MAGENT

Hemodynamics · LIVE

HFA-ICOS BCR-ABL TKI baseline CV risk

Classify published HFA-ICOS baseline cardiovascular risk before second- or third-generation multi-targeted kinase inhibitors for CML targeting BCR-ABL.

LIVE $0.005 USDC GET /api/calc/hfa_icos_bcr_abl

Markdown: /docs/hfa-icos-bcr-abl.md · Canonical: https://magentlab.com/docs/hfa-icos-bcr-abl

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Classify published HFA-ICOS baseline cardiovascular risk before second- or third-generation multi-targeted kinase inhibitors for CML targeting BCR-ABL.

When to use

When an agent needs the Lyon 2020 BCR-ABL TKI risk class and must not invent a 10-year CVD equation or a hold/monitor order.

When not to use

  • Not a medical device. Not a treatment, hold, dose, or monitoring order. Classes follow Lyon 2020 (low = no factor or one Medium 1; medium = 2–4 medium points; high = any high factor or ≥5 medium points; very high = any very-high factor).
  • magent does not compute a 10-year CVD risk equation. Caller assigns cvd_10y_risk_gt_20 for the paper row Cardiovascular disease 10-year risk score >20%.
  • magent does not measure ABPI, estimate pulmonary pressure, read an ECG or echocardiogram, or take a smoking history. Those rows are caller-assigned flags.
  • This BCR-ABL table has no 50–54% LVEF Medium 2 row. Age bands are mutually exclusive. Current or significant smoking is High on this table, not Medium 1.

Formula

HFA-ICOS BCR-ABL TKI (Lyon 2020) = very_high if arterial_vascular_disease or arterial_thrombosis_with_tki; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low (0 or one M1); medium_points = M2*2 + M1*1 only; High: heart_failure_or_lvsd, bcr_abl_tki_mediated_lvsd, abpi_le_0_9, pulmonary_arterial_hypertension, LVEF<50, QTc>=480, caller cvd_10y_risk_gt_20, age>=75, current_or_significant_smoker; M2: venous_thromboembolism, arrhythmia, borderline QTc (men 450<=QTc<480, women 460<=QTc<480), hypertension, age 65-74; M1: diabetes, hyperlipidemia, age 60-64, ckd, family_history_thrombophilia, obesity; age bands mutually exclusive; no LVEF 50-54 row; magent does not compute 10-year CVD risk

Citation

Title
Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society
Authors
Lyon AR, Dent S, Stanway S, et al.
Source
Eur J Heart Fail. 2020;22(11):1945-1960
DOI
10.1002/ejhf.1920

Worked example

Age 50, no factors

Given: abpi_le_0_9=falseage_years=50arrhythmia=falsearterial_thrombosis_with_tki=falsearterial_vascular_disease=falsebcr_abl_tki_mediated_lvsd=falseckd=falsecurrent_or_significant_smoker=falsecvd_10y_risk_gt_20=falsediabetes=falsefamily_history_thrombophilia=falseheart_failure_or_lvsd=falsehyperlipidemia=falsehypertension=falselvef_percent=60obesity=falsepulmonary_arterial_hypertension=falseqtc_ms=400sex=femalevenous_thromboembolism=false

  1. age 50 is <60 so no age points
  2. LVEF 60 and QTc 400 add no points
  3. all flags false including cvd_10y_risk_gt_20
  4. medium_points = 0; risk_level = low; cardiotoxicity_guide = <2%

Hypertension only

Given: abpi_le_0_9=falseage_years=50arrhythmia=falsearterial_thrombosis_with_tki=falsearterial_vascular_disease=falsebcr_abl_tki_mediated_lvsd=falseckd=falsecurrent_or_significant_smoker=falsecvd_10y_risk_gt_20=falsediabetes=falsefamily_history_thrombophilia=falseheart_failure_or_lvsd=falsehyperlipidemia=falsehypertension=truelvef_percent=60obesity=falsepulmonary_arterial_hypertension=falseqtc_ms=400sex=femalevenous_thromboembolism=false

  1. hypertension is Medium 2
  2. medium_points = 2; risk_level = medium; cardiotoxicity_guide = 2-9%

