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IVT Class III Harm contraindications
IVT contraindications
Apply Powers 2018 Table 6 Class III: Harm caller flags and return whether intravenous alteplase (IVT) is contraindicated. contraindicated is true iff any of the 15 published Harm flags is true.
Markdown: /docs/ivt-contraindications.md · Canonical: https://magentlab.com/docs/ivt-contraindications
Not a medical device. Not a diagnosis, dose, or listing recommendation.
What it computes
Apply Powers 2018 Table 6 Class III: Harm caller flags and return whether intravenous alteplase (IVT) is contraindicated. contraindicated is true iff any of the 15 published Harm flags is true.
When to use
When an agent already has caller-assigned Powers 2018 Table 6 Class III Harm flags and needs the published any-flag combination. magent does not read CT, assay coagulation, or examine the patient. Not Class I eligibility, not a time window, and not a dose.
When not to use
- Not a medical device and not a treatment order.
- Encodes Powers 2018 Table 6 Class III: Harm rows only. Does not encode Class III No Benefit rows (unclear/wake-up onset windows, extensive CT hypoattenuation), Class I eligibility, 0-3h vs 3-4.5h windows, or a dose.
- magent does not read CT, assay coagulation, or examine the patient. Each flag is caller-assigned.
- Not eligibility for tenecteplase. Intravenous alteplase (IVT) Harm flags only.
- Coagulopathy is one caller-assigned flag (platelets <100000/mm3 or INR >1.7 or aPTT >40 s or PT >15 s as in Table 6). magent does not assay labs.
- DOAC not cleared is caller-assigned from that Table 6 row (direct thrombin or factor Xa inhibitor AND labs not documented normal AND last dose not >48 h with normal renal function).
Formula
contraindicated iff ct_ich or ischemic_stroke_within_3_mo or severe_head_trauma_within_3_mo or posttraumatic_infarction_in_hospital or intracranial_spinal_surgery_within_3_mo or history_ich or sah_presentation or gi_malignancy_or_gi_bleed_21d or coagulopathy or lmwh_treatment_dose_within_24h or doac_not_cleared or gp2b3a_concurrent or infective_endocarditis or aortic_arch_dissection or intra_axial_neoplasm (Powers 2018 Table 6 Class III: Harm). Not Class III No Benefit (unclear/wake-up onset windows, extensive CT hypoattenuation). Not Class I eligibility. Not 0-3h vs 3-4.5h. Not a dose. magent does not read CT, assay coagulation, or examine the patient. Not a treatment order
Citation
- Authors
- Powers WJ, Rabinstein AA, Ackerson T, et al.
- Source
- Stroke. 2018;49(3):e46-e110
Worked example
All 15 Class III Harm flags false is not contraindicated
Given:
aortic_arch_dissection=falsecoagulopathy=falsect_ich=falsedoac_not_cleared=falsegi_malignancy_or_gi_bleed_21d=falsegp2b3a_concurrent=falsehistory_ich=falseinfective_endocarditis=falseintra_axial_neoplasm=falseintracranial_spinal_surgery_within_3_mo=falseischemic_stroke_within_3_mo=falselmwh_treatment_dose_within_24h=falseposttraumatic_infarction_in_hospital=falsesah_presentation=falsesevere_head_trauma_within_3_mo=false
- each Powers 2018 Table 6 Class III: Harm flag is false
- no Harm row is met
- contraindicated false
CT acute intracranial hemorrhage is contraindicated
Given:
aortic_arch_dissection=falsecoagulopathy=falsect_ich=truedoac_not_cleared=falsegi_malignancy_or_gi_bleed_21d=falsegp2b3a_concurrent=falsehistory_ich=falseinfective_endocarditis=falseintra_axial_neoplasm=falseintracranial_spinal_surgery_within_3_mo=falseischemic_stroke_within_3_mo=falselmwh_treatment_dose_within_24h=falseposttraumatic_infarction_in_hospital=falsesah_presentation=falsesevere_head_trauma_within_3_mo=false
- ct_ich true
- the other 14 Class III Harm flags are false
- any Harm flag is enough
- contraindicated true
Also searched as
- IVT contraindications
- intravenous alteplase contraindications
- Powers 2018 Table 6
- Class III Harm IVT
- IV alteplase exclusion criteria
- acute ischemic stroke IVT Harm rows
- Powers 2018 IVT contraindications
Try
Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.
