Medications · LIVE

ED-initiated buprenorphine

Return the D'Onofrio 2015 emergency-department-initiated buprenorphine milligram for protocol day 1, 2, or 3: 8 mg on day 1 and 16 mg on days 2 and 3.

LIVE $0.005 USDC GET /api/calc/ed_buprenorphine

Markdown: /docs/ed-buprenorphine.md · Canonical: https://magentlab.com/docs/ed-buprenorphine

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Return the D'Onofrio 2015 emergency-department-initiated buprenorphine milligram for protocol day 1, 2, or 3: 8 mg on day 1 and 16 mg on days 2 and 3.

When to use

When an agent needs the published D'Onofrio 2015 take-home milligram schedule for ED-initiated buprenorphine on protocol day 1, 2, or 3 and must not invent a home-induction tree, score COWS, or name a product brand.

When not to use

• Not a medical device. Deterministic published-schedule output only.
• Not a prescription. magent does not name a product, route, or formulation.
• Not an X-waiver or induction algorithm beyond the trial's day-1 8 mg and day-2/3 16 mg take-home schedule.
• magent does not score COWS.

Formula

dose_mg = (day == 1) ? 8 : 16

Citation

Title

Emergency Department-Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial

Authors

D'Onofrio G, O'Connor PG, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA

Source

JAMA. 2015;313(16):1636-1644

DOI

10.1001/jama.2015.3474

Worked example

Also searched as

• ED buprenorphine
• emergency department buprenorphine
• D'Onofrio buprenorphine
• ED-initiated buprenorphine
• buprenorphine day 1 8 mg
• buprenorphine take-home 16 mg
• opioid dependence ED induction

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/ed_buprenorphine?day=1

Full URL: https://api.magentlab.com/api/calc/ed_buprenorphine?day=1

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/ed_buprenorphine?day=1"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/ed_buprenorphine Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "day": "1"
    },
    {
      "day": "1"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/ed_buprenorphine",
  "items": [
    {
      "day": 1,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "D'Onofrio G, O'Connor PG, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA",
        "doi": "10.1001/jama.2015.3474",
        "id": "donofrio-2015",
        "pmid": "25919527",
        "source": "JAMA. 2015;313(16):1636-1644",
        "title": "Emergency Department-Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial"
      },
      "formula": "donofrio_2015",
      "formula_expression": "dose_mg = (day == 1) ? 8 : 16",
      "dose_mg": 8
    },
    {
      "day": 1,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "D'Onofrio G, O'Connor PG, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA",
        "doi": "10.1001/jama.2015.3474",
        "id": "donofrio-2015",
        "pmid": "25919527",
        "source": "JAMA. 2015;313(16):1636-1644",
        "title": "Emergency Department-Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial"
      },
      "formula": "donofrio_2015",
      "formula_expression": "dose_mg = (day == 1) ? 8 : 16",
      "dose_mg": 8
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "day": 1,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "D'Onofrio G, O'Connor PG, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA",
    "doi": "10.1001/jama.2015.3474",
    "id": "donofrio-2015",
    "pmid": "25919527",
    "source": "JAMA. 2015;313(16):1636-1644",
    "title": "Emergency Department-Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial"
  },
  "formula": "donofrio_2015",
  "formula_expression": "dose_mg = (day == 1) ? 8 : 16",
  "dose_mg": 8
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• COWS — Sum the eleven Wesson 2003 Clinical Opiate Withdrawal Scale (COWS) items from caller-assigned appendix integers and return the published total (max 48) with the published severity cutoffs.
• Naloxone infusion — Compute a continuous intravenous naloxone infusion rate as two-thirds of the caller-assigned reversal bolus each hour, using the Goldfrank 1986 text rule.
• Morphine milligram equivalents — Compute morphine milligram equivalents from a CDC 2022 table opioid and daily dose (or transdermal fentanyl mcg/hr).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.