Infection / VTE · LIVE

VACS Index 1.0 (Tate 2013)

VACS 1.0

Sum the Tate 2013 VACS Index 1.0 points after one year of antiretroviral therapy from age, CD4, HIV-1 RNA, hemoglobin, caller-assigned FIB-4 and eGFR, and hepatitis C.

LIVE $0.005 USDC GET /api/calc/vacs_1

Markdown: /docs/vacs-1.md · Canonical: https://magentlab.com/docs/vacs-1

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Tate 2013 VACS Index 1.0 points after one year of antiretroviral therapy from age, CD4, HIV-1 RNA, hemoglobin, caller-assigned FIB-4 and eGFR, and hepatitis C.

When to use

When an agent already has those seven caller-assigned values and needs the published VACS 1.0 point total. magent does not assay labs, compute FIB-4 or eGFR, or order ART.

When not to use

• Not a medical device and not a diagnosis of HIV, liver disease, kidney disease, or anemia. Not an antiretroviral, hepatitis C, or transfusion order.
• This is Tate 2013 VACS Index 1.0 only. It is not VACS 2.0 and does not use albumin, WBC, or BMI.
• FIB-4 and eGFR are caller-assigned. magent does not recompute FIB-4 and does not compute MDRD or CKD-EPI. Race is not an input.
• Tate 2013 does not name low, intermediate, or high mortality bands. The response is a point total (0–164), not a risk stratum or a patient-specific probability.

Formula

VACS 1.0 = age (<50 0; 50-64 12; ≥65 27) + cd4_cells_mm3 (≥500 0; 350-499 6; 200-349 6; 100-199 10; 50-99 28; <50 29) + hiv_rna_copies_ml (<500 0; 500-99999 7; ≥100000 14) + hemoglobin_g_dl (≥14 0; 12-13.9 10; 10-11.9 22; <10 38) + fib4 (<1.45 0; 1.45-3.25 6; >3.25 25) + egfr_ml_min_1_73m2 (≥60 0; 45-59.9 6; 30-44.9 8; <30 26) + hepatitis_c 5; Tate 2013 VACS Index column (Brown 2014 Table 1 reprint); max 164; caller-assigned FIB-4 and eGFR; not VACS 2.0

Citation

Title

The VACS Index: An internationally generalizable risk index for mortality after one year of antiretroviral therapy

Authors

Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, et al.

Source

AIDS. 2013;27(4):563-572

DOI

10.1097/QAD.0b013e32835b8c7f

Worked example

Also searched as

• VACS Index
• VACS 1.0
• Veterans Aging Cohort Study Index
• Tate 2013 VACS
• HIV mortality index after ART
• VACS Index 1.0

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/vacs_1?age=40&cd4_cells_mm3=600&hiv_rna_copies_ml=200&hemoglobin_g_dl=15&fib4=1.0&egfr_ml_min_1_73m2=90&hepatitis_c=false

