Liver · LIVE

Up-to-seven HCC transplant criteria

Up-to-seven

Apply Mazzaferro 2009 Up-to-seven criteria and return whether tumor_count plus largest_cm is 7 or less without microvascular invasion (meets_up_to_seven).

LIVE $0.005 USDC GET /api/calc/up_to_7

Markdown: /docs/up-to-7.md · Canonical: https://magentlab.com/docs/up-to-7

Not a medical device. Not a diagnosis, dose, or listing recommendation.

What it computes

Apply Mazzaferro 2009 Up-to-seven criteria and return whether tumor_count plus largest_cm is 7 or less without microvascular invasion (meets_up_to_seven).

When to use

When an agent already has tumor count, largest diameter in centimetres, and a microvascular-invasion flag as in Mazzaferro 2009, and needs the published Up-to-seven eligibility result. magent does not interpret imaging or histology.

When not to use

• Not a medical device.
• Not a transplant listing or organ-allocation order.
• Pathology/explant-style inputs as assigned by the caller. magent does not interpret imaging or histology.
• This tool is Mazzaferro 2009 Up-to-seven criteria only. Not Milan criteria and not Metroticket 2.0 AFP-adjusted-to-HCC-size criteria.
• Not a website contour calculator.
• Does not output a survival percentage. The paper's 71.2% 5-year overall survival subgroup was patients without microvascular invasion who fell within up-to-seven; this tool returns the boolean criteria result only.

Formula

meets_up_to_seven iff size_number_sum <= 7 and not microvascular_invasion; size_number_sum = tumor_count + largest_cm (Mazzaferro 2009 Up-to-seven)

Citation

Title

Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis

Authors

Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, Camerini T, Roayaie S, Schwartz ME, Gonzalez FJ, et al.

Source

Lancet Oncol. 2009;10(1):35-43

DOI

10.1016/S1470-2045(08)70284-5

Worked example

Also searched as

• Up-to-seven
• Up-to-7 criteria
• Mazzaferro 2009
• beyond Milan HCC
• HCC size plus number
• up to seven transplant
• hepatocellular carcinoma beyond Milan
• liver transplant HCC up-to-seven

Try

Opens the live endpoint. Unpaid browser requests show the paywall; agents should send Accept: application/json.

/api/calc/up_to_7?tumor_count=3&largest_cm=4&microvascular_invasion=false

Full URL: https://api.magentlab.com/api/calc/up_to_7?tumor_count=3&largest_cm=4&microvascular_invasion=false

Call

Expect HTTP 402 until you retry with PAYMENT-SIGNATURE. Incomplete query params return HTTP 400 before any quote or charge.

curl -i -H "Accept: application/json" "https://api.magentlab.com/api/calc/up_to_7?tumor_count=3&largest_cm=4&microvascular_invasion=false"

Parameters

Bulk (POST)

POST the same path with a JSON items array. The first item is the GET unit; each additional item is $0.002. Invalid items return HTTP 400 before settlement.

POST /api/calc/up_to_7 Max 25 unit_amount + extra_item_amount * (n - 1) extra $0.002 PREVIEW

• 1 to 25 items. Each item uses the same keys as the GET query parameters.
• POST of 1 item costs the same as GET. Lists longer than 25: chunk into multiple POSTs. Extra items still execute; do not pad dummy rows.
• The first invalid item fails the whole request (index in the 400 JSON). You are not charged.
• HTTP 200 is {count, path, items}. Each items[i] is the GET 200 body for that row.
• Catalog misses (empty matches, found=false) stay paid 200s inside that slot.
• x402 resource URL is this path plus n and body_sha256. Browsers that prefer text/html get the same paywall as GET; Pay retries POST with the same items.

Example request (fixture)

{
  "items": [
    {
      "largest_cm": "4",
      "microvascular_invasion": "false",
      "tumor_count": "3"
    },
    {
      "largest_cm": "4",
      "microvascular_invasion": "false",
      "tumor_count": "3"
    }
  ]
}

Open bulk paywall →

Opens a two-item fixture on the API host. Unpaid browsers get the same MetaMask paywall as GET; Pay retries POST with those items.

