Hematology · LIVE

Cryoprecipitate bag estimate

Compute a cryoprecipitate bag estimate from the AABB Technical Manual calculation as reprinted in Nascimento 2011: blood volume 70 mL/kg and 250 mg fibrinogen per bag.

LIVE $0.005 USDC GET /api/calc/cryoprecipitate

Markdown: /docs/cryoprecipitate.md · Canonical: https://magentlab.com/docs/cryoprecipitate

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute a cryoprecipitate bag estimate from the AABB Technical Manual calculation as reprinted in Nascimento 2011: blood volume 70 mL/kg and 250 mg fibrinogen per bag.

When to use

When an agent needs the published AABB cryoprecipitate bag arithmetic reprinted in Nascimento 2011 and must not invent a fibrinogen-concentrate brand dose, a major-haemorrhage pool, a product or ABO-group choice, or a transfusion order.

When not to use

• Not a medical device. Not a transfusion order.
• Nascimento 2011 notes that 100% recovery is likely false and fibrinogen per bag varies.
• magent does not choose a product or ABO group.
• Not a major-haemorrhage protocol.

Formula

blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250)

Citation

Title

Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma

Authors

Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC

Source

Transfus Med. 2011;21(6):394-401

DOI

10.1111/j.1365-3148.2011.01098.x

Worked example

Also searched as

• cryoprecipitate bags
• AABB cryoprecipitate
• fibrinogen replacement bags
• Nascimento 2011 cryoprecipitate
• cryoprecipitate dose
• cryo bag estimate
• AABB Technical Manual cryoprecipitate

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/cryoprecipitate?weight_kg=70&hematocrit_percent=40&current_fibrinogen_mg_dl=100&desired_fibrinogen_mg_dl=200

Full URL: https://api.magentlab.com/api/calc/cryoprecipitate?weight_kg=70&hematocrit_percent=40&current_fibrinogen_mg_dl=100&desired_fibrinogen_mg_dl=200

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/cryoprecipitate?weight_kg=70&hematocrit_percent=40&current_fibrinogen_mg_dl=100&desired_fibrinogen_mg_dl=200"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/cryoprecipitate Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "current_fibrinogen_mg_dl": "100",
      "desired_fibrinogen_mg_dl": "200",
      "hematocrit_percent": "40",
      "weight_kg": "70"
    },
    {
      "current_fibrinogen_mg_dl": "100",
      "desired_fibrinogen_mg_dl": "200",
      "hematocrit_percent": "40",
      "weight_kg": "70"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/cryoprecipitate",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC",
        "doi": "10.1111/j.1365-3148.2011.01098.x",
        "id": "nascimento-2011",
        "pmid": "21851429",
        "source": "Transfus Med. 2011;21(6):394-401",
        "title": "Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma"
      },
      "formula": "nascimento_2011",
      "formula_expression": "blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250)",
      "weight_kg": 70.0,
      "hematocrit_percent": 40.0,
      "bags": 12,
      "blood_volume_ml": 4.9e3,
      "current_fibrinogen_mg_dl": 100.0,
      "desired_fibrinogen_mg_dl": 200.0,
      "mg_fibrinogen": 2940.0,
      "plasma_volume_ml": 2940.0
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC",
        "doi": "10.1111/j.1365-3148.2011.01098.x",
        "id": "nascimento-2011",
        "pmid": "21851429",
        "source": "Transfus Med. 2011;21(6):394-401",
        "title": "Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma"
      },
      "formula": "nascimento_2011",
      "formula_expression": "blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250)",
      "weight_kg": 70.0,
      "hematocrit_percent": 40.0,
      "bags": 12,
      "blood_volume_ml": 4.9e3,
      "current_fibrinogen_mg_dl": 100.0,
      "desired_fibrinogen_mg_dl": 200.0,
      "mg_fibrinogen": 2940.0,
      "plasma_volume_ml": 2940.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Nascimento B, Rizoli S, Rubenfeld G, Lin Y, Callum J, Tien HC",
    "doi": "10.1111/j.1365-3148.2011.01098.x",
    "id": "nascimento-2011",
    "pmid": "21851429",
    "source": "Transfus Med. 2011;21(6):394-401",
    "title": "Cryoprecipitate transfusion: assessing appropriateness and dosing in trauma"
  },
  "formula": "nascimento_2011",
  "formula_expression": "blood_volume_ml = 70 * weight_kg; plasma_volume_ml = blood_volume_ml * (1 - hematocrit_percent/100); mg_fibrinogen = (desired_fibrinogen_mg_dl - current_fibrinogen_mg_dl) * plasma_volume_ml / 100; bags = ceil(mg_fibrinogen / 250)",
  "weight_kg": 70.0,
  "hematocrit_percent": 40.0,
  "bags": 12,
  "blood_volume_ml": 4.9e3,
  "current_fibrinogen_mg_dl": 100.0,
  "desired_fibrinogen_mg_dl": 200.0,
  "mg_fibrinogen": 2940.0,
  "plasma_volume_ml": 2940.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Plasma starting dose — Compute the BSH Green 2018 starting plasma volume from body weight: 15 mL/kg in the absence of major bleeding. Adult starting dose only.
• Kaplan plasma volume — Compute Kaplan 1990 estimated plasma volume for therapeutic plasma exchange from weight and hematocrit as a percent, returning one plasma volume in liters and milliliters.
• Ganzoni iron deficit — Compute the Ganzoni 1970 iron deficit from weight, measured hemoglobin, a caller-supplied target hemoglobin, and depot iron stores.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.