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HFA-ICOS RAF-MEK inhibitor baseline CV risk

Classify Lyon 2020 HFA-ICOS baseline cardiovascular risk before combination RAF and MEK inhibitors as very_high, high, medium, or low from that table's printed factors and the shared medium-point rule.

LIVE $0.005 USDC GET /api/calc/hfa_icos_raf_mek

Markdown: /docs/hfa-icos-raf-mek.md · Canonical: https://magentlab.com/docs/hfa-icos-raf-mek

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Classify Lyon 2020 HFA-ICOS baseline cardiovascular risk before combination RAF and MEK inhibitors as very_high, high, medium, or low from that table's printed factors and the shared medium-point rule.

When to use

When an agent already has age, LVEF, and the yes/no Lyon 2020 RAF-MEK table factors and needs the published HFA-ICOS class plus the expert-opinion cardiotoxicity guide. magent does not examine the patient, read an echocardiogram, or assay biomarkers. Not a treatment order.

When not to use

  • Not a medical device. Not a treatment order, monitoring schedule, or cardiotoxicity diagnosis.
  • This RAF-MEK table has no printed LVEF <50 High row and no High age band. Age ≥65 is Medium 1 only. LVEF <50 does not invent a High factor.
  • Cardiotoxicity percents are the paper's expert-opinion guide (<2% / 2-9% / 10-19% / ≥20%), not a patient-specific probability.
  • Flags are caller-assigned. magent does not diagnose heart failure, compute BMI or eGFR, or assay troponin or natriuretic peptides.

Formula

HFA-ICOS RAF-MEK (Lyon 2020): very_high if heart_failure_or_cardiomyopathy; high if mi_or_cabg or stable_angina or severe_valvular_heart_disease or prior_anthracycline or medium_points>=5; medium if medium_points 2-4; low if medium_points 0-1; medium_points = M2 (lvef 50-54, elevated_troponin, elevated_bnp, hypertension, prior_left_chest_or_mediastinal_rt) + M1 (arrhythmia, age>=65, diabetes, ckd, current_or_significant_smoker, obesity); LVEF <50 is not a printed High row on this table; age>=65 Medium 1 only (no High age band); cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%

Citation

Title
Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society
Authors
Lyon AR, Dent S, Stanway S, et al.
Source
Eur J Heart Fail. 2020;22(11):1945-1960
DOI
10.1002/ejhf.1920

Worked example

No printed factors

Given: age_years=50arrhythmia=falseckd=falsecurrent_or_significant_smoker=falsediabetes=falseelevated_bnp=falseelevated_troponin=falseheart_failure_or_cardiomyopathy=falsehypertension=falselvef_percent=60mi_or_cabg=falseobesity=falseprior_anthracycline=falseprior_left_chest_or_mediastinal_rt=falsesevere_valvular_heart_disease=falsestable_angina=false

  1. age 50 < 65 → no Medium 1; LVEF 60 ≥ 55 → no Medium 2
  2. medium_points = 0; risk_level = low; cardiotoxicity_guide <2%

Heart failure or cardiomyopathy

Given: age_years=50arrhythmia=falseckd=falsecurrent_or_significant_smoker=falsediabetes=falseelevated_bnp=falseelevated_troponin=falseheart_failure_or_cardiomyopathy=truehypertension=falselvef_percent=60mi_or_cabg=falseobesity=falseprior_anthracycline=falseprior_left_chest_or_mediastinal_rt=falsesevere_valvular_heart_disease=falsestable_angina=false

  1. heart_failure_or_cardiomyopathy is Very high
  2. risk_level = very_high; cardiotoxicity_guide >=20%

Prior anthracycline

Given: age_years=50arrhythmia=falseckd=falsecurrent_or_significant_smoker=falsediabetes=falseelevated_bnp=falseelevated_troponin=falseheart_failure_or_cardiomyopathy=falsehypertension=falselvef_percent=60mi_or_cabg=falseobesity=falseprior_anthracycline=trueprior_left_chest_or_mediastinal_rt=falsesevere_valvular_heart_disease=falsestable_angina=false