Current or significant smoker

Given: abpi_le_0_9=falseage_years=50arrhythmia=falsearterial_thrombosis_with_tki=falsearterial_vascular_disease=falsebcr_abl_tki_mediated_lvsd=falseckd=falsecurrent_or_significant_smoker=truecvd_10y_risk_gt_20=falsediabetes=falsefamily_history_thrombophilia=falseheart_failure_or_lvsd=falsehyperlipidemia=falsehypertension=falselvef_percent=60obesity=falsepulmonary_arterial_hypertension=falseqtc_ms=400sex=femalevenous_thromboembolism=false

  1. smoking is High on this table
  2. medium_points = 0; risk_level = high; cardiotoxicity_guide = 10-19%

Arterial vascular disease

Given: abpi_le_0_9=falseage_years=50arrhythmia=falsearterial_thrombosis_with_tki=falsearterial_vascular_disease=truebcr_abl_tki_mediated_lvsd=falseckd=falsecurrent_or_significant_smoker=falsecvd_10y_risk_gt_20=falsediabetes=falsefamily_history_thrombophilia=falseheart_failure_or_lvsd=falsehyperlipidemia=falsehypertension=falselvef_percent=60obesity=falsepulmonary_arterial_hypertension=falseqtc_ms=400sex=femalevenous_thromboembolism=false

  1. arterial_vascular_disease is Very high
  2. risk_level = very_high; cardiotoxicity_guide = >=20%

Also searched as

  • HFA-ICOS BCR-ABL
  • BCR-ABL TKI cardiovascular risk
  • HFA ICOS CML kinase inhibitor
  • cardio-oncology BCR-ABL baseline
  • Lyon 2020 BCR-ABL TKI

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/hfa_icos_bcr_abl?age_years=50&sex=female&lvef_percent=60&qtc_ms=400&arterial_vascular_disease=false&arterial_thrombosis_with_tki=false&heart_failure_or_lvsd=false&bcr_abl_tki_mediated_lvsd=false&abpi_le_0_9=false&pulmonary_arterial_hypertension=false&cvd_10y_risk_gt_20=false&current_or_significant_smoker=false&venous_thromboembolism=false&arrhythmia=false&hypertension=false&diabetes=false&hyperlipidemia=false&ckd=false&family_history_thrombophilia=false&obesity=false

Full URL: https://api.magentlab.com/api/calc/hfa_icos_bcr_abl?age_years=50&sex=female&lvef_percent=60&qtc_ms=400&arterial_vascular_disease=false&arterial_thrombosis_with_tki=false&heart_failure_or_lvsd=false&bcr_abl_tki_mediated_lvsd=false&abpi_le_0_9=false&pulmonary_arterial_hypertension=false&cvd_10y_risk_gt_20=false&current_or_significant_smoker=false&venous_thromboembolism=false&arrhythmia=false&hypertension=false&diabetes=false&hyperlipidemia=false&ckd=false&family_history_thrombophilia=false&obesity=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. 

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/hfa_icos_bcr_abl?age_years=50&sex=female&lvef_percent=60&qtc_ms=400&arterial_vascular_disease=false&arterial_thrombosis_with_tki=false&heart_failure_or_lvsd=false&bcr_abl_tki_mediated_lvsd=false&abpi_le_0_9=false&pulmonary_arterial_hypertension=false&cvd_10y_risk_gt_20=false&current_or_significant_smoker=false&venous_thromboembolism=false&arrhythmia=false&hypertension=false&diabetes=false&hyperlipidemia=false&ckd=false&family_history_thrombophilia=false&obesity=false"

