Infection / VTE · LIVE

CIRC (Garibaldi 2020)

Compute Garibaldi 2020 CIRC probabilities of progression to severe disease or death at hospital days 2, 4, and 7 from admission age, nursing-home residence, caller-assigned race term, Charlson CCI, BMI, symptoms, vitals, and listed laboratories using Appendix Table 1 coefficients on the published reference-patient cumulative incidences.

LIVE $0.005 USDC GET /api/calc/circ

Markdown: /docs/circ.md · Canonical: https://magentlab.com/docs/circ

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

When to use

When an agent already has the Appendix Table 1 admission profile assigned and needs the printed CIRC day-2/4/7 probabilities, not 4C, VACO, or COVID-GRAM, and not the death-only Appendix Table 2 model.

When not to use

Not a medical device and not a diagnosis. Not a triage, treatment, isolation, or disposition order.
magent does not assign race. The Non-White vs White term is caller-assigned as published; magent does not determine race or ethnicity.
magent does not assign Charlson diagnoses, read a chest film, or measure the patient. CCI, symptoms, fever, troponin detectability, and the D-dimer threshold flag are caller-assigned.
This tool applies Appendix Table 1 estimates to the printed reference cumulative incidences (day 2 10%, day 4 13%, day 7 15%). The competing-risk discharge Cox coefficients were not printed and are not used. Not the Appendix Table 2 death-only model.

Formula

delta = lp(x) - lp(x0); P(t) = 1-(1-P0(t))^exp(delta); Garibaldi 2020 Appendix Table 1 estimates; x0 White female age 60-74 not from a nursing home BMI 30 CCI 0 no symptoms no fever pulse 85 RR 21 leukocyte 6.8 ALC 1.0 ALT 30 albumin 3.7 GFR 71 CRP 5.7 hemoglobin 12.9 ferritin 545 troponin not detectable D-dimer not >1; P0 day2 0.10 day4 0.13 day7 0.15; age<60 -0.61 age>=75 -0.71; NH <75 -0.24 >=75 -0.22; male <60 0.31 60-74 -0.47 >=75 0.10; BMI per 5 0.17; Non-White vs White 0.08 (caller-assigned); CCI per 1 <60 0.19 60-74 -0.23 >=75 0.14; respiratory 0.81 GI -0.14 constitutional -0.57 taste/smell -0.30 fever>38.0 0.56; pulse per 10 -0.02; RR linear spline knot 18: <18 per unit -0.25, >=18 per unit 0.13; ln leukocyte -0.06 ln ALC -0.29 ln ALT 0.02; hemoglobin per 1 g/dL decrease 0.04; albumin per 0.5 g/dL decrease below 4 0.23; GFR per 10 -0.03; ln CRP 0.20 ln ferritin 0.11; troponin detectable <60 0.19 60-74 1.36 >=75 0.35; D-dimer >1 0.24; natural log; not Appendix Table 2 death-only; discharge competing-risk coefficients were not printed

Citation

Title: Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study
Authors: Garibaldi BT, Fiksel J, Muschelli J, et al.
Source: Ann Intern Med. 2021;174(1):33-41
DOI: 10.7326/M20-3905

Worked example

Appendix Table 1 reference patient

Given: age=65albumin_g_dl=3.7alt_u_l=30bmi=30cci=0constitutional_symptoms=falsecrp_mg_dl=5.7d_dimer_gt_1=falseferritin_ng_ml=545fever=falsegastrointestinal_symptoms=falsegfr=71hemoglobin_g_dl=12.9leukocyte_k=6.8loss_of_taste_smell=falselymphocyte_k=1.0nursing_home=falsepulse=85race=whiterespiratory_rate=21respiratory_symptoms=falsesex=femaletroponin_detectable=false

White female, age 65 (60-74), not from a nursing home, BMI 30, CCI 0, no symptoms, no fever, pulse 85, RR 21, leukocyte 6.8, ALC 1.0, ALT 30, hemoglobin 12.9, albumin 3.7, GFR 71, CRP 5.7, ferritin 545, troponin not detectable, D-dimer not >1
delta = 0 versus the published reference linear predictor
day-2/4/7 percents equal the printed reference cumulative incidences 10%, 13%, and 15%

