Emergency · LIVE

CARG chemotherapy toxicity (Hurria)

CARG-TT

Sum Hurria 2011 Table 5 CARG chemotherapy-toxicity weights and return low (0-5, 30%), intermediate (6-9, 52%), or high (10-19, 83%) grade 3-5 toxicity risk.

LIVE $0.005 USDC GET /api/calc/carg_tt

Markdown: /docs/carg-tt.md · Canonical: https://magentlab.com/docs/carg-tt

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum Hurria 2011 Table 5 CARG chemotherapy-toxicity weights and return low (0-5, 30%), intermediate (6-9, 52%), or high (10-19, 83%) grade 3-5 toxicity risk.

When to use

When an agent needs the published Hurria 2011 CARG point total and must not invent a chemotherapy order, invert GI/GU, or substitute the 2016 revision or CRASH.

When not to use

• Not a medical device and not a chemotherapy order. magent does not examine the patient or write a regimen.
• Hurria 2011 Table 5 only. Not the CARG-TT 2016 revision and not CRASH.
• Derived in patients ≥65; magent still applies the ≥72 point rule at any accepted age (18-120).
• GI or GU cancer is +2 when present (Hurria 2011 Table 5). Lung, breast, GYN, and other cancers are 0. This is not inverted.
• jelliffe_crcl_ml_min is the published Jelliffe ideal-weight creatinine clearance as assigned by the caller. magent does not compute Jelliffe from creatinine, age, or weight.
• Hemoglobin uses male <11 g/dL or female <10 g/dL. Hearing, falls, MOS walking, IADL medications, and MOS social activity are caller-assigned flags.
• Risk groups are the derivation bands: 0-5 low (30%), 6-9 intermediate (52%), 10-19 high (83%). Do not use 10-23.

Formula

CARG-TT = age_ge_72 (2) + gi_or_gu (2) + standard_dose (2) + polychemotherapy (2) + hemoglobin_low (3; male <11 g/dL or female <10 g/dL) + jelliffe_crcl_lt_34 (3) + hearing_fair_or_worse (2) + falls_last_6_months (3) + limited_walking_one_block (2) + needs_help_with_medications (1) + decreased_social_activity (1); Hurria 2011 Table 5; max 19; 0-5 low 30%, 6-9 intermediate 52%, 10-19 high 83%; GI/GU is +2 when present (not inverted); not CARG-TT 2016; not CRASH

Citation

Title

Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study

Authors

Hurria A, Togawa K, Mohile SG, et al.

Source

J Clin Oncol. 2011;29(25):3457-3465

DOI

10.1200/JCO.2011.34.7625

Worked example

Also searched as

• CARG chemotherapy toxicity
• Hurria chemotherapy toxicity score
• CARG-TT
• Cancer and Aging Research Group
• chemotherapy toxicity older adults
• CARG toxicity tool
• Hurria 2011 CARG

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/carg_tt?age=75&gi_or_gu=true&standard_dose=true&polychemotherapy=true&hemoglobin_g_dl=12&sex=male&jelliffe_crcl_ml_min=50&hearing_fair_or_worse=false&falls_last_6_months=false&limited_walking_one_block=false&needs_help_with_medications=false&decreased_social_activity=false

