Lipids · LIVE

SCORE2 10-year CVD risk

Compute the ESC 2021 SCORE2 10-year fatal plus non-fatal CVD percent for adults aged 40-69 from sex, current smoking, systolic blood pressure, non-HDL cholesterol, and European geographic risk region.

LIVE $0.005 USDC GET /api/calc/score2

Markdown: /docs/score2.md · Canonical: https://magentlab.com/docs/score2

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent already has those SCORE2 2021 predictors for a person aged 40-69 without prior CVD or diabetes and needs that paper's region-calibrated 10-year CVD percent. Not a diagnosis, statin order, SCORE2-OP, SCORE2-Diabetes, or 2013 pooled-cohort equation.

When not to use

Not a medical device. Not a diagnosis of cardiovascular disease. Not a statin order or treatment recommendation.
SCORE2 2021 for ages 40-69 only. Not SCORE2-OP (age 70 or older). Not SCORE2-Diabetes. Not intended for people with prior CVD or diabetes.
Not the 2013 ACC/AHA pooled-cohort equations. Not Reynolds. european_risk_region is the paper's geographic calibration (low, moderate, high, very_high), not race or ethnicity.
Charts display non-HDL. The published equation uses total and HDL cholesterol; magent evaluates it at the paper's HDL centering 1.3 mmol/L (TC = non-HDL + 1.3), matching the printed 50-year-old example (TC 5.5, HDL 1.3).
Caller assigns age, sex, smoking, blood pressure, non-HDL, and European risk region. magent does not assay lipids and does not measure blood pressure.

Formula

10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; charts display non-HDL mmol/L; equation uses TC and HDL at paper HDL centering 1.3 so TC=non-HDL+1.3, ctchol=(TC-6)/1, chdl=0; diabetes terms omitted (not SCORE2-Diabetes); men S0=0.9605 lp=0.3742*cage+0.6012*smoke+0.2777*csbp+0.1458*ctchol-0.2698*chdl-0.0755*cage*smoke-0.0255*cage*csbp-0.0281*cage*ctchol+0.0426*cage*chdl; women S0=0.9776 lp=0.4648*cage+0.7744*smoke+0.3131*csbp+0.1002*ctchol-0.2606*chdl-0.1088*cage*smoke-0.0277*cage*csbp-0.0226*cage*ctchol+0.0613*cage*chdl; region (scale1,scale2) men low (-0.5699,0.7476) moderate (-0.1565,0.8009) high (0.3207,0.9360) very_high (0.5836,0.8294); women low (-0.7380,0.7019) moderate (-0.3143,0.7701) high (0.5710,0.9369) very_high (0.9412,0.8329); SCORE2 2021 four-decimal coefficients (updated supplement Table 1); age 40-69; geographic region not race; not SCORE2-OP; not 2013 PCE

Citation

Title: SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe
Authors: SCORE2 working group and ESC Cardiovascular risk collaboration
Source: Eur Heart J. 2021;42(25):2439-2454
DOI: 10.1093/eurheartj/ehab309

Worked example

Low-risk region, male, age 50, current smoker, SBP 140, non-HDL 4.2 mmol/L (paper TC 5.5, HDL 1.3)

Given: age=50european_risk_region=lownon_hdl_mmol_l=4.2sbp_mm_hg=140sex=malesmoker=true

cage=(50-60)/5=-2; csbp=(140-120)/20=1; TC=4.2+1.3=5.5; ctchol=(5.5-6)=-0.5; chdl=0; smoke=1
men lp = 0.2315 (diabetes terms omitted)
uncal = 1-0.9605^exp(lp); low-risk men scale1=-0.5699 scale2=0.7476
risk_10y_percent 5.9 (paper prints 5.9% for this male smoker)

Same male smoker in the very-high-risk region

Given: age=50european_risk_region=very_highnon_hdl_mmol_l=4.2sbp_mm_hg=140sex=malesmoker=true

Same lp 0.2315; very_high men scale1=0.5836 scale2=0.8294
risk_10y_percent 14.0 (paper prints 14.0%)

Low-risk region, same labs, male nonsmoker

Given: age=50european_risk_region=lownon_hdl_mmol_l=4.2sbp_mm_hg=140sex=malesmoker=false

smoke=0 lowers lp to -0.5207
risk_10y_percent 3.4

Also searched as

SCORE2
ESC 2021 cardiovascular risk
10-year CVD risk Europe
European risk region SCORE2
non-HDL cholesterol CVD
SCORE2 age 40-69
fatal and non-fatal CVD

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/score2?age=50&sex=male&smoker=true&sbp_mm_hg=140&non_hdl_mmol_l=4.2&european_risk_region=low

