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Rome IV cyclic vomiting

Rome IV CVS

Apply the Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b diagnostic criteria and return whether the published CVS box holds (rome_iv_cvs) plus the supportive migraine_history flag.

LIVE $0.005 USDC GET /api/calc/rome_iv_cvs

Markdown: /docs/rome-iv-cvs.md · Canonical: https://magentlab.com/docs/rome-iv-cvs

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b diagnostic criteria and return whether the published CVS box holds (rome_iv_cvs) plus the supportive migraine_history flag.

When to use

When an agent already has the eight caller-assigned Stanghellini 2016 Rome IV adult CVS B3b flags and needs whether the published CVS box holds. magent does not examine the patient.

When not to use

Not a medical device.
Not a diagnosis. magent does not diagnose cyclic vomiting syndrome.
The caller assigns the eight flags. magent does not examine the patient.
This tool is Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b only. Migraine history is supportive and not required for rome_iv_cvs. Not cannabinoid hyperemesis syndrome. Not pediatric or child Rome IV CVS. Not Rome IV IBS (Mearin 2016).

Formula

rome_iv_cvs iff stereotypical_episodes_acute_lt_1_week and at_least_three_episodes_prior_year and at_least_two_episodes_past_6_months and episodes_at_least_1_week_apart and absence_of_vomiting_between_episodes and fulfilled_last_3_months and onset_at_least_6_months; migraine_history is supportive and not required (Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b)

Citation

Title: Gastroduodenal Disorders
Authors: Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ
Source: Gastroenterology. 2016;150(6):1380-1392
DOI: 10.1053/j.gastro.2016.02.011

Worked example

Seven required flags and migraine history

Given: absence_of_vomiting_between_episodes=trueat_least_three_episodes_prior_year=trueat_least_two_episodes_past_6_months=trueepisodes_at_least_1_week_apart=truefulfilled_last_3_months=truemigraine_history=trueonset_at_least_6_months=truestereotypical_episodes_acute_lt_1_week=true

Stereotypical episodes of vomiting with acute onset and duration under 1 week is true
At least 3 discrete episodes in the prior year, 2 in the past 6 months, and episodes at least 1 week apart are true
Absence of vomiting between episodes is true
Criteria fulfilled for the last 3 months and onset at least 6 months prior are true
Migraine history is true (supportive, not required)
rome_iv_cvs is true

Seven required flags without migraine history

Given: absence_of_vomiting_between_episodes=trueat_least_three_episodes_prior_year=trueat_least_two_episodes_past_6_months=trueepisodes_at_least_1_week_apart=truefulfilled_last_3_months=truemigraine_history=falseonset_at_least_6_months=truestereotypical_episodes_acute_lt_1_week=true

All seven required flags hold
Migraine history is false
rome_iv_cvs is true because migraine_history is supportive and not required

Also searched as

Rome IV CVS
Rome IV cyclic vomiting
cyclic vomiting syndrome
Stanghellini 2016 CVS
adult cyclic vomiting Rome IV
Rome IV B3b
cyclic vomiting diagnostic criteria
Rome IV gastroduodenal CVS

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/rome_iv_cvs?stereotypical_episodes_acute_lt_1_week=true&at_least_three_episodes_prior_year=true&at_least_two_episodes_past_6_months=true&episodes_at_least_1_week_apart=true&absence_of_vomiting_between_episodes=true&fulfilled_last_3_months=true&onset_at_least_6_months=true&migraine_history=true

Full URL: https://api.magentlab.com/api/calc/rome_iv_cvs?stereotypical_episodes_acute_lt_1_week=true&at_least_three_episodes_prior_year=true&at_least_two_episodes_past_6_months=true&episodes_at_least_1_week_apart=true&absence_of_vomiting_between_episodes=true&fulfilled_last_3_months=true&onset_at_least_6_months=true&migraine_history=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/rome_iv_cvs?stereotypical_episodes_acute_lt_1_week=true&at_least_three_episodes_prior_year=true&at_least_two_episodes_past_6_months=true&episodes_at_least_1_week_apart=true&absence_of_vomiting_between_episodes=true&fulfilled_last_3_months=true&onset_at_least_6_months=true&migraine_history=true"