Parameters

Name Type Required Description
age_years integer required Age in years (integer 18-100). Lyon 2020 BCR-ABL table: ≥75 High; 65-74 Medium 2; 60-64 Medium 1 (paper row Age ≥60 years under the higher bands); <60 none. Bands do not stack. magent does not examine the patient.
sex string required Sex male or female. Selects the borderline QTc Medium 2 window (men 450≤QTc<480; women 460≤QTc<480). magent does not read an ECG.
lvef_percent number required Left-ventricular ejection fraction in percent (10-80). <50 is High. This table has no 50-54 Medium 2 LVEF row; ≥50 adds no LVEF points. magent does not read an echocardiogram.
qtc_ms number required QTc in milliseconds (300-700). ≥480 is High. Borderline Medium 2 is men 450≤QTc<480 and women 460≤QTc<480. magent does not measure QTc.
arterial_vascular_disease boolean required Caller-assigned arterial vascular disease (IHD, PCI, CABG, stable angina, TIA, stroke, or PVD). Very high. magent does not diagnose vascular disease.
arterial_thrombosis_with_tki boolean required Caller-assigned arterial thrombosis associated with a BCR-ABL TKI. Very high. magent does not diagnose thrombosis.
heart_failure_or_lvsd boolean required Caller-assigned heart failure or left-ventricular systolic dysfunction. High. magent does not diagnose heart failure.
bcr_abl_tki_mediated_lvsd boolean required Caller-assigned BCR-ABL TKI-mediated LVSD. High. magent does not attribute LVSD to a TKI.
abpi_le_0_9 boolean required Caller-assigned abnormal ankle-brachial pressure index (paper: ABPI ≤0.9). High. magent does not measure ABPI.
pulmonary_arterial_hypertension boolean required Caller-assigned pulmonary arterial hypertension (paper: peak systolic PAP ≥35 mmHg when estimated on echocardiography). High. magent does not estimate pulmonary pressure.
cvd_10y_risk_gt_20 boolean required Caller-assigned paper row Cardiovascular disease 10-year risk score >20%. High. magent does not compute SCORE2, PCE, or any other 10-year CVD equation.
current_or_significant_smoker boolean required Caller-assigned current smoker or significant smoking history. High on this BCR-ABL table (not Medium 1). magent does not take a smoking history.
venous_thromboembolism boolean required Caller-assigned venous thromboembolism (DVT or PE). Medium 2. magent does not diagnose VTE.
arrhythmia boolean required Caller-assigned arrhythmia (paper: atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation). Medium 2. magent does not read a rhythm strip.
hypertension boolean required Caller-assigned hypertension (paper: SBP >140 mmHg or DBP >90 mmHg, or on treatment). Medium 2. magent does not measure blood pressure.
diabetes boolean required Caller-assigned diabetes (paper: HbA1c >7.0% or >53 mmol/mol, or on treatment). Medium 1. magent does not diagnose diabetes.
hyperlipidemia boolean required Caller-assigned hyperlipidemia (paper: non-HDL cholesterol >3.8 mmol/L or >145 mg/dL). Medium 1. magent does not assay lipids.
ckd boolean required Caller-assigned chronic kidney disease (paper: eGFR <60 mL/min/1.73 m²). Medium 1. magent does not compute eGFR.
family_history_thrombophilia boolean required Caller-assigned family history of thrombophilia. Medium 1. magent does not take a family history.
obesity boolean required Caller-assigned obesity (paper: BMI >30 kg/m²). Medium 1. magent does not compute BMI.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/hfa_icos_bcr_abl Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