  1. prior_anthracycline is High
  2. risk_level = high; cardiotoxicity_guide 10-19%

Hypertension only

Given: age_years=50arrhythmia=falseckd=falsecurrent_or_significant_smoker=falsediabetes=falseelevated_bnp=falseelevated_troponin=falseheart_failure_or_cardiomyopathy=falsehypertension=truelvef_percent=60mi_or_cabg=falseobesity=falseprior_anthracycline=falseprior_left_chest_or_mediastinal_rt=falsesevere_valvular_heart_disease=falsestable_angina=false

  1. hypertension is Medium 2
  2. medium_points = 2; risk_level = medium; cardiotoxicity_guide 2-9%

Age 70 only

Given: age_years=70arrhythmia=falseckd=falsecurrent_or_significant_smoker=falsediabetes=falseelevated_bnp=falseelevated_troponin=falseheart_failure_or_cardiomyopathy=falsehypertension=falselvef_percent=60mi_or_cabg=falseobesity=falseprior_anthracycline=falseprior_left_chest_or_mediastinal_rt=falsesevere_valvular_heart_disease=falsestable_angina=false

  1. age ≥65 is Medium 1; no High age band on this table
  2. medium_points = 1; risk_level = low (one Medium 1)

Also searched as

  • HFA-ICOS RAF-MEK
  • RAF MEK inhibitor cardiotoxicity
  • Lyon 2020 RAF-MEK
  • combination RAF MEK baseline risk
  • cardio-oncology RAF MEK

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/hfa_icos_raf_mek?age_years=50&lvef_percent=60&heart_failure_or_cardiomyopathy=false&mi_or_cabg=false&stable_angina=false&severe_valvular_heart_disease=false&prior_anthracycline=false&elevated_troponin=false&elevated_bnp=false&hypertension=false&prior_left_chest_or_mediastinal_rt=false&arrhythmia=false&diabetes=false&ckd=false&current_or_significant_smoker=false&obesity=false

Full URL: https://api.magentlab.com/api/calc/hfa_icos_raf_mek?age_years=50&lvef_percent=60&heart_failure_or_cardiomyopathy=false&mi_or_cabg=false&stable_angina=false&severe_valvular_heart_disease=false&prior_anthracycline=false&elevated_troponin=false&elevated_bnp=false&hypertension=false&prior_left_chest_or_mediastinal_rt=false&arrhythmia=false&diabetes=false&ckd=false&current_or_significant_smoker=false&obesity=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge. 

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/hfa_icos_raf_mek?age_years=50&lvef_percent=60&heart_failure_or_cardiomyopathy=false&mi_or_cabg=false&stable_angina=false&severe_valvular_heart_disease=false&prior_anthracycline=false&elevated_troponin=false&elevated_bnp=false&hypertension=false&prior_left_chest_or_mediastinal_rt=false&arrhythmia=false&diabetes=false&ckd=false&current_or_significant_smoker=false&obesity=false"

