Hematology · LIVE

MYSEC-PM (post-PV/ET myelofibrosis)

MYSEC-PM

Sum the Passamonti 2017 MYSEC-PM (myelofibrosis secondary to PV/ET prognostic model) and return low (<11), intermediate_1 (≥11 and <14), intermediate_2 (≥14 and <16), or high (≥16).

LIVE $0.005 USDC GET /api/calc/mysec_pm

Markdown: /docs/mysec-pm.md · Canonical: https://magentlab.com/docs/mysec-pm

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Passamonti 2017 MYSEC-PM (myelofibrosis secondary to PV/ET prognostic model) and return low (<11), intermediate_1 (≥11 and <14), intermediate_2 (≥14 and <16), or high (≥16).

When to use

When an agent needs the published MYSEC-PM point total and risk group for post-polycythemia vera or post-essential thrombocythemia myelofibrosis and must not invent a PMF/DIPSS result, a GIPSS genetics score, or a transplant listing.

When not to use

• Not a medical device and not a myelofibrosis diagnosis or treatment choice. magent does not examine the patient.
• This is Passamonti 2017 MYSEC-PM for post-PV and post-ET myelofibrosis only. Not DIPSS or DIPSS Plus for primary myelofibrosis. Not GIPSS. Not a transplant listing.
• magent does not sequence CALR. calr_unmutated is a caller-assigned genotype flag (JAK2, MPL, or triple-negative).
• magent does not assay hemoglobin, platelets, or circulating blasts. Labs are caller-supplied. Provide hemoglobin_g_dl or hemoglobin_g_l, not both.
• Median OS years (low NR; intermediate_1 9.3; intermediate_2 4.4; high 2) are Passamonti 2017 cohort medians, not an individual survival prediction.

Formula

MYSEC-PM = 0.15*age_years + hemoglobin_lt_11 2 + blasts_ge_3 2 + calr_unmutated 2 + platelets_lt_150 1 + constitutional_symptoms 1; Passamonti 2017; low <11, intermediate_1 ≥11 and <14, intermediate_2 ≥14 and <16, high ≥16

Citation

Title

A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis

Authors

Passamonti F, Giorgino T, Mora B, Guglielmelli P, Rumi E, Maffioli M, Rambaldi A, Caramella M, Komrokji R, Gotlib J, Kiladjian JJ, Cervantes F, Devos T, Palandri F, De Stefano V, Ruggeri M, Silver RT, Benevolo G, Albano F, Caramazza D, Merli M, Pietra D, Casalone R, Rotunno G, Barbui T, Cazzola M, Vannucchi AM

Source

Leukemia. 2017;31(12):2726-2731

DOI

10.1038/leu.2017.169

Worked example

Also searched as

• MYSEC-PM
• MYSEC PM
• post-PV myelofibrosis prognostic model
• post-ET myelofibrosis score
• Passamonti 2017 myelofibrosis
• secondary myelofibrosis prognostic model
• CALR-unmutated myelofibrosis score
• myelofibrosis after polycythemia vera

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/mysec_pm?age=40&hemoglobin_g_dl=10&platelets_10e9_l=200&blasts_percent=6&calr_unmutated=false&constitutional_symptoms=false

