IMPEDE VTE score

IMPEDE VTE

Compute the Sanfilippo 2019 IMPEDE VTE score for venous thromboembolism in multiple myeloma from caller-assigned Table 3 factors and return the published 6-month risk group.

LIVE $0.005 USDC GET /api/calc/impede_vte

Markdown: /docs/impede-vte.md · Canonical: https://magentlab.com/docs/impede-vte

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the Sanfilippo 2019 IMPEDE VTE score for venous thromboembolism in multiple myeloma from caller-assigned Table 3 factors and return the published 6-month risk group.

When to use

When an agent needs the published Sanfilippo 2019 IMPEDE VTE score for a patient with multiple myeloma and must not substitute Khorana or SAVED, invent a prophylaxis order, or assign race or ethnicity.

When not to use

Not a medical device.
Not a diagnosis of VTE. magent does not diagnose venous thromboembolism.
Not a prophylaxis order. This tool does not recommend a drug or start thromboprophylaxis.
Not SAVED. Not Khorana. This tool is Sanfilippo 2019 Table 3 IMPEDE VTE only.
Caller-assigned Asian/Pacific Islander as used in Sanfilippo 2019. magent does not assign race or ethnicity.
bmi_ge_25 is a caller-assigned BMI ≥25 kg/m2 flag; magent does not compute BMI from height or weight.
Dexamethasone high is total monthly dosing >160 mg as in Sanfilippo 2019; not the NCCN ≥480 mg definition. none is not on dexamethasone (0 points).
Score is not clamped at zero. Risk groups are derivation 6-month cumulative incidence: ≤3 low 3.3%, 4-7 intermediate 8.3%, ≥8 high 15.2%.

Formula

IMPEDE VTE (Sanfilippo 2019 Table 3) = imid (4) + bmi_ge_25 (1) + pelvic_hip_femur_fracture (4) + esa (1) + doxorubicin (3) + dexamethasone (none 0, low 2, high 4; high if total monthly dosing >160 mg) + asian_pacific_islander (-3) + vte_history (5) + tunneled_line (2) + thromboprophylaxis (none 0, prophylactic -3, therapeutic -4); unclamped; <=3 low 3.3%, 4-7 intermediate 8.3%, >=8 high 15.2%

Citation

Title: Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score
Authors: Sanfilippo KM, Luo S, Wang TF, Fiala M, Schoen M, Wildes TM, Mikhael J, Kuderer NM, Calverley DC, Keller J, Thomas T, Carson KR, Gage BF
Source: Am J Hematol. 2019;94(11):1176-1184
DOI: 10.1002/ajh.25603

Worked example

All factors absent

Given: asian_pacific_islander=falsebmi_ge_25=falsedexamethasone=nonedoxorubicin=falseesa=falseimid=falsepelvic_hip_femur_fracture=falsethromboprophylaxis=nonetunneled_line=falsevte_history=false

All flags false; dexamethasone none; thromboprophylaxis none
Score = 0 (unclamped); risk low; six_month_vte_percent 3.3

IMiD plus pelvic, hip, or femur fracture is high

Given: asian_pacific_islander=falsebmi_ge_25=falsedexamethasone=nonedoxorubicin=falseesa=falseimid=truepelvic_hip_femur_fracture=truethromboprophylaxis=nonetunneled_line=falsevte_history=false

imid → 4; pelvic_hip_femur_fracture → 4
Score = 8; risk high; six_month_vte_percent 15.2

Also searched as

IMPEDE VTE
IMPEDE-VTE score
Sanfilippo myeloma VTE
multiple myeloma VTE score
IMiD VTE risk
IMPEDE venous thromboembolism

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/impede_vte?imid=false&bmi_ge_25=false&pelvic_hip_femur_fracture=false&esa=false&doxorubicin=false&dexamethasone=none&asian_pacific_islander=false&vte_history=false&tunneled_line=false&thromboprophylaxis=none

Full URL: https://api.magentlab.com/api/calc/impede_vte?imid=false&bmi_ge_25=false&pelvic_hip_femur_fracture=false&esa=false&doxorubicin=false&dexamethasone=none&asian_pacific_islander=false&vte_history=false&tunneled_line=false&thromboprophylaxis=none

