Simplified MIPI (mantle cell lymphoma)

MIPI

Sum the Hoster 2008 simplified MIPI (mantle cell lymphoma international prognostic index) from age, ECOG, LDH/ULN, and WBC and return low (0–3), intermediate (4–5), or high (6–11).

LIVE $0.005 USDC GET /api/calc/mipi

Markdown: /docs/mipi.md · Canonical: https://magentlab.com/docs/mipi

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Hoster 2008 simplified MIPI (mantle cell lymphoma international prognostic index) from age, ECOG, LDH/ULN, and WBC and return low (0–3), intermediate (4–5), or high (6–11).

When to use

When an agent needs the published simplified MIPI point total and risk group and must not invent a lymphoma diagnosis, and must not substitute continuous MIPI or MIPI-c.

When not to use

Not a medical device and not a lymphoma diagnosis or treatment choice. magent does not examine the patient.
This is the simplified MIPI (Hoster 2008), not the continuous MIPI (log10 WBC formula) and not MIPI-c (Ki-67).
magent does not assign ECOG, assay LDH, or measure WBC. ldh_uln_ratio is the caller-assigned LDH/ULN ratio; WBC is caller-assigned.

Formula

simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11

Citation

Title: A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma
Authors: Hoster E, Dreyling M, Klapper W, et al.
Source: Blood. 2008;111(2):558-565
DOI: 10.1182/blood-2007-06-095331

Worked example

Age 40, ECOG 0, LDH/ULN 0.5, WBC 5 ×10^9/L

Given: age=40ecog=0ldh_uln_ratio=0.5wbc_k_ul=5

Age 40 <50 → 0; ECOG 0 is 0–1 → 0; LDH/ULN 0.5 <0.67 → 0; WBC 5 <6.7 → 0
Score = 0 (max 11); risk_group = low

Age 70, ECOG 4, LDH/ULN 1.5, WBC 15 ×10^9/L

Given: age=70ecog=4ldh_uln_ratio=1.5wbc_k_ul=15

Age ≥70 → 3; ECOG 2–4 → 2; LDH/ULN ≥1.5 → 3; WBC ≥15 → 3
Score = 11 (max 11); risk_group = high (6–11)

Also searched as

MIPI
simplified MIPI
mantle cell lymphoma international prognostic index
Hoster MIPI
MCL MIPI
MIPI score
mantle cell prognostic index

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/mipi?age=40&ecog=0&ldh_uln_ratio=0.5&wbc_k_ul=5

Full URL: https://api.magentlab.com/api/calc/mipi?age=40&ecog=0&ldh_uln_ratio=0.5&wbc_k_ul=5

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/mipi?age=40&ecog=0&ldh_uln_ratio=0.5&wbc_k_ul=5"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (18-120). <50 scores 0; 50–59 scores 1; 60–69 scores 2; ≥70 scores 3 (Hoster 2008 simplified MIPI). 50 and 59 score 1; 60 and 69 score 2; 70 scores 3.
`ecog`	integer	required	ECOG performance status 0-4 as assigned by the caller (Hoster 2008 simplified MIPI). 0–1 scores 0; 2–4 scores 2. magent does not assign ECOG.
`ldh_uln_ratio`	number	required	Serum LDH divided by the laboratory ULN (0.1-20). <0.67 scores 0; 0.67–<1.0 scores 1; 1.0–<1.5 scores 2; ≥1.5 scores 3 (0.67 scores 1; 0.99 scores 1; 1.0 scores 2; 1.49 scores 2; 1.5 scores 3). magent does not assay LDH.
`wbc_k_ul`	number	optional	WBC in 10^3/µL (same as 10^9/L). Provide wbc_k_ul or wbc_ul, not both. Range 0.01-500. Converted to ×10^9/L: <6.7 scores 0; 6.7–<10 scores 1; 10–<15 scores 2; ≥15 scores 3 (6.7 scores 1; 9.999 scores 1; 10 scores 2; 14.999 scores 2; 15 scores 3).
`wbc_ul`	number	optional	WBC in cells/µL (same as cells/mm^3). Provide wbc_k_ul or wbc_ul, not both. Range 10-500000. Converted to ×10^9/L (= wbc_ul/1000): <6.7 scores 0; 6.7–<10 scores 1; 10–<15 scores 2; ≥15 scores 3 (6.7 scores 1; 9.999 scores 1; 10 scores 2; 14.999 scores 2; 15 scores 3).