Example 200 (fixture)

{
  "count": 2,
  "path": "/api/calc/up_to_7",
  "items": [
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, Camerini T, Roayaie S, Schwartz ME, Gonzalez FJ, et al.",
        "doi": "10.1016/S1470-2045(08)70284-5",
        "id": "mazzaferro-2009",
        "pmid": "19058754",
        "source": "Lancet Oncol. 2009;10(1):35-43",
        "title": "Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis"
      },
      "formula": "up_to_7",
      "formula_expression": "meets_up_to_seven iff size_number_sum <= 7 and not microvascular_invasion; size_number_sum = tumor_count + largest_cm (Mazzaferro 2009 Up-to-seven)",
      "criteria": [
        {
          "factor": "size_number_sum_le_7",
          "met": true
        },
        {
          "factor": "no_microvascular_invasion",
          "met": true
        }
      ],
      "largest_cm": 4.0,
      "tumor_count": 3,
      "size_number_sum": 7.0,
      "meets_up_to_seven": true,
      "microvascular_invasion": false
    },
    {
      "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
      "citation": {
        "authors": "Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, Camerini T, Roayaie S, Schwartz ME, Gonzalez FJ, et al.",
        "doi": "10.1016/S1470-2045(08)70284-5",
        "id": "mazzaferro-2009",
        "pmid": "19058754",
        "source": "Lancet Oncol. 2009;10(1):35-43",
        "title": "Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis"
      },
      "formula": "up_to_7",
      "formula_expression": "meets_up_to_seven iff size_number_sum <= 7 and not microvascular_invasion; size_number_sum = tumor_count + largest_cm (Mazzaferro 2009 Up-to-seven)",
      "criteria": [
        {
          "factor": "size_number_sum_le_7",
          "met": true
        },
        {
          "factor": "no_microvascular_invasion",
          "met": true
        }
      ],
      "largest_cm": 4.0,
      "tumor_count": 3,
      "size_number_sum": 7.0,
      "meets_up_to_seven": true,
      "microvascular_invasion": false
    }
  ]
}

Response

Example JSON

Machine form of the same example. Frozen fixture. Not a live lookup.

{
  "disclaimer": "Not a medical device. Deterministic published-formula or published-code output for autonomous agents. A licensed clinician remains responsible for patient care and billing submissions.",
  "citation": {
    "authors": "Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, Camerini T, Roayaie S, Schwartz ME, Gonzalez FJ, et al.",
    "doi": "10.1016/S1470-2045(08)70284-5",
    "id": "mazzaferro-2009",
    "pmid": "19058754",
    "source": "Lancet Oncol. 2009;10(1):35-43",
    "title": "Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis"
  },
  "formula": "up_to_7",
  "formula_expression": "meets_up_to_seven iff size_number_sum <= 7 and not microvascular_invasion; size_number_sum = tumor_count + largest_cm (Mazzaferro 2009 Up-to-seven)",
  "criteria": [
    {
      "factor": "size_number_sum_le_7",
      "met": true
    },
    {
      "factor": "no_microvascular_invasion",
      "met": true
    }
  ],
  "largest_cm": 4.0,
  "tumor_count": 3,
  "size_number_sum": 7.0,
  "meets_up_to_seven": true,
  "microvascular_invasion": false
}

Client errors (HTTP 400)

Invalid params return 400 without charge. Shared HTTP 402 and 503 meanings: Payments.

Related tools

• Milan — Apply Mazzaferro 1996 Milan criteria and return whether the published size, count, vascular-invasion, and extrahepatic rules all hold (meets_milan).
• Metroticket 2.0 — Apply Mazzaferro 2018 Metroticket 2.0 AFP-adjusted-to-HCC-size criteria and return whether a published 70% 5-year HCC-specific survival band holds (meets_70pct_hcc_specific_survival).

Payment

Unpaid requests return HTTP 402 even if query parameters or POST items are missing or invalid, so CDP and agents can index the path. After a PAYMENT-SIGNATURE, invalid params return HTTP 400 JSON before settlement. magent does not charge. Fix the params, then request a new 402 quote for that complete URL. Catalog misses (empty matches, found=false) are valid paid 200s. Unpaid valid requests return HTTP 402 with a base64 PAYMENT-REQUIRED header. HTTP 503 is not a new quote: retry the same PAYMENT-SIGNATURE. Full handshake and shared payment errors: Payments. Stdio MCP: /docs/mcp.

Guarantees

• HTTP 402 is unpaid, including a missing query. After PAYMENT-SIGNATURE, invalid parameters return HTTP 400 before settlement. You are not charged. HTTP 402 never includes the tool JSON.
• exact: settlement finishes before the tool (paymentFlow upfront). batch-settlement: verify/deposit before the tool; chargedCumulativeAmount commits after HTTP 2xx. Uncertain or failed settlement fails closed (HTTP 503). Retry the same PAYMENT-SIGNATURE.
• HTTP 402 is unpaid only. Do not sign a second authorization because of a 503.
• Execution is timeout-bounded and concurrency-capped.
• Calculator inputs are stored encrypted for allowlisted operators (Magent Console). They are not in public logs, SSH lookups, catalog, or rollups. Request logs store path without query.