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/impede_vte?imid=false&bmi_ge_25=false&pelvic_hip_femur_fracture=false&esa=false&doxorubicin=false&dexamethasone=none&asian_pacific_islander=false&vte_history=false&tunneled_line=false&thromboprophylaxis=none"

Parameters

Name	Type	Required	Description
`imid`	boolean	required	Immunomodulatory drug (IMiD) as assigned by the caller (Sanfilippo 2019 Table 3). true or false. 4 points if true.
`bmi_ge_25`	boolean	required	BMI ≥25 kg/m2 as assigned by the caller (Sanfilippo 2019 Table 3). true or false. magent does not compute BMI from height or weight. 1 point if true.
`pelvic_hip_femur_fracture`	boolean	required	Pelvic, hip, or femur fracture as assigned by the caller (Sanfilippo 2019 Table 3). true or false. 4 points if true.
`esa`	boolean	required	Erythropoiesis-stimulating agent as assigned by the caller (Sanfilippo 2019 Table 3). true or false. 1 point if true.
`doxorubicin`	boolean	required	Doxorubicin as assigned by the caller (Sanfilippo 2019 Table 3). true or false. 3 points if true.
`dexamethasone`	string	required · none, low, high	Dexamethasone as assigned by the caller (Sanfilippo 2019 Table 3). none (not on dexamethasone) scores 0; low (dexamethasone used at total monthly dosing ≤160 mg) scores 2; high (total monthly dosing >160 mg) scores 4. Not the NCCN ≥480 mg definition.
`asian_pacific_islander`	boolean	required	Caller-assigned ethnicity/race Asian/Pacific Islander as used in Sanfilippo 2019. true or false. magent does not assign race or ethnicity. −3 if true.
`vte_history`	boolean	required	History of VTE before multiple myeloma as assigned by the caller (Sanfilippo 2019 Table 3). true or false. 5 points if true.
`tunneled_line`	boolean	required	Tunneled line / central venous catheter as assigned by the caller (Sanfilippo 2019 Table 3). true or false. 2 points if true.
`thromboprophylaxis`	string	required · none, prophylactic, therapeutic	Existing thromboprophylaxis as assigned by the caller (Sanfilippo 2019 Table 3). Mutually exclusive. none scores 0; prophylactic (prophylactic LMWH or aspirin) scores −3; therapeutic (therapeutic LMWH or warfarin) scores −4.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/impede_vte Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "asian_pacific_islander": "false",
      "bmi_ge_25": "false",
      "dexamethasone": "none",
      "doxorubicin": "false",
      "esa": "false",
      "imid": "false",
      "pelvic_hip_femur_fracture": "false",
      "thromboprophylaxis": "none",
      "tunneled_line": "false",
      "vte_history": "false"
    },
    {
      "asian_pacific_islander": "false",
      "bmi_ge_25": "false",
      "dexamethasone": "none",
      "doxorubicin": "false",
      "esa": "false",
      "imid": "false",
      "pelvic_hip_femur_fracture": "false",
      "thromboprophylaxis": "none",
      "tunneled_line": "false",
      "vte_history": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/impede_vte",
  "items": [
    {
      "components": [
        {
          "factor": "imid",
          "points": 0,
          "present": false
        },
        {
          "factor": "bmi_ge_25",
          "points": 0,
          "present": false
        },
        {
          "factor": "pelvic_hip_femur_fracture",
          "points": 0,
          "present": false
        },
        {
          "factor": "esa",
          "points": 0,
          "present": false
        },
        {
          "factor": "doxorubicin",
          "points": 0,
          "present": false
        },
        {
          "value": "none",
          "factor": "dexamethasone",
          "points": 0,
          "present": false
        },
        {
          "factor": "asian_pacific_islander",
          "points": 0,
          "present": false
        },
        {
          "factor": "vte_history",
          "points": 0,
          "present": false
        },