  • 1 to 25 items. Each item uses the same keys as the GET query parameters.
  • POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
  • The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
  • HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
  • Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
  • x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "abpi_le_0_9": "false",
      "age_years": "50",
      "arrhythmia": "false",
      "arterial_thrombosis_with_tki": "false",
      "arterial_vascular_disease": "false",
      "bcr_abl_tki_mediated_lvsd": "false",
      "ckd": "false",
      "current_or_significant_smoker": "false",
      "cvd_10y_risk_gt_20": "false",
      "diabetes": "false",
      "family_history_thrombophilia": "false",
      "heart_failure_or_lvsd": "false",
      "hyperlipidemia": "false",
      "hypertension": "false",
      "lvef_percent": "60",
      "obesity": "false",
      "pulmonary_arterial_hypertension": "false",
      "qtc_ms": "400",
      "sex": "female",
      "venous_thromboembolism": "false"
    },
    {
      "abpi_le_0_9": "false",
      "age_years": "50",
      "arrhythmia": "false",
      "arterial_thrombosis_with_tki": "false",
      "arterial_vascular_disease": "false",
      "bcr_abl_tki_mediated_lvsd": "false",
      "ckd": "false",
      "current_or_significant_smoker": "false",
      "cvd_10y_risk_gt_20": "false",
      "diabetes": "false",
      "family_history_thrombophilia": "false",
      "heart_failure_or_lvsd": "false",
      "hyperlipidemia": "false",
      "hypertension": "false",
      "lvef_percent": "60",
      "obesity": "false",
      "pulmonary_arterial_hypertension": "false",
      "qtc_ms": "400",
      "sex": "female",
      "venous_thromboembolism": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/hfa_icos_bcr_abl",
  "items": [
    {
      "components": [
        {
          "factor": "arterial_vascular_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "arterial_thrombosis_with_tki",
          "points": 0,
          "present": false
        },
        {
          "factor": "heart_failure_or_lvsd",
          "points": 0,
          "present": false
        },
        {
          "factor": "bcr_abl_tki_mediated_lvsd",
          "points": 0,
          "present": false
        },
        {
          "factor": "abpi_le_0_9",
          "points": 0,
          "present": false
        },
        {
          "factor": "pulmonary_arterial_hypertension",
          "points": 0,
          "present": false
        },
        {
          "factor": "lvef_lt_50",
          "points": 0,
          "present": false
        },
        {
          "factor": "qtc_ge_480",
          "points": 0,
          "present": false
        },
        {
          "factor": "cvd_10y_risk_gt_20",
          "points": 0,
          "present": false
        },
        {
          "factor": "age_ge_75",
          "points": 0,
          "present": false
        },
        {
          "factor": "current_or_significant_smoker",
          "points": 0,
          "present": false
        },
        {
          "factor": "venous_thromboembolism",
          "points": 0,
          "present": false
        },
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false
        },
        {
          "factor": "borderline_qtc",
          "points": 0,
          "present": false
        },
        {
          "factor": "hypertension",
          "points": 0,
          "present": false
        },
        {
          "factor": "age_65_74",
          "points": 0,
          "present": false
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false
        },
        {
          "factor": "hyperlipidemia",
          "points": 0,
          "present": false
        },
        {
          "factor": "age_60_64",
          "points": 0,
          "present": false
        },
        {
          "factor": "ckd",
          "points": 0,
          "present": false
        },
        {
          "factor": "family_history_thrombophilia",
          "points": 0,
          "present": false
        },
        {
          "factor": "obesity",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Lyon AR, Dent S, Stanway S, et al.",
        "doi": "10.1002/ejhf.1920",
        "id": "lyon-2020",
        "pmid": "32458582",
        "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
        "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
      },
      "formula": "hfa_icos_bcr_abl",