Full URL: https://api.magentlab.com/api/calc/ivt_contraindications?ct_ich=false&ischemic_stroke_within_3_mo=false&severe_head_trauma_within_3_mo=false&posttraumatic_infarction_in_hospital=false&intracranial_spinal_surgery_within_3_mo=false&history_ich=false&sah_presentation=false&gi_malignancy_or_gi_bleed_21d=false&coagulopathy=false&lmwh_treatment_dose_within_24h=false&doac_not_cleared=false&gp2b3a_concurrent=false&infective_endocarditis=false&aortic_arch_dissection=false&intra_axial_neoplasm=false
Call
Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params
return HTTP 400 before any quote or charge.
curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ivt_contraindications?ct_ich=false&ischemic_stroke_within_3_mo=false&severe_head_trauma_within_3_mo=false&posttraumatic_infarction_in_hospital=false&intracranial_spinal_surgery_within_3_mo=false&history_ich=false&sah_presentation=false&gi_malignancy_or_gi_bleed_21d=false&coagulopathy=false&lmwh_treatment_dose_within_24h=false&doac_not_cleared=false&gp2b3a_concurrent=false&infective_endocarditis=false&aortic_arch_dissection=false&intra_axial_neoplasm=false"
Parameters
| Name | Type | Required | Description |
|---|---|---|---|
ct_ich |
boolean | required | CT reveals acute intracranial hemorrhage as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read CT. |
ischemic_stroke_within_3_mo |
boolean | required | Prior ischemic stroke within 3 months as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not date prior strokes. |
severe_head_trauma_within_3_mo |
boolean | required | Recent severe head trauma within 3 months as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient. |
posttraumatic_infarction_in_hospital |
boolean | required | Posttraumatic infarction in the acute in-hospital phase as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient. |
intracranial_spinal_surgery_within_3_mo |
boolean | required | Intracranial or spinal surgery within 3 months as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read an operative note. |
history_ich |
boolean | required | History of intracranial hemorrhage as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read prior imaging. |
sah_presentation |
boolean | required | Presentation most consistent with subarachnoid hemorrhage as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient. |
gi_malignancy_or_gi_bleed_21d |
boolean | required | Structural GI malignancy or GI bleed within 21 days as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient. |
coagulopathy |
boolean | required | Caller-assigned coagulopathy as in Table 6 (platelets <100000/mm3 or INR >1.7 or aPTT >40 s or PT >15 s). One flag. true or false. magent does not assay labs. |
lmwh_treatment_dose_within_24h |
boolean | required | Treatment-dose LMWH within the previous 24 h as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read a medication list. |
doac_not_cleared |
boolean | required | Taking a direct thrombin or factor Xa inhibitor AND labs not documented normal AND last dose not >48 h with normal renal function, as assigned by the caller from that Table 6 row. true or false. magent does not assay labs. |
gp2b3a_concurrent |
boolean | required | Concurrent GP IIb/IIIa inhibitor as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read a medication list. |
infective_endocarditis |
boolean | required | Symptoms consistent with infective endocarditis as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient. |
aortic_arch_dissection |
boolean | required | Known or suspected aortic arch dissection as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not examine the patient. |
intra_axial_neoplasm |
boolean | required | Intra-axial intracranial neoplasm as assigned by the caller (Powers 2018 Table 6 Class III: Harm). true or false. magent does not read imaging. |
Bulk (POST)
POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.
- 1 to 25 items. Each item uses the same keys as the GET query parameters.
- POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
- The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
- HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
- Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
- x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.