Parameters

Name Type Required Description
age_years integer required Age in whole years (18-100). Lyon 2020 RAF-MEK table: age ≥65 is Medium 1. There is no High age band on this table. magent does not read an identity document.
lvef_percent integer required Baseline LVEF in whole percent (10-80) as assigned by the caller. 50-54 is Medium 2. ≥55 adds no points. This table has no printed LVEF <50 High row; LVEF <50 does not raise risk_level by itself. magent does not read an echocardiogram.
heart_failure_or_cardiomyopathy boolean required Heart failure or cardiomyopathy as assigned by the caller (Lyon 2020 RAF-MEK table). true is Very high. magent does not diagnose heart failure.
mi_or_cabg boolean required Myocardial infarction or CABG as assigned by the caller (Lyon 2020 RAF-MEK table). true is High.
stable_angina boolean required Stable angina as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not diagnose angina.
severe_valvular_heart_disease boolean required Severe valvular heart disease as assigned by the caller (Lyon 2020 RAF-MEK table). true is High.
prior_anthracycline boolean required Prior anthracycline exposure as assigned by the caller (Lyon 2020 RAF-MEK table). true is High. magent does not read a chemotherapy record.
elevated_troponin boolean required Elevated baseline troponin above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay troponin.
elevated_bnp boolean required Elevated baseline BNP or NT-proBNP above the local laboratory upper limit of normal as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not assay natriuretic peptides.
hypertension boolean required Hypertension (systolic >140 mm Hg or diastolic >90 mm Hg, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2. magent does not measure blood pressure.
prior_left_chest_or_mediastinal_rt boolean required Prior radiotherapy to the left chest or mediastinum as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 2.
arrhythmia boolean required Atrial fibrillation, atrial flutter, ventricular tachycardia, or ventricular fibrillation as assigned by the caller (Lyon 2020 RAF-MEK table footnote). true is Medium 1. magent does not read an ECG.
diabetes boolean required Diabetes mellitus (glycated haemoglobin >7.0% or >53 mmol/mol, or on treatment) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not assay haemoglobin A1c.
ckd boolean required Chronic kidney disease (estimated glomerular filtration rate <60 mL/min/1.73 m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute eGFR.
current_or_significant_smoker boolean required Current smoker or significant smoking history as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1.
obesity boolean required Obesity (BMI >30 kg/m2) as assigned by the caller (Lyon 2020 RAF-MEK table). true is Medium 1. magent does not compute BMI.

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/hfa_icos_raf_mek Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

