IWG-2 typical Alzheimer's criteria

IWG-2 typical AD

Apply Dubois 2014 IWG-2 typical AD research criteria from caller-assigned hippocampal-type memory, in-vivo pathology, and exclusion flags. magent does not examine the patient or assay CSF/PET.

LIVE $0.005 USDC GET /api/calc/iwg2_ad

Markdown: /docs/iwg2-ad.md · Canonical: https://magentlab.com/docs/iwg2-ad

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply Dubois 2014 IWG-2 typical AD research criteria from caller-assigned hippocampal-type memory, in-vivo pathology, and exclusion flags. magent does not examine the patient or assay CSF/PET.

When to use

When an agent already has IWG-2 typical AD phenotype and pathology flags as assigned by the caller and needs the published typical_ad result. Not NINCDS-ADRDA, not NIA-AA, not DSM, and not a diagnosis.

When not to use

Not a medical device.
Not a diagnosis. IWG-2 typical AD is research diagnostic criteria only.
Typical AD phenotype only. This tool does not implement IWG-2 atypical AD phenotypes (posterior cortical atrophy, logopenic variant, frontal variant, or Down syndrome).
magent does not examine the patient, assay CSF, or read amyloid PET. All flags are caller-assigned.
Not NIA-AA ATN. Not NINCDS-ADRDA. Not DSM.

Formula

typical_ad iff no_better_explanation AND early_episodic_memory AND (csf_abeta_and_tau OR amyloid_pet OR autosomal_dominant_mutation) (Dubois 2014 IWG-2 typical AD). Not NINCDS-ADRDA. Not NIA-AA. Not DSM. magent does not examine the patient or assay CSF/PET.

Citation

Title: Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria
Authors: Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL
Source: Lancet Neurol. 2014;13(6):614-629
DOI: 10.1016/S1474-4422(14)70090-0

Worked example

Typical AD by CSF Aβ and tau

Given: amyloid_pet=falseautosomal_dominant_mutation=falsecsf_abeta_and_tau=trueearly_episodic_memory=trueno_better_explanation=true

early_episodic_memory true (hippocampal-type phenotype as assigned by the caller)
csf_abeta_and_tau true; amyloid_pet false; autosomal_dominant_mutation false → in_vivo_pathology true
no_better_explanation true → typical_ad true

Amyloid PET pathology with typical phenotype

Given: amyloid_pet=trueautosomal_dominant_mutation=falsecsf_abeta_and_tau=falseearly_episodic_memory=trueno_better_explanation=true

early_episodic_memory true and no_better_explanation true
amyloid_pet true; CSF and mutation false → in_vivo_pathology true
typical_ad true

Memory phenotype without in-vivo pathology

Given: amyloid_pet=falseautosomal_dominant_mutation=falsecsf_abeta_and_tau=falseearly_episodic_memory=trueno_better_explanation=true

early_episodic_memory true and no_better_explanation true
csf_abeta_and_tau, amyloid_pet, and autosomal_dominant_mutation all false → in_vivo_pathology false
typical_ad false

Also searched as

IWG-2
IWG-2 criteria
International Working Group 2
Dubois 2014
IWG-2 Alzheimer's
typical AD IWG-2
IWG 2 Alzheimer
Dubois IWG-2 criteria

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/iwg2_ad?early_episodic_memory=true&csf_abeta_and_tau=true&amyloid_pet=false&autosomal_dominant_mutation=false&no_better_explanation=true

Full URL: https://api.magentlab.com/api/calc/iwg2_ad?early_episodic_memory=true&csf_abeta_and_tau=true&amyloid_pet=false&autosomal_dominant_mutation=false&no_better_explanation=true

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/iwg2_ad?early_episodic_memory=true&csf_abeta_and_tau=true&amyloid_pet=false&autosomal_dominant_mutation=false&no_better_explanation=true"

Parameters

Name	Type	Required	Description
`early_episodic_memory`	boolean	required	Early and significant episodic memory impairment of the hippocampal type (IWG-2 specific phenotype for typical AD), as assigned by the caller. true or false. magent does not examine the patient.
`csf_abeta_and_tau`	boolean	required	Decreased Aβ1-42 together with increased T-tau or P-tau in CSF, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not assay CSF.
`amyloid_pet`	boolean	required	Increased tracer retention on amyloid PET, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not read PET.
`autosomal_dominant_mutation`	boolean	required	Proven AD autosomal-dominant mutation in PSEN1, PSEN2, or APP, as assigned by the caller (Dubois 2014 IWG-2 in-vivo AD pathology). true or false. magent does not sequence genes.
`no_better_explanation`	boolean	required	Exclusion of other disorders that could account for the phenotype, as assigned by the caller (Dubois 2014 IWG-2). true or false. magent does not examine the patient.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/iwg2_ad Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

