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SSIGN score for clear cell RCC (Frank 2002)

SSIGN score

Sum the Frank 2002 SSIGN score from caller-assigned 1997 TNM, tumor size, nuclear grade, and coagulative necrosis, and return the published cancer-specific survival row.

LIVE $0.005 USDC GET /api/calc/ssign

Markdown: /docs/ssign.md · Canonical: https://magentlab.com/docs/ssign

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Frank 2002 SSIGN score from caller-assigned 1997 TNM, tumor size, nuclear grade, and coagulative necrosis, and return the published cancer-specific survival row.

When to use

When an agent already has 1997 pathologic T, N, and M, tumor size in cm, nuclear grade, and coagulative necrosis and needs the published SSIGN total and CSS row. magent does not stage the tumor or read slides, and must not invent an RCC diagnosis or a later-TNM conversion.

When not to use

• Not a medical device. magent does not stage the tumor or read pathology.
• 1997 TNM weights from Frank 2002 only. Not 2002 or 2010 TNM. pT4 scores 0 as published. The caller maps TNM; magent does not convert later editions.
• Size uses unrounded cm; 5.0 cm scores 2. Magent clamp 0.1-40 cm is not a published range.
• Published CSS percents are Frank 2002 cohort Kaplan-Meier rows, not an individualized prediction or a treatment recommendation.
• Not UISS. Not an RCC diagnosis. Clear-cell radical-nephrectomy cohort only.

Formula

SSIGN = t_1997 (t1 0, t2 1, t3/t3a/t3b/t3c 2, t4 0) + n_1997 (n0/nx 0, n1/n2 2) + m_1997 (m0 0, m1 4) + tumor_size_cm >=5 2 + fuhrman (1-2 0, 3 1, 4 3) + necrosis 2; Frank 2002 1997 TNM only; max 15; CSS rows 0-1, 2, 3, 4, 5, 6, 7, 8, 9, ge_10

Citation

Title

An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score

Authors

Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H

Source

J Urol. 2002;168(6):2395-2400

DOI

10.1016/s0022-5347(05)64153-5

Worked example

Also searched as

• SSIGN
• SSIGN score
• Stage Size Grade Necrosis
• clear cell RCC SSIGN
• Frank 2002 SSIGN
• RCC SSIGN
• SSIGN renal cell
• coagulative necrosis RCC score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/ssign?t_1997=t1&n_1997=n0&m_1997=m0&tumor_size_cm=3&fuhrman=1&necrosis=false

