formula": "gipss",
  "formula_expression": "GIPSS = karyotype (favorable 0, unfavorable 1, vhr 2) + absence of type 1/like CALR 1 + asxl1_mutated 1 + srsf2_mutated 1 + u2af1_q157_mutated 1; Tefferi 2018; max 6; low 0, intermediate_1 1, intermediate_2 2, high ≥3",
  "max_score": 6,
  "score": 0,
  "risk_group": "low",
  "asxl1_mutated": false,
  "calr_type1_like": true,
  "five_year_survival_percent": 94,
  "karyotype": "favorable",
  "median_survival_years": 26.4,
  "srsf2_mutated": false,
  "u2af1_q157_mutated": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_gipss_karyotype`	karyotype must be favorable, unfavorable, or vhr (Tefferi 2018 GIPSS revised cytogenetic tiers). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

DIPSS — Sum the Passamonti 2010 DIPSS (dynamic international prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1–2), intermediate_2 (3–4), or high (5–6).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.