Liver · LIVE

Metroticket 2.0 AFP-adjusted HCC transplant criteria

Metroticket 2.0

Apply Mazzaferro 2018 Metroticket 2.0 AFP-adjusted-to-HCC-size criteria and return whether a published 70% 5-year HCC-specific survival band holds (meets_70pct_hcc_specific_survival).

LIVE $0.005 USDC GET /api/calc/metroticket_2

Markdown: /docs/metroticket-2.md · Canonical: https://magentlab.com/docs/metroticket-2

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply Mazzaferro 2018 Metroticket 2.0 AFP-adjusted-to-HCC-size criteria and return whether a published 70% 5-year HCC-specific survival band holds (meets_70pct_hcc_specific_survival).

When to use

When an agent already has tumor count, largest diameter in centimetres, and serum AFP in ng/mL as in Mazzaferro 2018, and needs the published 70% HCC-specific survival eligibility result. magent does not interpret imaging or assay AFP.

When not to use

• Not a medical device.
• Not a transplant listing or organ-allocation order.
• magent does not interpret imaging or assay AFP. tumor_count, largest_cm, and afp_ng_ml are caller-assigned.
• This tool is Mazzaferro 2018 AFP-adjusted-to-HCC-size 70% 5-year HCC-specific survival criteria only. Not Milan criteria, not UCSF criteria, and not Metroticket 1.0 contours.
• Not the online competing-risk survival percentages at hcc-olt-metroticket.org.

Formula

meets_70pct_hcc_specific_survival iff (afp_ng_ml < 200 and size_number_sum <= 7) or (200 <= afp_ng_ml < 400 and size_number_sum <= 5) or (400 <= afp_ng_ml <= 1000 and size_number_sum <= 4); size_number_sum = tumor_count + largest_cm; afp_ng_ml > 1000 is always false (Mazzaferro 2018 AFP-adjusted-to-HCC-size 70% 5-year HCC-specific survival)

Citation

Title

Metroticket 2.0 Model for Analysis of Competing Risks of Death After Liver Transplantation for Hepatocellular Carcinoma

Authors

Mazzaferro V, Sposito C, Zhou J, Pinna AD, De Carlis L, Fan J, Cescon M, Di Sandro S, Yi-feng H, Lauterio A, Bongini M, Mariani L

Source

Gastroenterology. 2018;154(1):128-139

DOI

10.1053/j.gastro.2017.09.025

Worked example

Also searched as

• Metroticket 2.0
• Mazzaferro 2018
• AFP-adjusted HCC criteria
• HCC transplant AFP size
• AFP-adjusted to HCC size
• 70 percent HCC-specific survival
• hepatocellular carcinoma transplant AFP
• liver transplant HCC AFP

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/metroticket_2?tumor_count=1&largest_cm=3&afp_ng_ml=50

Full URL: https://api.magentlab.com/api/calc/metroticket_2?tumor_count=1&largest_cm=3&afp_ng_ml=50

