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Leibovich 2018 histology-specific RCC models

Leibovich 2018 RCC models

Sum the Leibovich 2018 progression-free score from caller-assigned histology, 2010 T and N, tumor size, nuclear grade, and necrosis, and return the published risk grouping for that histology.

LIVE $0.005 USDC GET /api/calc/leibovich_2018

Markdown: /docs/leibovich-2018.md · Canonical: https://magentlab.com/docs/leibovich-2018

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Sum the Leibovich 2018 progression-free score from caller-assigned histology, 2010 T and N, tumor size, nuclear grade, and necrosis, and return the published risk grouping for that histology.

When to use

When an agent already has surgical histology (clear cell, papillary, or chromophobe), 2010 pathologic T and N, size in cm, nuclear grade, and necrosis and needs the 2018 PFS total and low/intermediate/high group. magent does not stage the tumor or read slides, and must not invent an RCC diagnosis, SSIGN, or the 2003 Leibovich Cancer table.

When not to use

• Not a medical device. magent does not stage the tumor or read pathology.
• Leibovich 2018 histology-specific models only. Not Frank 2002 SSIGN (1997 TNM, size 5 cm, pT4 0). Not the 2003 Leibovich Cancer table (2002 TNM, T1b 2, T2 3, T3-4 4, necrosis 1, N1/N2).
• ccRCC uses 2010 TNM tokens and additive PFS points. The 2018 paper also published a nine-factor ccRCC PFS conversion (symptoms, sarcomatoid, fat, thrombus, extension) and a separate CSS score; those extra factors are not inputs here.
• Papillary groups use grade plus T as a fat/thrombus proxy. Chromophobe groups use T as a fat proxy plus N; sarcomatoid is not an input. Chromophobe has no CSS model in the paper.
• Size uses unrounded cm; 10.0 cm scores 1 on ccRCC. Magent clamp 0.1-30 cm is not a published range.
• Published groups are cohort strata, not an individualized prediction or a treatment recommendation. Not an RCC diagnosis.

Formula

ccRCC PFS (Leibovich 2018, 2010 TNM): t_stage (t1a/t1b/t2a 0, t2b 2, t3a/t3b/t3c 3, t4 4) + n_stage (nx/n0 0, n1 2) + tumor_size_cm >=10 1 + nuclear_grade (1-2 0, 3 1, 4 3) + necrosis 2; max 12; risk low 0-2, intermediate 3-5, high >=6. papillary PFS groups: low grade 1-2 and t1-t2; intermediate grade 3 and t1-t2; high grade 4 or t3a-t4 (fat or thrombus). chromophobe PFS groups: low t1-t2 and nx/n0; intermediate t3a-t4 and nx/n0 (fat); high n1. Not Frank 2002 SSIGN. Not Leibovich 2003. No chromophobe CSS model.

Citation

Title

Predicting Oncologic Outcomes in Renal Cell Carcinoma After Surgery

Authors

Leibovich BC, Lohse CM, Cheville JC, Zaid HB, Boorjian SA, Frank I, Thompson RH, Parker WP

Source

Eur Urol. 2018;73(5):772-780

DOI

10.1016/j.eururo.2018.01.005

Worked example

Also searched as

• Leibovich 2018
• 2018 Leibovich model
• ccRCC progression score
• papillary RCC risk group
• chromophobe RCC risk group
• histology-specific RCC score
• 2010 TNM RCC score
• Leibovich PFS groups

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/leibovich_2018?histology=clear_cell&t_stage=t1a&n_stage=n0&tumor_size_cm=3&nuclear_grade=2&necrosis=false