  • 1 to 25 items. Each item uses the same keys as the GET query parameters.
  • POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
  • The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
  • HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
  • Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
  • x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "age_years": "50",
      "arrhythmia": "false",
      "ckd": "false",
      "current_or_significant_smoker": "false",
      "diabetes": "false",
      "elevated_bnp": "false",
      "elevated_troponin": "false",
      "heart_failure_or_cardiomyopathy": "false",
      "hypertension": "false",
      "lvef_percent": "60",
      "mi_or_cabg": "false",
      "obesity": "false",
      "prior_anthracycline": "false",
      "prior_left_chest_or_mediastinal_rt": "false",
      "severe_valvular_heart_disease": "false",
      "stable_angina": "false"
    },
    {
      "age_years": "50",
      "arrhythmia": "false",
      "ckd": "false",
      "current_or_significant_smoker": "false",
      "diabetes": "false",
      "elevated_bnp": "false",
      "elevated_troponin": "false",
      "heart_failure_or_cardiomyopathy": "false",
      "hypertension": "false",
      "lvef_percent": "60",
      "mi_or_cabg": "false",
      "obesity": "false",
      "prior_anthracycline": "false",
      "prior_left_chest_or_mediastinal_rt": "false",
      "severe_valvular_heart_disease": "false",
      "stable_angina": "false"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/hfa_icos_raf_mek",
  "items": [
    {
      "components": [
        {
          "factor": "heart_failure_or_cardiomyopathy",
          "points": 0,
          "present": false,
          "tier": "very_high"
        },
        {
          "factor": "mi_or_cabg",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "stable_angina",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "severe_valvular_heart_disease",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "value": 60,
          "factor": "lvef_50_54",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "elevated_troponin",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "elevated_bnp",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "value": 50,
          "factor": "age_ge_65",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "hypertension",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "ckd",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "prior_anthracycline",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "prior_left_chest_or_mediastinal_rt",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "current_or_significant_smoker",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "obesity",
          "points": 0,
          "present": false,
          "tier": "medium"
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Lyon AR, Dent S, Stanway S, et al.",
        "doi": "10.1002/ejhf.1920",
        "id": "lyon-2020",
        "pmid": "32458582",
        "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
        "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
      },
      "formula": "hfa_icos_raf_mek",
      "formula_expression": "HFA-ICOS RAF-MEK (Lyon 2020): very_high if heart_failure_or_cardiomyopathy; high if mi_or_cabg or stable_angina or severe_valvular_heart_disease or prior_anthracycline or medium_points>=5; medium if medium_points 2-4; low if medium_points 0-1; medium_points = M2 (lvef 50-54, elevated_troponin, elevated_bnp, hypertension, prior_left_chest_or_mediastinal_rt) + M1 (arrhythmia, age>=65, diabetes, ckd, current_or_significant_smoker, obesity); LVEF <50 is not a printed High row on this table; age>=65 Medium 1 only (no High age band); cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
      "age_years": 50,
      "cardiotoxicity_guide": "<2%",
      "lvef_percent": 60,
      "medium_points": 0,
      "risk_level": "low"
    },
    {
      "components": [
        {
          "factor": "heart_failure_or_cardiomyopathy",
          "points": 0,
          "present": false,
          "tier": "very_high"
        },
        {
          "factor": "mi_or_cabg",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "stable_angina",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "severe_valvular_heart_disease",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "value": 60,
          "factor": "lvef_50_54",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "arrhythmia",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "elevated_troponin",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "elevated_bnp",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "value": 50,
          "factor": "age_ge_65",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "hypertension",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "diabetes",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "ckd",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "prior_anthracycline",
          "points": 0,
          "present": false,
          "tier": "high"
        },
        {
          "factor": "prior_left_chest_or_mediastinal_rt",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "current_or_significant_smoker",
          "points": 0,
          "present": false,
          "tier": "medium"
        },
        {
          "factor": "obesity",
          "points": 0,
          "present": false,
          "tier": "medium"
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Lyon AR, Dent S, Stanway S, et al.",
        "doi": "10.1002/ejhf.1920",
        "id": "lyon-2020",
        "pmid": "32458582",
        "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
        "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
      },
      "formula": "hfa_icos_raf_mek",
      "formula_expression": "HFA-ICOS RAF-MEK (Lyon 2020): very_high if heart_failure_or_cardiomyopathy; high if mi_or_cabg or stable_angina or severe_valvular_heart_disease or prior_anthracycline or medium_points>=5; medium if medium_points 2-4; low if medium_points 0-1; medium_points = M2 (lvef 50-54, elevated_troponin, elevated_bnp, hypertension, prior_left_chest_or_mediastinal_rt) + M1 (arrhythmia, age>=65, diabetes, ckd, current_or_significant_smoker, obesity); LVEF <50 is not a printed High row on this table; age>=65 Medium 1 only (no High age band); cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
      "age_years": 50,
      "cardiotoxicity_guide": "<2%",
      "lvef_percent": 60,
      "medium_points": 0,
      "risk_level": "low"
    }
  ]
}

Response

Field Type Description
formula string hfa_icos_raf_mek
formula_expression string Exact expression used
age_years integer Age in years used for the ≥65 Medium 1 band
lvef_percent integer LVEF percent used for the 50-54 Medium 2 band
risk_level string very_high, high, medium, or low from the Lyon 2020 RAF-MEK table and the shared HFA-ICOS medium-point rule (0-1 low, 2-4 medium, ≥5 high). A class, not a treatment order. LVEF <50 is not a printed High factor on this table.
medium_points integer Sum of Medium 1 and Medium 2 points only (High and Very high are not added)
cardiotoxicity_guide string Lyon 2020 expert-opinion cardiotoxicity guide: <2% (low), 2-9% (medium), 10-19% (high), >=20% (very_high). A guide, not a patient-specific probability.
components array Per-factor present, points, and tier
citation object Lyon et al. Eur J Heart Fail 2020 citation
disclaimer string Not-a-device notice

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup. 

