Hematology · LIVE

ICE score (Lee 2019)

ICE

Sum Lee 2019 Immune Effector Cell-Associated Encephalopathy (ICE) item points and return the 0-10 total. Not ASTCT ICANS grading.

LIVE $0.005 USDC GET /api/calc/ice

Markdown: /docs/ice.md · Canonical: https://magentlab.com/docs/ice

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum Lee 2019 Immune Effector Cell-Associated Encephalopathy (ICE) item points and return the 0-10 total. Not ASTCT ICANS grading.

When to use

When an agent has caller-assigned ICE exam item scores and needs the published 0-10 point total. Not for ICANS grading (related astct-icans takes a caller-assigned ice_score).

When not to use

• Not a medical device and not a diagnosis of ICANS or encephalopathy.
• ICE points only (Lee 2019). Not ASTCT ICANS consensus grading (that is related astct-icans, which takes a caller-assigned ice_score). magent does not map ICE totals to an ICANS grade.
• orientation, naming, following_commands, writing, and attention are caller-assigned. magent does not perform the ICE exam or examine the patient.
• Not ASTCT CRS (related astct-crs).

Formula

ICE = orientation (0-4; year, month, city, hospital) + naming (0-3; three objects) + following_commands (1) + writing (1) + attention (1; count backward from 100 by tens); max 10. ICE points only; not ASTCT ICANS grade. magent does not perform the exam

Citation

Title

ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells

Authors

Lee DW, Santomasso BD, Locke FL, et al.

Source

Biol Blood Marrow Transplant. 2019;25(4):625-638

DOI

10.1016/j.bbmt.2018.12.758

Worked example

Also searched as

• ICE score
• Immune Effector Cell-Associated Encephalopathy
• ICE encephalopathy score
• CAR-T encephalopathy ICE
• Lee 2019 ICE
• immune effector cell encephalopathy

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/ice?orientation=4&naming=3&following_commands=true&writing=true&attention=true

Full URL: https://api.magentlab.com/api/calc/ice?orientation=4&naming=3&following_commands=true&writing=true&attention=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ice?orientation=4&naming=3&following_commands=true&writing=true&attention=true"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/ice Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "attention": "true",
      "following_commands": "true",
      "naming": "3",
      "orientation": "4",
      "writing": "true"
    },
    {
      "attention": "true",
      "following_commands": "true",
      "naming": "3",
      "orientation": "4",
      "writing": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/ice",
  "items": [
    {
      "components": [
        {
          "value": 4,
          "factor": "orientation",
          "points": 4,
          "present": true
        },
        {
          "value": 3,
          "factor": "naming",
          "points": 3,
          "present": true
        },
        {
          "factor": "following_commands",
          "points": 1,
          "present": true
        },
        {
          "factor": "writing",
          "points": 1,
          "present": true
        },
        {
          "factor": "attention",
          "points": 1,
          "present": true
        }
      ],
      "writing": true,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Lee DW, Santomasso BD, Locke FL, et al.",
        "doi": "10.1016/j.bbmt.2018.12.758",
        "id": "lee-2019",
        "source": "Biol Blood Marrow Transplant. 2019;25(4):625-638",
        "title": "ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells"
      },
      "formula": "ice",
      "formula_expression": "ICE = orientation (0-4; year, month, city, hospital) + naming (0-3; three objects) + following_commands (1) + writing (1) + attention (1; count backward from 100 by tens); max 10. ICE points only; not ASTCT ICANS grade. magent does not perform the exam",
      "max_score": 10,
      "score": 10,
      "attention": true,
      "following_commands": true,
      "naming": 3,
      "orientation": 4
    },
    {
      "components": [
        {
          "value": 4,
          "factor": "orientation",
          "points": 4,
          "present": true
        },
        {
          "value": 3,
          "factor": "naming",
          "points": 3,
          "present": true
        },
        {
          "factor": "following_commands",
          "points": 1,
          "present": true
        },
        {
          "factor": "writing",
          "points": 1,
          "present": true
        },
        {
          "factor": "attention",
          "points": 1,
          "present": true
        }
      ],
      "writing": true,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Lee DW, Santomasso BD, Locke FL, et al.",
        "doi": "10.1016/j.bbmt.2018.12.758",
        "id": "lee-2019",
        "source": "Biol Blood Marrow Transplant. 2019;25(4):625-638",
        "title": "ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells"
      },
      "formula": "ice",
      "formula_expression": "ICE = orientation (0-4; year, month, city, hospital) + naming (0-3; three objects) + following_commands (1) + writing (1) + attention (1; count backward from 100 by tens); max 10. ICE points only; not ASTCT ICANS grade. magent does not perform the exam",
      "max_score": 10,
      "score": 10,
      "attention": true,
      "following_commands": true,
      "naming": 3,
      "orientation": 4
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 4,
      "factor": "orientation",
      "points": 4,
      "present": true
    },
    {
      "value": 3,
      "factor": "naming",
      "points": 3,
      "present": true
    },
    {
      "factor": "following_commands",
      "points": 1,
      "present": true
    },
    {
      "factor": "writing",
      "points": 1,
      "present": true
    },
    {
      "factor": "attention",
      "points": 1,
      "present": true
    }
  ],
  "writing": true,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Lee DW, Santomasso BD, Locke FL, et al.",
    "doi": "10.1016/j.bbmt.2018.12.758",
    "id": "lee-2019",
    "source": "Biol Blood Marrow Transplant. 2019;25(4):625-638",
    "title": "ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells"
  },
  "formula": "ice",
  "formula_expression": "ICE = orientation (0-4; year, month, city, hospital) + naming (0-3; three objects) + following_commands (1) + writing (1) + attention (1; count backward from 100 by tens); max 10. ICE points only; not ASTCT ICANS grade. magent does not perform the exam",
  "max_score": 10,
  "score": 10,
  "attention": true,
  "following_commands": true,
  "naming": 3,
  "orientation": 4
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• ASTCT ICANS — Apply Lee 2019 Table 6 adult ASTCT ICANS consensus grading and return the overall grade (0-4) as the most severe of the ICE, depressed LOC, seizure, motor, and ICP/edema domains, with icans true when grade is 1 or greater.
• ASTCT CRS — Apply Lee 2019 ASTCT Table 1 cytokine release syndrome grading and return grade 0–4 from caller-assigned fever, fever waiver, hypotension, and hypoxia. Grade is the more severe of hypotension versus hypoxia. Organ toxicities do not influence grade. Not ICANS.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.