Parameters

Name	Type	Required	Description
`stereotypical_episodes_acute_lt_1_week`	boolean	required	Stereotypical episodes of vomiting regarding onset (acute) and duration (<1 week) (Stanghellini 2016 Rome IV adult B3b). true or false as assigned by the caller. magent does not examine the patient.
`at_least_three_episodes_prior_year`	boolean	required	At least 3 discrete vomiting episodes in the prior year, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.
`at_least_two_episodes_past_6_months`	boolean	required	At least 2 discrete vomiting episodes in the past 6 months, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.
`episodes_at_least_1_week_apart`	boolean	required	Discrete vomiting episodes occurring at least 1 week apart, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.
`absence_of_vomiting_between_episodes`	boolean	required	Absence of vomiting between episodes; milder symptoms between cycles are allowed (Stanghellini 2016). true or false as assigned by the caller. magent does not examine the patient.
`fulfilled_last_3_months`	boolean	required	Criteria fulfilled for the last 3 months, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.
`onset_at_least_6_months`	boolean	required	Symptom onset at least 6 months prior to diagnosis, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.
`migraine_history`	boolean	required	Personal history of migraine or family history of migraine, a supportive criterion that is not required for rome_iv_cvs (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/rome_iv_cvs Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "absence_of_vomiting_between_episodes": "true",
      "at_least_three_episodes_prior_year": "true",
      "at_least_two_episodes_past_6_months": "true",
      "episodes_at_least_1_week_apart": "true",
      "fulfilled_last_3_months": "true",
      "migraine_history": "true",
      "onset_at_least_6_months": "true",
      "stereotypical_episodes_acute_lt_1_week": "true"
    },
    {
      "absence_of_vomiting_between_episodes": "true",
      "at_least_three_episodes_prior_year": "true",
      "at_least_two_episodes_past_6_months": "true",
      "episodes_at_least_1_week_apart": "true",
      "fulfilled_last_3_months": "true",
      "migraine_history": "true",
      "onset_at_least_6_months": "true",
      "stereotypical_episodes_acute_lt_1_week": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/rome_iv_cvs",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ",
        "doi": "10.1053/j.gastro.2016.02.011",
        "id": "stanghellini-2016",
        "pmid": "27147122",
        "source": "Gastroenterology. 2016;150(6):1380-1392",
        "title": "Gastroduodenal Disorders"
      },
      "formula": "rome_iv_cvs",
      "formula_expression": "rome_iv_cvs iff stereotypical_episodes_acute_lt_1_week and at_least_three_episodes_prior_year and at_least_two_episodes_past_6_months and episodes_at_least_1_week_apart and absence_of_vomiting_between_episodes and fulfilled_last_3_months and onset_at_least_6_months; migraine_history is supportive and not required (Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b)",
      "criteria": [
        {
          "factor": "stereotypical_episodes_acute_lt_1_week",
          "met": true
        },
        {
          "factor": "at_least_three_episodes_prior_year",
          "met": true
        },
        {
          "factor": "at_least_two_episodes_past_6_months",
          "met": true
        },
        {
          "factor": "episodes_at_least_1_week_apart",
          "met": true
        },
        {
          "factor": "absence_of_vomiting_between_episodes",
          "met": true
        },
        {
          "factor": "fulfilled_last_3_months",
          "met": true
        },
        {
          "factor": "onset_at_least_6_months",
          "met": true
        },
        {
          "factor": "migraine_history",
          "met": true
        }
      ],
      "migraine_history": true,
      "rome_iv_cvs": true
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ",
        "doi": "10.1053/j.gastro.2016.02.011",
        "id": "stanghellini-2016",
        "pmid": "27147122",
        "source": "Gastroenterology. 2016;150(6):1380-1392",
        "title": "Gastroduodenal Disorders"
      },
      "formula": "rome_iv_cvs",
      "formula_expression": "rome_iv_cvs iff stereotypical_episodes_acute_lt_1_week and at_least_three_episodes_prior_year and at_least_two_episodes_past_6_months and episodes_at_least_1_week_apart and absence_of_vomiting_between_episodes and fulfilled_last_3_months and onset_at_least_6_months; migraine_history is supportive and not required (Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b)",
      "criteria": [
        {
          "factor": "stereotypical_episodes_acute_lt_1_week",
          "met": true
        },
        {
          "factor": "at_least_three_episodes_prior_year",
          "met": true
        },
        {
          "factor": "at_least_two_episodes_past_6_months",
          "met": true
        },
        {
          "factor": "episodes_at_least_1_week_apart",
          "met": true
        },
        {
          "factor": "absence_of_vomiting_between_episodes",
          "met": true
        },
        {
          "factor": "fulfilled_last_3_months",
          "met": true
        },
        {
          "factor": "onset_at_least_6_months",
          "met": true
        },
        {
          "factor": "migraine_history",
          "met": true
        }
      ],
      "migraine_history": true,
      "rome_iv_cvs": true
    }
  ]
}

