Neonatal · LIVE

Neonatal early-onset sepsis risk

Return the Puopolo 2011 logistic prior probability of neonatal early-onset infection at birth from maternal temperature, gestational age, rupture of membranes, GBS, and intrapartum antibiotics, then the Escobar 2014 posterior after a caller-assigned well, equivocal, or ill exam. Infants ≥34 weeks.

LIVE $0.005 USDC GET /api/calc/neonatal_eos

Markdown: /docs/neonatal-eos.md · Canonical: https://magentlab.com/docs/neonatal-eos

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Return the Puopolo 2011 logistic prior probability of neonatal early-onset infection at birth from maternal temperature, gestational age, rupture of membranes, GBS, and intrapartum antibiotics, then the Escobar 2014 posterior after a caller-assigned well, equivocal, or ill exam. Infants ≥34 weeks.

When to use

When an agent already has maternal intrapartum temperature, gestational age ≥34 weeks, ROM hours, GBS status, antibiotic timing flags, a published incidence (0.3-0.6 per 1000), and a caller-assigned Escobar 2014 clinical category, and needs the published prior and posterior risks per 1000. magent does not examine the infant or order antibiotics.

When not to use

• Not a medical device. Not a sepsis diagnosis. Not an antibiotic order. magent does not examine the infant.
• Puopolo 2011 applies to infants ≥34 weeks. Gestational age below 34 weeks is rejected.
• The prior intercept is the published incidence-specific constant (0.3/0.4/0.5/0.6 per 1000), which replaces the 47.8398 case-control term printed with the coefficient list.
• clinical_category is caller-assigned from Escobar 2014 (well / equivocal / ill). Posterior uses that paper's conservative upper-95% CI likelihood ratios (0.41 / 5.0 / 21.2). magent does not observe vital signs or assign the category.

Formula

SRS = 1/(1+exp(−βx)); βx = intercept(eos_incidence_per_1000) + 0.8680×maternal_temp_f + (−6.9325)×GA + 0.0877×GA² + 1.2256×(ROM_h+0.05)^0.2 + (−1.0488)×gbs_or_any_abx_2h + (−1.1861)×broad_spectrum_abx_4h + GBS(positive 0.5771, unknown 0.0427, negative 0). Intercepts replace the printed 47.8398 case-control constant: 0.3→40.0528, 0.4→40.3415, 0.5→40.5656, 0.6→40.7489. Posterior odds = prior odds × Escobar 2014 conservative upper-95% CI LRs (well 0.41, equivocal 5.0, ill 21.2). Infants ≥34 weeks. Not a sepsis diagnosis or antibiotic order.

Citation

Title

Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors

Authors

Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, Smith M, Escobar GJ

Source

Pediatrics. 2011;128(5):e1155-e1163

DOI

10.1542/peds.2010-3464

Worked example

Also searched as

• early onset sepsis
• neonatal EOS risk
• Puopolo EOS
• newborn sepsis probability
• GBS early-onset infection
• intrapartum sepsis risk
• Escobar clinical EOS

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/neonatal_eos?gestational_age_weeks=40.0&maternal_temp_f=98.6&rom_hours=0&gbs=negative&gbs_or_any_abx_2h=false&broad_spectrum_abx_4h=false&eos_incidence_per_1000=0.5&clinical_category=well

Full URL: https://api.magentlab.com/api/calc/neonatal_eos?gestational_age_weeks=40.0&maternal_temp_f=98.6&rom_hours=0&gbs=negative&gbs_or_any_abx_2h=false&broad_spectrum_abx_4h=false&eos_incidence_per_1000=0.5&clinical_category=well