Full URL: https://api.magentlab.com/api/calc/carg_tt?age=75&gi_or_gu=true&standard_dose=true&polychemotherapy=true&hemoglobin_g_dl=12&sex=male&jelliffe_crcl_ml_min=50&hearing_fair_or_worse=false&falls_last_6_months=false&limited_walking_one_block=false&needs_help_with_medications=false&decreased_social_activity=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/carg_tt?age=75&gi_or_gu=true&standard_dose=true&polychemotherapy=true&hemoglobin_g_dl=12&sex=male&jelliffe_crcl_ml_min=50&hearing_fair_or_worse=false&falls_last_6_months=false&limited_walking_one_block=false&needs_help_with_medications=false&decreased_social_activity=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/carg_tt Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age": "75",
      "decreased_social_activity": "false",
      "falls_last_6_months": "false",
      "gi_or_gu": "true",
      "hearing_fair_or_worse": "false",
      "hemoglobin_g_dl": "12",
      "jelliffe_crcl_ml_min": "50",
      "limited_walking_one_block": "false",
      "needs_help_with_medications": "false",
      "polychemotherapy": "true",
      "sex": "male",
      "standard_dose": "true"
    },
    {
      "age": "75",
      "decreased_social_activity": "false",
      "falls_last_6_months": "false",
      "gi_or_gu": "true",
      "hearing_fair_or_worse": "false",
      "hemoglobin_g_dl": "12",
      "jelliffe_crcl_ml_min": "50",
      "limited_walking_one_block": "false",
      "needs_help_with_medications": "false",
      "polychemotherapy": "true",
      "sex": "male",
      "standard_dose": "true"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/carg_tt",
  "items": [
    {
      "components": [
        {
          "value": 75,
          "factor": "age_ge_72",
          "points": 2,
          "present": true
        },
        {
          "factor": "gi_or_gu",
          "points": 2,
          "present": true
        },
        {
          "factor": "standard_dose",
          "points": 2,
          "present": true
        },
        {
          "factor": "polychemotherapy",
          "points": 2,
          "present": true
        },
        {
          "value": {
            "sex": "male",
            "hemoglobin_g_dl": 12.0
          },
          "factor": "hemoglobin_low",
          "points": 0,
          "present": false
        },
        {
          "value": 50.0,
          "factor": "jelliffe_crcl_lt_34",
          "points": 0,
          "present": false
        },
        {
          "factor": "hearing_fair_or_worse",
          "points": 0,
          "present": false
        },
        {
          "factor": "falls_last_6_months",
          "points": 0,
          "present": false
        },
        {
          "factor": "limited_walking_one_block",
          "points": 0,
          "present": false
        },
        {
          "factor": "needs_help_with_medications",
          "points": 0,
          "present": false
        },
        {
          "factor": "decreased_social_activity",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hurria A, Togawa K, Mohile SG, et al.",
        "doi": "10.1200/JCO.2011.34.7625",
        "id": "hurria-2011",
        "pmid": "21810685",
        "source": "J Clin Oncol. 2011;29(25):3457-3465",
        "title": "Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study"
      },
      "formula": "carg_tt",
      "formula_expression": "CARG-TT = age_ge_72 (2) + gi_or_gu (2) + standard_dose (2) + polychemotherapy (2) + hemoglobin_low (3; male <11 g/dL or female <10 g/dL) + jelliffe_crcl_lt_34 (3) + hearing_fair_or_worse (2) + falls_last_6_months (3) + limited_walking_one_block (2) + needs_help_with_medications (1) + decreased_social_activity (1); Hurria 2011 Table 5; max 19; 0-5 low 30%, 6-9 intermediate 52%, 10-19 high 83%; GI/GU is +2 when present (not inverted); not CARG-TT 2016; not CRASH",
      "max_score": 19,
      "score": 8,
      "risk_group": "intermediate",
      "grade_3_to_5_toxicity_percent": 52
    },
    {
      "components": [
        {
          "value": 75,
          "factor": "age_ge_72",
          "points": 2,
          "present": true
        },
        {
          "factor": "gi_or_gu",
          "points": 2,
          "present": true
        },
        {
          "factor": "standard_dose",
          "points": 2,
          "present": true
        },
        {