Example request (fixture)
{
"items": [
{
"aortic_arch_dissection": "false",
"coagulopathy": "false",
"ct_ich": "false",
"doac_not_cleared": "false",
"gi_malignancy_or_gi_bleed_21d": "false",
"gp2b3a_concurrent": "false",
"history_ich": "false",
"infective_endocarditis": "false",
"intra_axial_neoplasm": "false",
"intracranial_spinal_surgery_within_3_mo": "false",
"ischemic_stroke_within_3_mo": "false",
"lmwh_treatment_dose_within_24h": "false",
"posttraumatic_infarction_in_hospital": "false",
"sah_presentation": "false",
"severe_head_trauma_within_3_mo": "false"
},
{
"aortic_arch_dissection": "false",
"coagulopathy": "false",
"ct_ich": "false",
"doac_not_cleared": "false",
"gi_malignancy_or_gi_bleed_21d": "false",
"gp2b3a_concurrent": "false",
"history_ich": "false",
"infective_endocarditis": "false",
"intra_axial_neoplasm": "false",
"intracranial_spinal_surgery_within_3_mo": "false",
"ischemic_stroke_within_3_mo": "false",
"lmwh_treatment_dose_within_24h": "false",
"posttraumatic_infarction_in_hospital": "false",
"sah_presentation": "false",
"severe_head_trauma_within_3_mo": "false"
}
]
}
Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.
Example 200 (fixture)
{
"count": 2,
"path": "/api/calc/ivt_contraindications",
"items": [
{
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"citation": {
"authors": "Powers WJ, Rabinstein AA, Ackerson T, et al.",
"doi": "10.1161/STR.0000000000000158",
"id": "powers-2018",
"pmid": "29133354",
"source": "Stroke. 2018;49(3):e46-e110",
"title": "2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association"
},
"formula": "ivt_contraindications",
"formula_expression": "contraindicated iff ct_ich or ischemic_stroke_within_3_mo or severe_head_trauma_within_3_mo or posttraumatic_infarction_in_hospital or intracranial_spinal_surgery_within_3_mo or history_ich or sah_presentation or gi_malignancy_or_gi_bleed_21d or coagulopathy or lmwh_treatment_dose_within_24h or doac_not_cleared or gp2b3a_concurrent or infective_endocarditis or aortic_arch_dissection or intra_axial_neoplasm (Powers 2018 Table 6 Class III: Harm). Not Class III No Benefit (unclear/wake-up onset windows, extensive CT hypoattenuation). Not Class I eligibility. Not 0-3h vs 3-4.5h. Not a dose. magent does not read CT, assay coagulation, or examine the patient. Not a treatment order",
"criteria": [
{
"factor": "ct_ich",
"met": false
},
{
"factor": "ischemic_stroke_within_3_mo",
"met": false
},
{
"factor": "severe_head_trauma_within_3_mo",
"met": false
},
{
"factor": "posttraumatic_infarction_in_hospital",
"met": false
},
{
"factor": "intracranial_spinal_surgery_within_3_mo",
"met": false
},
{
"factor": "history_ich",
"met": false
},
{
"factor": "sah_presentation",
"met": false
},
{
"factor": "gi_malignancy_or_gi_bleed_21d",
"met": false
},
{
"factor": "coagulopathy",
"met": false
},
{
"factor": "lmwh_treatment_dose_within_24h",
"met": false
},
{
"factor": "doac_not_cleared",
"met": false
},
{
"factor": "gp2b3a_concurrent",
"met": false
},
{
"factor": "infective_endocarditis",
"met": false
},
{
"factor": "aortic_arch_dissection",
"met": false
},
{
"factor": "intra_axial_neoplasm",
"met": false
},
{
"factor": "contraindicated",
"met": false
}
],
"aortic_arch_dissection": false,
"coagulopathy": false,
"contraindicated": false,
"ct_ich": false,
"doac_not_cleared": false,
"gi_malignancy_or_gi_bleed_21d": false,
"gp2b3a_concurrent": false,
"history_ich": false,
"infective_endocarditis": false,
"intra_axial_neoplasm": false,
"intracranial_spinal_surgery_within_3_mo": false,
"ischemic_stroke_within_3_mo": false,
"lmwh_treatment_dose_within_24h": false,
"posttraumatic_infarction_in_hospital": false,
"sah_presentation": false,
"severe_head_trauma_within_3_mo": false
},
{
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"citation": {
"authors": "Powers WJ, Rabinstein AA, Ackerson T, et al.",
"doi": "10.1161/STR.0000000000000158",
"id": "powers-2018",
"pmid": "29133354",
"source": "Stroke. 2018;49(3):e46-e110",
"title": "2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association"
},
"formula": "ivt_contraindications",
