Lipids · LIVE

SCORE2-Diabetes 10-year CVD risk

Compute the ESC 2023 SCORE2-Diabetes 10-year fatal plus non-fatal CVD percent for adults aged 40-79 with type 2 diabetes from sex, current smoking, systolic blood pressure, total and HDL cholesterol, age at diabetes diagnosis, IFCC HbA1c, eGFR, and European geographic risk region.

LIVE $0.005 USDC GET /api/calc/score2_diabetes

Markdown: /docs/score2-diabetes.md · Canonical: https://magentlab.com/docs/score2-diabetes

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the ESC 2023 SCORE2-Diabetes 10-year fatal plus non-fatal CVD percent for adults aged 40-79 with type 2 diabetes from sex, current smoking, systolic blood pressure, total and HDL cholesterol, age at diabetes diagnosis, IFCC HbA1c, eGFR, and European geographic risk region.

When to use

When an agent already has those SCORE2-Diabetes 2023 predictors for a person aged 40-79 with type 2 diabetes and no prior CVD and needs that paper's region-calibrated 10-year CVD percent. Not a diagnosis, statin order, SCORE2, or SCORE2-OP.

When not to use

• Not a medical device. Not a diagnosis of cardiovascular disease. Not a statin order or treatment recommendation.
• SCORE2-Diabetes 2023 for type 2 diabetes, ages 40-79 only. Not SCORE2 (no diabetes-specific labs). Not SCORE2-OP. Not intended for people without diabetes or with prior CVD.
• european_risk_region is the paper's geographic calibration (low, moderate, high, very_high), not race or ethnicity.
• HbA1c is IFCC mmol/mol, not % DCCT. Caller assigns age, sex, smoking, blood pressure, lipids, diagnosis age, HbA1c, eGFR, and European risk region. magent does not assay lipids, HbA1c, or eGFR and does not measure blood pressure.

Formula

10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; ctc=(TC-6)/1; chdl=(HDL-1.3)/0.5; cdiabage=(age_at_dx-50)/5; chba1c=(HbA1c_mmol_mol-31)/9.34; cegfr=(ln(eGFR)-4.5)/0.15; diabetes=1; men S0=0.9605 lp=0.5368*cage+0.4774*smoke+0.1322*csbp+0.6457*diabetes+0.1102*ctc-0.1087*chdl-0.0672*cage*smoke-0.0268*cage*csbp-0.0983*cage*diabetes-0.0181*cage*ctc+0.0095*cage*chdl-0.0998*diabetes*cdiabage+0.0955*chba1c-0.0591*cegfr+0.0058*cegfr^2-0.0134*cage*chba1c+0.0115*cage*cegfr; women S0=0.9776 lp=0.6624*cage+0.6139*smoke+0.1421*csbp+0.8096*diabetes+0.1127*ctc-0.1568*chdl-0.1122*cage*smoke-0.0167*cage*csbp-0.1272*cage*diabetes-0.0200*cage*ctc+0.0186*cage*chdl-0.118*diabetes*cdiabage+0.1173*chba1c-0.0640*cegfr+0.0062*cegfr^2-0.0196*cage*chba1c+0.0169*cage*cegfr; region scale1/scale2 SCORE2 age<70 and SCORE2-OP age 70-79; age 40-79; type 2 diabetes only; geographic region not race; not SCORE2; not SCORE2-OP

Citation

Title

SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe

Authors

SCORE2-Diabetes working group and ESC Cardiovascular risk collaboration

Source

Eur Heart J. 2023;44(28):2544-2556

DOI

10.1093/eurheartj/ehad260

Worked example

Also searched as

• SCORE2-Diabetes
• ESC 2023 diabetes CVD risk
• 10-year CVD risk type 2 diabetes
• European risk region diabetes
• HbA1c eGFR cardiovascular risk
• SCORE2 diabetes age 40-79
• fatal and non-fatal CVD diabetes

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/score2_diabetes?age=60&sex=male&smoker=false&sbp_mm_hg=140&total_cholesterol_mmol_l=5.5&hdl_mmol_l=1.3&age_at_diabetes_diagnosis=60&hba1c_mmol_mol=50&egfr_ml_min_1_73m2=90&european_risk_region=moderate

Full URL: https://api.magentlab.com/api/calc/score2_diabetes?age=60&sex=male&smoker=false&sbp_mm_hg=140&total_cholesterol_mmol_l=5.5&hdl_mmol_l=1.3&age_at_diabetes_diagnosis=60&hba1c_mmol_mol=50&egfr_ml_min_1_73m2=90&european_risk_region=moderate

