Hematology · LIVE

Rai 1975 CLL staging

Rai

Apply Rai 1975 original clinical staging of chronic lymphocytic leukemia and return rai_stage 0-4 from four caller-assigned flags.

LIVE $0.005 USDC GET /api/calc/rai

Markdown: /docs/rai.md · Canonical: https://magentlab.com/docs/rai

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply Rai 1975 original clinical staging of chronic lymphocytic leukemia and return rai_stage 0-4 from four caller-assigned flags.

When to use

When an agent already has lymphadenopathy, hepatosplenomegaly, anemia (Hb <11 g/dL), and thrombocytopenia (platelets <100,000/mm3) assigned as in Rai 1975 for a patient recognized as CLL, and needs the published original stage. magent does not examine the patient or read a CBC.

When not to use

• Not a medical device.
• Not a CLL diagnosis. Lymphocytosis is assumed; this tool is for a patient already recognized as having chronic lymphocytic leukemia.
• magent does not examine the patient or read a CBC. The caller assigns lymphadenopathy, hepatosplenomegaly, anemia_hb_lt_11, and thrombocytopenia_plt_lt_100 using the 1975 cutoffs (hemoglobin <11 g/dL; platelets <100,000/mm3).
• This tool is original Rai 1975 stages 0-IV only. It is not modified Rai (low / intermediate / high grouping).
• This tool is not Binet staging (Binet C uses hemoglobin <10 g/dL).

Formula

rai_stage = 4 if thrombocytopenia_plt_lt_100; else 3 if anemia_hb_lt_11; else 2 if hepatosplenomegaly; else 1 if lymphadenopathy; else 0 (lymphocytosis only). Original Rai 1975 stages 0-IV. Not modified Rai. Not Binet.

Citation

Title

Clinical staging of chronic lymphocytic leukemia

Authors

Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS

Source

Blood. 1975;46(2):219-234

DOI

10.1182/blood.v46.2.219.219

Worked example

Also searched as

• Rai staging
• Rai classification
• Rai 1975
• CLL Rai stage
• chronic lymphocytic leukemia staging
• Rai stages 0-IV
• original Rai staging
• Rai CLL

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/rai?lymphadenopathy=false&hepatosplenomegaly=false&anemia_hb_lt_11=false&thrombocytopenia_plt_lt_100=false

Full URL: https://api.magentlab.com/api/calc/rai?lymphadenopathy=false&hepatosplenomegaly=false&anemia_hb_lt_11=false&thrombocytopenia_plt_lt_100=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/rai?lymphadenopathy=false&hepatosplenomegaly=false&anemia_hb_lt_11=false&thrombocytopenia_plt_lt_100=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/rai Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "anemia_hb_lt_11": "false",
      "hepatosplenomegaly": "false",
      "lymphadenopathy": "false",
      "thrombocytopenia_plt_lt_100": "false"
    },
    {
      "anemia_hb_lt_11": "false",
      "hepatosplenomegaly": "false",
      "lymphadenopathy": "false",
      "thrombocytopenia_plt_lt_100": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/rai",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS",
        "doi": "10.1182/blood.v46.2.219.219",
        "id": "rai-1975",
        "pmid": "1139039",
        "source": "Blood. 1975;46(2):219-234",
        "title": "Clinical staging of chronic lymphocytic leukemia"
      },
      "formula": "rai",
      "formula_expression": "rai_stage = 4 if thrombocytopenia_plt_lt_100; else 3 if anemia_hb_lt_11; else 2 if hepatosplenomegaly; else 1 if lymphadenopathy; else 0 (lymphocytosis only). Original Rai 1975 stages 0-IV. Not modified Rai. Not Binet.",
      "criteria": [
        {
          "factor": "thrombocytopenia_plt_lt_100",
          "met": false
        },
        {
          "factor": "anemia_hb_lt_11",
          "met": false
        },
        {
          "factor": "hepatosplenomegaly",
          "met": false
        },
        {
          "factor": "lymphadenopathy",
          "met": false
        }
      ],
      "thrombocytopenia_plt_lt_100": false,
      "anemia_hb_lt_11": false,
      "hepatosplenomegaly": false,
      "lymphadenopathy": false,
      "rai_stage": 0
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS",
        "doi": "10.1182/blood.v46.2.219.219",
        "id": "rai-1975",
        "pmid": "1139039",
        "source": "Blood. 1975;46(2):219-234",
        "title": "Clinical staging of chronic lymphocytic leukemia"
      },
      "formula": "rai",
      "formula_expression": "rai_stage = 4 if thrombocytopenia_plt_lt_100; else 3 if anemia_hb_lt_11; else 2 if hepatosplenomegaly; else 1 if lymphadenopathy; else 0 (lymphocytosis only). Original Rai 1975 stages 0-IV. Not modified Rai. Not Binet.",
      "criteria": [
        {
          "factor": "thrombocytopenia_plt_lt_100",
          "met": false
        },
        {
          "factor": "anemia_hb_lt_11",
          "met": false
        },
        {
          "factor": "hepatosplenomegaly",
          "met": false
        },
        {
          "factor": "lymphadenopathy",
          "met": false
        }
      ],
      "thrombocytopenia_plt_lt_100": false,
      "anemia_hb_lt_11": false,
      "hepatosplenomegaly": false,
      "lymphadenopathy": false,
      "rai_stage": 0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS",
    "doi": "10.1182/blood.v46.2.219.219",
    "id": "rai-1975",
    "pmid": "1139039",
    "source": "Blood. 1975;46(2):219-234",
    "title": "Clinical staging of chronic lymphocytic leukemia"
  },
  "formula": "rai",
  "formula_expression": "rai_stage = 4 if thrombocytopenia_plt_lt_100; else 3 if anemia_hb_lt_11; else 2 if hepatosplenomegaly; else 1 if lymphadenopathy; else 0 (lymphocytosis only). Original Rai 1975 stages 0-IV. Not modified Rai. Not Binet.",
  "criteria": [
    {
      "factor": "thrombocytopenia_plt_lt_100",
      "met": false
    },
    {
      "factor": "anemia_hb_lt_11",
      "met": false
    },
    {
      "factor": "hepatosplenomegaly",
      "met": false
    },
    {
      "factor": "lymphadenopathy",
      "met": false
    }
  ],
  "thrombocytopenia_plt_lt_100": false,
  "anemia_hb_lt_11": false,
  "hepatosplenomegaly": false,
  "lymphadenopathy": false,
  "rai_stage": 0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• CLL-IPI — Sum the 2016 CLL-IPI (chronic lymphocytic leukaemia international prognostic index) and return low (0–1), intermediate (2–3), high (4–6), or very_high (7–10).
• Binet — Apply Binet 1981 chronic lymphocytic leukemia staging and return stage A, B, or C from caller-assigned anemia (Hb <10 g/dL), thrombocytopenia (platelets <100×10^9/L), and involved lymphoid areas (0-5).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.