        {
          "factor": "tunneled_line",
          "points": 0,
          "present": false
        },
        {
          "value": "none",
          "factor": "thromboprophylaxis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sanfilippo KM, Luo S, Wang TF, Fiala M, Schoen M, Wildes TM, Mikhael J, Kuderer NM, Calverley DC, Keller J, Thomas T, Carson KR, Gage BF",
        "doi": "10.1002/ajh.25603",
        "id": "sanfilippo-2019-impede",
        "pmid": "31374145",
        "source": "Am J Hematol. 2019;94(11):1176-1184",
        "title": "Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score"
      },
      "formula": "impede_vte",
      "formula_expression": "IMPEDE VTE (Sanfilippo 2019 Table 3) = imid (4) + bmi_ge_25 (1) + pelvic_hip_femur_fracture (4) + esa (1) + doxorubicin (3) + dexamethasone (none 0, low 2, high 4; high if total monthly dosing >160 mg) + asian_pacific_islander (-3) + vte_history (5) + tunneled_line (2) + thromboprophylaxis (none 0, prophylactic -3, therapeutic -4); unclamped; <=3 low 3.3%, 4-7 intermediate 8.3%, >=8 high 15.2%",
      "max_score": 24,
      "score": 0,
      "risk": "low",
      "asian_pacific_islander": false,
      "bmi_ge_25": false,
      "dexamethasone": "none",
      "doxorubicin": false,
      "esa": false,
      "imid": false,
      "pelvic_hip_femur_fracture": false,
      "six_month_vte_percent": 3.3,
      "thromboprophylaxis": "none",
      "tunneled_line": false,
      "vte_history": false
    },
    {
      "components": [
        {
          "factor": "imid",
          "points": 0,
          "present": false
        },
        {
          "factor": "bmi_ge_25",
          "points": 0,
          "present": false
        },
        {
          "factor": "pelvic_hip_femur_fracture",
          "points": 0,
          "present": false
        },
        {
          "factor": "esa",
          "points": 0,
          "present": false
        },
        {
          "factor": "doxorubicin",
          "points": 0,
          "present": false
        },
        {
          "value": "none",
          "factor": "dexamethasone",
          "points": 0,
          "present": false
        },
        {
          "factor": "asian_pacific_islander",
          "points": 0,
          "present": false
        },
        {
          "factor": "vte_history",
          "points": 0,
          "present": false
        },
        {
          "factor": "tunneled_line",
          "points": 0,
          "present": false
        },
        {
          "value": "none",
          "factor": "thromboprophylaxis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Sanfilippo KM, Luo S, Wang TF, Fiala M, Schoen M, Wildes TM, Mikhael J, Kuderer NM, Calverley DC, Keller J, Thomas T, Carson KR, Gage BF",
        "doi": "10.1002/ajh.25603",
        "id": "sanfilippo-2019-impede",
        "pmid": "31374145",
        "source": "Am J Hematol. 2019;94(11):1176-1184",
        "title": "Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score"
      },
      "formula": "impede_vte",
      "formula_expression": "IMPEDE VTE (Sanfilippo 2019 Table 3) = imid (4) + bmi_ge_25 (1) + pelvic_hip_femur_fracture (4) + esa (1) + doxorubicin (3) + dexamethasone (none 0, low 2, high 4; high if total monthly dosing >160 mg) + asian_pacific_islander (-3) + vte_history (5) + tunneled_line (2) + thromboprophylaxis (none 0, prophylactic -3, therapeutic -4); unclamped; <=3 low 3.3%, 4-7 intermediate 8.3%, >=8 high 15.2%",
      "max_score": 24,
      "score": 0,
      "risk": "low",
      "asian_pacific_islander": false,
      "bmi_ge_25": false,
      "dexamethasone": "none",
      "doxorubicin": false,
      "esa": false,
      "imid": false,
      "pelvic_hip_femur_fracture": false,
      "six_month_vte_percent": 3.3,
      "thromboprophylaxis": "none",
      "tunneled_line": false,
      "vte_history": false
    }
  ]
}

