CLL-IPI (chronic lymphocytic leukaemia)

CLL-IPI

Sum the 2016 CLL-IPI (chronic lymphocytic leukaemia international prognostic index) and return low (0–1), intermediate (2–3), high (4–6), or very_high (7–10).

LIVE $0.005 USDC GET /api/calc/cll_ipi

Markdown: /docs/cll-ipi.md · Canonical: https://magentlab.com/docs/cll-ipi

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the 2016 CLL-IPI (chronic lymphocytic leukaemia international prognostic index) and return low (0–1), intermediate (2–3), high (4–6), or very_high (7–10).

When to use

When an agent needs the published CLL-IPI point total and risk group and must not invent a CLL diagnosis or treatment choice, and must not substitute Shipp IPI or MIPI.

When not to use

Not a medical device and not a CLL diagnosis or treatment choice. magent does not examine the patient.
This is the 2016 CLL-IPI (Lancet Oncol), not the Shipp 1993 five-factor IPI for aggressive non-Hodgkin lymphoma, not MIPI, and not Rai or Binet stage alone.
magent does not assay TP53, IGHV, or beta-2 microglobulin, and does not assign Binet or Rai stage. tp53_abnormal, ighv_unmutated, and advanced_stage are caller-assigned flags.

Formula

CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10

Citation

Title: An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)
Authors: The International CLL-IPI working group
Source: Lancet Oncol. 2016;17(6):779-790
DOI: 10.1016/S1470-2045(16)30029-8

Worked example

Age 50, no adverse factors

Given: advanced_stage=falseage=50beta2_microglobulin_mg_l=2.0ighv_unmutated=falsetp53_abnormal=false

tp53_abnormal false → 0; ighv_unmutated false → 0; beta2_microglobulin 2.0 is not >3.5 → 0; advanced_stage false → 0; age 50 is not >65 → 0
Score = 0 (max 10); risk_group = low

All five adverse factors

Given: advanced_stage=trueage=66beta2_microglobulin_mg_l=4.0ighv_unmutated=truetp53_abnormal=true

tp53_abnormal → 4; ighv_unmutated → 2; beta2_microglobulin >3.5 → 2; advanced_stage → 1; age >65 → 1
Score = 10 (max 10); risk_group = very_high (7–10)

Also searched as

CLL-IPI
CLL international prognostic index
chronic lymphocytic leukaemia IPI
chronic lymphocytic leukemia prognostic index
CLL IPI 2016
International CLL-IPI
TP53 IGHV CLL score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/cll_ipi?tp53_abnormal=false&ighv_unmutated=false&beta2_microglobulin_mg_l=2.0&advanced_stage=false&age=50

Full URL: https://api.magentlab.com/api/calc/cll_ipi?tp53_abnormal=false&ighv_unmutated=false&beta2_microglobulin_mg_l=2.0&advanced_stage=false&age=50

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/cll_ipi?tp53_abnormal=false&ighv_unmutated=false&beta2_microglobulin_mg_l=2.0&advanced_stage=false&age=50"