Full URL: https://api.magentlab.com/api/calc/vacs_1?age=40&cd4_cells_mm3=600&hiv_rna_copies_ml=200&hemoglobin_g_dl=15&fib4=1.0&egfr_ml_min_1_73m2=90&hepatitis_c=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/vacs_1?age=40&cd4_cells_mm3=600&hiv_rna_copies_ml=200&hemoglobin_g_dl=15&fib4=1.0&egfr_ml_min_1_73m2=90&hepatitis_c=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/vacs_1 Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "40",
      "cd4_cells_mm3": "600",
      "egfr_ml_min_1_73m2": "90",
      "fib4": "1.0",
      "hemoglobin_g_dl": "15",
      "hepatitis_c": "false",
      "hiv_rna_copies_ml": "200"
    },
    {
      "age": "40",
      "cd4_cells_mm3": "600",
      "egfr_ml_min_1_73m2": "90",
      "fib4": "1.0",
      "hemoglobin_g_dl": "15",
      "hepatitis_c": "false",
      "hiv_rna_copies_ml": "200"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/vacs_1",
  "items": [
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 600,
          "factor": "cd4_cells_mm3",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "hiv_rna_copies_ml",
          "points": 0,
          "present": false
        },
        {
          "value": 15.0,
          "factor": "hemoglobin_g_dl",
          "points": 0,
          "present": false
        },
        {
          "value": 1.0,
          "factor": "fib4",
          "points": 0,
          "present": false
        },
        {
          "value": 90.0,
          "factor": "egfr_ml_min_1_73m2",
          "points": 0,
          "present": false
        },
        {
          "factor": "hepatitis_c",
          "points": 0,
          "present": false
        }
      ],
      "age": 40,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, et al.",
        "doi": "10.1097/QAD.0b013e32835b8c7f",
        "id": "tate-2013",
        "pmid": "23242319",
        "source": "AIDS. 2013;27(4):563-572",
        "title": "The VACS Index: An internationally generalizable risk index for mortality after one year of antiretroviral therapy"
      },
      "formula": "vacs_1",
      "formula_expression": "VACS 1.0 = age (<50 0; 50-64 12; ≥65 27) + cd4_cells_mm3 (≥500 0; 350-499 6; 200-349 6; 100-199 10; 50-99 28; <50 29) + hiv_rna_copies_ml (<500 0; 500-99999 7; ≥100000 14) + hemoglobin_g_dl (≥14 0; 12-13.9 10; 10-11.9 22; <10 38) + fib4 (<1.45 0; 1.45-3.25 6; >3.25 25) + egfr_ml_min_1_73m2 (≥60 0; 45-59.9 6; 30-44.9 8; <30 26) + hepatitis_c 5; Tate 2013 VACS Index column (Brown 2014 Table 1 reprint); max 164; caller-assigned FIB-4 and eGFR; not VACS 2.0",
      "max_score": 164,
      "score": 0,
      "hemoglobin_g_dl": 15.0,
      "egfr_ml_min_1_73m2": 90.0,
      "fib4": 1.0,
      "cd4_cells_mm3": 600,
      "hepatitis_c": false,
      "hiv_rna_copies_ml": 200.0
    },
    {
      "components": [
        {
          "value": 40,
          "factor": "age",
          "points": 0,
          "present": false
        },
        {
          "value": 600,
          "factor": "cd4_cells_mm3",
          "points": 0,
          "present": false
        },
        {
          "value": 200.0,
          "factor": "hiv_rna_copies_ml",
          "points": 0,
          "present": false
        },
        {
          "value": 15.0,
          "factor": "hemoglobin_g_dl",
          "points": 0,
          "present": false
        },
        {
          "value": 1.0,
          "factor": "fib4",
          "points": 0,
          "present": false
        },
        {
          "value": 90.0,
          "factor": "egfr_ml_min_1_73m2",
          "points": 0,
          "present": false
        },
        {
          "factor": "hepatitis_c",
          "points": 0,
          "present": false
        }
      ],
      "age": 40,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, et al.",
        "doi": "10.1097/QAD.0b013e32835b8c7f",
        "id": "tate-2013",
        "pmid": "23242319",
        "source": "AIDS. 2013;27(4):563-572",
        "title": "The VACS Index: An internationally generalizable risk index for mortality after one year of antiretroviral therapy"
      },
      "formula": "vacs_1",
      "formula_expression": "VACS 1.0 = age (<50 0; 50-64 12; ≥65 27) + cd4_cells_mm3 (≥500 0; 350-499 6; 200-349 6; 100-199 10; 50-99 28; <50 29) + hiv_rna_copies_ml (<500 0; 500-99999 7; ≥100000 14) + hemoglobin_g_dl (≥14 0; 12-13.9 10; 10-11.9 22; <10 38) + fib4 (<1.45 0; 1.45-3.25 6; >3.25 25) + egfr_ml_min_1_73m2 (≥60 0; 45-59.9 6; 30-44.9 8; <30 26) + hepatitis_c 5; Tate 2013 VACS Index column (Brown 2014 Table 1 reprint); max 164; caller-assigned FIB-4 and eGFR; not VACS 2.0",
      "max_score": 164,
      "score": 0,
      "hemoglobin_g_dl": 15.0,
      "egfr_ml_min_1_73m2": 90.0,
      "fib4": 1.0,
      "cd4_cells_mm3": 600,
      "hepatitis_c": false,
      "hiv_rna_copies_ml": 200.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 40,
      "factor": "age",
      "points": 0,
      "present": false
    },
    {
      "value": 600,
      "factor": "cd4_cells_mm3",
      "points": 0,
      "present": false
    },
    {
      "value": 200.0,
      "factor": "hiv_rna_copies_ml",
      "points": 0,
      "present": false
    },
    {
      "value": 15.0,
      "factor": "hemoglobin_g_dl",
      "points": 0,
      "present": false
    },
    {
      "value": 1.0,
      "factor": "fib4",
      "points": 0,
      "present": false
    },
    {
      "value": 90.0,
      "factor": "egfr_ml_min_1_73m2",
      "points": 0,
      "present": false
    },
    {
      "factor": "hepatitis_c",
      "points": 0,
      "present": false
    }
  ],
  "age": 40,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, et al.",
    "doi": "10.1097/QAD.0b013e32835b8c7f",
    "id": "tate-2013",
    "pmid": "23242319",
    "source": "AIDS. 2013;27(4):563-572",
    "title": "The VACS Index: An internationally generalizable risk index for mortality after one year of antiretroviral therapy"
  },
  "formula": "vacs_1",
  "formula_expression": "VACS 1.0 = age (<50 0; 50-64 12; ≥65 27) + cd4_cells_mm3 (≥500 0; 350-499 6; 200-349 6; 100-199 10; 50-99 28; <50 29) + hiv_rna_copies_ml (<500 0; 500-99999 7; ≥100000 14) + hemoglobin_g_dl (≥14 0; 12-13.9 10; 10-11.9 22; <10 38) + fib4 (<1.45 0; 1.45-3.25 6; >3.25 25) + egfr_ml_min_1_73m2 (≥60 0; 45-59.9 6; 30-44.9 8; <30 26) + hepatitis_c 5; Tate 2013 VACS Index column (Brown 2014 Table 1 reprint); max 164; caller-assigned FIB-4 and eGFR; not VACS 2.0",
  "max_score": 164,
  "score": 0,
  "hemoglobin_g_dl": 15.0,
  "egfr_ml_min_1_73m2": 90.0,
  "fib4": 1.0,
  "cd4_cells_mm3": 600,
  "hepatitis_c": false,
  "hiv_rna_copies_ml": 200.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

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Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.