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NCCN-IPI for DLBCL (Zhou)

NCCN-IPI

Sum the Zhou 2014 NCCN International Prognostic Index (enhanced IPI for DLBCL treated in the rituximab era) and return low (0–1), low_intermediate (2–3), high_intermediate (4–5), or high (6–8).

LIVE $0.005 USDC GET /api/calc/nccn_ipi

Markdown: /docs/nccn-ipi.md · Canonical: https://magentlab.com/docs/nccn-ipi

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Zhou 2014 NCCN International Prognostic Index (enhanced IPI for DLBCL treated in the rituximab era) and return low (0–1), low_intermediate (2–3), high_intermediate (4–5), or high (6–8).

When to use

When an agent needs the published NCCN-IPI point total and risk group for DLBCL treated in the rituximab era and must not invent a DLBCL diagnosis or treatment choice, and must not substitute Shipp IPI, R-IPI, or CNS-IPI.

When not to use

• Not a medical device and not a DLBCL diagnosis or treatment choice. magent does not examine the patient.
• This is Zhou 2014 NCCN-IPI (enhanced IPI for DLBCL in the rituximab era). It is not Shipp IPI (binary age >60, extranodal sites >1), not R-IPI, and not CNS-IPI.
• magent does not stage lymphoma, image extranodal sites, assign ECOG, or assay LDH. stage_iii_or_iv and extranodal_major are caller-assigned flags; extranodal_major is major-organ involvement (bone marrow, CNS, liver/GI tract, or lung), not IPI more than one extranodal site; ECOG is a caller-assigned integer 0–4; ldh_uln_ratio is the caller-assigned LDH/ULN ratio.

Formula

NCCN-IPI = age (≤40 0, 41–60 1, 61–75 2, ≥76 3) + LDH/ULN (≤1 0, >1–3 1, >3 2) + stage_iii_or_iv 1 + extranodal_major 1 + ecog_ge_2 1; Zhou 2014; max 8; low 0-1, low_intermediate 2-3, high_intermediate 4-5, high 6-8

Citation

Title

An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era

Authors

Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, Nademanee A, Kaminski MS, Czuczman MS, Millenson M, Niland J, Gascoyne RD, Connors JM, Friedberg JW, Winter JN

Source

Blood. 2014;123(6):837-842

DOI

10.1182/blood-2013-09-524108

Worked example

Also searched as

• NCCN-IPI
• NCCN IPI
• enhanced IPI
• Zhou NCCN-IPI
• DLBCL NCCN-IPI
• NCCN International Prognostic Index
• enhanced International Prognostic Index
• rituximab-era IPI

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/nccn_ipi?age=40&ecog=0&ldh_uln_ratio=0.9&stage_iii_or_iv=false&extranodal_major=false