Parameters

Name	Type	Required	Description
`tp53_abnormal`	boolean	required	del(17p) and/or TP53 mutation as assigned by the caller (CLL-IPI 2016). true scores 4. magent does not assay TP53.
`ighv_unmutated`	boolean	required	Unmutated IGHV as assigned by the caller (CLL-IPI 2016). true scores 2. magent does not sequence IGHV.
`beta2_microglobulin_mg_l`	number	required	Serum beta-2 microglobulin in mg/L (0.2-40). >3.5 scores 2 (CLL-IPI 2016). 3.5 is the ≤3.5 arm and scores 0. magent does not assay beta-2 microglobulin.
`advanced_stage`	boolean	required	Binet B/C or Rai I–IV as assigned by the caller (CLL-IPI 2016). true scores 1. false is Binet A / Rai 0. magent does not stage CLL.
`age`	integer	required	Age in years (18-120). Age >65 scores 1 (CLL-IPI 2016). Age 65 is the ≤65 arm and scores 0.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/cll_ipi Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "advanced_stage": "false",
      "age": "50",
      "beta2_microglobulin_mg_l": "2.0",
      "ighv_unmutated": "false",
      "tp53_abnormal": "false"
    },
    {
      "advanced_stage": "false",
      "age": "50",
      "beta2_microglobulin_mg_l": "2.0",
      "ighv_unmutated": "false",
      "tp53_abnormal": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/cll_ipi",
  "items": [
    {
      "components": [
        {
          "factor": "tp53_abnormal",
          "points": 0,
          "present": false
        },
        {
          "factor": "ighv_unmutated",
          "points": 0,
          "present": false
        },
        {
          "value": 2.0,
          "factor": "beta2_microglobulin_gt_3_5",
          "points": 0,
          "present": false
        },
        {
          "factor": "advanced_stage",
          "points": 0,
          "present": false
        },
        {
          "value": 50,
          "factor": "age_gt_65",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "The International CLL-IPI working group",
        "doi": "10.1016/S1470-2045(16)30029-8",
        "id": "cll-ipi-2016",
        "pmid": "27153538",
        "source": "Lancet Oncol. 2016;17(6):779-790",
        "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)"
      },
      "formula": "cll_ipi",
      "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10",
      "age_years": 50,
      "max_score": 10,
      "score": 0,
      "beta2_microglobulin_mg_l": 2.0,
      "risk_group": "low"
    },
    {
      "components": [
        {
          "factor": "tp53_abnormal",
          "points": 0,
          "present": false
        },
        {
          "factor": "ighv_unmutated",
          "points": 0,
          "present": false
        },
        {
          "value": 2.0,
          "factor": "beta2_microglobulin_gt_3_5",
          "points": 0,
          "present": false
        },
        {
          "factor": "advanced_stage",
          "points": 0,
          "present": false
        },
        {
          "value": 50,
          "factor": "age_gt_65",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "The International CLL-IPI working group",
        "doi": "10.1016/S1470-2045(16)30029-8",
        "id": "cll-ipi-2016",
        "pmid": "27153538",
        "source": "Lancet Oncol. 2016;17(6):779-790",
        "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)"
      },
      "formula": "cll_ipi",
      "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10",
      "age_years": 50,
      "max_score": 10,
      "score": 0,
      "beta2_microglobulin_mg_l": 2.0,
      "risk_group": "low"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	cll_ipi
`formula_expression`	string	Exact expression used
`score`	integer	CLL-IPI points 0-10
`max_score`	integer	Always 10
`risk_group`	string	low when score is 0-1, intermediate when 2-3, high when 4-6, very_high when 7-10 (CLL-IPI 2016). Not a CLL diagnosis. Not Shipp IPI. Not MIPI.
`age_years`	integer	Age used for the >65 criterion
`beta2_microglobulin_mg_l`	number	Serum beta-2 microglobulin in mg/L used for the >3.5 criterion
`components`	array	Per-factor points
`citation`	object	International CLL-IPI working group Lancet Oncol 2016 citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "factor": "tp53_abnormal",
      "points": 0,
      "present": false
    },
    {
      "factor": "ighv_unmutated",
      "points": 0,
      "present": false
    },
    {
      "value": 2.0,
      "factor": "beta2_microglobulin_gt_3_5",
      "points": 0,
      "present": false
    },
    {
      "factor": "advanced_stage",
      "points": 0,
      "present": false
    },
    {
      "value": 50,
      "factor": "age_gt_65",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "The International CLL-IPI working group",
    "doi": "10.1016/S1470-2045(16)30029-8",
    "id": "cll-ipi-2016",
    "pmid": "27153538",
    "source": "Lancet Oncol. 2016;17(6):779-790",
    "title": "An international prognostic index for patients with chronic lymphocytic leukaemia (CLL-IPI)"
  },
  "formula": "cll_ipi",
  "formula_expression": "CLL-IPI = tp53_abnormal 4 + ighv_unmutated 2 + beta2_microglobulin_gt_3_5 2 + advanced_stage 1 + age_gt_65 1; International CLL-IPI working group 2016; max 10; low 0-1, intermediate 2-3, high 4-6, very_high 7-10",
  "age_years": 50,
  "max_score": 10,
  "score": 0,
  "beta2_microglobulin_mg_l": 2.0,
  "risk_group": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_beta2_microglobulin`	beta2_microglobulin_mg_l must be a number from 0.2 to 40 (Greipp 2005 ISS). Returned before settlement; you are not charged.
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

IPI — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).
MIPI — Sum the Hoster 2008 simplified MIPI (mantle cell lymphoma international prognostic index) from age, ECOG, LDH/ULN, and WBC and return low (0–3), intermediate (4–5), or high (6–11).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.