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Simplified AIH criteria (Hennes)

Simplified AIH

Sum the Hennes 2008 simplified autoimmune-hepatitis criteria (Table 2) from caller-assigned autoantibody, IgG, histology, and viral-hepatitis points and return not_aih (<6), probable (6), or definite (≥7).

LIVE $0.005 USDC GET /api/calc/simplified_aih

Markdown: /docs/simplified-aih.md · Canonical: https://magentlab.com/docs/simplified-aih

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent already has Hennes 2008 Table 2 points assigned and needs the published total and band, not an autoimmune-hepatitis diagnosis and not the original IAHG 1999 score.

When not to use

Not a medical device and not an autoimmune-hepatitis diagnosis or treatment choice. magent does not examine the patient.
This is the Hennes 2008 simplified score (Table 2), not the original IAHG 1999 scoring system.
magent does not titer autoantibodies, assay IgG vs ULN, or read liver histology. autoantibody_points, igg_points, histology, and viral_hepatitis_absent are caller-assigned.
This API does not collect names, MRNs, or dates of birth.

Formula

simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite

Citation

Title: Simplified criteria for the diagnosis of autoimmune hepatitis
Authors: Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group
Source: Hepatology. 2008;48(1):169-176
DOI: 10.1002/hep.22322

Worked example

Typical histology with maximum autoantibody, IgG, and viral points

Given: autoantibody_points=2histology=typicaligg_points=2viral_hepatitis_absent=true

autoantibody_points 2; igg_points 2; histology typical → 2; viral_hepatitis_absent true → 2
Score = 8 (max 8); aih_band = definite

Compatible histology with IgG 1 point

Given: autoantibody_points=2histology=compatibleigg_points=1viral_hepatitis_absent=true

autoantibody_points 2; igg_points 1; histology compatible → 1; viral_hepatitis_absent true → 2
Score = 6 (max 8); aih_band = probable

Also searched as

simplified AIH
Hennes 2008 AIH
simplified autoimmune hepatitis
IAHG simplified criteria
simplified AIH score
autoimmune hepatitis simplified score
Hennes AIH criteria
simplified diagnostic criteria AIH

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/simplified_aih?autoantibody_points=2&igg_points=2&histology=typical&viral_hepatitis_absent=true

Full URL: https://api.magentlab.com/api/calc/simplified_aih?autoantibody_points=2&igg_points=2&histology=typical&viral_hepatitis_absent=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/simplified_aih?autoantibody_points=2&igg_points=2&histology=typical&viral_hepatitis_absent=true"