Full URL: https://api.magentlab.com/api/calc/score2?age=50&sex=male&smoker=true&sbp_mm_hg=140&non_hdl_mmol_l=4.2&european_risk_region=low

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/score2?age=50&sex=male&smoker=true&sbp_mm_hg=140&non_hdl_mmol_l=4.2&european_risk_region=low"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (integer 40-69). SCORE2 2021 is for ages 40-69. Not SCORE2-OP (age 70 or older).
`sex`	string	required · female, male	Sex used by the sex-specific SCORE2 2021 coefficients (female or male).
`smoker`	boolean	required	Current cigarette smoking as assigned by the caller (true or false). magent does not take a smoking history.
`sbp_mm_hg`	number	required	Systolic blood pressure in mm Hg (50-250). Enters as (SBP-120)/20. magent does not measure blood pressure.
`non_hdl_mmol_l`	number	required	Non-HDL cholesterol in mmol/L (1-12). SCORE2 charts display non-HDL. The published equation uses TC and HDL at the paper HDL centering 1.3 mmol/L (TC = non-HDL + 1.3). The printed 50-year-old example is TC 5.5 and HDL 1.3 (non-HDL 4.2). magent does not assay lipids.
`european_risk_region`	string	required · low, moderate, high, very_high	Geographic SCORE2 2021 calibration region (low, moderate, high, or very_high) as printed in that paper. Not race. Not ethnicity.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/score2 Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "50",
      "european_risk_region": "low",
      "non_hdl_mmol_l": "4.2",
      "sbp_mm_hg": "140",
      "sex": "male",
      "smoker": "true"
    },
    {
      "age": "50",
      "european_risk_region": "low",
      "non_hdl_mmol_l": "4.2",
      "sbp_mm_hg": "140",
      "sex": "male",
      "smoker": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/score2",
  "items": [
    {
      "age": 50,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "SCORE2 working group and ESC Cardiovascular risk collaboration",
        "doi": "10.1093/eurheartj/ehab309",
        "id": "score2-2021",
        "pmid": "34120177",
        "source": "Eur Heart J. 2021;42(25):2439-2454",
        "title": "SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe"
      },
      "formula": "score2",
      "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; charts display non-HDL mmol/L; equation uses TC and HDL at paper HDL centering 1.3 so TC=non-HDL+1.3, ctchol=(TC-6)/1, chdl=0; diabetes terms omitted (not SCORE2-Diabetes); men S0=0.9605 lp=0.3742*cage+0.6012*smoke+0.2777*csbp+0.1458*ctchol-0.2698*chdl-0.0755*cage*smoke-0.0255*cage*csbp-0.0281*cage*ctchol+0.0426*cage*chdl; women S0=0.9776 lp=0.4648*cage+0.7744*smoke+0.3131*csbp+0.1002*ctchol-0.2606*chdl-0.1088*cage*smoke-0.0277*cage*csbp-0.0226*cage*ctchol+0.0613*cage*chdl; region (scale1,scale2) men low (-0.5699,0.7476) moderate (-0.1565,0.8009) high (0.3207,0.9360) very_high (0.5836,0.8294); women low (-0.7380,0.7019) moderate (-0.3143,0.7701) high (0.5710,0.9369) very_high (0.9412,0.8329); SCORE2 2021 four-decimal coefficients (updated supplement Table 1); age 40-69; geographic region not race; not SCORE2-OP; not 2013 PCE",
      "sex": "male",
      "linear_predictor": 0.2315,
      "sbp_mm_hg": 140.0,
      "smoker": true,
      "risk_10y_percent": 5.9,
      "european_risk_region": "low",
      "hdl_mmol_l": 1.3,
      "non_hdl_mmol_l": 4.2,
      "total_cholesterol_mmol_l": 5.5
    },
    {
      "age": 50,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "SCORE2 working group and ESC Cardiovascular risk collaboration",
        "doi": "10.1093/eurheartj/ehab309",
        "id": "score2-2021",
        "pmid": "34120177",
        "source": "Eur Heart J. 2021;42(25):2439-2454",
        "title": "SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe"
      },
      "formula": "score2",
      "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; charts display non-HDL mmol/L; equation uses TC and HDL at paper HDL centering 1.3 so TC=non-HDL+1.3, ctchol=(TC-6)/1, chdl=0; diabetes terms omitted (not SCORE2-Diabetes); men S0=0.9605 lp=0.3742*cage+0.6012*smoke+0.2777*csbp+0.1458*ctchol-0.2698*chdl-0.0755*cage*smoke-0.0255*cage*csbp-0.0281*cage*ctchol+0.0426*cage*chdl; women S0=0.9776 lp=0.4648*cage+0.7744*smoke+0.3131*csbp+0.1002*ctchol-0.2606*chdl-0.1088*cage*smoke-0.0277*cage*csbp-0.0226*cage*ctchol+0.0613*cage*chdl; region (scale1,scale2) men low (-0.5699,0.7476) moderate (-0.1565,0.8009) high (0.3207,0.9360) very_high (0.5836,0.8294); women low (-0.7380,0.7019) moderate (-0.3143,0.7701) high (0.5710,0.9369) very_high (0.9412,0.8329); SCORE2 2021 four-decimal coefficients (updated supplement Table 1); age 40-69; geographic region not race; not SCORE2-OP; not 2013 PCE",
      "sex": "male",
      "linear_predictor": 0.2315,
      "sbp_mm_hg": 140.0,
      "smoker": true,
      "risk_10y_percent": 5.9,
      "european_risk_region": "low",
      "hdl_mmol_l": 1.3,
      "non_hdl_mmol_l": 4.2,
      "total_cholesterol_mmol_l": 5.5
    }
  ]
}