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/metroticket_2?tumor_count=1&largest_cm=3&afp_ng_ml=50"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/metroticket_2 Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "afp_ng_ml": "50",
      "largest_cm": "3",
      "tumor_count": "1"
    },
    {
      "afp_ng_ml": "50",
      "largest_cm": "3",
      "tumor_count": "1"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/metroticket_2",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Mazzaferro V, Sposito C, Zhou J, Pinna AD, De Carlis L, Fan J, Cescon M, Di Sandro S, Yi-feng H, Lauterio A, Bongini M, Mariani L",
        "doi": "10.1053/j.gastro.2017.09.025",
        "id": "mazzaferro-2018",
        "pmid": "28989060",
        "source": "Gastroenterology. 2018;154(1):128-139",
        "title": "Metroticket 2.0 Model for Analysis of Competing Risks of Death After Liver Transplantation for Hepatocellular Carcinoma"
      },
      "formula": "metroticket_2",
      "formula_expression": "meets_70pct_hcc_specific_survival iff (afp_ng_ml < 200 and size_number_sum <= 7) or (200 <= afp_ng_ml < 400 and size_number_sum <= 5) or (400 <= afp_ng_ml <= 1000 and size_number_sum <= 4); size_number_sum = tumor_count + largest_cm; afp_ng_ml > 1000 is always false (Mazzaferro 2018 AFP-adjusted-to-HCC-size 70% 5-year HCC-specific survival)",
      "criteria": [
        {
          "factor": "afp_lt_200_sum_le_7",
          "met": true
        },
        {
          "factor": "afp_200_400_sum_le_5",
          "met": false
        },
        {
          "factor": "afp_400_1000_sum_le_4",
          "met": false
        }
      ],
      "largest_cm": 3.0,
      "tumor_count": 1,
      "afp_ng_ml": 50.0,
      "meets_70pct_hcc_specific_survival": true,
      "size_number_sum": 4.0
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Mazzaferro V, Sposito C, Zhou J, Pinna AD, De Carlis L, Fan J, Cescon M, Di Sandro S, Yi-feng H, Lauterio A, Bongini M, Mariani L",
        "doi": "10.1053/j.gastro.2017.09.025",
        "id": "mazzaferro-2018",
        "pmid": "28989060",
        "source": "Gastroenterology. 2018;154(1):128-139",
        "title": "Metroticket 2.0 Model for Analysis of Competing Risks of Death After Liver Transplantation for Hepatocellular Carcinoma"
      },
      "formula": "metroticket_2",
      "formula_expression": "meets_70pct_hcc_specific_survival iff (afp_ng_ml < 200 and size_number_sum <= 7) or (200 <= afp_ng_ml < 400 and size_number_sum <= 5) or (400 <= afp_ng_ml <= 1000 and size_number_sum <= 4); size_number_sum = tumor_count + largest_cm; afp_ng_ml > 1000 is always false (Mazzaferro 2018 AFP-adjusted-to-HCC-size 70% 5-year HCC-specific survival)",
      "criteria": [
        {
          "factor": "afp_lt_200_sum_le_7",
          "met": true
        },
        {
          "factor": "afp_200_400_sum_le_5",
          "met": false
        },
        {
          "factor": "afp_400_1000_sum_le_4",
          "met": false
        }
      ],
      "largest_cm": 3.0,
      "tumor_count": 1,
      "afp_ng_ml": 50.0,
      "meets_70pct_hcc_specific_survival": true,
      "size_number_sum": 4.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Mazzaferro V, Sposito C, Zhou J, Pinna AD, De Carlis L, Fan J, Cescon M, Di Sandro S, Yi-feng H, Lauterio A, Bongini M, Mariani L",
    "doi": "10.1053/j.gastro.2017.09.025",
    "id": "mazzaferro-2018",
    "pmid": "28989060",
    "source": "Gastroenterology. 2018;154(1):128-139",
    "title": "Metroticket 2.0 Model for Analysis of Competing Risks of Death After Liver Transplantation for Hepatocellular Carcinoma"
  },
  "formula": "metroticket_2",
  "formula_expression": "meets_70pct_hcc_specific_survival iff (afp_ng_ml < 200 and size_number_sum <= 7) or (200 <= afp_ng_ml < 400 and size_number_sum <= 5) or (400 <= afp_ng_ml <= 1000 and size_number_sum <= 4); size_number_sum = tumor_count + largest_cm; afp_ng_ml > 1000 is always false (Mazzaferro 2018 AFP-adjusted-to-HCC-size 70% 5-year HCC-specific survival)",
  "criteria": [
    {
      "factor": "afp_lt_200_sum_le_7",
      "met": true
    },
    {
      "factor": "afp_200_400_sum_le_5",
      "met": false
    },
    {
      "factor": "afp_400_1000_sum_le_4",
      "met": false
    }
  ],
  "largest_cm": 3.0,
  "tumor_count": 1,
  "afp_ng_ml": 50.0,
  "meets_70pct_hcc_specific_survival": true,
  "size_number_sum": 4.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Milan — Apply Mazzaferro 1996 Milan criteria and return whether the published size, count, vascular-invasion, and extrahepatic rules all hold (meets_milan).
• BCLC — Apply Reig 2022 BCLC staging and return bclc_stage (0, A, B, C, or D) with the published expected median survival. Stage only. Not a treatment recommendation.
• mRECIST — Apply Lencioni 2010 modified RECIST (mRECIST) for hepatocellular carcinoma and return target-lesion overall response CR, PR, SD, or PD from caller-assigned viable-tumor flags.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.