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Rome IV chronic nausea vomiting syndrome

Rome IV CNVS

Apply the Stanghellini 2016 Rome IV chronic nausea vomiting syndrome (CNVS, B3a) diagnostic criteria and return whether the published CNVS box holds (rome_iv_cnvs).

LIVE $0.005 USDC GET /api/calc/rome_iv_cnvs

Markdown: /docs/rome-iv-cnvs.md · Canonical: https://magentlab.com/docs/rome-iv-cnvs

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Stanghellini 2016 Rome IV chronic nausea vomiting syndrome (CNVS, B3a) diagnostic criteria and return whether the published CNVS box holds (rome_iv_cnvs).

When to use

When an agent already has the five caller-assigned Stanghellini 2016 Rome IV chronic nausea vomiting syndrome flags and needs whether the published CNVS box holds. magent does not take a history or read endoscopy.

When not to use

Not a medical device.
Not a diagnosis. magent does not diagnose chronic nausea vomiting syndrome.
The caller assigns the five flags. magent does not take a history or read endoscopy.
This tool is Stanghellini 2016 Rome IV chronic nausea vomiting syndrome (B3a) only. Criterion 1 (bothersome nausea at least 1 day per week and/or one or more vomiting episodes per week) is one caller flag, not two. Not cyclic vomiting syndrome (CVS). Not cannabinoid hyperemesis syndrome (CHS). Not rumination.

Formula

rome_iv_cnvs iff bothersome_nausea_or_vomiting_weekly and self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded and no_organic_systemic_metabolic_explanation and fulfilled_last_3_months and onset_at_least_6_months (Stanghellini 2016 Rome IV chronic nausea vomiting syndrome)

Citation

Title: Gastroduodenal Disorders
Authors: Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ
Source: Gastroenterology. 2016;150(6):1380-1392
DOI: 10.1053/j.gastro.2016.02.011

Worked example

All five required flags

Given: bothersome_nausea_or_vomiting_weekly=truefulfilled_last_3_months=trueno_organic_systemic_metabolic_explanation=trueonset_at_least_6_months=trueself_induced_vomiting_eating_disorders_regurgitation_rumination_excluded=true

Bothersome nausea at least 1 day per week and/or one or more vomiting episodes per week is true as one flag
Self-induced vomiting, eating disorders, regurgitation, and rumination are excluded
No organic, systemic, or metabolic explanation including at upper endoscopy is true
Criteria fulfilled for the last 3 months and onset at least 6 months prior are true
rome_iv_cnvs is true

Four required flags without 6-month onset

Given: bothersome_nausea_or_vomiting_weekly=truefulfilled_last_3_months=trueno_organic_systemic_metabolic_explanation=trueonset_at_least_6_months=falseself_induced_vomiting_eating_disorders_regurgitation_rumination_excluded=true

Four required flags hold
Onset at least 6 months prior is false
rome_iv_cnvs is false

Also searched as

Rome IV CNVS
Rome IV chronic nausea vomiting syndrome
Stanghellini 2016 CNVS
chronic nausea vomiting syndrome Rome IV
Rome IV B3a CNVS
gastroduodenal CNVS
chronic nausea and vomiting syndrome
Rome IV chronic nausea and vomiting

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/rome_iv_cnvs?bothersome_nausea_or_vomiting_weekly=true&self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded=true&no_organic_systemic_metabolic_explanation=true&fulfilled_last_3_months=true&onset_at_least_6_months=true

Full URL: https://api.magentlab.com/api/calc/rome_iv_cnvs?bothersome_nausea_or_vomiting_weekly=true&self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded=true&no_organic_systemic_metabolic_explanation=true&fulfilled_last_3_months=true&onset_at_least_6_months=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/rome_iv_cnvs?bothersome_nausea_or_vomiting_weekly=true&self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded=true&no_organic_systemic_metabolic_explanation=true&fulfilled_last_3_months=true&onset_at_least_6_months=true"