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/mipi Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "40",
      "ecog": "0",
      "ldh_uln_ratio": "0.5",
      "wbc_k_ul": "5"
    },
    {
      "age": "40",
      "ecog": "0",
      "ldh_uln_ratio": "0.5",
      "wbc_k_ul": "5"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/mipi",
  "items": [
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog",
          "points": 0,
          "present": false
        },
        {
          "value": 0.5,
          "factor": "ldh_uln_ratio",
          "points": 0,
          "present": false
        },
        {
          "value": 5.0e3,
          "factor": "wbc",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hoster E, Dreyling M, Klapper W, et al.",
        "doi": "10.1182/blood-2007-06-095331",
        "id": "hoster-2008",
        "pmid": "17934064",
        "source": "Blood. 2008;111(2):558-565",
        "title": "A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma"
      },
      "formula": "mipi",
      "formula_expression": "simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11",
      "age_years": 40,
      "max_score": 11,
      "score": 0,
      "wbc_10e9_l": 5.0,
      "wbc_ul": 5.0e3,
      "risk_group": "low",
      "ecog": 0,
      "ldh_uln_ratio": 0.5
    },
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 0,
          "factor": "ecog",
          "points": 0,
          "present": false
        },
        {
          "value": 0.5,
          "factor": "ldh_uln_ratio",
          "points": 0,
          "present": false
        },
        {
          "value": 5.0e3,
          "factor": "wbc",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hoster E, Dreyling M, Klapper W, et al.",
        "doi": "10.1182/blood-2007-06-095331",
        "id": "hoster-2008",
        "pmid": "17934064",
        "source": "Blood. 2008;111(2):558-565",
        "title": "A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma"
      },
      "formula": "mipi",
      "formula_expression": "simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11",
      "age_years": 40,
      "max_score": 11,
      "score": 0,
      "wbc_10e9_l": 5.0,
      "wbc_ul": 5.0e3,
      "risk_group": "low",
      "ecog": 0,
      "ldh_uln_ratio": 0.5
    }
  ]
}

Response

Field	Type	Description
`formula`	string	mipi
`formula_expression`	string	Exact expression used
`score`	integer	Simplified MIPI points 0-11
`max_score`	integer	Always 11
`risk_group`	string	low when score is 0-3, intermediate when 4-5, high when 6-11 (Hoster 2008 simplified MIPI). Not a lymphoma diagnosis. Not continuous MIPI. Not MIPI-c.
`age_years`	integer	Age used for the simplified MIPI age bands
`ecog`	integer	Caller-assigned ECOG 0-4 used for 0–1 vs 2–4
`ldh_uln_ratio`	number	Caller-assigned LDH/ULN ratio used for scoring
`wbc_ul`	number	Normalized WBC in cells/µL used for scoring
`wbc_10e9_l`	number	WBC converted to ×10^9/L (wbc_ul / 1000) for Hoster 2008 simplified MIPI bands
`components`	array	Per-factor points
`citation`	object	Hoster 2008 Blood citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 40,
      "factor": "age",
      "points": 0,
      "present": false
    },
    {
      "value": 0,
      "factor": "ecog",
      "points": 0,
      "present": false
    },
    {
      "value": 0.5,
      "factor": "ldh_uln_ratio",
      "points": 0,
      "present": false
    },
    {
      "value": 5.0e3,
      "factor": "wbc",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Hoster E, Dreyling M, Klapper W, et al.",
    "doi": "10.1182/blood-2007-06-095331",
    "id": "hoster-2008",
    "pmid": "17934064",
    "source": "Blood. 2008;111(2):558-565",
    "title": "A new prognostic index (MIPI) for patients with advanced-stage mantle cell lymphoma"
  },
  "formula": "mipi",
  "formula_expression": "simplified MIPI = age (<50 0, 50–59 1, 60–69 2, ≥70 3) + ECOG (0–1 0, 2–4 2) + LDH/ULN (<0.67 0, 0.67–<1.0 1, 1.0–<1.5 2, ≥1.5 3) + WBC ×10^9/L (<6.7 0, 6.7–<10 1, 10–<15 2, ≥15 3); Hoster 2008; max 11; low 0-3, intermediate 4-5, high 6-11",
  "age_years": 40,
  "max_score": 11,
  "score": 0,
  "wbc_10e9_l": 5.0,
  "wbc_ul": 5.0e3,
  "risk_group": "low",
  "ecog": 0,
  "ldh_uln_ratio": 0.5
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_ecog`	ecog must be an integer from 0 to 4 (Shipp 1993 IPI). Returned before settlement; you are not charged.
400	`invalid_ldh_ratio`	ldh_uln_ratio must be a number from 0.1 to 20 (Hoster 2008 simplified MIPI). Returned before settlement; you are not charged.
400	`invalid_wbc`	wbc_k_ul (0.01-500) or wbc_ul (10-500000) is required Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

IPI — Sum the Shipp 1993 five-factor International Prognostic Index (all ages) and return low (0–1), low_intermediate (2), high_intermediate (3), or high (4–5).
FLIPI — Sum the Solal-Céligny 2004 FLIPI adverse factors for follicular lymphoma and return low (0–1), intermediate (2), or high (≥3).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.