1 to 25 items. Each item uses the same keys as the GET query parameters.
POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "amyloid_pet": "false",
      "autosomal_dominant_mutation": "false",
      "csf_abeta_and_tau": "true",
      "early_episodic_memory": "true",
      "no_better_explanation": "true"
    },
    {
      "amyloid_pet": "false",
      "autosomal_dominant_mutation": "false",
      "csf_abeta_and_tau": "true",
      "early_episodic_memory": "true",
      "no_better_explanation": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/iwg2_ad",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL",
        "doi": "10.1016/S1474-4422(14)70090-0",
        "id": "dubois-2014",
        "pmid": "24849861",
        "source": "Lancet Neurol. 2014;13(6):614-629",
        "title": "Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria"
      },
      "formula": "iwg2_ad",
      "formula_expression": "typical_ad iff no_better_explanation AND early_episodic_memory AND (csf_abeta_and_tau OR amyloid_pet OR autosomal_dominant_mutation) (Dubois 2014 IWG-2 typical AD). Not NINCDS-ADRDA. Not NIA-AA. Not DSM. magent does not examine the patient or assay CSF/PET.",
      "criteria": [
        {
          "factor": "early_episodic_memory",
          "met": true
        },
        {
          "factor": "csf_abeta_and_tau",
          "met": true
        },
        {
          "factor": "amyloid_pet",
          "met": false
        },
        {
          "factor": "autosomal_dominant_mutation",
          "met": false
        },
        {
          "factor": "no_better_explanation",
          "met": true
        },
        {
          "factor": "in_vivo_pathology",
          "met": true
        }
      ],
      "in_vivo_pathology": true,
      "typical_ad": true
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL",
        "doi": "10.1016/S1474-4422(14)70090-0",
        "id": "dubois-2014",
        "pmid": "24849861",
        "source": "Lancet Neurol. 2014;13(6):614-629",
        "title": "Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria"
      },
      "formula": "iwg2_ad",
      "formula_expression": "typical_ad iff no_better_explanation AND early_episodic_memory AND (csf_abeta_and_tau OR amyloid_pet OR autosomal_dominant_mutation) (Dubois 2014 IWG-2 typical AD). Not NINCDS-ADRDA. Not NIA-AA. Not DSM. magent does not examine the patient or assay CSF/PET.",
      "criteria": [
        {
          "factor": "early_episodic_memory",
          "met": true
        },
        {
          "factor": "csf_abeta_and_tau",
          "met": true
        },
        {
          "factor": "amyloid_pet",
          "met": false
        },
        {
          "factor": "autosomal_dominant_mutation",
          "met": false
        },
        {
          "factor": "no_better_explanation",
          "met": true
        },
        {
          "factor": "in_vivo_pathology",
          "met": true
        }
      ],
      "in_vivo_pathology": true,
      "typical_ad": true
    }
  ]
}

Response

Field	Type	Description
`formula`	string	iwg2_ad
`formula_expression`	string	Published Dubois 2014 IWG-2 typical AD rule
`typical_ad`	boolean	true iff no_better_explanation, early_episodic_memory, and in-vivo AD pathology (CSF, amyloid PET, or mutation). Not a diagnosis. Typical AD research criteria only.
`in_vivo_pathology`	boolean	true iff csf_abeta_and_tau or amyloid_pet or autosomal_dominant_mutation. magent does not assay CSF or read PET.
`criteria`	array	Per-factor Tree rows early_episodic_memory, csf_abeta_and_tau, amyloid_pet, autosomal_dominant_mutation, no_better_explanation, and derived in_vivo_pathology, each with factor and met
`citation`	object	Dubois 2014 Lancet Neurol IWG-2 citation
`disclaimer`	string	Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Dubois B, Feldman HH, Jacova C, Hampel H, Molinuevo JL, Blennow K, DeKosky ST, Gauthier S, Selkoe D, Bateman R, Cappa S, Crutch S, Engelborghs S, Frisoni GB, Fox NC, Galasko D, Habert MO, Jicha GA, Nordberg A, Pasquier F, Rabinovici G, Robert P, Rowe C, Salloway S, Sarazin M, Epelbaum S, de Souza LC, Vellas B, Visser PJ, Schneider L, Stern Y, Scheltens P, Cummings JL",
    "doi": "10.1016/S1474-4422(14)70090-0",
    "id": "dubois-2014",
    "pmid": "24849861",
    "source": "Lancet Neurol. 2014;13(6):614-629",
    "title": "Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria"
  },
  "formula": "iwg2_ad",
  "formula_expression": "typical_ad iff no_better_explanation AND early_episodic_memory AND (csf_abeta_and_tau OR amyloid_pet OR autosomal_dominant_mutation) (Dubois 2014 IWG-2 typical AD). Not NINCDS-ADRDA. Not NIA-AA. Not DSM. magent does not examine the patient or assay CSF/PET.",
  "criteria": [
    {
      "factor": "early_episodic_memory",
      "met": true
    },
    {
      "factor": "csf_abeta_and_tau",
      "met": true
    },
    {
      "factor": "amyloid_pet",
      "met": false
    },
    {
      "factor": "autosomal_dominant_mutation",
      "met": false
    },
    {
      "factor": "no_better_explanation",
      "met": true
    },
    {
      "factor": "in_vivo_pathology",
      "met": true
    }
  ],
  "in_vivo_pathology": true,
  "typical_ad": true
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP	Code	When
400	`invalid_flag`	boolean clinical flags must be true or false Returned before settlement; you are not charged.
400	`invalid_items`	POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400	`invalid_item_count`	items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400	`invalid_item`	each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

NINCDS-ADRDA — Echo the caller-assigned McKhann 1984 NINCDS-ADRDA diagnostic category (definite, probable, possible, or unlikely) with the published defining-features description. magent does not examine the patient. Not NIA-AA 2011/2018. Not DSM.
AMT-10 — Sum the ten Hodkinson 1972 AMT-10 items from caller-assigned correct/incorrect flags and return the 0–10 total. Hodkinson 1972 did not publish a diagnostic cutoff.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
Execution is timeout-bounded and concurrency-capped.
Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.