Neurology · LIVE

IV alteplase dose (NINDS)

Alteplase stroke dose

Compute NINDS 1995 intravenous alteplase milligrams from weight: 0.9 mg/kg capped at 90 mg, with 10% as a bolus and the remainder over 60 minutes.

LIVE $0.005 USDC GET /api/calc/alteplase_stroke

Markdown: /docs/alteplase-stroke.md · Canonical: https://magentlab.com/docs/alteplase-stroke

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute NINDS 1995 intravenous alteplase milligrams from weight: 0.9 mg/kg capped at 90 mg, with 10% as a bolus and the remainder over 60 minutes.

When to use

When an agent needs published NINDS 1995 alteplase milligram arithmetic and must not invent eligibility, door-to-needle time, blood-pressure targets, or a tenecteplase dose.

When not to use

• Not a medical device. A licensed clinician remains responsible for the prescription and administration.
• Not a prescription and not an eligibility screen. magent does not encode NINDS exclusion criteria, door-to-needle time, or blood-pressure targets.
• Alteplase milligrams only. Not tenecteplase.

Formula

total_mg = min(0.9 * weight_kg, 90.0); bolus_mg = 0.10 * total_mg; infusion_mg = 0.90 * total_mg; infusion_minutes = 60

Citation

Title

Tissue plasminogen activator for acute ischemic stroke

Authors

National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group

Source

N Engl J Med. 1995;333(24):1581-1587

DOI

10.1056/NEJM199512143332401

Worked example

Also searched as

• alteplase dose
• IV alteplase milligrams
• NINDS alteplase dose
• stroke alteplase weight
• alteplase bolus infusion
• 0.9 mg/kg alteplase
• alteplase 90 mg cap

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/alteplase_stroke?weight_kg=80

Full URL: https://api.magentlab.com/api/calc/alteplase_stroke?weight_kg=80

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/alteplase_stroke?weight_kg=80"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/alteplase_stroke Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "weight_kg": "80"
    },
    {
      "weight_kg": "80"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/alteplase_stroke",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group",
        "doi": "10.1056/NEJM199512143332401",
        "id": "ninds-1995",
        "pmid": "7477192",
        "source": "N Engl J Med. 1995;333(24):1581-1587",
        "title": "Tissue plasminogen activator for acute ischemic stroke"
      },
      "formula": "alteplase_stroke",
      "formula_expression": "total_mg = min(0.9 * weight_kg, 90.0); bolus_mg = 0.10 * total_mg; infusion_mg = 0.90 * total_mg; infusion_minutes = 60",
      "weight_kg": 80.0,
      "bolus_mg": 7.2,
      "capped": false,
      "infusion_mg": 64.8,
      "infusion_minutes": 60,
      "total_mg": 72.0
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group",
        "doi": "10.1056/NEJM199512143332401",
        "id": "ninds-1995",
        "pmid": "7477192",
        "source": "N Engl J Med. 1995;333(24):1581-1587",
        "title": "Tissue plasminogen activator for acute ischemic stroke"
      },
      "formula": "alteplase_stroke",
      "formula_expression": "total_mg = min(0.9 * weight_kg, 90.0); bolus_mg = 0.10 * total_mg; infusion_mg = 0.90 * total_mg; infusion_minutes = 60",
      "weight_kg": 80.0,
      "bolus_mg": 7.2,
      "capped": false,
      "infusion_mg": 64.8,
      "infusion_minutes": 60,
      "total_mg": 72.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group",
    "doi": "10.1056/NEJM199512143332401",
    "id": "ninds-1995",
    "pmid": "7477192",
    "source": "N Engl J Med. 1995;333(24):1581-1587",
    "title": "Tissue plasminogen activator for acute ischemic stroke"
  },
  "formula": "alteplase_stroke",
  "formula_expression": "total_mg = min(0.9 * weight_kg, 90.0); bolus_mg = 0.10 * total_mg; infusion_mg = 0.90 * total_mg; infusion_minutes = 60",
  "weight_kg": 80.0,
  "bolus_mg": 7.2,
  "capped": false,
  "infusion_mg": 64.8,
  "infusion_minutes": 60,
  "total_mg": 72.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• NIHSS — Sum Brott 1989 NIH stroke scale points from 15 caller-assigned examination integers, including pupillary response and plantar reflex. Weaker-limb motor arm and leg. Does not apply later total-score severity bands.
• LAMS — Sum Llanes 2004 LAMS points from caller-assigned facial droop, arm drift, and grip (LAPSS motor items).
• ABCD2 score — Compute the ABCD2 score as age, blood pressure, caller-assigned clinical features, symptom duration, and diabetes.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.