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Reynolds Risk Score

Compute the Ridker JAMA 2007 Reynolds Risk Score 10-year CVD percent for women using clinically simplified Model B (age, SBP, hsCRP, total cholesterol, HDL-C, HbA1c if diabetic, current smoking, and parental MI before age 60).

LIVE $0.005 USDC GET /api/calc/reynolds

Markdown: /docs/reynolds.md · Canonical: https://magentlab.com/docs/reynolds

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Compute the Ridker JAMA 2007 Reynolds Risk Score 10-year CVD percent for women using clinically simplified Model B (age, SBP, hsCRP, total cholesterol, HDL-C, HbA1c if diabetic, current smoking, and parental MI before age 60).

When to use

When an agent already has those Model B predictors for a woman aged 45-84 and needs that paper's 10-year CVD percent. Not a diagnosis, statin order, or 2013 pooled-cohort equation.

When not to use

• Not a medical device. Not a diagnosis of cardiovascular disease. Not a statin order or treatment recommendation.
• Ridker JAMA 2007 Model B for women aged 45 years or older only (magent accepts 45-84). Not the Reynolds algorithm for men (Ridker Circulation 2008).
• Not ATP-III. Not the 2013 ACC/AHA pooled-cohort equations. No race parameter.
• Caller assigns labs, blood pressure, diabetes, smoking, and parental MI before age 60. magent does not assay lipids, hsCRP, or HbA1c and does not measure blood pressure.

Formula

10-year CVD risk (%) = [1 - 0.98634^(exp(B - 22.325))] * 100; B = 0.0799*age + 3.137*ln(SBP) + 0.180*ln(hsCRP) + 1.382*ln(total cholesterol) - 1.172*ln(HDL-C) + 0.134*HbA1c(%) [if diabetic] + 0.818 [if current smoker] + 0.438 [if family history of premature MI]; Ridker JAMA 2007 Model B women; natural log; cholesterol and HDL mg/dL; hsCRP mg/L; SBP mm Hg; not men; not ATP-III; not 2013 PCE

Citation

Title

Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score

Authors

Ridker PM, Buring JE, Rifai N, Cook NR

Source

JAMA. 2007;297(6):611-619

DOI

10.1001/jama.297.6.611

Worked example

Also searched as

• Reynolds Risk Score
• Ridker 2007
• women CVD risk hsCRP
• Reynolds Model B
• 10-year CVD risk women
• parental MI before 60
• hsCRP cholesterol HDL risk

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/reynolds?age=55&sbp_mm_hg=125&hscrp_mg_l=2&total_cholesterol_mg_dl=200&hdl_mg_dl=50&diabetes=false&smoker=false&family_mi_before_60=false

