Neurology · LIVE

2017 McDonald criteria for multiple sclerosis

McDonald 2017

Apply Thompson 2018 / 2017 McDonald criteria for typical clinically isolated syndrome and return whether mcdonald_ms holds from caller-assigned typical CIS, no better explanation, attacks, lesions, DIS, MRI DIT, and CSF-specific oligoclonal bands.

LIVE $0.005 USDC GET /api/calc/mcdonald_2017

Markdown: /docs/mcdonald-2017.md · Canonical: https://magentlab.com/docs/mcdonald-2017

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply Thompson 2018 / 2017 McDonald criteria for typical clinically isolated syndrome and return whether mcdonald_ms holds from caller-assigned typical CIS, no better explanation, attacks, lesions, DIS, MRI DIT, and CSF-specific oligoclonal bands.

When to use

When an agent already has typical CIS versus not, whether a better explanation exists, ≥2-attack and ≥2-lesion flags, and caller-assigned 2017 DIS, MRI DIT, and CSF-specific OCB, and needs the published relapsing/CIS combination. magent does not read MRI or assay CSF.

When not to use

• Not a medical device and not a diagnosis of multiple sclerosis.
• Relapsing / typical CIS pathway only. Does not implement the 2017 primary progressive MS (PPMS) row.
• Not the 2010 McDonald criteria (symptomatic lesions were excluded from DIS and DIT then; 2017 counts symptomatic and cortical lesions).
• Not MAGNIMS 2016 as a second system.
• magent does not read MRI and does not assay CSF. DIS, MRI DIT, and CSF-specific oligoclonal bands are caller-assigned.
• Remain vigilant for NMOSD (neuromyelitis optica spectrum disorder) and other better explanations; no_better_explanation is caller-assigned.

Formula

mcdonald_ms iff typical_cis and no_better_explanation and ((two_or_more_attacks and two_or_more_lesions) or (two_or_more_attacks and not two_or_more_lesions and dis) or (not two_or_more_attacks and two_or_more_lesions and (dit_mri or csf_specific_ocb)) or (not two_or_more_attacks and not two_or_more_lesions and dis and (dit_mri or csf_specific_ocb))) (Thompson 2018 / 2017 McDonald typical CIS). CSF-specific OCB may substitute for MRI DIT when DIS is met. Not PPMS. Not 2010 McDonald. magent does not read MRI or assay CSF. Not a diagnosis

Citation

Title

Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria

Authors

Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA

Source

Lancet Neurol. 2018;17(2):162-173

DOI

10.1016/S1474-4422(17)30470-2

Worked example

Also searched as

• McDonald criteria 2017
• 2017 McDonald MS diagnosis
• Thompson 2018 McDonald
• CIS dissemination in space
• CSF-specific oligoclonal bands
• McDonald DIS DIT
• multiple sclerosis diagnostic criteria
• clinically isolated syndrome MS

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/mcdonald_2017?typical_cis=true&no_better_explanation=true&two_or_more_attacks=true&two_or_more_lesions=true&dis=false&dit_mri=false&csf_specific_ocb=false