Response

Field	Type	Description
`formula`	string	score2
`formula_expression`	string	SCORE2 2021 sex-specific coefficients and region scale1/scale2
`age`	integer	Age in years used (40-69)
`sex`	string	female or male used
`smoker`	boolean	Caller-assigned current smoking used
`sbp_mm_hg`	number	Systolic BP used, mm Hg
`non_hdl_mmol_l`	number	Non-HDL cholesterol used, mmol/L
`total_cholesterol_mmol_l`	number	TC used as non-HDL + 1.3 mmol/L (paper HDL centering)
`hdl_mmol_l`	number	HDL used, always 1.3 mmol/L (paper centering / printed example)
`european_risk_region`	string	Geographic calibration region used
`linear_predictor`	number	Sex-specific linear predictor lp, 4 decimals
`risk_10y_percent`	number	Calibrated 10-year fatal+non-fatal CVD risk percent, 1 decimal
`citation`	object	SCORE2 working group Eur Heart J 2021 citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "age": 50,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "SCORE2 working group and ESC Cardiovascular risk collaboration",
    "doi": "10.1093/eurheartj/ehab309",
    "id": "score2-2021",
    "pmid": "34120177",
    "source": "Eur Heart J. 2021;42(25):2439-2454",
    "title": "SCORE2 risk prediction algorithms: new models to estimate 10-year risk of cardiovascular disease in Europe"
  },
  "formula": "score2",
  "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; charts display non-HDL mmol/L; equation uses TC and HDL at paper HDL centering 1.3 so TC=non-HDL+1.3, ctchol=(TC-6)/1, chdl=0; diabetes terms omitted (not SCORE2-Diabetes); men S0=0.9605 lp=0.3742*cage+0.6012*smoke+0.2777*csbp+0.1458*ctchol-0.2698*chdl-0.0755*cage*smoke-0.0255*cage*csbp-0.0281*cage*ctchol+0.0426*cage*chdl; women S0=0.9776 lp=0.4648*cage+0.7744*smoke+0.3131*csbp+0.1002*ctchol-0.2606*chdl-0.1088*cage*smoke-0.0277*cage*csbp-0.0226*cage*ctchol+0.0613*cage*chdl; region (scale1,scale2) men low (-0.5699,0.7476) moderate (-0.1565,0.8009) high (0.3207,0.9360) very_high (0.5836,0.8294); women low (-0.7380,0.7019) moderate (-0.3143,0.7701) high (0.5710,0.9369) very_high (0.9412,0.8329); SCORE2 2021 four-decimal coefficients (updated supplement Table 1); age 40-69; geographic region not race; not SCORE2-OP; not 2013 PCE",
  "sex": "male",
  "linear_predictor": 0.2315,
  "sbp_mm_hg": 140.0,
  "smoker": true,
  "risk_10y_percent": 5.9,
  "european_risk_region": "low",
  "hdl_mmol_l": 1.3,
  "non_hdl_mmol_l": 4.2,
  "total_cholesterol_mmol_l": 5.5
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_age`	age must be an integer from 18 to 120 Returned before settlement; you are not charged.
400	`invalid_sex`	sex must be female or male Returned before settlement; you are not charged.
400	`invalid_systolic_bp`	systolic_mm_hg or systolic_bp_mm_hg must be a number from 50 to 250. Returned before settlement; you are not charged.
400	`invalid_score2_region`	european_risk_region must be low, moderate, high, or very_high as printed in SCORE2 2021 (geographic calibration, not race). Returned before settlement; you are not charged.
400	`invalid_score2`	SCORE2 2021 inputs must match that paper's age 40-69, sex, smoking, systolic BP, non-HDL cholesterol, and European risk region. Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

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Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.