Reference patient with fever >38.0 C

Given: age=65albumin_g_dl=3.7alt_u_l=30bmi=30cci=0constitutional_symptoms=falsecrp_mg_dl=5.7d_dimer_gt_1=falseferritin_ng_ml=545fever=truegastrointestinal_symptoms=falsegfr=71hemoglobin_g_dl=12.9leukocyte_k=6.8loss_of_taste_smell=falselymphocyte_k=1.0nursing_home=falsepulse=85race=whiterespiratory_rate=21respiratory_symptoms=falsesex=femaletroponin_detectable=false

Same Appendix Table 1 reference profile except fever true adds 0.56
delta = 0.56; P(t) = 1-(1-P0(t))^exp(0.56)

Also searched as

CIRC
Garibaldi 2020
COVID-19 Inpatient Risk Calculator
inpatient severe disease risk
admission progression CIRC
JH CIRC day 2 4 7

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/circ?age=65&sex=female&race=white&nursing_home=false&bmi=30&cci=0&respiratory_symptoms=false&gastrointestinal_symptoms=false&constitutional_symptoms=false&loss_of_taste_smell=false&fever=false&pulse=85&respiratory_rate=21&leukocyte_k=6.8&lymphocyte_k=1.0&alt_u_l=30&hemoglobin_g_dl=12.9&albumin_g_dl=3.7&gfr=71&crp_mg_dl=5.7&ferritin_ng_ml=545&troponin_detectable=false&d_dimer_gt_1=false

Full URL: https://api.magentlab.com/api/calc/circ?age=65&sex=female&race=white&nursing_home=false&bmi=30&cci=0&respiratory_symptoms=false&gastrointestinal_symptoms=false&constitutional_symptoms=false&loss_of_taste_smell=false&fever=false&pulse=85&respiratory_rate=21&leukocyte_k=6.8&lymphocyte_k=1.0&alt_u_l=30&hemoglobin_g_dl=12.9&albumin_g_dl=3.7&gfr=71&crp_mg_dl=5.7&ferritin_ng_ml=545&troponin_detectable=false&d_dimer_gt_1=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/circ?age=65&sex=female&race=white&nursing_home=false&bmi=30&cci=0&respiratory_symptoms=false&gastrointestinal_symptoms=false&constitutional_symptoms=false&loss_of_taste_smell=false&fever=false&pulse=85&respiratory_rate=21&leukocyte_k=6.8&lymphocyte_k=1.0&alt_u_l=30&hemoglobin_g_dl=12.9&albumin_g_dl=3.7&gfr=71&crp_mg_dl=5.7&ferritin_ng_ml=545&troponin_detectable=false&d_dimer_gt_1=false"

