Hematology · LIVE

Binet 1981 CLL staging

Binet

Apply Binet 1981 chronic lymphocytic leukemia staging and return stage A, B, or C from caller-assigned anemia (Hb <10 g/dL), thrombocytopenia (platelets <100×10^9/L), and involved lymphoid areas (0-5).

LIVE $0.005 USDC GET /api/calc/binet

Markdown: /docs/binet.md · Canonical: https://magentlab.com/docs/binet

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply Binet 1981 chronic lymphocytic leukemia staging and return stage A, B, or C from caller-assigned anemia (Hb <10 g/dL), thrombocytopenia (platelets <100×10^9/L), and involved lymphoid areas (0-5).

When to use

When an agent already has CLL with lymphocytosis and caller-assigned anemia, thrombocytopenia, and Binet five-area count, and needs the published Binet 1981 stage. magent does not diagnose CLL and does not examine the patient.

When not to use

• Not a medical device.
• Not a CLL diagnosis. The caller already has CLL with lymphocytosis; magent does not diagnose CLL.
• magent does not examine the patient or count lymph-node areas. The caller assigns the five-area count after Binet's uni/bilateral rule (cervical, axillary, inguinal — uni or bilateral counts as one area each — plus spleen, plus liver).
• This tool is Binet 1981 staging only. Not Rai staging (Rai anemia is Hb <11), not modified Rai, and not CLL-IPI. No A/B/C substages and no survival months.

Formula

Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)

Citation

Title

A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis

Authors

Binet JL, Auquier A, Dighiero G, et al.

Source

Cancer. 1981;48(1):198-206

DOI

10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V

Worked example

Also searched as

• Binet staging
• Binet CLL
• Binet classification
• chronic lymphocytic leukemia staging
• Binet 1981
• CLL Binet stage
• Binet A B C
• lymphoid areas Binet

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/binet?anemia_hb_lt_10=false&thrombocytopenia_plt_lt_100=false&involved_areas=1

Full URL: https://api.magentlab.com/api/calc/binet?anemia_hb_lt_10=false&thrombocytopenia_plt_lt_100=false&involved_areas=1

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/binet?anemia_hb_lt_10=false&thrombocytopenia_plt_lt_100=false&involved_areas=1"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/binet Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "anemia_hb_lt_10": "false",
      "involved_areas": "1",
      "thrombocytopenia_plt_lt_100": "false"
    },
    {
      "anemia_hb_lt_10": "false",
      "involved_areas": "1",
      "thrombocytopenia_plt_lt_100": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/binet",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Binet JL, Auquier A, Dighiero G, et al.",
        "doi": "10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V",
        "id": "binet-1981",
        "pmid": "7237385",
        "source": "Cancer. 1981;48(1):198-206",
        "title": "A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis"
      },
      "formula": "binet",
      "formula_expression": "Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)",
      "criteria": [
        {
          "factor": "anemia_hb_lt_10",
          "met": false
        },
        {
          "factor": "thrombocytopenia_plt_lt_100",
          "met": false
        },
        {
          "factor": "involved_areas_ge_3",
          "met": false
        }
      ],
      "binet_stage": "A",
      "anemia_hb_lt_10": false,
      "involved_areas": 1,
      "thrombocytopenia_plt_lt_100": false
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Binet JL, Auquier A, Dighiero G, et al.",
        "doi": "10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V",
        "id": "binet-1981",
        "pmid": "7237385",
        "source": "Cancer. 1981;48(1):198-206",
        "title": "A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis"
      },
      "formula": "binet",
      "formula_expression": "Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)",
      "criteria": [
        {
          "factor": "anemia_hb_lt_10",
          "met": false
        },
        {
          "factor": "thrombocytopenia_plt_lt_100",
          "met": false
        },
        {
          "factor": "involved_areas_ge_3",
          "met": false
        }
      ],
      "binet_stage": "A",
      "anemia_hb_lt_10": false,
      "involved_areas": 1,
      "thrombocytopenia_plt_lt_100": false
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Binet JL, Auquier A, Dighiero G, et al.",
    "doi": "10.1002/1097-0142(19810701)48:1<198::AID-CNCR2820480131>3.0.CO;2-V",
    "id": "binet-1981",
    "pmid": "7237385",
    "source": "Cancer. 1981;48(1):198-206",
    "title": "A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis"
  },
  "formula": "binet",
  "formula_expression": "Binet C if anemia_hb_lt_10 or thrombocytopenia_plt_lt_100; else B if involved_areas >= 3; else A (involved_areas 0-2) (Binet 1981)",
  "criteria": [
    {
      "factor": "anemia_hb_lt_10",
      "met": false
    },
    {
      "factor": "thrombocytopenia_plt_lt_100",
      "met": false
    },
    {
      "factor": "involved_areas_ge_3",
      "met": false
    }
  ],
  "binet_stage": "A",
  "anemia_hb_lt_10": false,
  "involved_areas": 1,
  "thrombocytopenia_plt_lt_100": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• CLL-IPI — Sum the 2016 CLL-IPI (chronic lymphocytic leukaemia international prognostic index) and return low (0–1), intermediate (2–3), high (4–6), or very_high (7–10).
• Rai — Apply Rai 1975 original clinical staging of chronic lymphocytic leukemia and return rai_stage 0-4 from four caller-assigned flags.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.