Parameters

Name	Type	Required	Description
`autoantibody_points`	integer	required · 0, 1, 2	Caller-assigned Hennes 2008 Table 2 autoantibody points (0, 1, or 2; max 2 across ANA/SMA/LKM/SLA). 0: not scoring. 1: ANA or SMA ≥1:40. 2: ANA or SMA ≥1:80 or LKM ≥1:40 or SLA positive. magent does not titer autoantibodies.
`igg_points`	integer	required · 0, 1, 2	Caller-assigned Hennes 2008 Table 2 IgG points (0, 1, or 2). 0: IgG ≤ULN. 1: IgG >ULN. 2: IgG >1.10×ULN. magent does not assay IgG vs ULN.
`histology`	string	required · none, compatible, typical	Caller-assigned Hennes 2008 Table 2 liver histology. none scores 0 (hepatitis is required for histology points). compatible scores 1. typical scores 2. magent does not read liver histology.
`viral_hepatitis_absent`	boolean	required	Caller-assigned Hennes 2008 Table 2 viral hepatitis absence. true scores 2; false scores 0. magent does not interpret viral serology.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/simplified_aih Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "autoantibody_points": "2",
      "histology": "typical",
      "igg_points": "2",
      "viral_hepatitis_absent": "true"
    },
    {
      "autoantibody_points": "2",
      "histology": "typical",
      "igg_points": "2",
      "viral_hepatitis_absent": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/simplified_aih",
  "items": [
    {
      "components": [
        {
          "value": 2,
          "factor": "autoantibody_points",
          "points": 2,
          "present": true
        },
        {
          "value": 2,
          "factor": "igg_points",
          "points": 2,
          "present": true
        },
        {
          "value": "typical",
          "factor": "histology",
          "points": 2,
          "present": true
        },
        {
          "factor": "viral_hepatitis_absent",
          "points": 2,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group",
        "doi": "10.1002/hep.22322",
        "id": "hennes-2008",
        "pmid": "18537184",
        "source": "Hepatology. 2008;48(1):169-176",
        "title": "Simplified criteria for the diagnosis of autoimmune hepatitis"
      },
      "formula": "simplified_aih",
      "formula_expression": "simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite",
      "max_score": 8,
      "score": 8,
      "aih_band": "definite"
    },
    {
      "components": [
        {
          "value": 2,
          "factor": "autoantibody_points",
          "points": 2,
          "present": true
        },
        {
          "value": 2,
          "factor": "igg_points",
          "points": 2,
          "present": true
        },
        {
          "value": "typical",
          "factor": "histology",
          "points": 2,
          "present": true
        },
        {
          "factor": "viral_hepatitis_absent",
          "points": 2,
          "present": true
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group",
        "doi": "10.1002/hep.22322",
        "id": "hennes-2008",
        "pmid": "18537184",
        "source": "Hepatology. 2008;48(1):169-176",
        "title": "Simplified criteria for the diagnosis of autoimmune hepatitis"
      },
      "formula": "simplified_aih",
      "formula_expression": "simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite",
      "max_score": 8,
      "score": 8,
      "aih_band": "definite"
    }
  ]
}

Response

Field	Type	Description
`formula`	string	simplified_aih
`formula_expression`	string	Exact expression used
`score`	integer	Simplified AIH points 0-8
`max_score`	integer	Always 8
`aih_band`	string	not_aih when score is <6, probable when 6, definite when ≥7 (Hennes 2008 Table 2). Not an autoimmune-hepatitis diagnosis. Not the original IAHG 1999 score.
`components`	array	Per-factor points
`citation`	object	Hennes 2008 Hepatology citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 2,
      "factor": "autoantibody_points",
      "points": 2,
      "present": true
    },
    {
      "value": 2,
      "factor": "igg_points",
      "points": 2,
      "present": true
    },
    {
      "value": "typical",
      "factor": "histology",
      "points": 2,
      "present": true
    },
    {
      "factor": "viral_hepatitis_absent",
      "points": 2,
      "present": true
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Hennes EM, Zeniya M, Czaja AJ, Parés A, Dalekos GN, Krawitt EL, Bittencourt PL, Porta G, Boberg KM, Hofer H, Francesconi F, Dufour JF, Vergani D, Lohse AW; International Autoimmune Hepatitis Group",
    "doi": "10.1002/hep.22322",
    "id": "hennes-2008",
    "pmid": "18537184",
    "source": "Hepatology. 2008;48(1):169-176",
    "title": "Simplified criteria for the diagnosis of autoimmune hepatitis"
  },
  "formula": "simplified_aih",
  "formula_expression": "simplified AIH = autoantibody_points (0-2) + igg_points (0-2) + histology (none 0, compatible 1, typical 2) + viral_hepatitis_absent (true 2); Hennes 2008 Table 2; max 8; <6 not_aih, 6 probable, ≥7 definite",
  "max_score": 8,
  "score": 8,
  "aih_band": "definite"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_aih_autoantibody`	autoantibody_points must be 0, 1, or 2 (Hennes 2008 Table 2; max 2 across ANA/SMA/LKM/SLA). Returned before settlement; you are not charged.
400	`invalid_aih_igg`	igg_points must be 0, 1, or 2 (Hennes 2008: 0 ≤ULN, 1 >ULN, 2 >1.10×ULN). Returned before settlement; you are not charged.
400	`invalid_aih_histology`	histology must be none, compatible, or typical (Hennes 2008; hepatitis is required for histology points). Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

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Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.