Full URL: https://api.magentlab.com/api/calc/mcdonald_2017?typical_cis=true&no_better_explanation=true&two_or_more_attacks=true&two_or_more_lesions=true&dis=false&dit_mri=false&csf_specific_ocb=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/mcdonald_2017?typical_cis=true&no_better_explanation=true&two_or_more_attacks=true&two_or_more_lesions=true&dis=false&dit_mri=false&csf_specific_ocb=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/mcdonald_2017 Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "csf_specific_ocb": "false",
      "dis": "false",
      "dit_mri": "false",
      "no_better_explanation": "true",
      "two_or_more_attacks": "true",
      "two_or_more_lesions": "true",
      "typical_cis": "true"
    },
    {
      "csf_specific_ocb": "false",
      "dis": "false",
      "dit_mri": "false",
      "no_better_explanation": "true",
      "two_or_more_attacks": "true",
      "two_or_more_lesions": "true",
      "typical_cis": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/mcdonald_2017",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA",
        "doi": "10.1016/S1474-4422(17)30470-2",
        "id": "thompson-2018",
        "pmid": "29275977",
        "source": "Lancet Neurol. 2018;17(2):162-173",
        "title": "Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria"
      },
      "formula": "mcdonald_2017",
      "formula_expression": "mcdonald_ms iff typical_cis and no_better_explanation and ((two_or_more_attacks and two_or_more_lesions) or (two_or_more_attacks and not two_or_more_lesions and dis) or (not two_or_more_attacks and two_or_more_lesions and (dit_mri or csf_specific_ocb)) or (not two_or_more_attacks and not two_or_more_lesions and dis and (dit_mri or csf_specific_ocb))) (Thompson 2018 / 2017 McDonald typical CIS). CSF-specific OCB may substitute for MRI DIT when DIS is met. Not PPMS. Not 2010 McDonald. magent does not read MRI or assay CSF. Not a diagnosis",
      "criteria": [
        {
          "factor": "typical_cis",
          "met": true
        },
        {
          "factor": "no_better_explanation",
          "met": true
        },
        {
          "factor": "two_or_more_attacks",
          "met": true
        },
        {
          "factor": "two_or_more_lesions",
          "met": true
        },
        {
          "factor": "dis",
          "met": false
        },
        {
          "factor": "dit_mri",
          "met": false
        },
        {
          "factor": "csf_specific_ocb",
          "met": false
        },
        {
          "factor": "relapsing_cis_pathway",
          "met": true
        },
        {
          "factor": "mcdonald_ms",
          "met": true
        }
      ],
      "csf_specific_ocb": false,
      "dis": false,
      "dit_mri": false,
      "mcdonald_ms": true,
      "no_better_explanation": true,
      "two_or_more_attacks": true,
      "two_or_more_lesions": true,
      "typical_cis": true
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA",
        "doi": "10.1016/S1474-4422(17)30470-2",
        "id": "thompson-2018",
        "pmid": "29275977",
        "source": "Lancet Neurol. 2018;17(2):162-173",
        "title": "Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria"
      },
      "formula": "mcdonald_2017",
      "formula_expression": "mcdonald_ms iff typical_cis and no_better_explanation and ((two_or_more_attacks and two_or_more_lesions) or (two_or_more_attacks and not two_or_more_lesions and dis) or (not two_or_more_attacks and two_or_more_lesions and (dit_mri or csf_specific_ocb)) or (not two_or_more_attacks and not two_or_more_lesions and dis and (dit_mri or csf_specific_ocb))) (Thompson 2018 / 2017 McDonald typical CIS). CSF-specific OCB may substitute for MRI DIT when DIS is met. Not PPMS. Not 2010 McDonald. magent does not read MRI or assay CSF. Not a diagnosis",
      "criteria": [
        {
          "factor": "typical_cis",
          "met": true
        },
        {
          "factor": "no_better_explanation",
          "met": true
        },
        {
          "factor": "two_or_more_attacks",
          "met": true
        },
        {
          "factor": "two_or_more_lesions",
          "met": true
        },
        {
          "factor": "dis",
          "met": false
        },
        {
          "factor": "dit_mri",
          "met": false
        },
        {
          "factor": "csf_specific_ocb",
          "met": false
        },
        {
          "factor": "relapsing_cis_pathway",
          "met": true
        },
        {
          "factor": "mcdonald_ms",
          "met": true
        }
      ],
      "csf_specific_ocb": false,
      "dis": false,
      "dit_mri": false,
      "mcdonald_ms": true,
      "no_better_explanation": true,
      "two_or_more_attacks": true,
      "two_or_more_lesions": true,
      "typical_cis": true
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Thompson AJ, Banwell BL, Barkhof F, Carroll WM, Coetzee T, Comi G, Correale J, Fazekas F, Filippi M, Freedman MS, Fujihara K, Galetta SL, Hartung HP, Kappos L, Lublin FD, Marrie RA, Miller AE, Miller DH, Montalban X, Mowry EM, Sorensen PS, Tintoré M, Traboulsee AL, Trojano M, Uitdehaag BMJ, Vukusic S, Waubant E, Weinshenker BG, Reingold SC, Cohen JA",
    "doi": "10.1016/S1474-4422(17)30470-2",
    "id": "thompson-2018",
    "pmid": "29275977",
    "source": "Lancet Neurol. 2018;17(2):162-173",
    "title": "Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria"
  },
  "formula": "mcdonald_2017",
  "formula_expression": "mcdonald_ms iff typical_cis and no_better_explanation and ((two_or_more_attacks and two_or_more_lesions) or (two_or_more_attacks and not two_or_more_lesions and dis) or (not two_or_more_attacks and two_or_more_lesions and (dit_mri or csf_specific_ocb)) or (not two_or_more_attacks and not two_or_more_lesions and dis and (dit_mri or csf_specific_ocb))) (Thompson 2018 / 2017 McDonald typical CIS). CSF-specific OCB may substitute for MRI DIT when DIS is met. Not PPMS. Not 2010 McDonald. magent does not read MRI or assay CSF. Not a diagnosis",
  "criteria": [
    {
      "factor": "typical_cis",
      "met": true
    },
    {
      "factor": "no_better_explanation",
      "met": true
    },
    {
      "factor": "two_or_more_attacks",
      "met": true
    },
    {
      "factor": "two_or_more_lesions",
      "met": true
    },
    {
      "factor": "dis",
      "met": false
    },
    {
      "factor": "dit_mri",
      "met": false
    },
    {
      "factor": "csf_specific_ocb",
      "met": false
    },
    {
      "factor": "relapsing_cis_pathway",
      "met": true
    },
    {
      "factor": "mcdonald_ms",
      "met": true
    }
  ],
  "csf_specific_ocb": false,
  "dis": false,
  "dit_mri": false,
  "mcdonald_ms": true,
  "no_better_explanation": true,
  "two_or_more_attacks": true,
  "two_or_more_lesions": true,
  "typical_cis": true
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Disease Steps — Return the caller-assigned Hohol 1995 Disease Steps integer 0-6 with the published description. magent does not examine gait.
• Glasgow Coma Scale — Compute the Glasgow Coma Scale as the sum of caller-assigned eye, verbal, and motor integers. The 1974 or 1976 edition is required.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.