{
  "components": [
    {
      "factor": "heart_failure_or_cardiomyopathy",
      "points": 0,
      "present": false,
      "tier": "very_high"
    },
    {
      "factor": "mi_or_cabg",
      "points": 0,
      "present": false,
      "tier": "high"
    },
    {
      "factor": "stable_angina",
      "points": 0,
      "present": false,
      "tier": "high"
    },
    {
      "factor": "severe_valvular_heart_disease",
      "points": 0,
      "present": false,
      "tier": "high"
    },
    {
      "value": 60,
      "factor": "lvef_50_54",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "arrhythmia",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "elevated_troponin",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "elevated_bnp",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "value": 50,
      "factor": "age_ge_65",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "hypertension",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "diabetes",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "ckd",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "prior_anthracycline",
      "points": 0,
      "present": false,
      "tier": "high"
    },
    {
      "factor": "prior_left_chest_or_mediastinal_rt",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "current_or_significant_smoker",
      "points": 0,
      "present": false,
      "tier": "medium"
    },
    {
      "factor": "obesity",
      "points": 0,
      "present": false,
      "tier": "medium"
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Lyon AR, Dent S, Stanway S, et al.",
    "doi": "10.1002/ejhf.1920",
    "id": "lyon-2020",
    "pmid": "32458582",
    "source": "Eur J Heart Fail. 2020;22(11):1945-1960",
    "title": "Baseline cardiovascular risk assessment in cancer patients scheduled to receive cardiotoxic cancer therapies: a position statement and new risk assessment tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in collaboration with the International Cardio-Oncology Society"
  },
  "formula": "hfa_icos_raf_mek",
  "formula_expression": "HFA-ICOS RAF-MEK (Lyon 2020): very_high if heart_failure_or_cardiomyopathy; high if mi_or_cabg or stable_angina or severe_valvular_heart_disease or prior_anthracycline or medium_points>=5; medium if medium_points 2-4; low if medium_points 0-1; medium_points = M2 (lvef 50-54, elevated_troponin, elevated_bnp, hypertension, prior_left_chest_or_mediastinal_rt) + M1 (arrhythmia, age>=65, diabetes, ckd, current_or_significant_smoker, obesity); LVEF <50 is not a printed High row on this table; age>=65 Medium 1 only (no High age band); cardiotoxicity_guide low <2%, medium 2-9%, high 10-19%, very_high >=20%",
  "age_years": 50,
  "cardiotoxicity_guide": "<2%",
  "lvef_percent": 60,
  "medium_points": 0,
  "risk_level": "low"
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

HTTP Code When
400 invalid_hfa_icos_raf_mek Lyon 2020 HFA-ICOS RAF-MEK inhibitor inputs must match that table's age, LVEF, and yes/no factors. Returned before settlement; you are not charged.
400 invalid_items POST body must be a JSON object with only an items array Returned before settlement; you are not charged.
400 invalid_item_count items must be an array of 1 to 25 objects Returned before settlement; you are not charged.
400 invalid_item each items entry must be a JSON object Returned before settlement; you are not charged.

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  • HFA-ICOS anthracycline baseline CV risk — Apply the Lyon 2020 HFA-ICOS anthracycline baseline cardiovascular risk proforma from caller-assigned age, LVEF, and published Very high, High, Medium 2, and Medium 1 factors. Returns risk_level, medium_points, and the paper's expert-opinion cardiotoxicity_guide.
  • NYHA — Return the 1994 NYHA functional capacity class 1-4 from a caller-assigned integer, with the published class description.
  • MAGGIC — Sum the Pocock 2013 MAGGIC integer chart from thirteen caller-supplied heart-failure predictors and return the published Table 4 1-year and 3-year death probabilities for scores 0-50.
  • HCM Risk-SCD — Compute the O'Mahony 2014 HCM Risk-SCD 5-year sudden cardiac death probability from maximal wall thickness, left-atrial diameter, maximal LVOT gradient, family history of SCD, NSVT, unexplained syncope, and age.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

  • HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
  • exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
  • HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
  • Execution is timeout-bounded and concurrency-capped.
  • Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.