"formula_expression": "contraindicated iff ct_ich or ischemic_stroke_within_3_mo or severe_head_trauma_within_3_mo or posttraumatic_infarction_in_hospital or intracranial_spinal_surgery_within_3_mo or history_ich or sah_presentation or gi_malignancy_or_gi_bleed_21d or coagulopathy or lmwh_treatment_dose_within_24h or doac_not_cleared or gp2b3a_concurrent or infective_endocarditis or aortic_arch_dissection or intra_axial_neoplasm (Powers 2018 Table 6 Class III: Harm). Not Class III No Benefit (unclear/wake-up onset windows, extensive CT hypoattenuation). Not Class I eligibility. Not 0-3h vs 3-4.5h. Not a dose. magent does not read CT, assay coagulation, or examine the patient. Not a treatment order",
"criteria": [
{
"factor": "ct_ich",
"met": false
},
{
"factor": "ischemic_stroke_within_3_mo",
"met": false
},
{
"factor": "severe_head_trauma_within_3_mo",
"met": false
},
{
"factor": "posttraumatic_infarction_in_hospital",
"met": false
},
{
"factor": "intracranial_spinal_surgery_within_3_mo",
"met": false
},
{
"factor": "history_ich",
"met": false
},
{
"factor": "sah_presentation",
"met": false
},
{
"factor": "gi_malignancy_or_gi_bleed_21d",
"met": false
},
{
"factor": "coagulopathy",
"met": false
},
{
"factor": "lmwh_treatment_dose_within_24h",
"met": false
},
{
"factor": "doac_not_cleared",
"met": false
},
{
"factor": "gp2b3a_concurrent",
"met": false
},
{
"factor": "infective_endocarditis",
"met": false
},
{
"factor": "aortic_arch_dissection",
"met": false
},
{
"factor": "intra_axial_neoplasm",
"met": false
},
{
"factor": "contraindicated",
"met": false
}
],
"aortic_arch_dissection": false,
"coagulopathy": false,
"contraindicated": false,
"ct_ich": false,
"doac_not_cleared": false,
"gi_malignancy_or_gi_bleed_21d": false,
"gp2b3a_concurrent": false,
"history_ich": false,
"infective_endocarditis": false,
"intra_axial_neoplasm": false,
"intracranial_spinal_surgery_within_3_mo": false,
"ischemic_stroke_within_3_mo": false,
"lmwh_treatment_dose_within_24h": false,
"posttraumatic_infarction_in_hospital": false,
"sah_presentation": false,
"severe_head_trauma_within_3_mo": false
}
]
}
Response
| Field | Type | Description |
|---|---|---|
formula |
string | ivt_contraindications |
formula_expression |
string | Powers 2018 Table 6 Class III: Harm any-flag combination |
ct_ich |
boolean | Caller-assigned ct_ich flag used |
ischemic_stroke_within_3_mo |
boolean | Caller-assigned ischemic_stroke_within_3_mo flag used |
severe_head_trauma_within_3_mo |
boolean | Caller-assigned severe_head_trauma_within_3_mo flag used |
posttraumatic_infarction_in_hospital |
boolean | Caller-assigned posttraumatic_infarction_in_hospital flag used |
intracranial_spinal_surgery_within_3_mo |
boolean | Caller-assigned intracranial_spinal_surgery_within_3_mo flag used |
history_ich |
boolean | Caller-assigned history_ich flag used |
sah_presentation |
boolean | Caller-assigned sah_presentation flag used |
gi_malignancy_or_gi_bleed_21d |
boolean | Caller-assigned gi_malignancy_or_gi_bleed_21d flag used |
coagulopathy |
boolean | Caller-assigned coagulopathy flag used |
lmwh_treatment_dose_within_24h |
boolean | Caller-assigned lmwh_treatment_dose_within_24h flag used |
doac_not_cleared |
boolean | Caller-assigned doac_not_cleared flag used |
gp2b3a_concurrent |
boolean | Caller-assigned gp2b3a_concurrent flag used |
infective_endocarditis |
boolean | Caller-assigned infective_endocarditis flag used |
aortic_arch_dissection |
boolean | Caller-assigned aortic_arch_dissection flag used |
intra_axial_neoplasm |
boolean | Caller-assigned intra_axial_neoplasm flag used |
contraindicated |
boolean | true iff any Powers 2018 Table 6 Class III: Harm caller flag is true. Not a treatment order. Not Class I eligibility. Not a dose. |
criteria |
array | Rows for each caller flag and contraindicated with factor and met |
citation |
object | Powers 2018 Stroke AHA/ASA acute ischemic stroke guideline citation |
disclaimer |
string | Not-a-device notice |
Example JSON
Machine form of the same example. Frozen fixture. Not a live lookup.