Full URL: https://api.magentlab.com/api/calc/mysec_pm?age=40&hemoglobin_g_dl=10&platelets_10e9_l=200&blasts_percent=6&calr_unmutated=false&constitutional_symptoms=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/mysec_pm?age=40&hemoglobin_g_dl=10&platelets_10e9_l=200&blasts_percent=6&calr_unmutated=false&constitutional_symptoms=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/mysec_pm Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "40",
      "blasts_percent": "6",
      "calr_unmutated": "false",
      "constitutional_symptoms": "false",
      "hemoglobin_g_dl": "10",
      "platelets_10e9_l": "200"
    },
    {
      "age": "40",
      "blasts_percent": "6",
      "calr_unmutated": "false",
      "constitutional_symptoms": "false",
      "hemoglobin_g_dl": "10",
      "platelets_10e9_l": "200"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/mysec_pm",
  "items": [
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 6.0,
          "present": true
        },
        {
          "value": 10.0,
          "factor": "hemoglobin_lt_11",
          "points": 2,
          "present": true
        },
        {
          "value": 6.0,
          "factor": "blasts_ge_3",
          "points": 2,
          "present": true
        },
        {
          "factor": "calr_unmutated",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "platelets_lt_150",
          "points": 0,
          "present": false
        },
        {
          "factor": "constitutional_symptoms",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Passamonti F, Giorgino T, Mora B, Guglielmelli P, Rumi E, Maffioli M, Rambaldi A, Caramella M, Komrokji R, Gotlib J, Kiladjian JJ, Cervantes F, Devos T, Palandri F, De Stefano V, Ruggeri M, Silver RT, Benevolo G, Albano F, Caramazza D, Merli M, Pietra D, Casalone R, Rotunno G, Barbui T, Cazzola M, Vannucchi AM",
        "doi": "10.1038/leu.2017.169",
        "id": "passamonti-2017",
        "pmid": "28561069",
        "source": "Leukemia. 2017;31(12):2726-2731",
        "title": "A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis"
      },
      "formula": "mysec_pm",
      "formula_expression": "MYSEC-PM = 0.15*age_years + hemoglobin_lt_11 2 + blasts_ge_3 2 + calr_unmutated 2 + platelets_lt_150 1 + constitutional_symptoms 1; Passamonti 2017; low <11, intermediate_1 ≥11 and <14, intermediate_2 ≥14 and <16, high ≥16",
      "score": 10.0,
      "age_years": 40,
      "platelets_10e9_l": 200.0,
      "hemoglobin_g_dl": 10.0,
      "risk_group": "low",
      "blasts_percent": 6.0,
      "constitutional_symptoms": false,
      "calr_unmutated": false,
      "median_os_years": null
    },
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 6.0,
          "present": true
        },
        {
          "value": 10.0,
          "factor": "hemoglobin_lt_11",
          "points": 2,
          "present": true
        },
        {
          "value": 6.0,
          "factor": "blasts_ge_3",
          "points": 2,
          "present": true
        },
        {
          "factor": "calr_unmutated",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "platelets_lt_150",
          "points": 0,
          "present": false
        },
        {
          "factor": "constitutional_symptoms",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Passamonti F, Giorgino T, Mora B, Guglielmelli P, Rumi E, Maffioli M, Rambaldi A, Caramella M, Komrokji R, Gotlib J, Kiladjian JJ, Cervantes F, Devos T, Palandri F, De Stefano V, Ruggeri M, Silver RT, Benevolo G, Albano F, Caramazza D, Merli M, Pietra D, Casalone R, Rotunno G, Barbui T, Cazzola M, Vannucchi AM",
        "doi": "10.1038/leu.2017.169",
        "id": "passamonti-2017",
        "pmid": "28561069",
        "source": "Leukemia. 2017;31(12):2726-2731",
        "title": "A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis"
      },
      "formula": "mysec_pm",
      "formula_expression": "MYSEC-PM = 0.15*age_years + hemoglobin_lt_11 2 + blasts_ge_3 2 + calr_unmutated 2 + platelets_lt_150 1 + constitutional_symptoms 1; Passamonti 2017; low <11, intermediate_1 ≥11 and <14, intermediate_2 ≥14 and <16, high ≥16",
      "score": 10.0,
      "age_years": 40,
      "platelets_10e9_l": 200.0,
      "hemoglobin_g_dl": 10.0,
      "risk_group": "low",
      "blasts_percent": 6.0,
      "constitutional_symptoms": false,
      "calr_unmutated": false,
      "median_os_years": null
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 40,
      "factor": "age",
      "points": 6.0,
      "present": true
    },
    {
      "value": 10.0,
      "factor": "hemoglobin_lt_11",
      "points": 2,
      "present": true
    },
    {
      "value": 6.0,
      "factor": "blasts_ge_3",
      "points": 2,
      "present": true
    },
    {
      "factor": "calr_unmutated",
      "points": 0,
      "present": false
    },
    {
      "value": 200.0,
      "factor": "platelets_lt_150",
      "points": 0,
      "present": false
    },
    {
      "factor": "constitutional_symptoms",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Passamonti F, Giorgino T, Mora B, Guglielmelli P, Rumi E, Maffioli M, Rambaldi A, Caramella M, Komrokji R, Gotlib J, Kiladjian JJ, Cervantes F, Devos T, Palandri F, De Stefano V, Ruggeri M, Silver RT, Benevolo G, Albano F, Caramazza D, Merli M, Pietra D, Casalone R, Rotunno G, Barbui T, Cazzola M, Vannucchi AM",
    "doi": "10.1038/leu.2017.169",
    "id": "passamonti-2017",
    "pmid": "28561069",
    "source": "Leukemia. 2017;31(12):2726-2731",
    "title": "A clinical-molecular prognostic model to predict survival in patients with post polycythemia vera and post essential thrombocythemia myelofibrosis"
  },
  "formula": "mysec_pm",
  "formula_expression": "MYSEC-PM = 0.15*age_years + hemoglobin_lt_11 2 + blasts_ge_3 2 + calr_unmutated 2 + platelets_lt_150 1 + constitutional_symptoms 1; Passamonti 2017; low <11, intermediate_1 ≥11 and <14, intermediate_2 ≥14 and <16, high ≥16",
  "score": 10.0,
  "age_years": 40,
  "platelets_10e9_l": 200.0,
  "hemoglobin_g_dl": 10.0,
  "risk_group": "low",
  "blasts_percent": 6.0,
  "constitutional_symptoms": false,
  "calr_unmutated": false,
  "median_os_years": null
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• DIPSS — Sum the Passamonti 2010 DIPSS (dynamic international prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1–2), intermediate_2 (3–4), or high (5–6).
• GIPSS — Sum the Tefferi 2018 GIPSS (genetically inspired prognostic scoring system) for primary myelofibrosis and return low (0), intermediate_1 (1), intermediate_2 (2), or high (≥3).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.