Full URL: https://api.magentlab.com/api/calc/ssign?t_1997=t1&n_1997=n0&m_1997=m0&tumor_size_cm=3&fuhrman=1&necrosis=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ssign?t_1997=t1&n_1997=n0&m_1997=m0&tumor_size_cm=3&fuhrman=1&necrosis=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/ssign Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "fuhrman": "1",
      "m_1997": "m0",
      "n_1997": "n0",
      "necrosis": "false",
      "t_1997": "t1",
      "tumor_size_cm": "3"
    },
    {
      "fuhrman": "1",
      "m_1997": "m0",
      "n_1997": "n0",
      "necrosis": "false",
      "t_1997": "t1",
      "tumor_size_cm": "3"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/ssign",
  "items": [
    {
      "components": [
        {
          "value": "t1",
          "factor": "t_1997",
          "points": 0,
          "present": true
        },
        {
          "value": "n0",
          "factor": "n_1997",
          "points": 0,
          "present": true
        },
        {
          "value": "m0",
          "factor": "m_1997",
          "points": 0,
          "present": true
        },
        {
          "value": 3.0,
          "factor": "tumor_size_cm",
          "points": 0,
          "present": false
        },
        {
          "value": 1,
          "factor": "fuhrman",
          "points": 0,
          "present": true
        },
        {
          "factor": "necrosis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H",
        "doi": "10.1016/s0022-5347(05)64153-5",
        "id": "frank-2002",
        "pmid": "12441925",
        "source": "J Urol. 2002;168(6):2395-2400",
        "title": "An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score"
      },
      "formula": "ssign",
      "formula_expression": "SSIGN = t_1997 (t1 0, t2 1, t3/t3a/t3b/t3c 2, t4 0) + n_1997 (n0/nx 0, n1/n2 2) + m_1997 (m0 0, m1 4) + tumor_size_cm >=5 2 + fuhrman (1-2 0, 3 1, 4 3) + necrosis 2; Frank 2002 1997 TNM only; max 15; CSS rows 0-1, 2, 3, 4, 5, 6, 7, 8, 9, ge_10",
      "max_score": 15,
      "score": 0,
      "css_10_year_percent": 97.1,
      "css_1_year_percent": 100.0,
      "css_3_year_percent": 99.7,
      "css_5_year_percent": 99.4,
      "css_7_year_percent": 98.7,
      "css_band": "0-1",
      "fuhrman": 1,
      "m_1997": "m0",
      "n_1997": "n0",
      "necrosis": false,
      "t_1997": "t1",
      "tumor_size_cm": 3.0
    },
    {
      "components": [
        {
          "value": "t1",
          "factor": "t_1997",
          "points": 0,
          "present": true
        },
        {
          "value": "n0",
          "factor": "n_1997",
          "points": 0,
          "present": true
        },
        {
          "value": "m0",
          "factor": "m_1997",
          "points": 0,
          "present": true
        },
        {
          "value": 3.0,
          "factor": "tumor_size_cm",
          "points": 0,
          "present": false
        },
        {
          "value": 1,
          "factor": "fuhrman",
          "points": 0,
          "present": true
        },
        {
          "factor": "necrosis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H",
        "doi": "10.1016/s0022-5347(05)64153-5",
        "id": "frank-2002",
        "pmid": "12441925",
        "source": "J Urol. 2002;168(6):2395-2400",
        "title": "An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score"
      },
      "formula": "ssign",
      "formula_expression": "SSIGN = t_1997 (t1 0, t2 1, t3/t3a/t3b/t3c 2, t4 0) + n_1997 (n0/nx 0, n1/n2 2) + m_1997 (m0 0, m1 4) + tumor_size_cm >=5 2 + fuhrman (1-2 0, 3 1, 4 3) + necrosis 2; Frank 2002 1997 TNM only; max 15; CSS rows 0-1, 2, 3, 4, 5, 6, 7, 8, 9, ge_10",
      "max_score": 15,
      "score": 0,
      "css_10_year_percent": 97.1,
      "css_1_year_percent": 100.0,
      "css_3_year_percent": 99.7,
      "css_5_year_percent": 99.4,
      "css_7_year_percent": 98.7,
      "css_band": "0-1",
      "fuhrman": 1,
      "m_1997": "m0",
      "n_1997": "n0",
      "necrosis": false,
      "t_1997": "t1",
      "tumor_size_cm": 3.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "t1",
      "factor": "t_1997",
      "points": 0,
      "present": true
    },
    {
      "value": "n0",
      "factor": "n_1997",
      "points": 0,
      "present": true
    },
    {
      "value": "m0",
      "factor": "m_1997",
      "points": 0,
      "present": true
    },
    {
      "value": 3.0,
      "factor": "tumor_size_cm",
      "points": 0,
      "present": false
    },
    {
      "value": 1,
      "factor": "fuhrman",
      "points": 0,
      "present": true
    },
    {
      "factor": "necrosis",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H",
    "doi": "10.1016/s0022-5347(05)64153-5",
    "id": "frank-2002",
    "pmid": "12441925",
    "source": "J Urol. 2002;168(6):2395-2400",
    "title": "An outcome prediction model for patients with clear cell renal cell carcinoma treated with radical nephrectomy based on tumor stage, size, grade and necrosis: the SSIGN score"
  },
  "formula": "ssign",
  "formula_expression": "SSIGN = t_1997 (t1 0, t2 1, t3/t3a/t3b/t3c 2, t4 0) + n_1997 (n0/nx 0, n1/n2 2) + m_1997 (m0 0, m1 4) + tumor_size_cm >=5 2 + fuhrman (1-2 0, 3 1, 4 3) + necrosis 2; Frank 2002 1997 TNM only; max 15; CSS rows 0-1, 2, 3, 4, 5, 6, 7, 8, 9, ge_10",
  "max_score": 15,
  "score": 0,
  "css_10_year_percent": 97.1,
  "css_1_year_percent": 100.0,
  "css_3_year_percent": 99.7,
  "css_5_year_percent": 99.4,
  "css_7_year_percent": 98.7,
  "css_band": "0-1",
  "fuhrman": 1,
  "m_1997": "m0",
  "n_1997": "n0",
  "necrosis": false,
  "t_1997": "t1",
  "tumor_size_cm": 3.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Fuhrman — Echo the caller-assigned Fuhrman 1982 nuclear grade (1-4) with the published nuclear-feature description. magent does not read slides. Not WHO/ISUP 2016.
• R.E.N.A.L. nephrometry — Sum the Kutikov 2009 R.E.N.A.L. nephrometry score for a renal mass from four caller-assigned published item points (radius, exophytic/endophytic, nearness, location) and return the integer total (4–12) plus anterior and hilar descriptors. Does not return complexity bands.
• UISS — Apply the Zisman 2002 localized N0M0 three-group UISS algorithm to caller-assigned 1997 pathological T, Fuhrman grade, and ECOG PS and return low_risk, intermediate_risk, or high_risk. Does not compute a predicted 5-year disease-specific survival.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.