Parameters

Name	Type	Required	Description
`age`	integer	required	Age in years (integer 18-120). Appendix Table 1 bands: <60 (term -0.61), 60-74 (reference 0), >=75 (term -0.71). Derivation excluded ages under 18.
`sex`	string	required · female, male	Sex as assigned by the caller. female is the Appendix Table 1 reference (0). male adds 0.31 if age<60, -0.47 if age 60-74, 0.10 if age>=75. magent does not assign sex.
`race`	string	required · white, nonwhite	Caller-assigned Garibaldi 2020 paper term Non-White race vs White race. white is the reference (0). nonwhite adds 0.08. magent does not assign race.
`nursing_home`	boolean	required	Admitted from a nursing home as assigned by the caller. false is the reference (0). true adds -0.24 if age<75, -0.22 if age>=75.
`bmi`	number	required	Body mass index in kg/m2 (10-80). Appendix Table 1: 0.17 per increment of 5 kg/m2 versus the reference BMI of 30. obesity in the response is BMI >= 30.
`cci`	integer	required	Caller-assigned Charlson comorbidity index (integer 0-37). Appendix Table 1 per 1-point: 0.19 if age<60, -0.23 if age 60-74, 0.14 if age>=75. Reference CCI 0. magent does not assign Charlson diagnoses.
`respiratory_symptoms`	boolean	required	Respiratory symptoms present vs absent as assigned by the caller. false is the reference. true adds 0.81.
`gastrointestinal_symptoms`	boolean	required	Gastrointestinal symptoms present vs absent as assigned by the caller. false is the reference. true adds -0.14.
`constitutional_symptoms`	boolean	required	Constitutional symptoms present vs absent as assigned by the caller. false is the reference. true adds -0.57.
`loss_of_taste_smell`	boolean	required	Loss of taste and smell present vs absent as assigned by the caller. false is the reference. true adds -0.30.
`fever`	boolean	required	Temperature >38.0 C within 24 hours of admission as assigned by the caller. false is the reference. true adds 0.56.
`pulse`	number	required	Pulse in beats/min (30-220). Appendix Table 1: -0.02 per increment of 10 versus the reference pulse of 85.
`respiratory_rate`	number	required	Respiratory rate in breaths/min (6-60). Appendix Table 1 linear spline with knot at 18: -0.25 per unit below 18, 0.13 per unit at or above 18. Reference RR 21.
`leukocyte_k`	number	required	Leukocyte count in K cells/mm3 (0.5-100). Appendix Table 1: -0.06 times the natural log. Reference 6.8.
`lymphocyte_k`	number	required	Absolute lymphocyte count in K cells/mm3 (0.1-10). Appendix Table 1: -0.29 times the natural log. Reference 1.0.
`alt_u_l`	number	required	Alanine aminotransferase in U/L (1-2000). Appendix Table 1: 0.02 times the natural log. Reference 30.0.
`hemoglobin_g_dl`	number	required	Hemoglobin in g/dL (4-20). Appendix Table 1: 0.04 per 1-point decrease versus the reference 12.9 g/dL.
`albumin_g_dl`	number	required	Albumin in g/dL (1-6). Appendix Table 1: 0.23 per 0.5 g/dL decrease below 4 g/dL (no term when albumin >= 4). Reference 3.7.
`gfr`	number	required	GFR in mL/min per 1.73 m2 (5-150). Appendix Table 1: -0.03 per increase of 10 versus the reference 71.
`crp_mg_dl`	number	required	C-reactive protein in mg/dL (0.1-50). Appendix Table 1: 0.20 times the natural log. Reference 5.7.