Full URL: https://api.magentlab.com/api/calc/reynolds?age=55&sbp_mm_hg=125&hscrp_mg_l=2&total_cholesterol_mg_dl=200&hdl_mg_dl=50&diabetes=false&smoker=false&family_mi_before_60=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/reynolds?age=55&sbp_mm_hg=125&hscrp_mg_l=2&total_cholesterol_mg_dl=200&hdl_mg_dl=50&diabetes=false&smoker=false&family_mi_before_60=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/reynolds Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "55",
      "diabetes": "false",
      "family_mi_before_60": "false",
      "hdl_mg_dl": "50",
      "hscrp_mg_l": "2",
      "sbp_mm_hg": "125",
      "smoker": "false",
      "total_cholesterol_mg_dl": "200"
    },
    {
      "age": "55",
      "diabetes": "false",
      "family_mi_before_60": "false",
      "hdl_mg_dl": "50",
      "hscrp_mg_l": "2",
      "sbp_mm_hg": "125",
      "smoker": "false",
      "total_cholesterol_mg_dl": "200"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/reynolds",
  "items": [
    {
      "b": 22.4031,
      "age": 55,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Ridker PM, Buring JE, Rifai N, Cook NR",
        "doi": "10.1001/jama.297.6.611",
        "id": "ridker-2007",
        "pmid": "17299196",
        "source": "JAMA. 2007;297(6):611-619",
        "title": "Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score"
      },
      "formula": "reynolds",
      "formula_expression": "10-year CVD risk (%) = [1 - 0.98634^(exp(B - 22.325))] * 100; B = 0.0799*age + 3.137*ln(SBP) + 0.180*ln(hsCRP) + 1.382*ln(total cholesterol) - 1.172*ln(HDL-C) + 0.134*HbA1c(%) [if diabetic] + 0.818 [if current smoker] + 0.438 [if family history of premature MI]; Ridker JAMA 2007 Model B women; natural log; cholesterol and HDL mg/dL; hsCRP mg/L; SBP mm Hg; not men; not ATP-III; not 2013 PCE",
      "diabetes": false,
      "hdl_mg_dl": 50.0,
      "sbp_mm_hg": 125.0,
      "smoker": false,
      "total_cholesterol_mg_dl": 200.0,
      "family_mi_before_60": false,
      "hscrp_mg_l": 2.0,
      "risk_percent": 1.5
    },
    {
      "b": 22.4031,
      "age": 55,
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Ridker PM, Buring JE, Rifai N, Cook NR",
        "doi": "10.1001/jama.297.6.611",
        "id": "ridker-2007",
        "pmid": "17299196",
        "source": "JAMA. 2007;297(6):611-619",
        "title": "Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score"
      },
      "formula": "reynolds",
      "formula_expression": "10-year CVD risk (%) = [1 - 0.98634^(exp(B - 22.325))] * 100; B = 0.0799*age + 3.137*ln(SBP) + 0.180*ln(hsCRP) + 1.382*ln(total cholesterol) - 1.172*ln(HDL-C) + 0.134*HbA1c(%) [if diabetic] + 0.818 [if current smoker] + 0.438 [if family history of premature MI]; Ridker JAMA 2007 Model B women; natural log; cholesterol and HDL mg/dL; hsCRP mg/L; SBP mm Hg; not men; not ATP-III; not 2013 PCE",
      "diabetes": false,
      "hdl_mg_dl": 50.0,
      "sbp_mm_hg": 125.0,
      "smoker": false,
      "total_cholesterol_mg_dl": 200.0,
      "family_mi_before_60": false,
      "hscrp_mg_l": 2.0,
      "risk_percent": 1.5
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "b": 22.4031,
  "age": 55,
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Ridker PM, Buring JE, Rifai N, Cook NR",
    "doi": "10.1001/jama.297.6.611",
    "id": "ridker-2007",
    "pmid": "17299196",
    "source": "JAMA. 2007;297(6):611-619",
    "title": "Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score"
  },
  "formula": "reynolds",
  "formula_expression": "10-year CVD risk (%) = [1 - 0.98634^(exp(B - 22.325))] * 100; B = 0.0799*age + 3.137*ln(SBP) + 0.180*ln(hsCRP) + 1.382*ln(total cholesterol) - 1.172*ln(HDL-C) + 0.134*HbA1c(%) [if diabetic] + 0.818 [if current smoker] + 0.438 [if family history of premature MI]; Ridker JAMA 2007 Model B women; natural log; cholesterol and HDL mg/dL; hsCRP mg/L; SBP mm Hg; not men; not ATP-III; not 2013 PCE",
  "diabetes": false,
  "hdl_mg_dl": 50.0,
  "sbp_mm_hg": 125.0,
  "smoker": false,
  "total_cholesterol_mg_dl": 200.0,
  "family_mi_before_60": false,
  "hscrp_mg_l": 2.0,
  "risk_percent": 1.5
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Framingham CHD — Sum Wilson 1998 sex-specific total-cholesterol point sheets (age, TC, HDL, JNC-V blood pressure, diabetes, smoking) and return the published 10-year CHD percent.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.