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/neonatal_eos?gestational_age_weeks=40.0&maternal_temp_f=98.6&rom_hours=0&gbs=negative&gbs_or_any_abx_2h=false&broad_spectrum_abx_4h=false&eos_incidence_per_1000=0.5&clinical_category=well"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/neonatal_eos Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "broad_spectrum_abx_4h": "false",
      "clinical_category": "well",
      "eos_incidence_per_1000": "0.5",
      "gbs": "negative",
      "gbs_or_any_abx_2h": "false",
      "gestational_age_weeks": "40.0",
      "maternal_temp_f": "98.6",
      "rom_hours": "0"
    },
    {
      "broad_spectrum_abx_4h": "false",
      "clinical_category": "well",
      "eos_incidence_per_1000": "0.5",
      "gbs": "negative",
      "gbs_or_any_abx_2h": "false",
      "gestational_age_weeks": "40.0",
      "maternal_temp_f": "98.6",
      "rom_hours": "0"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/neonatal_eos",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, Smith M, Escobar GJ",
        "doi": "10.1542/peds.2010-3464",
        "id": "puopolo-2011",
        "pmid": "22025590",
        "source": "Pediatrics. 2011;128(5):e1155-e1163",
        "title": "Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors"
      },
      "formula": "neonatal_eos",
      "formula_expression": "SRS = 1/(1+exp(−βx)); βx = intercept(eos_incidence_per_1000) + 0.8680×maternal_temp_f + (−6.9325)×GA + 0.0877×GA² + 1.2256×(ROM_h+0.05)^0.2 + (−1.0488)×gbs_or_any_abx_2h + (−1.1861)×broad_spectrum_abx_4h + GBS(positive 0.5771, unknown 0.0427, negative 0). Intercepts replace the printed 47.8398 case-control constant: 0.3→40.0528, 0.4→40.3415, 0.5→40.5656, 0.6→40.7489. Posterior odds = prior odds × Escobar 2014 conservative upper-95% CI LRs (well 0.41, equivocal 5.0, ill 21.2). Infants ≥34 weeks. Not a sepsis diagnosis or antibiotic order.",
      "broad_spectrum_abx_4h": false,
      "clinical_category": "well",
      "clinical_lr": 0.41,
      "eos_incidence_per_1000": 0.5,
      "gbs": "negative",
      "gbs_or_any_abx_2h": false,
      "gestational_age_weeks": 40.0,
      "maternal_temp_f": 98.6,
      "posterior_risk_per_1000": 0.0159,
      "prior_risk_per_1000": 0.0388,
      "rom_hours": 0.0
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, Smith M, Escobar GJ",
        "doi": "10.1542/peds.2010-3464",
        "id": "puopolo-2011",
        "pmid": "22025590",
        "source": "Pediatrics. 2011;128(5):e1155-e1163",
        "title": "Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors"
      },
      "formula": "neonatal_eos",
      "formula_expression": "SRS = 1/(1+exp(−βx)); βx = intercept(eos_incidence_per_1000) + 0.8680×maternal_temp_f + (−6.9325)×GA + 0.0877×GA² + 1.2256×(ROM_h+0.05)^0.2 + (−1.0488)×gbs_or_any_abx_2h + (−1.1861)×broad_spectrum_abx_4h + GBS(positive 0.5771, unknown 0.0427, negative 0). Intercepts replace the printed 47.8398 case-control constant: 0.3→40.0528, 0.4→40.3415, 0.5→40.5656, 0.6→40.7489. Posterior odds = prior odds × Escobar 2014 conservative upper-95% CI LRs (well 0.41, equivocal 5.0, ill 21.2). Infants ≥34 weeks. Not a sepsis diagnosis or antibiotic order.",
      "broad_spectrum_abx_4h": false,
      "clinical_category": "well",
      "clinical_lr": 0.41,
      "eos_incidence_per_1000": 0.5,
      "gbs": "negative",
      "gbs_or_any_abx_2h": false,
      "gestational_age_weeks": 40.0,
      "maternal_temp_f": 98.6,
      "posterior_risk_per_1000": 0.0159,
      "prior_risk_per_1000": 0.0388,
      "rom_hours": 0.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Puopolo KM, Draper D, Wi S, Newman TB, Zupancic J, Lieberman E, Smith M, Escobar GJ",
    "doi": "10.1542/peds.2010-3464",
    "id": "puopolo-2011",
    "pmid": "22025590",
    "source": "Pediatrics. 2011;128(5):e1155-e1163",
    "title": "Estimating the probability of neonatal early-onset infection on the basis of maternal risk factors"
  },
  "formula": "neonatal_eos",
  "formula_expression": "SRS = 1/(1+exp(−βx)); βx = intercept(eos_incidence_per_1000) + 0.8680×maternal_temp_f + (−6.9325)×GA + 0.0877×GA² + 1.2256×(ROM_h+0.05)^0.2 + (−1.0488)×gbs_or_any_abx_2h + (−1.1861)×broad_spectrum_abx_4h + GBS(positive 0.5771, unknown 0.0427, negative 0). Intercepts replace the printed 47.8398 case-control constant: 0.3→40.0528, 0.4→40.3415, 0.5→40.5656, 0.6→40.7489. Posterior odds = prior odds × Escobar 2014 conservative upper-95% CI LRs (well 0.41, equivocal 5.0, ill 21.2). Infants ≥34 weeks. Not a sepsis diagnosis or antibiotic order.",
  "broad_spectrum_abx_4h": false,
  "clinical_category": "well",
  "clinical_lr": 0.41,
  "eos_incidence_per_1000": 0.5,
  "gbs": "negative",
  "gbs_or_any_abx_2h": false,
  "gestational_age_weeks": 40.0,
  "maternal_temp_f": 98.6,
  "posterior_risk_per_1000": 0.0159,
  "prior_risk_per_1000": 0.0388,
  "rom_hours": 0.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Apgar score — Compute the Apgar newborn evaluation score as the sum of five caller-assigned 0-2 signs.
• Eat, Sleep, Console — Apply the Grossman 2018 Eat, Sleep, Console functional assessment from caller-assigned eat, sleep, and console flags. magent does not examine the infant.
• Rebound hyperbilirubinemia — Return the Chang 2017 three-variable rebound hyperbilirubinemia prediction score after inpatient phototherapy from gestational age, age at phototherapy initiation in days, TSB at termination, and a caller-supplied AAP phototherapy threshold. Scores <20 correspond to a <4% probability of rebound in that paper.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.