      "formula_expression": "HFA-ICOS BCR-ABL TKI (Lyon 2020) = very_high if arterial_vascular_disease or arterial_thrombosis_with_tki; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low (0 or one M1); medium_points = M2*2 + M1*1 only; High: heart_failure_or_lvsd, bcr_abl_tki_mediated_lvsd, abpi_le_0_9, pulmonary_arterial_hypertension, LVEF<50, QTc>=480, caller cvd_10y_risk_gt_20, age>=75, current_or_significant_smoker; M2: venous_thromboembolism, arrhythmia, borderline QTc (men 450<=QTc<480, women 460<=QTc<480), hypertension, age 65-74; M1: diabetes, hyperlipidemia, age 60-64, ckd, family_history_thrombophilia, obesity; age bands mutually exclusive; no LVEF 50-54 row; magent does not compute 10-year CVD risk",
      "age_years": 50,
      "sex": "female",
      "qtc_ms": 400.0,
      "cardiotoxicity_guide": "<2%",
      "lvef_percent": 60.0,
      "medium_points": 0,
      "risk_level": "low"
    },
    {
      "components": [
        {
          "factor": "arterial_vascular_disease",
          "points": 0,
          "present": false
        },
        {
          "factor": "arterial_thrombosis_with_tki",
          "points": 0,
          "present": false
        },
        {
          "factor": "heart_failure_or_lvsd",
          "points": 0,
          "present": false
        },
        {
          "factor": "bcr_abl_tki_mediated_lvsd",
          "points": 0,
          "present": false
        },
        {
          "factor": "abpi_le_0_9",
          "points": 0,
          "present": false
        },
        {
          "factor": "pulmonary_arterial_hypertension",
          "points": 0,
          "present": false
        },
        {
          "factor": "lvef_lt_50",
          "points": 0,
          "present": false
        },
        {
          "factor": "qtc_ge_480",
          "points": 0,
          "present": false
        },
        {
          "factor": "cvd_10y_risk_gt_20",
          "points": 0,
          "present": false
        },
        {
          "factor": "age_ge_75",
          "points": 0,
          "present": false
        },
        {
          "factor": "current_or_significant_smoker",
          "points": 0,
          "present": false
        },
        {
          "factor": "venous_thromboembolism",
          "points": 0,
          "present": false
        },
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false
        },
        {
          "factor": "borderline_qtc",
          "points": 0,
          "present": false
        },
        {
          "factor": "hypertension",
          "points": 0,
          "present": false
        },
        {
          "factor": "age_65_74",
          "points": 0,
          "present": false
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false
        },
        {
          "factor": "hyperlipidemia",
          "points": 0,
          "present": false
        },
        {
          "factor": "age_60_64",
          "points": 0,
          "present": false
        },
        {
          "factor": "ckd",
          "points": 0,
          "present": false
        },
        {
          "factor": "family_history_thrombophilia",
          "points": 0,
          "present": false
        },
        {
          "factor": "obesity",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Lyon AR, Dent S, Stanway S, et al.",
        "doi": "10.1002/ejhf.1920",
        "id": "lyon-2020",
        "pmid": "32458582",
        "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
        "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
      },
      "formula": "hfa_icos_bcr_abl",
      "formula_expression": "HFA-ICOS BCR-ABL TKI (Lyon 2020) = very_high if arterial_vascular_disease or arterial_thrombosis_with_tki; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low (0 or one M1); medium_points = M2*2 + M1*1 only; High: heart_failure_or_lvsd, bcr_abl_tki_mediated_lvsd, abpi_le_0_9, pulmonary_arterial_hypertension, LVEF<50, QTc>=480, caller cvd_10y_risk_gt_20, age>=75, current_or_significant_smoker; M2: venous_thromboembolism, arrhythmia, borderline QTc (men 450<=QTc<480, women 460<=QTc<480), hypertension, age 65-74; M1: diabetes, hyperlipidemia, age 60-64, ckd, family_history_thrombophilia, obesity; age bands mutually exclusive; no LVEF 50-54 row; magent does not compute 10-year CVD risk",
      "age_years": 50,
      "sex": "female",
      "qtc_ms": 400.0,
      "cardiotoxicity_guide": "<2%",
      "lvef_percent": 60.0,
      "medium_points": 0,
      "risk_level": "low"
    }
  ]
}

