Hematology · LIVE

IPS-E (early-stage asymptomatic CLL)

IPS-E

Sum the 2020 IPS-E (international prognostic score for asymptomatic early-stage chronic lymphocytic leukemia) and return low (0), intermediate (1), or high (2–3).

LIVE $0.005 USDC GET /api/calc/ips_e

Markdown: /docs/ips-e.md · Canonical: https://magentlab.com/docs/ips-e

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the 2020 IPS-E (international prognostic score for asymptomatic early-stage chronic lymphocytic leukemia) and return low (0), intermediate (1), or high (2–3).

When to use

When an agent needs the published IPS-E point total and risk band for early-stage asymptomatic CLL and must not invent a treatment start order, and must not substitute CLL-IPI, Rai, or Binet.

When not to use

• Not a medical device and not a CLL diagnosis or treatment start order. magent does not examine the patient.
• This is Condoluci 2020 IPS-E (time to first treatment in early-stage asymptomatic CLL), not CLL-IPI, not Rai, and not Binet.
• magent does not assay IGHV, count lymphocytes, or palpate lymph nodes. ighv_unmutated and palpable_lymph_nodes are caller-assigned flags; alc_k_ul is caller-supplied ALC.

Formula

IPS-E = ighv_unmutated 1 + alc_gt_15 1 + palpable_lymph_nodes 1; Condoluci 2020; max 3; low 0, intermediate 1, high 2-3

Citation

Title

International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia

Authors

Condoluci A, Terzi di Bergamo L, Langerbeins P, Hoechstetter MA, Herling CD, et al.

Source

Blood. 2020;135(21):1859-1869

DOI

10.1182/blood.2019003453

Worked example

Also searched as

• IPS-E
• international prognostic score early-stage CLL
• Condoluci IPS-E
• asymptomatic early-stage CLL score
• CLL time to first treatment score
• IPS E CLL
• early CLL prognostic score

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/ips_e?ighv_unmutated=false&alc_k_ul=10&palpable_lymph_nodes=false

Full URL: https://api.magentlab.com/api/calc/ips_e?ighv_unmutated=false&alc_k_ul=10&palpable_lymph_nodes=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ips_e?ighv_unmutated=false&alc_k_ul=10&palpable_lymph_nodes=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/ips_e Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "alc_k_ul": "10",
      "ighv_unmutated": "false",
      "palpable_lymph_nodes": "false"
    },
    {
      "alc_k_ul": "10",
      "ighv_unmutated": "false",
      "palpable_lymph_nodes": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/ips_e",
  "items": [
    {
      "components": [
        {
          "factor": "ighv_unmutated",
          "points": 0,
          "present": false
        },
        {
          "value": 10.0,
          "factor": "alc_gt_15",
          "points": 0,
          "present": false
        },
        {
          "factor": "palpable_lymph_nodes",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Condoluci A, Terzi di Bergamo L, Langerbeins P, Hoechstetter MA, Herling CD, et al.",
        "doi": "10.1182/blood.2019003453",
        "id": "condoluci-2020",
        "pmid": "32267500",
        "source": "Blood. 2020;135(21):1859-1869",
        "title": "International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia"
      },
      "formula": "ips_e",
      "formula_expression": "IPS-E = ighv_unmutated 1 + alc_gt_15 1 + palpable_lymph_nodes 1; Condoluci 2020; max 3; low 0, intermediate 1, high 2-3",
      "max_score": 3,
      "score": 0,
      "alc_k_ul": 10.0,
      "ighv_unmutated": false,
      "ips_e_risk": "low",
      "palpable_lymph_nodes": false
    },
    {
      "components": [
        {
          "factor": "ighv_unmutated",
          "points": 0,
          "present": false
        },
        {
          "value": 10.0,
          "factor": "alc_gt_15",
          "points": 0,
          "present": false
        },
        {
          "factor": "palpable_lymph_nodes",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Condoluci A, Terzi di Bergamo L, Langerbeins P, Hoechstetter MA, Herling CD, et al.",
        "doi": "10.1182/blood.2019003453",
        "id": "condoluci-2020",
        "pmid": "32267500",
        "source": "Blood. 2020;135(21):1859-1869",
        "title": "International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia"
      },
      "formula": "ips_e",
      "formula_expression": "IPS-E = ighv_unmutated 1 + alc_gt_15 1 + palpable_lymph_nodes 1; Condoluci 2020; max 3; low 0, intermediate 1, high 2-3",
      "max_score": 3,
      "score": 0,
      "alc_k_ul": 10.0,
      "ighv_unmutated": false,
      "ips_e_risk": "low",
      "palpable_lymph_nodes": false
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "factor": "ighv_unmutated",
      "points": 0,
      "present": false
    },
    {
      "value": 10.0,
      "factor": "alc_gt_15",
      "points": 0,
      "present": false
    },
    {
      "factor": "palpable_lymph_nodes",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Condoluci A, Terzi di Bergamo L, Langerbeins P, Hoechstetter MA, Herling CD, et al.",
    "doi": "10.1182/blood.2019003453",
    "id": "condoluci-2020",
    "pmid": "32267500",
    "source": "Blood. 2020;135(21):1859-1869",
    "title": "International prognostic score for asymptomatic early-stage chronic lymphocytic leukemia"
  },
  "formula": "ips_e",
  "formula_expression": "IPS-E = ighv_unmutated 1 + alc_gt_15 1 + palpable_lymph_nodes 1; Condoluci 2020; max 3; low 0, intermediate 1, high 2-3",
  "max_score": 3,
  "score": 0,
  "alc_k_ul": 10.0,
  "ighv_unmutated": false,
  "ips_e_risk": "low",
  "palpable_lymph_nodes": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• CLL-IPI — Sum the 2016 CLL-IPI (chronic lymphocytic leukaemia international prognostic index) and return low (0–1), intermediate (2–3), high (4–6), or very_high (7–10).
• Rai — Apply Rai 1975 original clinical staging of chronic lymphocytic leukemia and return rai_stage 0-4 from four caller-assigned flags.
• Binet — Apply Binet 1981 chronic lymphocytic leukemia staging and return stage A, B, or C from caller-assigned anemia (Hb <10 g/dL), thrombocytopenia (platelets <100×10^9/L), and involved lymphoid areas (0-5).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.