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/score2_diabetes?age=60&sex=male&smoker=false&sbp_mm_hg=140&total_cholesterol_mmol_l=5.5&hdl_mmol_l=1.3&age_at_diabetes_diagnosis=60&hba1c_mmol_mol=50&egfr_ml_min_1_73m2=90&european_risk_region=moderate"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/score2_diabetes Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "60",
      "age_at_diabetes_diagnosis": "60",
      "egfr_ml_min_1_73m2": "90",
      "european_risk_region": "moderate",
      "hba1c_mmol_mol": "50",
      "hdl_mmol_l": "1.3",
      "sbp_mm_hg": "140",
      "sex": "male",
      "smoker": "false",
      "total_cholesterol_mmol_l": "5.5"
    },
    {
      "age": "60",
      "age_at_diabetes_diagnosis": "60",
      "egfr_ml_min_1_73m2": "90",
      "european_risk_region": "moderate",
      "hba1c_mmol_mol": "50",
      "hdl_mmol_l": "1.3",
      "sbp_mm_hg": "140",
      "sex": "male",
      "smoker": "false",
      "total_cholesterol_mmol_l": "5.5"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/score2_diabetes",
  "items": [
    {
      "age": 60,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "SCORE2-Diabetes working group and ESC Cardiovascular risk collaboration",
        "doi": "10.1093/eurheartj/ehad260",
        "id": "score2-diabetes-2023",
        "pmid": "37247330",
        "source": "Eur Heart J. 2023;44(28):2544-2556",
        "title": "SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe"
      },
      "formula": "score2_diabetes",
      "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; ctc=(TC-6)/1; chdl=(HDL-1.3)/0.5; cdiabage=(age_at_dx-50)/5; chba1c=(HbA1c_mmol_mol-31)/9.34; cegfr=(ln(eGFR)-4.5)/0.15; diabetes=1; men S0=0.9605 lp=0.5368*cage+0.4774*smoke+0.1322*csbp+0.6457*diabetes+0.1102*ctc-0.1087*chdl-0.0672*cage*smoke-0.0268*cage*csbp-0.0983*cage*diabetes-0.0181*cage*ctc+0.0095*cage*chdl-0.0998*diabetes*cdiabage+0.0955*chba1c-0.0591*cegfr+0.0058*cegfr^2-0.0134*cage*chba1c+0.0115*cage*cegfr; women S0=0.9776 lp=0.6624*cage+0.6139*smoke+0.1421*csbp+0.8096*diabetes+0.1127*ctc-0.1568*chdl-0.1122*cage*smoke-0.0167*cage*csbp-0.1272*cage*diabetes-0.0200*cage*ctc+0.0186*cage*chdl-0.118*diabetes*cdiabage+0.1173*chba1c-0.0640*cegfr+0.0062*cegfr^2-0.0196*cage*chba1c+0.0169*cage*cegfr; region scale1/scale2 SCORE2 age<70 and SCORE2-OP age 70-79; age 40-79; type 2 diabetes only; geographic region not race; not SCORE2; not SCORE2-OP",
      "sex": "male",
      "linear_predictor": 0.7175,
      "egfr_ml_min_1_73m2": 90.0,
      "sbp_mm_hg": 140.0,
      "smoker": false,
      "risk_10y_percent": 11.0,
      "european_risk_region": "moderate",
      "hdl_mmol_l": 1.3,
      "total_cholesterol_mmol_l": 5.5,
      "age_at_diabetes_diagnosis": 60,
      "hba1c_mmol_mol": 50.0
    },
    {
      "age": 60,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "SCORE2-Diabetes working group and ESC Cardiovascular risk collaboration",
        "doi": "10.1093/eurheartj/ehad260",
        "id": "score2-diabetes-2023",
        "pmid": "37247330",
        "source": "Eur Heart J. 2023;44(28):2544-2556",
        "title": "SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe"
      },
      "formula": "score2_diabetes",