`ferritin_ng_ml`	number	required	Ferritin in ng/mL (10-20000). Appendix Table 1: 0.11 times the natural log. Reference 545.
`troponin_detectable`	boolean	required	Detectable troponin vs not as assigned by the caller. false is the reference. true adds 0.19 if age<60, 1.36 if age 60-74, 0.35 if age>=75.
`d_dimer_gt_1`	boolean	required	D-dimer above the Appendix Table 1 threshold (>1 mg/dL FEU) as assigned by the caller. false is the reference. true adds 0.24.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/circ Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "65",
      "albumin_g_dl": "3.7",
      "alt_u_l": "30",
      "bmi": "30",
      "cci": "0",
      "constitutional_symptoms": "false",
      "crp_mg_dl": "5.7",
      "d_dimer_gt_1": "false",
      "ferritin_ng_ml": "545",
      "fever": "false",
      "gastrointestinal_symptoms": "false",
      "gfr": "71",
      "hemoglobin_g_dl": "12.9",
      "leukocyte_k": "6.8",
      "loss_of_taste_smell": "false",
      "lymphocyte_k": "1.0",
      "nursing_home": "false",
      "pulse": "85",
      "race": "white",
      "respiratory_rate": "21",
      "respiratory_symptoms": "false",
      "sex": "female",
      "troponin_detectable": "false"
    },
    {
      "age": "65",
      "albumin_g_dl": "3.7",
      "alt_u_l": "30",
      "bmi": "30",
      "cci": "0",
      "constitutional_symptoms": "false",
      "crp_mg_dl": "5.7",
      "d_dimer_gt_1": "false",
      "ferritin_ng_ml": "545",
      "fever": "false",
      "gastrointestinal_symptoms": "false",
      "gfr": "71",
      "hemoglobin_g_dl": "12.9",
      "leukocyte_k": "6.8",
      "loss_of_taste_smell": "false",
      "lymphocyte_k": "1.0",
      "nursing_home": "false",
      "pulse": "85",
      "race": "white",
      "respiratory_rate": "21",
      "respiratory_symptoms": "false",
      "sex": "female",
      "troponin_detectable": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/circ",
  "items": [
    {
      "day_2_percent": 10.0,
      "cci": 0,
      "lymphocyte_k": 1.0,
      "fever": false,
      "day_7_percent": 15.0,
      "gastrointestinal_symptoms": false,
      "d_dimer_gt_1": false,
      "albumin_g_dl": 3.7,
      "sex": "female",
      "race": "white",
      "obesity": true,
      "age": 65,
      "leukocyte_k": 6.8,
      "bmi": 30.0,
      "pulse": 85.0,
      "crp_mg_dl": 5.7,
      "constitutional_symptoms": false,
      "formula": "circ",
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "gfr": 71.0,
      "citation": {
        "authors": "Garibaldi BT, Fiksel J, Muschelli J, et al.",
        "doi": "10.7326/M20-3905",
        "id": "garibaldi-2020-circ",
        "pmid": "32960645",
        "source": "Ann Intern Med. 2021;174(1):33-41",
        "title": "Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study"
      },
      "ferritin_ng_ml": 545.0,
      "day_4_percent": 13.0,
      "alt_u_l": 30.0,
      "logit_delta": 0.0,
      "troponin_detectable": false,