Response

Field	Type	Description
`formula`	string	impede_vte
`formula_expression`	string	Exact expression used
`score`	integer	Sanfilippo 2019 Table 3 total. Not clamped at 0.
`max_score`	integer	24 (sum of positive Table 3 weights)
`risk`	string	low when score ≤3, intermediate when 4-7, high when ≥8. Derivation-cohort 6-month groups. Not a diagnosis.
`six_month_vte_percent`	number	Derivation 6-month cumulative incidence percent: 3.3 (low), 8.3 (intermediate), or 15.2 (high).
`imid`	boolean	IMiD flag used
`bmi_ge_25`	boolean	Caller-assigned BMI ≥25 flag used
`pelvic_hip_femur_fracture`	boolean	Pelvic, hip, or femur fracture flag used
`esa`	boolean	ESA flag used
`doxorubicin`	boolean	Doxorubicin flag used
`dexamethasone`	string	Dexamethasone token used: none, low, or high
`asian_pacific_islander`	boolean	Caller-assigned Asian/Pacific Islander flag used
`vte_history`	boolean	VTE-before-MM flag used
`tunneled_line`	boolean	Tunneled line / CVC flag used
`thromboprophylaxis`	string	Thromboprophylaxis token used: none, prophylactic, or therapeutic
`components`	array	Per-factor points
`citation`	object	Sanfilippo 2019 Am J Hematol citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "factor": "imid",
      "points": 0,
      "present": false
    },
    {
      "factor": "bmi_ge_25",
      "points": 0,
      "present": false
    },
    {
      "factor": "pelvic_hip_femur_fracture",
      "points": 0,
      "present": false
    },
    {
      "factor": "esa",
      "points": 0,
      "present": false
    },
    {
      "factor": "doxorubicin",
      "points": 0,
      "present": false
    },
    {
      "value": "none",
      "factor": "dexamethasone",
      "points": 0,
      "present": false
    },
    {
      "factor": "asian_pacific_islander",
      "points": 0,
      "present": false
    },
    {
      "factor": "vte_history",
      "points": 0,
      "present": false
    },
    {
      "factor": "tunneled_line",
      "points": 0,
      "present": false
    },
    {
      "value": "none",
      "factor": "thromboprophylaxis",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Sanfilippo KM, Luo S, Wang TF, Fiala M, Schoen M, Wildes TM, Mikhael J, Kuderer NM, Calverley DC, Keller J, Thomas T, Carson KR, Gage BF",
    "doi": "10.1002/ajh.25603",
    "id": "sanfilippo-2019-impede",
    "pmid": "31374145",
    "source": "Am J Hematol. 2019;94(11):1176-1184",
    "title": "Predicting venous thromboembolism in multiple myeloma: development and validation of the IMPEDE VTE score"
  },
  "formula": "impede_vte",
  "formula_expression": "IMPEDE VTE (Sanfilippo 2019 Table 3) = imid (4) + bmi_ge_25 (1) + pelvic_hip_femur_fracture (4) + esa (1) + doxorubicin (3) + dexamethasone (none 0, low 2, high 4; high if total monthly dosing >160 mg) + asian_pacific_islander (-3) + vte_history (5) + tunneled_line (2) + thromboprophylaxis (none 0, prophylactic -3, therapeutic -4); unclamped; <=3 low 3.3%, 4-7 intermediate 8.3%, >=8 high 15.2%",
  "max_score": 24,
  "score": 0,
  "risk": "low",
  "asian_pacific_islander": false,
  "bmi_ge_25": false,
  "dexamethasone": "none",
  "doxorubicin": false,
  "esa": false,
  "imid": false,
  "pelvic_hip_femur_fracture": false,
  "six_month_vte_percent": 3.3,
  "thromboprophylaxis": "none",
  "tunneled_line": false,
  "vte_history": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_impede_vte`	IMPEDE-VTE inputs must match Sanfilippo 2019 Table 3 flags, dexamethasone none/low/high, and thromboprophylaxis none/prophylactic/therapeutic. Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

Khorana score — Compute the Khorana 2008 Blood predictive model for chemotherapy-associated thrombosis from caller-assigned cancer site, pre-chemotherapy labs, ESA use, and BMI ≥35.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.