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Kasymjanova NSCLC prognostic index

Kasymjanova PI

Apply the Kasymjanova 2010 prognostic index (PI 0–2) from caller-supplied CRP in mg/L and WBC in ×10^9/L.

LIVE $0.005 USDC GET /api/calc/kasymjanova

Markdown: /docs/kasymjanova.md · Canonical: https://magentlab.com/docs/kasymjanova

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply the Kasymjanova 2010 prognostic index (PI 0–2) from caller-supplied CRP in mg/L and WBC in ×10^9/L.

When to use

When an agent has pre-treatment CRP and WBC for advanced NSCLC and needs the published Kasymjanova 2010 PI, not GPS/mGPS, and not a chemotherapy order.

When not to use

  • Not a medical device. magent does not examine the patient and does not assay CRP or WBC.
  • This is the Kasymjanova 2010 advanced NSCLC prognostic index from CRP and WBC only. It is not Glasgow Prognostic Score (GPS), not McMillan mGPS, and not a chemotherapy order.
  • Not a cancer diagnosis or staging decision. Does not return survival months or percents.

Formula

PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2

Citation

Title
The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer
Authors
Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D
Source
Curr Oncol. 2010;17(4):52-58
DOI
10.3747/co.v17i4.567

Worked example

CRP 10 mg/L, WBC 11 ×10^9/L

Given: crp_mg_l=10wbc_10e9_l=11

  1. CRP 10 mg/L is ≤ 10, so CRP is not elevated
  2. WBC 11 ×10^9/L is ≤ 11, so WBC is not elevated
  3. PI 0

CRP 20 mg/L, WBC 15 ×10^9/L

Given: crp_mg_l=20wbc_10e9_l=15

  1. CRP 20 mg/L is > 10, so CRP is elevated (1)
  2. WBC 15 ×10^9/L is > 11, so WBC is elevated (1)
  3. PI 2

Also searched as

  • Kasymjanova PI
  • Kasymjanova prognostic index
  • NSCLC CRP WBC index
  • Kasymjanova 2010
  • advanced NSCLC inflammatory index
  • CRP WBC prognostic index NSCLC

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/kasymjanova?crp_mg_l=10&wbc_10e9_l=11

Full URL: https://api.magentlab.com/api/calc/kasymjanova?crp_mg_l=10&wbc_10e9_l=11

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. 

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/kasymjanova?crp_mg_l=10&wbc_10e9_l=11"

Parameters

Name Type Required Description
crp_mg_l number required C-reactive protein in mg/L (0-500), not mg/dL. Kasymjanova 2010 elevated CRP is >10 mg/L. CRP = 10 is not elevated. magent does not assay CRP.
wbc_10e9_l number required White-cell count in ×10^9/L (0.01-500). Kasymjanova 2010 elevated WBC is >11 ×10^9/L. WBC = 11 is not elevated. magent does not assay WBC.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/kasymjanova Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

  • 1 to 25 items. Each item uses the same keys as the GET query parameters.
  • POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
  • The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
  • HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
  • Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
  • x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "crp_mg_l": "10",
      "wbc_10e9_l": "11"
    },
    {
      "crp_mg_l": "10",
      "wbc_10e9_l": "11"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/kasymjanova",
  "items": [
    {
      "components": [
        {
          "value": 10.0,
          "factor": "crp_elevated",
          "points": 0,
          "present": false
        },
        {
          "value": 11.0,
          "factor": "wbc_elevated",
          "points": 0,
          "present": false
        }
      ],
      "pi": 0,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D",
        "doi": "10.3747/co.v17i4.567",
        "id": "kasymjanova-2010",
        "pmid": "20697518",
        "source": "Curr Oncol. 2010;17(4):52-58",
        "title": "The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer"
      },
      "formula": "kasymjanova",
      "formula_expression": "PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2",
      "max_score": 2,
      "score": 0,
      "crp_mg_l": 10.0,
      "wbc_10e9_l": 11.0
    },
    {
      "components": [
        {
          "value": 10.0,
          "factor": "crp_elevated",
          "points": 0,
          "present": false
        },
        {
          "value": 11.0,
          "factor": "wbc_elevated",
          "points": 0,
          "present": false
        }
      ],
      "pi": 0,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D",
        "doi": "10.3747/co.v17i4.567",
        "id": "kasymjanova-2010",
        "pmid": "20697518",
        "source": "Curr Oncol. 2010;17(4):52-58",
        "title": "The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer"
      },
      "formula": "kasymjanova",
      "formula_expression": "PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2",
      "max_score": 2,
      "score": 0,
      "crp_mg_l": 10.0,
      "wbc_10e9_l": 11.0
    }
  ]
}

Response

Field Type Description
formula string kasymjanova
formula_expression string Kasymjanova 2010 PI 0 / 1 / 2 rules in paper units (mg/L and ×10^9/L)
crp_mg_l number C-reactive protein used in mg/L
wbc_10e9_l number White-cell count used in ×10^9/L
pi integer 0, 1, or 2 (Kasymjanova 2010). Neither elevated is 0; exactly one is 1; both are 2. Not GPS/mGPS.
score integer PI points 0-2 (same as pi)
max_score integer 2
components array Per-marker points
citation object Kasymjanova et al. Curr Oncol 2010 citation
disclaimer string Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup. 

{
  "components": [
    {
      "value": 10.0,
      "factor": "crp_elevated",
      "points": 0,
      "present": false
    },
    {
      "value": 11.0,
      "factor": "wbc_elevated",
      "points": 0,
      "present": false
    }
  ],
  "pi": 0,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Kasymjanova G, MacDonald N, Agulnik JS, Cohen V, Pepe C, Kreisman H, Sharma R, Small D",
    "doi": "10.3747/co.v17i4.567",
    "id": "kasymjanova-2010",
    "pmid": "20697518",
    "source": "Curr Oncol. 2010;17(4):52-58",
    "title": "The predictive value of pre-treatment inflammatory markers in advanced non-small-cell lung cancer"
  },
  "formula": "kasymjanova",
  "formula_expression": "PI = crp_elevated + wbc_elevated; CRP elevated if crp_mg_l > 10 (≤10 not elevated); WBC elevated if wbc_10e9_l > 11 (≤11 not elevated); each 1; Kasymjanova 2010; max 2",
  "max_score": 2,
  "score": 0,
  "crp_mg_l": 10.0,
  "wbc_10e9_l": 11.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP Code When
400 invalid_crp crp_mg_l must be a number from 0 to 500. Returned before settlement; you are not charged.
400 invalid_wbc wbc_k_ul (0.01-500) or wbc_ul (10-500000) is required Returned before settlement; you are not charged.
400 invalid_items POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400 invalid_item_count items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400 invalid_item each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

  • mGPS — Apply the McMillan 2007 modified Glasgow Prognostic Score (mGPS) from caller-supplied CRP in mg/L and albumin.
  • ANC — Compute absolute neutrophil count from WBC and neutrophil plus band percents, plus a Bodey 1966 granulocyte band.
  • NCCN-IPI — Sum the Zhou 2014 NCCN International Prognostic Index (enhanced IPI for DLBCL treated in the rituximab era) and return low (0–1), low_intermediate (2–3), high_intermediate (4–5), or high (6–8).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

  • HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
  • exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
  • HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
  • Execution is timeout-bounded and concurrency-capped.
  • Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.