      "formula_expression": "delta = lp(x) - lp(x0); P(t) = 1-(1-P0(t))^exp(delta); Garibaldi 2020 Appendix Table 1 estimates; x0 White female age 60-74 not from a nursing home BMI 30 CCI 0 no symptoms no fever pulse 85 RR 21 leukocyte 6.8 ALC 1.0 ALT 30 albumin 3.7 GFR 71 CRP 5.7 hemoglobin 12.9 ferritin 545 troponin not detectable D-dimer not >1; P0 day2 0.10 day4 0.13 day7 0.15; age<60 -0.61 age>=75 -0.71; NH <75 -0.24 >=75 -0.22; male <60 0.31 60-74 -0.47 >=75 0.10; BMI per 5 0.17; Non-White vs White 0.08 (caller-assigned); CCI per 1 <60 0.19 60-74 -0.23 >=75 0.14; respiratory 0.81 GI -0.14 constitutional -0.57 taste/smell -0.30 fever>38.0 0.56; pulse per 10 -0.02; RR linear spline knot 18: <18 per unit -0.25, >=18 per unit 0.13; ln leukocyte -0.06 ln ALC -0.29 ln ALT 0.02; hemoglobin per 1 g/dL decrease 0.04; albumin per 0.5 g/dL decrease below 4 0.23; GFR per 10 -0.03; ln CRP 0.20 ln ferritin 0.11; troponin detectable <60 0.19 60-74 1.36 >=75 0.35; D-dimer >1 0.24; natural log; not Appendix Table 2 death-only; discharge competing-risk coefficients were not printed",
      "loss_of_taste_smell": false,
      "respiratory_symptoms": false,
      "nursing_home": false,
      "age_band": "60_74",
      "hemoglobin_g_dl": 12.9,
      "respiratory_rate": 21.0
    },
    {
      "day_2_percent": 10.0,
      "cci": 0,
      "lymphocyte_k": 1.0,
      "fever": false,
      "day_7_percent": 15.0,
      "gastrointestinal_symptoms": false,
      "d_dimer_gt_1": false,
      "albumin_g_dl": 3.7,
      "sex": "female",
      "race": "white",
      "obesity": true,
      "age": 65,
      "leukocyte_k": 6.8,
      "bmi": 30.0,
      "pulse": 85.0,
      "crp_mg_dl": 5.7,
      "constitutional_symptoms": false,
      "formula": "circ",
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "gfr": 71.0,
      "citation": {
        "authors": "Garibaldi BT, Fiksel J, Muschelli J, et al.",
        "doi": "10.7326/M20-3905",
        "id": "garibaldi-2020-circ",
        "pmid": "32960645",
        "source": "Ann Intern Med. 2021;174(1):33-41",
        "title": "Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study"
      },
      "ferritin_ng_ml": 545.0,
      "day_4_percent": 13.0,
      "alt_u_l": 30.0,
      "logit_delta": 0.0,
      "troponin_detectable": false,
      "formula_expression": "delta = lp(x) - lp(x0); P(t) = 1-(1-P0(t))^exp(delta); Garibaldi 2020 Appendix Table 1 estimates; x0 White female age 60-74 not from a nursing home BMI 30 CCI 0 no symptoms no fever pulse 85 RR 21 leukocyte 6.8 ALC 1.0 ALT 30 albumin 3.7 GFR 71 CRP 5.7 hemoglobin 12.9 ferritin 545 troponin not detectable D-dimer not >1; P0 day2 0.10 day4 0.13 day7 0.15; age<60 -0.61 age>=75 -0.71; NH <75 -0.24 >=75 -0.22; male <60 0.31 60-74 -0.47 >=75 0.10; BMI per 5 0.17; Non-White vs White 0.08 (caller-assigned); CCI per 1 <60 0.19 60-74 -0.23 >=75 0.14; respiratory 0.81 GI -0.14 constitutional -0.57 taste/smell -0.30 fever>38.0 0.56; pulse per 10 -0.02; RR linear spline knot 18: <18 per unit -0.25, >=18 per unit 0.13; ln leukocyte -0.06 ln ALC -0.29 ln ALT 0.02; hemoglobin per 1 g/dL decrease 0.04; albumin per 0.5 g/dL decrease below 4 0.23; GFR per 10 -0.03; ln CRP 0.20 ln ferritin 0.11; troponin detectable <60 0.19 60-74 1.36 >=75 0.35; D-dimer >1 0.24; natural log; not Appendix Table 2 death-only; discharge competing-risk coefficients were not printed",
      "loss_of_taste_smell": false,
      "respiratory_symptoms": false,
      "nursing_home": false,
      "age_band": "60_74",
      "hemoglobin_g_dl": 12.9,
      "respiratory_rate": 21.0
    }
  ]
}