          "factor": "polychemotherapy",
          "points": 2,
          "present": true
        },
        {
          "value": {
            "sex": "male",
            "hemoglobin_g_dl": 12.0
          },
          "factor": "hemoglobin_low",
          "points": 0,
          "present": false
        },
        {
          "value": 50.0,
          "factor": "jelliffe_crcl_lt_34",
          "points": 0,
          "present": false
        },
        {
          "factor": "hearing_fair_or_worse",
          "points": 0,
          "present": false
        },
        {
          "factor": "falls_last_6_months",
          "points": 0,
          "present": false
        },
        {
          "factor": "limited_walking_one_block",
          "points": 0,
          "present": false
        },
        {
          "factor": "needs_help_with_medications",
          "points": 0,
          "present": false
        },
        {
          "factor": "decreased_social_activity",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Hurria A, Togawa K, Mohile SG, et al.",
        "doi": "10.1200/JCO.2011.34.7625",
        "id": "hurria-2011",
        "pmid": "21810685",
        "source": "J Clin Oncol. 2011;29(25):3457-3465",
        "title": "Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study"
      },
      "formula": "carg_tt",
      "formula_expression": "CARG-TT = age_ge_72 (2) + gi_or_gu (2) + standard_dose (2) + polychemotherapy (2) + hemoglobin_low (3; male <11 g/dL or female <10 g/dL) + jelliffe_crcl_lt_34 (3) + hearing_fair_or_worse (2) + falls_last_6_months (3) + limited_walking_one_block (2) + needs_help_with_medications (1) + decreased_social_activity (1); Hurria 2011 Table 5; max 19; 0-5 low 30%, 6-9 intermediate 52%, 10-19 high 83%; GI/GU is +2 when present (not inverted); not CARG-TT 2016; not CRASH",
      "max_score": 19,
      "score": 8,
      "risk_group": "intermediate",
      "grade_3_to_5_toxicity_percent": 52
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": 75,
      "factor": "age_ge_72",
      "points": 2,
      "present": true
    },
    {
      "factor": "gi_or_gu",
      "points": 2,
      "present": true
    },
    {
      "factor": "standard_dose",
      "points": 2,
      "present": true
    },
    {
      "factor": "polychemotherapy",
      "points": 2,
      "present": true
    },
    {
      "value": {
        "sex": "male",
        "hemoglobin_g_dl": 12.0
      },
      "factor": "hemoglobin_low",
      "points": 0,
      "present": false
    },
    {
      "value": 50.0,
      "factor": "jelliffe_crcl_lt_34",
      "points": 0,
      "present": false
    },
    {
      "factor": "hearing_fair_or_worse",
      "points": 0,
      "present": false
    },
    {
      "factor": "falls_last_6_months",
      "points": 0,
      "present": false
    },
    {
      "factor": "limited_walking_one_block",
      "points": 0,
      "present": false
    },
    {
      "factor": "needs_help_with_medications",
      "points": 0,
      "present": false
    },
    {
      "factor": "decreased_social_activity",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Hurria A, Togawa K, Mohile SG, et al.",
    "doi": "10.1200/JCO.2011.34.7625",
    "id": "hurria-2011",
    "pmid": "21810685",
    "source": "J Clin Oncol. 2011;29(25):3457-3465",
    "title": "Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study"
  },
  "formula": "carg_tt",
  "formula_expression": "CARG-TT = age_ge_72 (2) + gi_or_gu (2) + standard_dose (2) + polychemotherapy (2) + hemoglobin_low (3; male <11 g/dL or female <10 g/dL) + jelliffe_crcl_lt_34 (3) + hearing_fair_or_worse (2) + falls_last_6_months (3) + limited_walking_one_block (2) + needs_help_with_medications (1) + decreased_social_activity (1); Hurria 2011 Table 5; max 19; 0-5 low 30%, 6-9 intermediate 52%, 10-19 high 83%; GI/GU is +2 when present (not inverted); not CARG-TT 2016; not CRASH",
  "max_score": 19,
  "score": 8,
  "risk_group": "intermediate",
  "grade_3_to_5_toxicity_percent": 52
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• G8 — Sum the eight Bellera 2012 G8 items (seven MNA items A, B, C, E, F, H, P plus age) and return whether the published ≤14 impaired-screen cutoff is met.
• Karnofsky — Return the Karnofsky 1949 Performance Status 10-100 from a caller-assigned integer, with a stable label.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.