Response

Field Type Description
formula string hfa_icos_bcr_abl
formula_expression string Exact expression used
age_years integer Age in years used
sex string male or female used for the QTc window
lvef_percent number LVEF percent used
qtc_ms number QTc in milliseconds used
medium_points integer Sum of Medium 1 (1 each) and Medium 2 (2 each) only
risk_level string very_high, high, medium, or low from the Lyon 2020 BCR-ABL table. A class, not a treatment order.
cardiotoxicity_guide string Lyon 2020 expert-opinion future-cardiotoxicity guide: <2% / 2-9% / 10-19% / >=20%
components array Per-factor presence and medium points
citation object Lyon et al. Eur J Heart Fail 2020 citation
disclaimer string Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup. 

{
  "components": [
    {
      "factor": "arterial_vascular_disease",
      "points": 0,
      "present": false
    },
    {
      "factor": "arterial_thrombosis_with_tki",
      "points": 0,
      "present": false
    },
    {
      "factor": "heart_failure_or_lvsd",
      "points": 0,
      "present": false
    },
    {
      "factor": "bcr_abl_tki_mediated_lvsd",
      "points": 0,
      "present": false
    },
    {
      "factor": "abpi_le_0_9",
      "points": 0,
      "present": false
    },
    {
      "factor": "pulmonary_arterial_hypertension",
      "points": 0,
      "present": false
    },
    {
      "factor": "lvef_lt_50",
      "points": 0,
      "present": false
    },
    {
      "factor": "qtc_ge_480",
      "points": 0,
      "present": false
    },
    {
      "factor": "cvd_10y_risk_gt_20",
      "points": 0,
      "present": false
    },
    {
      "factor": "age_ge_75",
      "points": 0,
      "present": false
    },
    {
      "factor": "current_or_significant_smoker",
      "points": 0,
      "present": false
    },
    {
      "factor": "venous_thromboembolism",
      "points": 0,
      "present": false
    },
    {
      "factor": "arrhythmia",
      "points": 0,
      "present": false
    },
    {
      "factor": "borderline_qtc",
      "points": 0,
      "present": false
    },
    {
      "factor": "hypertension",
      "points": 0,
      "present": false
    },
    {
      "factor": "age_65_74",
      "points": 0,
      "present": false
    },
    {
      "factor": "diabetes",
      "points": 0,
      "present": false
    },
    {
      "factor": "hyperlipidemia",
      "points": 0,
      "present": false
    },
    {
      "factor": "age_60_64",
      "points": 0,
      "present": false
    },
    {
      "factor": "ckd",
      "points": 0,
      "present": false
    },
    {
      "factor": "family_history_thrombophilia",
      "points": 0,
      "present": false
    },
    {
      "factor": "obesity",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Lyon AR, Dent S, Stanway S, et al.",
    "doi": "10.1002/ejhf.1920",
    "id": "lyon-2020",
    "pmid": "32458582",
    "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
    "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
  },
  "formula": "hfa_icos_bcr_abl",
  "formula_expression": "HFA-ICOS BCR-ABL TKI (Lyon 2020) = very_high if arterial_vascular_disease or arterial_thrombosis_with_tki; else high if any high factor or medium_points>=5; else medium if medium_points 2-4; else low (0 or one M1); medium_points = M2*2 + M1*1 only; High: heart_failure_or_lvsd, bcr_abl_tki_mediated_lvsd, abpi_le_0_9, pulmonary_arterial_hypertension, LVEF<50, QTc>=480, caller cvd_10y_risk_gt_20, age>=75, current_or_significant_smoker; M2: venous_thromboembolism, arrhythmia, borderline QTc (men 450<=QTc<480, women 460<=QTc<480), hypertension, age 65-74; M1: diabetes, hyperlipidemia, age 60-64, ckd, family_history_thrombophilia, obesity; age bands mutually exclusive; no LVEF 50-54 row; magent does not compute 10-year CVD risk",
  "age_years": 50,
  "sex": "female",
  "qtc_ms": 400.0,
  "cardiotoxicity_guide": "<2%",
  "lvef_percent": 60.0,
  "medium_points": 0,
  "risk_level": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP Code When
400 invalid_hfa_icos_bcr_abl Lyon 2020 HFA-ICOS BCR-ABL TKI inputs must match that table's age, LVEF, QTc, sex, caller-assigned 10-year CVD threshold, and yes/no factors. Returned before settlement; you are not charged.
400 invalid_items POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400 invalid_item_count items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400 invalid_item each items entry must be a JSON object Returned before settlement; you are not charged.

Related tools

  • HFA-ICOS anthracycline baseline CV risk — Apply the Lyon 2020 HFA-ICOS anthracycline baseline cardiovascular risk proforma from caller-assigned age, LVEF, and published Very high, High, Medium 2, and Medium 1 factors. Returns risk_level, medium_points, and the paper's expert-opinion cardiotoxicity_guide.
  • NYHA — Return the 1994 NYHA functional capacity class 1-4 from a caller-assigned integer, with the published class description.
  • MAGGIC — Sum the Pocock 2013 MAGGIC integer chart from thirteen caller-supplied heart-failure predictors and return the published Table 4 1-year and 3-year death probabilities for scores 0-50.
  • HCM Risk-SCD — Compute the O'Mahony 2014 HCM Risk-SCD 5-year sudden cardiac death probability from maximal wall thickness, left-atrial diameter, maximal LVOT gradient, family history of SCD, NSVT, unexplained syncope, and age.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

  • HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
  • exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
  • HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
  • Execution is timeout-bounded and concurrency-capped.
  • Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.