Response

Field	Type	Description
`formula`	string	rome_iv_cvs
`formula_expression`	string	Stanghellini 2016 Rome IV adult CVS B3b: stereotypical acute episodes <1 week, ≥3 episodes in the prior year and 2 in 6 months at least 1 week apart, absence of vomiting between episodes, last-3-months criteria, and 6-month onset; migraine_history is supportive and not required
`migraine_history`	boolean	Caller-assigned supportive migraine (personal or family) flag. Reported separately; not required for rome_iv_cvs.
`rome_iv_cvs`	boolean	true only when all seven required flags hold. migraine_history is not required. Not a diagnosis.
`criteria`	array	Per-factor rows with factor and met for the seven required flags plus supportive migraine_history
`citation`	object	Stanghellini 2016 Gastroenterology citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ",
    "doi": "10.1053/j.gastro.2016.02.011",
    "id": "stanghellini-2016",
    "pmid": "27147122",
    "source": "Gastroenterology. 2016;150(6):1380-1392",
    "title": "Gastroduodenal Disorders"
  },
  "formula": "rome_iv_cvs",
  "formula_expression": "rome_iv_cvs iff stereotypical_episodes_acute_lt_1_week and at_least_three_episodes_prior_year and at_least_two_episodes_past_6_months and episodes_at_least_1_week_apart and absence_of_vomiting_between_episodes and fulfilled_last_3_months and onset_at_least_6_months; migraine_history is supportive and not required (Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b)",
  "criteria": [
    {
      "factor": "stereotypical_episodes_acute_lt_1_week",
      "met": true
    },
    {
      "factor": "at_least_three_episodes_prior_year",
      "met": true
    },
    {
      "factor": "at_least_two_episodes_past_6_months",
      "met": true
    },
    {
      "factor": "episodes_at_least_1_week_apart",
      "met": true
    },
    {
      "factor": "absence_of_vomiting_between_episodes",
      "met": true
    },
    {
      "factor": "fulfilled_last_3_months",
      "met": true
    },
    {
      "factor": "onset_at_least_6_months",
      "met": true
    },
    {
      "factor": "migraine_history",
      "met": true
    }
  ],
  "migraine_history": true,
  "rome_iv_cvs": true
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_rome_iv_cvs`	Rome IV cyclic vomiting needs the eight Stanghellini 2016 adult B3b flags. Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

Rome IV CHS — Apply the Stanghellini 2016 Rome IV cannabinoid hyperemesis syndrome diagnostic criteria and return whether the published CHS box holds (rome_iv_chs) plus the supportive pathologic_bathing flag.
Rome IV FD — Apply the Stanghellini 2016 Rome IV B1 functional dyspepsia criteria and return whether PDS (B1a), EPS (B1b), and the published FD box hold (rome_iv_fd).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.