Full URL: https://api.magentlab.com/api/calc/leibovich_2018?histology=clear_cell&t_stage=t1a&n_stage=n0&tumor_size_cm=3&nuclear_grade=2&necrosis=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/leibovich_2018?histology=clear_cell&t_stage=t1a&n_stage=n0&tumor_size_cm=3&nuclear_grade=2&necrosis=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/leibovich_2018 Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "histology": "clear_cell",
      "n_stage": "n0",
      "necrosis": "false",
      "nuclear_grade": "2",
      "t_stage": "t1a",
      "tumor_size_cm": "3"
    },
    {
      "histology": "clear_cell",
      "n_stage": "n0",
      "necrosis": "false",
      "nuclear_grade": "2",
      "t_stage": "t1a",
      "tumor_size_cm": "3"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/leibovich_2018",
  "items": [
    {
      "components": [
        {
          "value": "t1a",
          "factor": "t_stage",
          "points": 0,
          "present": true
        },
        {
          "value": "n0",
          "factor": "n_stage",
          "points": 0,
          "present": true
        },
        {
          "value": 3.0,
          "factor": "tumor_size_cm",
          "points": 0,
          "present": false
        },
        {
          "value": 2,
          "factor": "nuclear_grade",
          "points": 0,
          "present": true
        },
        {
          "factor": "necrosis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Leibovich BC, Lohse CM, Cheville JC, Zaid HB, Boorjian SA, Frank I, Thompson RH, Parker WP",
        "doi": "10.1016/j.eururo.2018.01.005",
        "id": "leibovich-2018",
        "pmid": "29398265",
        "source": "Eur Urol. 2018;73(5):772-780",
        "title": "Predicting Oncologic Outcomes in Renal Cell Carcinoma After Surgery"
      },
      "formula": "leibovich_2018",
      "formula_expression": "ccRCC PFS (Leibovich 2018, 2010 TNM): t_stage (t1a/t1b/t2a 0, t2b 2, t3a/t3b/t3c 3, t4 4) + n_stage (nx/n0 0, n1 2) + tumor_size_cm >=10 1 + nuclear_grade (1-2 0, 3 1, 4 3) + necrosis 2; max 12; risk low 0-2, intermediate 3-5, high >=6. papillary PFS groups: low grade 1-2 and t1-t2; intermediate grade 3 and t1-t2; high grade 4 or t3a-t4 (fat or thrombus). chromophobe PFS groups: low t1-t2 and nx/n0; intermediate t3a-t4 and nx/n0 (fat); high n1. Not Frank 2002 SSIGN. Not Leibovich 2003. No chromophobe CSS model.",
      "max_score": 12,
      "score": 0,
      "risk": "low",
      "t_stage": "t1a",
      "histology": "clear_cell",
      "n_stage": "n0",
      "necrosis": false,
      "nuclear_grade": 2,
      "tumor_size_cm": 3.0
    },
    {
      "components": [
        {
          "value": "t1a",
          "factor": "t_stage",
          "points": 0,
          "present": true
        },
        {
          "value": "n0",
          "factor": "n_stage",
          "points": 0,
          "present": true
        },
        {
          "value": 3.0,
          "factor": "tumor_size_cm",
          "points": 0,
          "present": false
        },
        {
          "value": 2,
          "factor": "nuclear_grade",
          "points": 0,
          "present": true
        },
        {
          "factor": "necrosis",
          "points": 0,
          "present": false
        }
      ],
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Leibovich BC, Lohse CM, Cheville JC, Zaid HB, Boorjian SA, Frank I, Thompson RH, Parker WP",
        "doi": "10.1016/j.eururo.2018.01.005",
        "id": "leibovich-2018",
        "pmid": "29398265",
        "source": "Eur Urol. 2018;73(5):772-780",
        "title": "Predicting Oncologic Outcomes in Renal Cell Carcinoma After Surgery"
      },
      "formula": "leibovich_2018",
      "formula_expression": "ccRCC PFS (Leibovich 2018, 2010 TNM): t_stage (t1a/t1b/t2a 0, t2b 2, t3a/t3b/t3c 3, t4 4) + n_stage (nx/n0 0, n1 2) + tumor_size_cm >=10 1 + nuclear_grade (1-2 0, 3 1, 4 3) + necrosis 2; max 12; risk low 0-2, intermediate 3-5, high >=6. papillary PFS groups: low grade 1-2 and t1-t2; intermediate grade 3 and t1-t2; high grade 4 or t3a-t4 (fat or thrombus). chromophobe PFS groups: low t1-t2 and nx/n0; intermediate t3a-t4 and nx/n0 (fat); high n1. Not Frank 2002 SSIGN. Not Leibovich 2003. No chromophobe CSS model.",
      "max_score": 12,
      "score": 0,
      "risk": "low",
      "t_stage": "t1a",
      "histology": "clear_cell",
      "n_stage": "n0",
      "necrosis": false,
      "nuclear_grade": 2,
      "tumor_size_cm": 3.0
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "components": [
    {
      "value": "t1a",
      "factor": "t_stage",
      "points": 0,
      "present": true
    },
    {
      "value": "n0",
      "factor": "n_stage",
      "points": 0,
      "present": true
    },
    {
      "value": 3.0,
      "factor": "tumor_size_cm",
      "points": 0,
      "present": false
    },
    {
      "value": 2,
      "factor": "nuclear_grade",
      "points": 0,
      "present": true
    },
    {
      "factor": "necrosis",
      "points": 0,
      "present": false
    }
  ],
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Leibovich BC, Lohse CM, Cheville JC, Zaid HB, Boorjian SA, Frank I, Thompson RH, Parker WP",
    "doi": "10.1016/j.eururo.2018.01.005",
    "id": "leibovich-2018",
    "pmid": "29398265",
    "source": "Eur Urol. 2018;73(5):772-780",
    "title": "Predicting Oncologic Outcomes in Renal Cell Carcinoma After Surgery"
  },
  "formula": "leibovich_2018",
  "formula_expression": "ccRCC PFS (Leibovich 2018, 2010 TNM): t_stage (t1a/t1b/t2a 0, t2b 2, t3a/t3b/t3c 3, t4 4) + n_stage (nx/n0 0, n1 2) + tumor_size_cm >=10 1 + nuclear_grade (1-2 0, 3 1, 4 3) + necrosis 2; max 12; risk low 0-2, intermediate 3-5, high >=6. papillary PFS groups: low grade 1-2 and t1-t2; intermediate grade 3 and t1-t2; high grade 4 or t3a-t4 (fat or thrombus). chromophobe PFS groups: low t1-t2 and nx/n0; intermediate t3a-t4 and nx/n0 (fat); high n1. Not Frank 2002 SSIGN. Not Leibovich 2003. No chromophobe CSS model.",
  "max_score": 12,
  "score": 0,
  "risk": "low",
  "t_stage": "t1a",
  "histology": "clear_cell",
  "n_stage": "n0",
  "necrosis": false,
  "nuclear_grade": 2,
  "tumor_size_cm": 3.0
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• SSIGN score — Sum the Frank 2002 SSIGN score from caller-assigned 1997 TNM, tumor size, nuclear grade, and coagulative necrosis, and return the published cancer-specific survival row.
• Fuhrman — Echo the caller-assigned Fuhrman 1982 nuclear grade (1-4) with the published nuclear-feature description. magent does not read slides. Not WHO/ISUP 2016.

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.