{
"disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
"citation": {
"authors": "Powers WJ, Rabinstein AA, Ackerson T, et al.",
"doi": "10.1161/STR.0000000000000158",
"id": "powers-2018",
"pmid": "29133354",
"source": "Stroke. 2018;49(3):e46-e110",
"title": "2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association"
},
"formula": "ivt_contraindications",
"formula_expression": "contraindicated iff ct_ich or ischemic_stroke_within_3_mo or severe_head_trauma_within_3_mo or posttraumatic_infarction_in_hospital or intracranial_spinal_surgery_within_3_mo or history_ich or sah_presentation or gi_malignancy_or_gi_bleed_21d or coagulopathy or lmwh_treatment_dose_within_24h or doac_not_cleared or gp2b3a_concurrent or infective_endocarditis or aortic_arch_dissection or intra_axial_neoplasm (Powers 2018 Table 6 Class III: Harm). Not Class III No Benefit (unclear/wake-up onset windows, extensive CT hypoattenuation). Not Class I eligibility. Not 0-3h vs 3-4.5h. Not a dose. magent does not read CT, assay coagulation, or examine the patient. Not a treatment order",
"criteria": [
{
"factor": "ct_ich",
"met": false
},
{
"factor": "ischemic_stroke_within_3_mo",
"met": false
},
{
"factor": "severe_head_trauma_within_3_mo",
"met": false
},
{
"factor": "posttraumatic_infarction_in_hospital",
"met": false
},
{
"factor": "intracranial_spinal_surgery_within_3_mo",
"met": false
},
{
"factor": "history_ich",
"met": false
},
{
"factor": "sah_presentation",
"met": false
},
{
"factor": "gi_malignancy_or_gi_bleed_21d",
"met": false
},
{
"factor": "coagulopathy",
"met": false
},
{
"factor": "lmwh_treatment_dose_within_24h",
"met": false
},
{
"factor": "doac_not_cleared",
"met": false
},
{
"factor": "gp2b3a_concurrent",
"met": false
},
{
"factor": "infective_endocarditis",
"met": false
},
{
"factor": "aortic_arch_dissection",
"met": false
},
{
"factor": "intra_axial_neoplasm",
"met": false
},
{
"factor": "contraindicated",
"met": false
}
],
"aortic_arch_dissection": false,
"coagulopathy": false,
"contraindicated": false,
"ct_ich": false,
"doac_not_cleared": false,
"gi_malignancy_or_gi_bleed_21d": false,
"gp2b3a_concurrent": false,
"history_ich": false,
"infective_endocarditis": false,
"intra_axial_neoplasm": false,
"intracranial_spinal_surgery_within_3_mo": false,
"ischemic_stroke_within_3_mo": false,
"lmwh_treatment_dose_within_24h": false,
"posttraumatic_infarction_in_hospital": false,
"sah_presentation": false,
"severe_head_trauma_within_3_mo": false
}
Client errors (HTTP 400)
Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.
| HTTP | Code | When |
|---|---|---|
| 400 | invalid_ivt |
IVT contraindication flags must each be true or false as published in Powers 2018 Table 6 Class III Harm rows. Returned before settlement; you are not charged. |
| 400 | invalid_items |
POST body must be a JSON object with only an items array Returned before settlement; you are not charged. |
| 400 | invalid_item_count |
items must be an array of 1 to 25 objects Returned before settlement; you are not charged. |
| 400 | invalid_item |
each items entry must be a JSON object Returned before settlement; you are not charged. |
Related tools
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- NIHSS — Sum Brott 1989 NIH stroke scale points from 15 caller-assigned examination integers, including pupillary response and plantar reflex. Weaker-limb motor arm and leg. Does not apply later total-score severity bands.
Payment
Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64
PAYMENT-REQUIRED
header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake
and shared payment errors: Payments.
Stdio MCP: /docs/mcp.
Guarantees
- HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
- exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
- HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
- Execution is timeout-bounded and concurrency-capped.
- Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.