Parameters

Name	Type	Required	Description
`bothersome_nausea_or_vomiting_weekly`	boolean	required	Bothersome (severe enough to impact usual activities) nausea at least 1 day per week and/or one or more vomiting episodes per week (Stanghellini 2016 Rome IV CNVS B3a). One caller flag covering nausea and/or vomiting. true or false as assigned by the caller. magent does not take a history.
`self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded`	boolean	required	Self-induced vomiting, eating disorders, regurgitation, and rumination have been excluded (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.
`no_organic_systemic_metabolic_explanation`	boolean	required	No evidence of organic, systemic, or metabolic disease likely to explain the symptoms on routine investigations including at upper endoscopy, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not read endoscopy.
`fulfilled_last_3_months`	boolean	required	Criteria fulfilled for the last 3 months, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.
`onset_at_least_6_months`	boolean	required	Symptom onset at least 6 months prior to diagnosis, as assigned (Stanghellini 2016). true or false as assigned by the caller. magent does not take a history.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/rome_iv_cnvs Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "bothersome_nausea_or_vomiting_weekly": "true",
      "fulfilled_last_3_months": "true",
      "no_organic_systemic_metabolic_explanation": "true",
      "onset_at_least_6_months": "true",
      "self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded": "true"
    },
    {
      "bothersome_nausea_or_vomiting_weekly": "true",
      "fulfilled_last_3_months": "true",
      "no_organic_systemic_metabolic_explanation": "true",
      "onset_at_least_6_months": "true",
      "self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/rome_iv_cnvs",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ",
        "doi": "10.1053/j.gastro.2016.02.011",
        "id": "stanghellini-2016",
        "pmid": "27147122",
        "source": "Gastroenterology. 2016;150(6):1380-1392",
        "title": "Gastroduodenal Disorders"
      },
      "formula": "rome_iv_cnvs",
      "formula_expression": "rome_iv_cnvs iff bothersome_nausea_or_vomiting_weekly and self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded and no_organic_systemic_metabolic_explanation and fulfilled_last_3_months and onset_at_least_6_months (Stanghellini 2016 Rome IV chronic nausea vomiting syndrome)",
      "criteria": [
        {
          "factor": "bothersome_nausea_or_vomiting_weekly",
          "met": true
        },
        {
          "factor": "self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded",
          "met": true
        },
        {
          "factor": "no_organic_systemic_metabolic_explanation",
          "met": true
        },
        {
          "factor": "fulfilled_last_3_months",
          "met": true
        },
        {
          "factor": "onset_at_least_6_months",
          "met": true
        }
      ],
      "rome_iv_cnvs": true
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ",
        "doi": "10.1053/j.gastro.2016.02.011",
        "id": "stanghellini-2016",
        "pmid": "27147122",
        "source": "Gastroenterology. 2016;150(6):1380-1392",
        "title": "Gastroduodenal Disorders"
      },
      "formula": "rome_iv_cnvs",
      "formula_expression": "rome_iv_cnvs iff bothersome_nausea_or_vomiting_weekly and self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded and no_organic_systemic_metabolic_explanation and fulfilled_last_3_months and onset_at_least_6_months (Stanghellini 2016 Rome IV chronic nausea vomiting syndrome)",
      "criteria": [
        {
          "factor": "bothersome_nausea_or_vomiting_weekly",
          "met": true
        },
        {
          "factor": "self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded",
          "met": true
        },
        {
          "factor": "no_organic_systemic_metabolic_explanation",
          "met": true
        },
        {
          "factor": "fulfilled_last_3_months",
          "met": true
        },
        {
          "factor": "onset_at_least_6_months",
          "met": true
        }
      ],
      "rome_iv_cnvs": true
    }
  ]
}

Response

Field	Type	Description
`formula`	string	rome_iv_cnvs
`formula_expression`	string	Stanghellini 2016 Rome IV chronic nausea vomiting syndrome B3a: bothersome nausea at least 1 day per week and/or one or more vomiting episodes per week as one flag, self-induced vomiting eating disorders regurgitation and rumination excluded, no organic systemic or metabolic explanation including at upper endoscopy, last-3-months criteria, and 6-month onset
`rome_iv_cnvs`	boolean	true only when all five required flags hold. Not a diagnosis.
`criteria`	array	Per-factor rows with factor and met for the five required flags
`citation`	object	Stanghellini 2016 Gastroenterology citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Stanghellini V, Chan FKL, Hasler WL, Malagelada JR, Suzuki H, Tack J, Talley NJ",
    "doi": "10.1053/j.gastro.2016.02.011",
    "id": "stanghellini-2016",
    "pmid": "27147122",
    "source": "Gastroenterology. 2016;150(6):1380-1392",
    "title": "Gastroduodenal Disorders"
  },
  "formula": "rome_iv_cnvs",
  "formula_expression": "rome_iv_cnvs iff bothersome_nausea_or_vomiting_weekly and self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded and no_organic_systemic_metabolic_explanation and fulfilled_last_3_months and onset_at_least_6_months (Stanghellini 2016 Rome IV chronic nausea vomiting syndrome)",
  "criteria": [
    {
      "factor": "bothersome_nausea_or_vomiting_weekly",
      "met": true
    },
    {
      "factor": "self_induced_vomiting_eating_disorders_regurgitation_rumination_excluded",
      "met": true
    },
    {
      "factor": "no_organic_systemic_metabolic_explanation",
      "met": true
    },
    {
      "factor": "fulfilled_last_3_months",
      "met": true
    },
    {
      "factor": "onset_at_least_6_months",
      "met": true
    }
  ],
  "rome_iv_cnvs": true
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_rome_iv_cnvs`	Rome IV chronic nausea vomiting needs the Stanghellini 2016 gastroduodenal CNVS flags. Returned before settlement; you are not charged.
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

Rome IV CVS — Apply the Stanghellini 2016 Rome IV adult cyclic vomiting syndrome B3b diagnostic criteria and return whether the published CVS box holds (rome_iv_cvs) plus the supportive migraine_history flag.
Rome IV CHS — Apply the Stanghellini 2016 Rome IV cannabinoid hyperemesis syndrome diagnostic criteria and return whether the published CHS box holds (rome_iv_chs) plus the supportive pathologic_bathing flag.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.