Full URL: https://api.magentlab.com/api/calc/nccn_ipi?age=40&ecog=0&ldh_uln_ratio=0.9&stage_iii_or_iv=false&extranodal_major=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/nccn_ipi?age=40&ecog=0&ldh_uln_ratio=0.9&stage_iii_or_iv=false&extranodal_major=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/nccn_ipi Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "40",
      "ecog": "0",
      "extranodal_major": "false",
      "ldh_uln_ratio": "0.9",
      "stage_iii_or_iv": "false"
    },
    {
      "age": "40",
      "ecog": "0",
      "extranodal_major": "false",
      "ldh_uln_ratio": "0.9",
      "stage_iii_or_iv": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/nccn_ipi",
  "items": [
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 0.9,
          "factor": "ldh_uln_ratio",
          "points": 0,
          "present": false
        },
        {
          "factor": "stage_iii_or_iv",
          "points": 0,
          "present": false
        },
        {
          "factor": "extranodal_major",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog_ge_2",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, Nademanee A, Kaminski MS, Czuczman MS, Millenson M, Niland J, Gascoyne RD, Connors JM, Friedberg JW, Winter JN",
        "doi": "10.1182/blood-2013-09-524108",
        "id": "zhou-2014",
        "pmid": "24264230",
        "source": "Blood. 2014;123(6):837-842",
        "title": "An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era"
      },
      "formula": "nccn_ipi",
      "formula_expression": "NCCN-IPI = age (≤40 0, 41–60 1, 61–75 2, ≥76 3) + LDH/ULN (≤1 0, >1–3 1, >3 2) + stage_iii_or_iv 1 + extranodal_major 1 + ecog_ge_2 1; Zhou 2014; max 8; low 0-1, low_intermediate 2-3, high_intermediate 4-5, high 6-8",
      "age_years": 40,
      "max_score": 8,
      "score": 0,
      "ecog": 0,
      "ldh_uln_ratio": 0.9,
      "extranodal_major": false,
      "nccn_ipi_risk": "low"
    },
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 0.9,
          "factor": "ldh_uln_ratio",
          "points": 0,
          "present": false
        },
        {
          "factor": "stage_iii_or_iv",
          "points": 0,
          "present": false
        },
        {
          "factor": "extranodal_major",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog_ge_2",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, Nademanee A, Kaminski MS, Czuczman MS, Millenson M, Niland J, Gascoyne RD, Connors JM, Friedberg JW, Winter JN",
        "doi": "10.1182/blood-2013-09-524108",
        "id": "zhou-2014",
        "pmid": "24264230",
        "source": "Blood. 2014;123(6):837-842",
        "title": "An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era"
      },
      "formula": "nccn_ipi",
      "formula_expression": "NCCN-IPI = age (≤40 0, 41–60 1, 61–75 2, ≥76 3) + LDH/ULN (≤1 0, >1–3 1, >3 2) + stage_iii_or_iv 1 + extranodal_major 1 + ecog_ge_2 1; Zhou 2014; max 8; low 0-1, low_intermediate 2-3, high_intermediate 4-5, high 6-8",
      "age_years": 40,
      "max_score": 8,
      "score": 0,
      "ecog": 0,
      "ldh_uln_ratio": 0.9,
      "extranodal_major": false,
      "nccn_ipi_risk": "low"
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 40,
      "factor": "age",
      "points": 0,
      "present": false
    },
    {
      "value": 0.9,
      "factor": "ldh_uln_ratio",
      "points": 0,
      "present": false
    },
    {
      "factor": "stage_iii_or_iv",
      "points": 0,
      "present": false
    },
    {
      "factor": "extranodal_major",
      "points": 0,
      "present": false
    },
    {
      "value": 0,
      "factor": "ecog_ge_2",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Zhou Z, Sehn LH, Rademaker AW, Gordon LI, Lacasce AS, Crosby-Thompson A, Vanderplas A, Zelenetz AD, Abel GA, Rodriguez MA, Nademanee A, Kaminski MS, Czuczman MS, Millenson M, Niland J, Gascoyne RD, Connors JM, Friedberg JW, Winter JN",
    "doi": "10.1182/blood-2013-09-524108",
    "id": "zhou-2014",
    "pmid": "24264230",
    "source": "Blood. 2014;123(6):837-842",
    "title": "An enhanced International Prognostic Index (NCCN-IPI) for patients with diffuse large B-cell lymphoma treated in the rituximab era"
  },
  "formula": "nccn_ipi",
  "formula_expression": "NCCN-IPI = age (≤40 0, 41–60 1, 61–75 2, ≥76 3) + LDH/ULN (≤1 0, >1–3 1, >3 2) + stage_iii_or_iv 1 + extranodal_major 1 + ecog_ge_2 1; Zhou 2014; max 8; low 0-1, low_intermediate 2-3, high_intermediate 4-5, high 6-8",
  "age_years": 40,
  "max_score": 8,
  "score": 0,
  "ecog": 0,
  "ldh_uln_ratio": 0.9,
  "extranodal_major": false,
  "nccn_ipi_risk": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• IPI — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).
• CNS-IPI — Sum the Schmitz 2016 CNS International Prognostic Index (Shipp IPI factors plus kidney/adrenal involvement) and return low (0–1), intermediate (2–3), or high (4–6).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.