Response

Field	Type	Description
`formula`	string	circ
`formula_expression`	string	Garibaldi 2020 Appendix Table 1 linear predictor and day-2/4/7 CIF
`age`	integer	Input age in years
`sex`	string	female or male
`race`	string	white or nonwhite (caller-assigned)
`nursing_home`	boolean	Caller-assigned nursing-home flag
`bmi`	number	Input BMI in kg/m2
`cci`	integer	Caller-assigned Charlson comorbidity index
`respiratory_symptoms`	boolean	Caller-assigned respiratory-symptom flag
`gastrointestinal_symptoms`	boolean	Caller-assigned gastrointestinal-symptom flag
`constitutional_symptoms`	boolean	Caller-assigned constitutional-symptom flag
`loss_of_taste_smell`	boolean	Caller-assigned loss-of-taste-and-smell flag
`fever`	boolean	Caller-assigned fever >38.0 C flag
`pulse`	number	Input pulse in beats/min
`respiratory_rate`	number	Input respiratory rate in breaths/min
`leukocyte_k`	number	Input leukocyte count in K cells/mm3
`lymphocyte_k`	number	Input absolute lymphocyte count in K cells/mm3
`alt_u_l`	number	Input ALT in U/L
`hemoglobin_g_dl`	number	Input hemoglobin in g/dL
`albumin_g_dl`	number	Input albumin in g/dL
`gfr`	number	Input GFR in mL/min per 1.73 m2
`crp_mg_dl`	number	Input CRP in mg/dL
`ferritin_ng_ml`	number	Input ferritin in ng/mL
`troponin_detectable`	boolean	Caller-assigned detectable-troponin flag
`d_dimer_gt_1`	boolean	Caller-assigned D-dimer-above-threshold flag
`age_band`	string	Appendix Table 1 age band used (lt_60, 60_74, ge_75)
`obesity`	boolean	true when BMI is 30 kg/m2 or greater
`logit_delta`	number	lp(x) minus lp of the published reference patient, 4 decimals
`day_2_percent`	number	Severe disease or death percent by day 2, 1 decimal
`day_4_percent`	number	Severe disease or death percent by day 4, 1 decimal
`day_7_percent`	number	Severe disease or death percent by day 7, 1 decimal
`citation`	object	Garibaldi 2020 CIRC citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "day_2_percent": 10.0,
  "cci": 0,
  "lymphocyte_k": 1.0,
  "fever": false,
  "day_7_percent": 15.0,
  "gastrointestinal_symptoms": false,
  "d_dimer_gt_1": false,
  "albumin_g_dl": 3.7,
  "sex": "female",
  "race": "white",
  "obesity": true,
  "age": 65,
  "leukocyte_k": 6.8,
  "bmi": 30.0,
  "pulse": 85.0,
  "crp_mg_dl": 5.7,
  "constitutional_symptoms": false,
  "formula": "circ",
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "gfr": 71.0,
  "citation": {
    "authors": "Garibaldi BT, Fiksel J, Muschelli J, et al.",
    "doi": "10.7326/M20-3905",
    "id": "garibaldi-2020-circ",
    "pmid": "32960645",
    "source": "Ann Intern Med. 2021;174(1):33-41",
    "title": "Patient Trajectories Among Persons Hospitalized for COVID-19: A Cohort Study"
  },
  "ferritin_ng_ml": 545.0,
  "day_4_percent": 13.0,
  "alt_u_l": 30.0,
  "logit_delta": 0.0,
  "troponin_detectable": false,
  "formula_expression": "delta = lp(x) - lp(x0); P(t) = 1-(1-P0(t))^exp(delta); Garibaldi 2020 Appendix Table 1 estimates; x0 White female age 60-74 not from a nursing home BMI 30 CCI 0 no symptoms no fever pulse 85 RR 21 leukocyte 6.8 ALC 1.0 ALT 30 albumin 3.7 GFR 71 CRP 5.7 hemoglobin 12.9 ferritin 545 troponin not detectable D-dimer not >1; P0 day2 0.10 day4 0.13 day7 0.15; age<60 -0.61 age>=75 -0.71; NH <75 -0.24 >=75 -0.22; male <60 0.31 60-74 -0.47 >=75 0.10; BMI per 5 0.17; Non-White vs White 0.08 (caller-assigned); CCI per 1 <60 0.19 60-74 -0.23 >=75 0.14; respiratory 0.81 GI -0.14 constitutional -0.57 taste/smell -0.30 fever>38.0 0.56; pulse per 10 -0.02; RR linear spline knot 18: <18 per unit -0.25, >=18 per unit 0.13; ln leukocyte -0.06 ln ALC -0.29 ln ALT 0.02; hemoglobin per 1 g/dL decrease 0.04; albumin per 0.5 g/dL decrease below 4 0.23; GFR per 10 -0.03; ln CRP 0.20 ln ferritin 0.11; troponin detectable <60 0.19 60-74 1.36 >=75 0.35; D-dimer >1 0.24; natural log; not Appendix Table 2 death-only; discharge competing-risk coefficients were not printed",
  "loss_of_taste_smell": false,
  "respiratory_symptoms": false,
  "nursing_home": false,
  "age_band": "60_74",
  "hemoglobin_g_dl": 12.9,
  "respiratory_rate": 21.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_circ`	CIRC inputs must match Garibaldi 2020 admission age, nursing-home residence, comorbidities, obesity, respiratory findings, and listed laboratory bands. Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

VACO Index — Compute the King 2020 VACO Index 30-day all-cause mortality probability from age, sex, a caller-assigned unadjusted Charlson comorbidity index, and history of myocardial infarction or peripheral vascular disease using Supplement S3 coefficients.
4C — Sum the Knight 2020 ISARIC 4C Mortality Score items and return the published Table 5 band (low, intermediate, high, or very high).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.