      "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; ctc=(TC-6)/1; chdl=(HDL-1.3)/0.5; cdiabage=(age_at_dx-50)/5; chba1c=(HbA1c_mmol_mol-31)/9.34; cegfr=(ln(eGFR)-4.5)/0.15; diabetes=1; men S0=0.9605 lp=0.5368*cage+0.4774*smoke+0.1322*csbp+0.6457*diabetes+0.1102*ctc-0.1087*chdl-0.0672*cage*smoke-0.0268*cage*csbp-0.0983*cage*diabetes-0.0181*cage*ctc+0.0095*cage*chdl-0.0998*diabetes*cdiabage+0.0955*chba1c-0.0591*cegfr+0.0058*cegfr^2-0.0134*cage*chba1c+0.0115*cage*cegfr; women S0=0.9776 lp=0.6624*cage+0.6139*smoke+0.1421*csbp+0.8096*diabetes+0.1127*ctc-0.1568*chdl-0.1122*cage*smoke-0.0167*cage*csbp-0.1272*cage*diabetes-0.0200*cage*ctc+0.0186*cage*chdl-0.118*diabetes*cdiabage+0.1173*chba1c-0.0640*cegfr+0.0062*cegfr^2-0.0196*cage*chba1c+0.0169*cage*cegfr; region scale1/scale2 SCORE2 age<70 and SCORE2-OP age 70-79; age 40-79; type 2 diabetes only; geographic region not race; not SCORE2; not SCORE2-OP",
      "sex": "male",
      "linear_predictor": 0.7175,
      "egfr_ml_min_1_73m2": 90.0,
      "sbp_mm_hg": 140.0,
      "smoker": false,
      "risk_10y_percent": 11.0,
      "european_risk_region": "moderate",
      "hdl_mmol_l": 1.3,
      "total_cholesterol_mmol_l": 5.5,
      "age_at_diabetes_diagnosis": 60,
      "hba1c_mmol_mol": 50.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "age": 60,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "SCORE2-Diabetes working group and ESC Cardiovascular risk collaboration",
    "doi": "10.1093/eurheartj/ehad260",
    "id": "score2-diabetes-2023",
    "pmid": "37247330",
    "source": "Eur Heart J. 2023;44(28):2544-2556",
    "title": "SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe"
  },
  "formula": "score2_diabetes",
  "formula_expression": "10-year fatal+non-fatal CVD % = 100*(1-exp(-exp(scale1+scale2*ln(-ln(1-uncal))))); uncal=1-S0^exp(lp); cage=(age-60)/5; csbp=(SBP-120)/20; ctc=(TC-6)/1; chdl=(HDL-1.3)/0.5; cdiabage=(age_at_dx-50)/5; chba1c=(HbA1c_mmol_mol-31)/9.34; cegfr=(ln(eGFR)-4.5)/0.15; diabetes=1; men S0=0.9605 lp=0.5368*cage+0.4774*smoke+0.1322*csbp+0.6457*diabetes+0.1102*ctc-0.1087*chdl-0.0672*cage*smoke-0.0268*cage*csbp-0.0983*cage*diabetes-0.0181*cage*ctc+0.0095*cage*chdl-0.0998*diabetes*cdiabage+0.0955*chba1c-0.0591*cegfr+0.0058*cegfr^2-0.0134*cage*chba1c+0.0115*cage*cegfr; women S0=0.9776 lp=0.6624*cage+0.6139*smoke+0.1421*csbp+0.8096*diabetes+0.1127*ctc-0.1568*chdl-0.1122*cage*smoke-0.0167*cage*csbp-0.1272*cage*diabetes-0.0200*cage*ctc+0.0186*cage*chdl-0.118*diabetes*cdiabage+0.1173*chba1c-0.0640*cegfr+0.0062*cegfr^2-0.0196*cage*chba1c+0.0169*cage*cegfr; region scale1/scale2 SCORE2 age<70 and SCORE2-OP age 70-79; age 40-79; type 2 diabetes only; geographic region not race; not SCORE2; not SCORE2-OP",
  "sex": "male",
  "linear_predictor": 0.7175,
  "egfr_ml_min_1_73m2": 90.0,
  "sbp_mm_hg": 140.0,
  "smoker": false,
  "risk_10y_percent": 11.0,
  "european_risk_region": "moderate",
  "hdl_mmol_l": 1.3,
  "total_cholesterol_mmol_l": 5.5,
  "age_at_diabetes_diagnosis": 60,
  "hba1c_mmol_mol": 50.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• SCORE2 10-year CVD risk — Compute the ESC 2021 SCORE2 10-year fatal plus non-fatal CVD percent for adults aged 40-69 from sex, current smoking, systolic blood pressure, non-HDL cholesterol, and European geographic risk region.
• FINDRISC — Sum the original Lindström 2003 seven-item Finnish diabetes risk score (FINDRISC, 0–20) and return at_risk when the total is ≥9.
• Bang diabetes screening — Sum the Bang 2009 Table 2 development screening score for undiagnosed diabetes and return high_risk when the total is ≥5.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.